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Simulation of Flow and Mass Transfer in Microfluidic Systems of Human Body
, Ph.D. Dissertation Sharif University of Technology ; Abd Khodaei, Mohammad Jafar (Supervisor) ; Farhadi, Fathollah (Supervisor) ; Pishvaie, Mahmoud Reza (Supervisor)
Abstract
The effects of gravity and inertia dominate our experiences of the physical world. But as systems are reduced in size, phenomena such as diffusion, surface tension and viscosity become ever more important; at the microscale they can dominate and result in a world that operates very differently from the macroscopic world. Kidney is one of the vital organs in which fluid and mass transfer occur between blood flow in microvessels and urine in microchannels called nephron. The present work is aimed at applying microchannel theory to study renal system. First, a n efficient numerical orthogonal collocation method has been employed to solve the steady-state formulation of electrolyte transport in...
Urine Analysis by a Microfluidic Paper-Based Device for Renal Function Test
, M.Sc. Thesis Sharif University of Technology ; Saadatmand, Maryam (Supervisor)
Abstract
Chronic kidney disease is one of the silent diseases that progresses slowly, often without symptoms, and can eventually lead to kidney loss. Early detection of this disease can help diagnose it and prevent further problems. Urinary creatinine is an effective biomarker for early diagnosis of chronic kidney disease, but methods available in clinics are problematic for people living in disadvantaged areas because of the high cost and the need for 24-hour urine collection. Currently, paper-based microfluidic devices are being developed because they are easy to manufacture, inexpensive, the fluid is permeable by capillary force, and no additional equipment is needed. In this work, to fabricate a...