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Lithium perchlorate mediated three-component preparation of α-aminonitriles under solvent-free conditions
, Article Synthetic Communications ; Volume 34, Issue 7 , 2004 , Pages 1207-1214 ; 00397911 (ISSN) ; Saidi, M. R ; Sharif University of Technology
2004
Abstract
A three-component reaction between aliphatic or aromatic aldehyde, an amine and trimethylsilyl cyanide mediated by solid LiClO4, gave amino nitriles in good to excellent yields. The reaction proceeded smoothly under solvent-free conditions without any side products