Sharif Digital Repository

The COVID-19 outbreak has triggered a massive research, but still urgent detection and treatment of this virus seems a public concern. The spread of viruses in aqueous environments underlined efficient virus treatment processes as a hot challenge. This review critically and comprehensively enables identifying and classifying advanced biochemical, membrane-based and disinfection processes for effective treatment of virus-contaminated water and wastewater. Understanding the functions of individual and combined/multi-stage processes in terms of manufacturing and economical parameters makes this contribution a different story from available review papers. Moreover, this review discusses... 

Background: The development of colon cancer has been described as a multistep process of carcinogenesis. Understanding molecular and cellular changes underlying this process is required to determine potential biomarkers and therapeutic targets in colon cancers. Several molecular entities, including glypicans, are implicated in cancer development. Among these is glypican-6, which is overexpressed in a limited number of cancers. This study aims to characterise the glypican-6 expression in different types of colon cancer. Methods: Immunohistochemistry was used to characterise glypican-6 expression in a panel of archived formalin-fixed, paraffin-embedded colon tissue types. These types included... 

This paper proposes a robust investment and operation model to attend the power and heat needs of a microgrid (MG) connected to the distribution system. The optimization algorithm decides on the best investment and operation of combined heat and power (CHP), boilers, PV power generation and battery energy storage systems (BESS). For the BESS, the algorithm estimates the optimal energy storage capacity (MWh) as well as the maximum hourly delivery capacity (MW). The non-linear and non-concave heat rate chart is recast by a mix-integer linear model to have a tractable and precise model. The model considers the uncertain in some parameters using probability density function (pdf) to portrait its... 

Background: cervical cancer is one of the most common malignancies in women worldwide and its management remains challenging and complex. As Cytochrome4Z1 (CYP4Z1) is overex-pressed in many tumours, its expression in cervical cancer is unknown. Therefore, the present study aimed to evaluate CYP4Z1 expression in cervical cancers. Methods: CYP4Z1 expression was immunohistochemically assessed in 100 cases of cervical cancers along with ten normal cervix tissues, and the enzyme’s relationship to several clinicopathological features and survival was explored. Results: CYP4Z1 was strongly expressed in 55% of cervical cancer patients. Normal cervix samples were negative for CYP4Z1 expression.... 

In the endurance time (ET) method, structures are subjected to a specially designed intensifying ground acceleration function and their performance is judged based on their response at various excitation levels. A range of equivalent intensities can be covered in a single numerical or experimental simulation, thus significantly reducing the computational demand as compared to full nonlinear response-history analyses. The applied excitation intensity at various times has been correlated with those of the scaled ground motions. Response spectra of seven ground motions on stiff soil were used to produce intensifying acceleration functions that at each time window produce a response spectrum... 

Permeability reduction in porous media as a result of frail and tenuous fine particles migration would decrease the productivity index in the subterranean reservoirs. During reservoir stimulation by injecting fluids into the reservoir, as the salinity condition of the formation brine changes, fine particles initiate the triggering process. In this study, MgO-based nanofluid as a fines fixation agent was stably prepared based on the particle size distribution and characterized through transmission electron microscopy analysis. Afterward, several core flooding tests were performed using Berea sandstone cores to study the effect of nanofluid injection on fines fixation in the water shock... 

The dynamic equivalent inclusion method (DEIM) which was first proposed by Fu and Mura (1983), in its original context has some shortcomings, which were pointed out and remedied by Shodja and Delfani (2009) who introduced the new consistency conditions along with the related micromechanically substantiated notion of eigenstress and eigenbody-force fields. However, these theories are bound to elastic media with isotropic phases. The present work extends the idea of the above-mentioned new DEIM to the dynamic electro-mechanical equivalent inclusion method (DEMEIM) for the treatment of the scattering of SH-waves by a two-phase circular piezoelectric obstacle bonded to a third phase... 

This paper puts forth a wavelet-based methodology for generating endurance time (ET) excitations. Conventional simulating practice expresses signals by acceleration values which are then computed via unconstrained nonlinear optimization. Dynamic characteristics of signals, including frequency content, are not represented directly in this type of variable definition. In this study, a new algorithm is developed to generate ET excitations in discrete wavelet transform (DWT) space. In this algorithm, signals are represented by transform coefficients. In addition, objective functions are modified in order to obtain transform coefficients and return the objective function values. The proposed... 

The endurance time (ET) method is a dynamic analysis in which structures are subjected to intensifying excitations, also known as ET excitation functions (ETEF). The ET method is a tool for structural response prediction. The main advantage of the ET method over conventional approaches is its much lower demand for computational efforts. The concept of acceleration spectra is used in generating existing ETEFs. It is expected that ETEF acceleration spectra increase consistently with time and remain proportional to a target spectrum. Nonlinear unconstrained optimization is commonly used to generate ETEFs. Generating new ETEFs is a complicated time-consuming mathematical problem. If the target... 

The relatively large number of structural elements and the variety of design code requirements complicate the design process of tall buildings. This process is exacerbated when the target is to obtain the seismic code-compliant optimal design with minimum weight. The present paper aims at providing a practical methodology for the optimal design of steel tall building structures considering the constraints imposed by typical building codes. The applicability of the proposed approach is demonstrated through the determination of the optimal seismic design for 20-, 40-, and 60-story buildings with a framed tube as well as a tube-in-tube system. Such a design gives rise to a basis for the fair... 

