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bioglass
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Electrophoretic Deposition of Alginate-Bioglass-Nanodiamond Nanocomposites and Evolution of their Bioactivity
, M.Sc. Thesis Sharif University of Technology ; Simchi, Abdollreza (Supervisor)
Abstract
Recently, diamond nanoparticles have attracted interest for biomedical applications such as drug delivery, targeted cancer therapies, fabrication of tissue scaffolds and biosensors. In the present work, elecrophoretic deposition (EPD) of nanodiamond-bioactive glass-alginate nanocomposite was studied. In vitro bioactivity and biocompatibility of the nanocomposite were evaluated in simulated body fluid (SBF) and by MTT assay. The EPD process was performed under different conditions in order to obtain a uniform coating on the surface of 316L stainless steel substrate. The stability of the suspension was determined via optical sedimentation method and zeta potential analysis. It was found that...
Design and Fabrication of Biodegradable Polymeric Scaffold with nano-Bioglass for Osteoblast cell Growth
, M.Sc. Thesis Sharif University of Technology ; Vossoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor) ; Tamjid Shabesteri, Elnaz (Co-Advisor)
Abstract
Treatment of critical-size bone defects caused by sport injuries, accidents, trauma, infection, and osteoporosis remains a major clinical challenge. In order to repair or regenerate large bone defects, bioactive three-dimensional scaffolds play a key role due to their multilevel porous structure, high surface area, enhanced mass transport and diffusion. Many studies reported that macropore diameters greater than 500 µm can lead to vascularized bone tissue. In this study, a hierarchically porous composite scaffold was prepared. Hierarchically porous silk fibroin- bioactive glass composite and fibroin scaffold were fabricated with controlled architecture and interconnected structure with...
Synthesis of Antibiotic-eluting Chitosan-based Composite Coating by Electrophoretic Deposition for Bone Implants
, M.Sc. Thesis Sharif University of Technology ; Simchi, Abdol Reza (Supervisor) ; Bagheri, Reza (Supervisor)
Abstract
Drug-eluting bone implant coatings is a new era that has gained a lot of attention in recent years. In this matter, drug is loaded in the coating and local and targeted release of the drug results in preventing the side effects of implantation and increasing the healing process of the patient. The aim of this project was to synthesis the antibiotic eluting chitosan-based composite using electrophoretic deposition for bone implant coating. By using electrophoretic deposition chitosan and chitosan-bioglass composite coatings were synthesized. Then the probability of loading of drug into coating by using electrophoretic deposition was evaluated and by using this process chitosan and...