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targeted-drug-delivery
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Electrospray: novel fabrication method for biodegradable polymeric nanoparticles for further applications in drug delivery systems
, Article NANOCON 2009 - 1st International Conference, Conference Proceedings ; 2009 , Pages 324-331 ; 9788087294130 (ISBN) ; Vossoughi, M ; Sharif University of Technology
TANGER Ltd
2009
Abstract
Electrospray is an old processing technique that has recently been rediscovered. This technology is revolutionizing the biomaterials and nanotechnology fields by opening up new areas of research in fabricating drug delivery nano-devices. Due to their size, nanoparticles have the advantage of reaching less accessible sites in the body by escaping phagocytosis and entering tiny capillaries. Nanoparticles also have the unique property to accumulate at the site of inflammation and therefore, are very suitable for targeted drug delivery. The feasibility of fabricating relatively monodispersed polymeric nanoparticles by electrospray method in a modified electrospray setup is demonstrated in this...
In vitro bactericidal and drug release properties of vancomycin-amino surface functionalized bioactive glass nanoparticles
, Article Materials Chemistry and Physics ; Volume 241 , 2020 ; Ghorbani, M ; Bagheri, K.P ; Shokrgozar, M. A ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
Bioactive glass has been used clinically in bone repair applications for bone grafting because of its prominent physiochemical and osteogenic properties. Various attempts have been made to enhance bioactive glass efficiency in combination with other biomaterials such as antibiotics and growth factors. In present study, we developed a modification of bioactive glass nanoparticles that insured long term antibacterial effect. Bioactive glass nanoparticles (BGNs) were functionalized with (3-Aminopropyl) triethoxysilane (APTS), then vancomycin (VAN) was immobilized onto BGNs-APTS via EDC/NHS cross-linking process. Another study group namely BGNs-VAN was synthesized as a control group without any...
Core-sheath gelatin based electrospun nanofibers for dual delivery release of biomolecules and therapeutics
, Article Materials Science and Engineering C ; Volume 108 , 2020 ; Lotfi, R ; Tamjid, E ; Shokrgozar, M. A ; Simchi, A ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
Coaxial electrospinning with the ability to use simultaneously two separate solvents provides a promising strategy for drug delivery. Nevertheless, controlled release of hydrophilic and sensitive therapeutics from slow biodegradable polymers is still challenging. To address this gap, we fabricated core-sheath fibers for dual delivery of lysozyme, as a model protein, and phenytoin sodium as a small therapeutic molecule. The sheath was processed by a gelatin solution while the core fibers were fabricated from an aqueous gelatin/PVA solution. Microstructural studies by transmission and scanning electron microscopy reveal the formation of homogeneous core-sheath nanofibers with an outer and...
Nonlinear composite adaptive control of cancer chemotherapy with online identification of uncertain parameters
, Article Biomedical Signal Processing and Control ; Volume 49 , 2019 , Pages 360-374 ; 17468094 (ISSN) ; Moradi, H ; Sharif University of Technology
Elsevier Ltd
2019
Abstract
A new composite adaptive control strategy is developed for both of the reduction of cancer tumor volume and the online identification of tumor parameters during the drug delivery process in chemotherapy. This control strategy is developed for three different nonlinear mathematical cell-kill models of the cancer tumor including the log-kill hypothesis, Norton-Simon hypothesis and Emax hypothesis. All of these models are considered to have fully parametric uncertainties. The stability, tracking convergence and parameters identification convergence during the chemotherapy process are proved using the Lyapunov method. For the first time, the parameters identification of the uncertain...
Modeling of an ultrasound system in targeted drug delivery to abdominal aortic aneurysm: a patient-specificin silico study based on ligand-receptor binding
, Article IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control ; Volume 69, Issue 3 , 2022 , Pages 967-974 ; 08853010 (ISSN) ; Boroumand, A ; Ebrahimi, S ; Kalantarnia, F ; Maleki, S ; Moradi, H ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2022
Abstract
Targeted drug delivery methods have shown a significant impact on enhancing drug delivery efficiency and reducing drug side effects. While various stimuli have been used to promote the drug delivery process, applying ultrasound (US) waves to control drug particles through the human body, noninvasively, has drawn the scientist's attention. However, microcarriers delivery reaches the aneurysmal artery by US waves that exert volumetric forces on blood, and drug carriers, which can therefore affect blood flow patterns and movement pathways of drug carriers, have not yet been studied. In this study, we developed a 3-D patient-specific model of abdominal aortic aneurysm (AAA) to evaluate the...
