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Biomechanical analysis of actin cytoskeleton function based on a spring network cell model
, Article Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science ; Volume 231, Issue 7 , 2017 , Pages 1308-1323 ; 09544062 (ISSN) ; Saidi, M. S ; Firoozabadi, B ; Sharif University of Technology
SAGE Publications Ltd
2017
Abstract
In this study, a new method for the simulation of the time-dependent behavior of actin cytoskeleton during cell shape change is proposed. For this purpose, a three-dimensional model of endothelial cell consisting of cell membrane, nucleus membrane, and main components of cytoskeleton, namely actin filaments, microtubules, and intermediate filaments is utilized. Actin binding proteins, which play a key role in regulating actin cytoskeleton behavior, are also simulated by using a novel technique. The actin cytoskeleton in this model is more dynamic and adoptable during cell deformation in comparison to previous models. The proposed model is subjected to compressive force between parallel micro...
Simulation of Dynamic Behavior of Endothelial Cell During Compression Test
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Firoozabadi, Bahar (Supervisor)
Abstract
Investigation of the behavior of living cells in different biological conditions could play a key role in exploring the main reasons of humans' disorders and diseases. In this regard, many researchers are studying different subjects related to the living cells. Although most of these research activities are based on experimental methods, numerical approach could be utilized to investigate some topics which cannot be studied by experimental methods.In this study a three dimensional model of endothelial cell is proposed for the investigation of cell performance during compression test. The model consists of cell membrane, nucleus and main components of cytoskeleton, namely actin filaments,...