Purpose: Triple-negative breast cancer (TNBC) is characterized by high mortality rate, and its clinical management is difficult and complex. Therefore, there is a need for extensive efforts aimed at accelerating the discovery of novel therapies for TNBC. CYP4Z1 has been implicated in the development of breast cancer. The current study aimed at characterizing the expression of CYP4Z1 on TNBC. Materials and Methods: Using immunohistochemistry, CYP4Z1 expression was evaluated on 122 TNBC samples, four samples of breast cancers expressing ER, PR, and HER-2, and four samples of normal breast tissues. The association between the enzyme and various histopathological features and survival of... 

This paper presents a two layer texture modeling method to recognize architectural distortion in mammograms. We propose a method that models a Gaussian mixture on the Curvelet coefficients and the outputs of Spiculated Lesion Filters. The Curvelet transform and the Spiculated Lesion Filters have been applied to extract textural features of mammograms in literature. However the key difference between this study and the previous ones is that in our approach, a Gaussian mixture models the textural features extracted by the Curvelet transform and the Spiculated Lesion Filters. The results of the current study are shown in the form of accuracy and the area under the receiver operating... 

In this study, two moving-bed biofilm reactors (MBBR1 and MBBR2) filled with different size of carrier media (Kaldnes K1 and Kaldnes K1 micro, respectively) were subjected to soluble (sugar and sodium acetate (Ac)) substrate and mixture of soluble and particulate (particulate potato starch (PS)) substrate in a very high organic loading rate (12 kgCOD/m3·d) at different temperatures (26 and 15°C, in MBBR1 and MBBR2, respectively). The effects of carrier type and substrate on biofilm structure and reactor performance have been studied. Starch was removed by adsorption at the biofilm surface and hydrolyzed which caused substrate gradient in MBBR1, however, hydrolyzed uniformly within biofilm in... 

I-vectors have proved to be the most effective features for text-independent speaker verification in recent researches. In this article a new scheme is proposed to utilize i-vectors in text-prompted speaker verification in a simple while effective manner. In order to examine this scheme empirically, a telephony dataset of Persian month names is introduced. Experiments show that the proposed scheme reduces the EER by 31% compared to the state-of-the-art State-GMM-MAP method. Furthermore it is shown that using HMM instead of GMM for universal background modeling leads to 15% reduction in EER  

The Endurance Time (ET) method is a new dynamic pushover procedure in which structures are subjected to gradually intensifying acceleration functions and their performance is assessed based on the length of the time interval that they can satisfy required performance objectives. In this paper, the accuracy of the Endurance Time method in estimating average deformation demands of low and medium rise steel frames using ETASOf series of ET acceleration functions has been investigated. The precision of the ET method in predicting the response of steel frames in nonlinear analysis is investigated by considering a simple set of moment-resisting frames. An elastic-perfectly-plastic material model... 

Cylindrical shells constitute the main structural component in pressure vessels and pipelines. Buckling is one of the main failure considerations when designing these cylindrical shells. Defects such as cracks may develop during manufacturing or service life of these structures. These defects can severely affect their buckling behavior due to high stress field generated around these defects. Finite Element Analyses are performed to study the buckling behavior of cylindrical shells with and without a crack, under various internal pressures. Effects of crack length and its orientation on the buckling loads of cylindrical shells having a through or a thumbnail crack are studied. The results... 

Sub-surface cracks in pipelines with internal pressure may severely affect their dynamic response. The extreme cases of these cracks are when these cracks go through the thickness of the pipes. Dynamic responses of cracked and un-cracked pipes with fixed ends and under various internal pressures were evaluated experimentally and theoretically. In the experimental part, the effects of pipe internal pressure on the resonant frequencies and damping of the pipe were evaluated. In the theoretical part, finite element analyses were performed to find dynamic response of pipes with various crack length and orientation respect to the axis of the pipe. The experimental results showed resonant... 

Cylindrical shells constitute the main structural component in pressure vessels and pipelines. Buckling is one of the main failure considerations when designing these cylindrical shells. Defects such as cracks may develop during manufacturing or service life of these structures. These defects can severely affect their buckling behavior due to high stress field generated around these defects. Finite Element Analyses are performed to study the buckling behavior of cylindrical shells with and without a crack, under various internal pressures. Effects of crack length and its orientation on the buckling loads of cylindrical shells having a through or a thumbnail crack are studied. The results... 

This study aims to show the efficiency of a proposed spectral matching technique for the reduction of required ground motions in the dynamic time history analysis. In this non-stationary spectral matching approach, unconstrained optimization is employed to adjust the signal to match a target spectrum. Adjustment factors of discrete wavelet transform (DWT) coefficients associated with the signals are then considered as decision variables and the Levenberg-Marquardt algorithm is employed to find the optimum values of DWT coefficients. This matching algorithm turns out to be quite effective in the spectral matching objective, where matching at multiple damping ratios can be readily achieved.... 

Alkalis, surfactants and/or polymers are usually injected in the injector wells so that the injection fluids can sweep through the reservoir and mobilize/recover more oil. However, the formation of stable emulsion due to the residual chemicals in the recovered crude oil poses problems in the primary separation process. This study focuses on the effect of Alkali-Surfactant-Polymer injection on creaming and coalescence of crude oil and water emulsion produced in the primary gravity separator. In addition, a model is developed in this work to predict the separation effectiveness of oil and water emulsion containing ASP. In this work, the effect of ASP on the stability and the separation of...