Targeted drug delivery of magnetic microbubble for abdominal aortic aneurysm: an in silico study
, Article Biomechanics and Modeling in Mechanobiology ; Volume 21, Issue 2 , 2022 , Pages 735-753 ; 16177959 (ISSN) ; Ebrahimi, S ; Ghorbani, G ; Alishiri, M ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Targeted drug delivery (TDD) to abdominal aortic aneurysm (AAA) using a controlled and efficient approach has recently been a significant challenge. In this study, by using magnetic microbubbles (MMBs) under a magnetic field, we investigated the MMBs performance in TDD to AAA based on the amount of surface density of MMBs (SDMM) adhered to the AAA lumen. The results showed that among the types of MMBs studied in the presence of the magnetic field, micromarkers are the best type of microbubble with a −50 % increase in SDMM adhered to the critical area of AAA. The results show that applying a magnetic field causes the amount of SDMM adhered to the whole area of AAA to increase −1.54 times...
Protein corona impact on nanoparticle-cell interactions: Toward an energy-based model of endocytosis
, Article Journal of Physics Condensed Matter ; Volume 32, Issue 11 , 2020 ; Mehrafrooz, B ; Montazeri, A ; Naghdabadi, R ; Sharif University of Technology
Institute of Physics Publishing
2020
Abstract
Upon incubation of nanoparticles in biological fluids, a new layer called the protein corona is formed on their surface affecting the interactions between nanoparticles and targeted cells during the endocytosis process. In the present study, a mathematical model based on the diffusion of membrane mobile receptors is proposed. Opposing the endocytosis proceeding, membrane bending and tension energies are named as resistant energy. Also, the binding energy and free-energy associated with the configurational entropy are collectively termed promoter energy. Utilizing this model, endocytosis of gold nanoparticle (GNP) is simulated to explore the biological media effect. The results reveal that...
Forced and free vibrational analysis of viscoelastic nanotubes conveying fluid subjected to moving load in hygro-thermo-magnetic environments with surface effects
, Article Archives of Civil and Mechanical Engineering ; Volume 22, Issue 4 , 2022 ; 16449665 (ISSN) ; Alibeigloo, A ; Borjalilou, V ; Koochakianfard, O ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Forced and free vibrational analyses of viscoelastic nanotubes containing fluid under a moving load in complex environments incorporating surface effects are conducted based on the nonlocal strain gradient theory and the Rayleigh beam model. To model the internal nanoflow, the slip boundary condition is employed. Adopting the Galerkin discretization approach, the reduced-order dynamic model of the system is acquired. Analytical and numerical methods are exploited to determine the dynamic response of the system. The impacts of geometry, scale parameter ratio, Knudsen number, fluid velocity, rotary inertia parameter, viscoelastic parameter, surface residual stress, surface elastic modulus, and...
Drug delivery systems and materials for wound healing applications
, Article Advanced Drug Delivery Reviews ; Volume 127 , 2018 , Pages 138-166 ; 0169409X (ISSN) ; Rinoldi, C ; Schot, M ; Saheb Kashaf, S ; Sharifi, F ; Jalilian, E ; Nuutila, K ; Giatsidis, G ; Mostafalu, P ; Derakhshandeh, H ; Yue, K ; Swieszkowski, W ; Memic, A ; Tamayol, A ; Khademhosseini, A ; Sharif University of Technology
Elsevier B.V
2018
Abstract
Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug...
Customizing nano-chitosan for sustainable drug delivery
, Article Journal of Controlled Release ; Volume 350 , 2022 , Pages 175-192 ; 01683659 (ISSN) ; Vahidi, O ; Moghbeli, M ; Ahmadi, S ; Asadnia, M ; Akhavan, O ; Seidi, F ; Rabiee, M ; Saeb, M. R ; Webster, T. J ; Varma, R. S ; Sharifi, E ; Zarrabi, A ; Rabiee, N ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in...
Metal-organic frameworks-based nanomaterials for drug delivery
, Article Materials ; Volume 14, Issue 13 , 2021 ; 19961944 (ISSN) ; Rabiee, N ; Mozafari, M ; Mostafavi, E ; Sharif University of Technology
MDPI AG
2021
Abstract
The composition and topology of metal-organic frameworks (MOFs) are exceptionally tailorable; moreover, they are extremely porous and represent an excellent Brunauer–Emmett–Teller (BET) surface area (≈3000–6000 m2·g−1). Nanoscale MOFs (NMOFs), as cargo nanocarriers, have increasingly attracted the attention of scientists and biotechnologists during the past decade, in parallel with the evolution in the use of porous nanomaterials in biomedicine. Compared to other nanoparticle-based delivery systems, such as porous nanosilica, nanomicelles, and dendrimer-encapsulated nanoparticles, NMOFs are more flexible, have a higher biodegradability potential, and can be more easily functionalized to meet...
Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery
, Article Journal of Materials Chemistry B ; Volume 8, Issue 32 , 2020 , Pages 7275-7287 ; Ji, J ; Lotocki, V ; Moquin, A ; Hanna, R ; Frounchi, M ; Maysinger, D ; Kakkar, A ; Sharif University of Technology
Royal Society of Chemistry
2020
Abstract
Easily assembled and biocompatible chitosan/hyaluronic acid nanoparticles with multiple stimuli-responsive ability are ideally suited for efficient delivery of therapeutic agents under specific endogenous triggers. We report a simple and versatile strategy to formulate oxidative stress and pH-responsive chitosan/hyaluronic acid nanocarriers with high encapsulation efficiencies of small drug molecules and nerve growth factor protein. This is achieved through invoking the dual role of a thioketal-based weak organic acid to disperse and functionalize low molecular weight chitosan in one-pot. Thioketal embedded chitosan/hyaluronic acid nanostructures respond to oxidative stress and show...
Stimuli-responsive chitosan as an advantageous platform for efficient delivery of bioactive agents
, Article Journal of Controlled Release ; Volume 317 , 2020 , Pages 216-231 ; Tavakolian, M ; Yazdani, H ; Frounchi, M ; van de Ven, T. G. M ; Maysinger, D ; Kakkar, A ; Sharif University of Technology
Elsevier B.V
2020
Abstract
Despite a diverse range of active pharmaceutical agents currently at our disposal, high morbidity rate diseases continue to pose a major health crisis globally. One of the important parameters in this regard is the controlled cargo delivery at desired sites. Among a variety of synthetic and natural macromolecular systems, chitosan, an abundant biopolymer, offers a platform for tailored architectures that could have high loading capacity of cargo, target and deliver. Stimuli directed accumulation of vehicles and drug release is an area of direct relevance to biomedical applications. In this review, we highlight essential characteristics of modified chitosan that present themselves for...
Rigorous silica solubility estimation in superheated steam: Smart modeling and comparative study
, Article Environmental Progress and Sustainable Energy ; Volume 38, Issue 4 , 2019 ; 19447442 (ISSN) ; Shokrollahi, A ; Esmaeili Jaghdan, Z ; Ghazanfari, M. H ; Sharif University of Technology
John Wiley and Sons Inc
2019
Abstract
One of the main issues of wastewater treatment is the silica deposition in steam turbines. Evaporation of silica with the steam in adequate concentration is one of the main sources of scale formation in steam turbines. In this study, the authors introduce the utilization of a genetic-based approach—gene expression programming (GEP)—for solubility prognostication of the silica in superheated steam of boilers with respect to water silica content and pressure. The result of GEP mathematical approach is a new algebraic formula to achieve our goals. Developed model predicts the silica solubility in the range of 0.8–22.1 MPa and 1–500 mg/kg for pressure and boiler water silica content,...
Electrophoretic encapsulation for slow release of vancomycin from perpendicular TiO2 nanotubes grown on Ti6Al4V electrodes
, Article Materials Research Express ; Volume 6, Issue 12 , 2019 ; 20531591 (ISSN) ; https://iopscience.iop.org/article/10.1088/2053-1591/ab6c98 ; Ahmadi Seyedkhani, S ; Sadrnezhaad, S. K ; Sharif University of Technology
Institute of Physics Publishing
2019
Abstract
Ordered perpendicular TiO2 nanotubes (TNT) with 405 to 952 nm length and 60 to 90 nm diameter were grown via 40 to 120 min anodization of Ti6Al4V flat substrates. The samples were called TNT-40, -60, -80, -100, and -120. Vancomycin was loaded on the bare and anodized electrodes by separate immersion and electrophoretic (EP) deposition procedures. EP loading resulted in storage capacity of 5221.86 μg cm-2 for TNT-80 which was much higher than 1036.75 μg cm-2 of immersed sample. Drug release comprised of three stages: (i) burst release (78% for the bare, and 23% for the TNT-80 sample), (ii) gradual transport (21% for the bare, and 64% for the TNT-80 sample), and (iii) equilibrium. Transfer...
Electrophoretic encapsulation for slow release of vancomycin from perpendicular TiO2 nanotubes grown on Ti6Al4V electrodes
, Article Materials Research Express ; Volume 6, Issue 12 , 2019 ; 20531591 (ISSN) ; Ahmadi Seyedkhani, S ; Sadrnezhaad, S. K ; Sharif University of Technology
Institute of Physics Publishing
2019
Abstract
Ordered perpendicular TiO2 nanotubes (TNT) with 405 to 952 nm length and 60 to 90 nm diameter were grown via 40 to 120 min anodization of Ti6Al4V flat substrates. The samples were called TNT-40, -60, -80, -100, and -120. Vancomycin was loaded on the bare and anodized electrodes by separate immersion and electrophoretic (EP) deposition procedures. EP loading resulted in storage capacity of 5221.86 μg cm-2 for TNT-80 which was much higher than 1036.75 μg cm-2 of immersed sample. Drug release comprised of three stages: (i) burst release (78% for the bare, and 23% for the TNT-80 sample), (ii) gradual transport (21% for the bare, and 64% for the TNT-80 sample), and (iii) equilibrium. Transfer...
