Sharif Digital Repository

The Lab On a CD (LOCD), also known as Centrifugal Microfluidics, has evolved into a sophisticated platform for performing biomedical assays due to its marvelous miniaturization and accurate simulation of biological reactions. Among the numerous applications of the LOCD is fluid mixing. In this paper a centrifugal, serpentine micromixer is simulated and reformed toward better mixing performance. The micromixer was chosen to be curved as a curved design was found to be thrice as functional and compact as a rectilinear design, mixing-wise. The two angular velocity and opening radius parameters were originally hypothesized to affect mixing performance. Effect of angular velocity was studied over... 

The secondary flow of PTT fluids in rectangular cross-sectional plane of microchannels under combined effects of electroosmotic and pressure driving forces is the subject of the present study. Employing second-order central finite difference method in a very refined grid network, we investigate the effect of electrokinetic and geometric parameters on the pattern, strength and the average of the secondary flow. In this regard, we try to illustrate the deformations of recirculating vortices due to change in the dimensionless Debye–Hückel and zeta potential parameters as well as channel aspect ratio. We demonstrate that, in the presence of thick electric double layers, significant alteration... 

The performance of Co-flow fluidic thrust vectoring is a function of secondary flow characteristics and the fluidic nozzle geometry. In terms of nozzle geometry, wall shape and the secondary slot aspect ratio are the main parameters that control the vector angle. The present study aims to find a high quality wall shape to achieve the best thrust vectoring performance, which is characterized by the maximum thrust deflection angle with respect to the injected secondary air. A 3D computational fluid dynamics (CFD) model is employed to investigate the flow characteristics in thrust vectoring system. This model is validated using experimental data collected from the deflection of exhaust gases of... 

Mixing is an essential operation in many microfluidic devices. Droplet-based micromixers utilize droplets for mixing enhancement. In the present study, a novel three-dimensional simulation is conducted which has the ability to capture not only the mixing process, but also the chemical reactions inside liquid droplets. This two-phase model is used for simulating the reacting flow inside a serpentine microchannel and explores the effects of droplet size and reaction rate on the production and consumption of species in droplets. It is observed that the chemical reaction in each droplet, begins from its front area. Furthermore, it is shown that the production of species does not depend on water... 

The Lab On a CD (LOCD), also known as Centrifugal Microfluidics, has evolved into a sophisticated platform for performing biomedical assays due to its marvelous miniaturization and accurate simulation of biological reactions. Among the numerous applications of the LOCD is fluid mixing. In this paper a centrifugal, serpentine micromixer is simulated and reformed toward better mixing performance. The micromixer was chosen to be curved as a curved design was found to be thrice as functional and compact as a rectilinear design, mixing-wise. The two angular velocity and opening radius parameters were originally hypothesized to affect mixing performance. Effect of angular velocity was studied over... 

This paper presents a comprehensive 3D numerical simulation of reacting flows in micro scale dimension through centrifugal, or Lab-On-a-CD (LOCD), and pressure-driven, or Lab-On-a-Chip (LOC) devices. Three different serpentine channel configurations (rectangular, triangular and sinusoidal) are investigated. In these configurations, two chemical species enter from two inlets and according to an irreversible chemical reaction, start yielding other species. Both Newtonian and generalized Newtonian fluids are considered in the simulations and the results are compared for both LOC and LOCD devices. Besides, the effects of different parameters such as the aspect ratio of channels’ cross section,... 

Inertial particle focusing as a powerful passive method is widely used in diagnostic test devices. It is common to use a curved channel in this approach to achieve particle focusing through balancing of the secondary flow drag force and the inertial lift force. Here, we present a focusing device on a disk based on the interaction of secondary flow drag force, inertial lift force, and centrifugal forces to focus particles. By choosing a channel whose cross section has a low aspect ratio, the mixing effect of the secondary flow becomes negligible. To calculate inertial lift force, which is exerted on the particle from the fluid, the interaction between the fluid and particle is investigated... 

The feasibility of using fluidic thrust-vectoring system, as a control technique for the longitudinal and lateral trim purpose was investigated in this study. For this purpose, integration of a Co-flow method into the propulsion unit of a conceptual aerial vehicle was assumed. The focus of the research presented was to estimate the required thrust vector angle in order to trim the aerial vehicle in different flight phases. Since the fluidic thrust vectoring requires secondary air flow to deflect the engine exhaust gas, this research also provides an analytical toolset for preliminary sizing of a suitable secondary air supply. It was found that thrust vectoring could be an effective mean of... 

A new impeller configuration with innovatively-designed shrouds is introduced, and its impact on the pressure head and efficiency of the semi-open centrifugal pump is explored using experimental and numerical approaches. The proposed design includes attaching specific plates called bladelets to a semi-open impeller to limit the secondary flows over the blades resulting in an increase in the pump head and efficiency. Hydraulic performance of a centrifugal pump with three different bladelets at angles of 30°, 60°, and 90° is investigated experimentally, and the results are compared to semi-open and closed impellers. The values of pressure head and efficiency of the proposed centrifugal pump... 

Chemical bioreactions are an important aspect of many recent microfluidic devices, and their applications in biomedical science have been growing worldwide. Droplet-based microreactors are among the attractive types of unit operations, which utilize droplets for enhancement in both mixing and chemical reactions. In the present study, a finite-volume-method (FVM) numerical investigation is conducted based on the volume-of-fluid (VOF) applying for the droplet-based flows. This multiphase computational modeling is used for the study of the chemical reaction and mixing phenomenon inside a serpentine microchannel and explores the effects of the aspect ratio (i.e., AR = height/width) of...