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Numerical Modeling of Treatment of Liver Tissue Cancer by Using High Intensity Focused Ultrasound (Hifu)
, Ph.D. Dissertation Sharif University of Technology ; Firoozabadi, Bahar (Supervisor)
Abstract
In recent years, the incidence rate of liver cancer has increased sharply and nowadays liver cancer is known as the second leading cause of cancer death in the world. Surgical resection is usually used to treat malignant hepatic tumors. However, in some cases, surgical resection is not possible because of some reasons, such as tumor size and location. In these cases, other minimally invasive ablation methods such as radio-frequency ablation, microwave ablation, and high intensity focused ultrasound (HIFU) can be used. HIFU has some advantages such as noninvasiveness, high penetration depth, and low cost in comparison to the other ablation techniques such as radiofrequency ablation. In HIFU...
Numerical study of the effect of vascular bed on heat transfer during high intensity focused ultrasound (HIFU) ablation of the liver tumor
, Article Journal of Thermal Biology ; Volume 86 , 2019 ; 03064565 (ISSN) ; Firoozabadi, B ; Sharif University of Technology
Elsevier Ltd
2019
Abstract
In this study, the influence of vascular bed comprising terminal arterial branches on heat transfer in a liver tumor exposed to high intensity focused ultrasound (HIFU) is studied numerically. Also, the effect of vascular density on temperature distribution is investigated. A coupled set of acoustics, thermal, and fluid models is used to calculate the temperature distribution in the liver. The numerical model is established based on the Westervelt and bioheat equations along with the Navier-Stokes equations. Moreover, the acoustic streaming effect is included with Newtonian and non-Newtonian flow assumptions. It is found that in a vascular bed comprising terminal arterial branches, the...