Sharif Digital Repository

Monitoring conformational changes in ion channels is essential to understand their gating mechanism. Here, we explore the structural dynamics of four outer membrane proteins with different structures and functions in the slowest nonzero modes of vibration. Normal mode analysis was performed on the modified elastic network model of channel in the membrane. According to our results, when membrane proteins were analyzed in the dominant mode, the composed pores, TolC and α-hemolysin showed large motions at the intramembrane β-barrel region while, in other porins, OmpA and OmpF, largest motions observed in the region of external flexible loops. A criterion based on equipartition theorem was used... 

One of the major limitations of the multilevel converters is the voltage unbalance between different levels. The techniques to balance the voltage between the different levels normally involve voltage clamping or capacitor charge and discharge control. However, traditional Flying Capacitor Converter (FCC) may be quite limited by the voltage unbalance of flying-capacitors that is the most serious problem. This paper describes operating principles of a new softswitching seven-level converter topology based on FCC for self-voltage stabilization and balancing. By adding power electronic devices to the traditional FCC topology, the proposed topology regulates the DC bus voltage and balances the...