Curcumin incorporated PVA-borax dual delivery hydrogels as potential wound dressing materials—Correlation between viscoelastic properties and curcumin release rate
, Article Journal of Applied Polymer Science ; Volume 135, Issue 45 , 2018 ; 00218995 (ISSN) ; Pircheraghi, G ; Bagheri, R ; Sharif University of Technology
John Wiley and Sons Inc
2018
Abstract
Poly(vinyl alcohol) (PVA) is a biocompatible polymer which can be physically crosslinked by Borax to form hydrogel. PVA-Borax (PB) hydrogel is a promising candidate for drug delivery system. Therefore, it is necessary to find the quantitative relationship between drug release rate and network structure of PB hydrogels to predict and control drug release rate. In this work, at first step the optimum ratio of Borax: PVA was determined by studying the interactions between PVA chains and Borax molecules by means of Fourier transform infrared spectroscopy, while viscoelastic properties of prepared PB hydrogels were measured in the oscillatory shear flow field. In the following, curcumin as a...
Gold nanoparticles loaded into niosomes: A novel approach for enhanced antitumor activity against human ovarian cancer
, Article Advanced Powder Technology ; Volume 32, Issue 12 , 2021 , Pages 4711-4722 ; 09218831 (ISSN) ; Ferdowsian, S ; Hajrasouliha, S ; Kazempoor, R ; Mirzaie, A ; Sedigh Dakkali, M ; Akbarzadeh, I ; Mohammadmahdi Meybodi, S ; Mirghafouri, M ; Sharif University of Technology
Elsevier B.V
2021
Abstract
In the current study, gold nanoparticles (AuNPs) were prepared using the green synthesis method using Artemisia annua extract, loaded into niosomes, and investigated their cytotoxicity and apoptotic effects. To optimize the niosomal formulation containing AuNPs, the effects of surfactants: cholesterol molar ratio, Span 60: Tween 60 M ratio, and AuNP concentration (µg/mL) were investigated. After examining the drug release profile, mathematical models were assessed to predict release kinetic. The cytotoxicity of noisome encapsulated AuNPs and free AuNPs was evaluated against human ovarian cancer cell line (A2780) by MTT assay. The apoptotic/necrosis ratio was studied using flow cytometry as...
Doxorubicin-conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy
, Article Journal of Drug Targeting ; Volume 26, Issue 3 , 2018 , Pages 267-277 ; 1061186X (ISSN) ; Eskandani, M ; Johari Ahar, M ; Nemati, A ; Akbari, H ; Davaran, S ; Omidi, Y ; Sharif University of Technology
Taylor and Francis Ltd
2018
Abstract
Nanoscaled quantum dots (QDs), with unique optical properties have been used for the development of theranostics. Here, InP/ZnS QDs were synthesised and functionalised with folate (QD-FA), D-glucosamine (QD-GA) or both (QD-FA-GA). The bi-functionalised QDs were further conjugated with doxorubicin (QD-FA-GA-DOX). Optimum Indium to fatty acid (In:MA) ratio was 1:3.5. Transmission electron microscopy (TEM) micrographs revealed spherical morphology for the QDs (11 nm). Energy-dispersive spectroscopy (EDS) spectrum confirmed the chemical composition of the QDs. MTT analysis in the OVCAR-3 cells treated with bare QDs, QD-FA, QD-GA, QD-FA-GA and QD-FA-GA-DOX (0.2 mg/mL of QDs) after 24 h indicated...
2D MXene nanocomposites: electrochemical and biomedical applications
, Article Environmental Science: Nano ; Volume 9, Issue 11 , 2022 , Pages 4038-4068 ; 20518153 (ISSN) ; Nourmohammadi Khiarak, B ; Tao, R ; Wang, Z ; Ahmadi, S ; Hassanpour, M ; Rabiee, M ; Saeb, M. R ; Lima, E. C ; Rabiee, N ; Sharif University of Technology
Royal Society of Chemistry
2022
Abstract
In recent years, key questions about the interaction of 2D MXene nanomaterials in electrochemical and biomedical applications have been raised. Most research has focused on clarifying the exclusive properties of the materials; however, only limited reports have described the biomedical applications of 2D nanomaterials. 2D MXenes are monolayer atomic nanosheets resulting from MAX phase ceramics. The hydrophilic properties, metallic conductivity, stability, and exclusive physiochemical performances make them promising materials for electrochemical and biomedical applications, including CO2 reduction, H2 evolution, energy conversion and storage, supercapacitors, stimuli-responsive drug delivery...