Loading...
Search for:
akhavan--o
0.014 seconds
Total 109 records
Curcumin-reduced graphene oxide sheets and their effects on human breast cancer cells
, Article Materials Science and Engineering C ; Volume 55 , 2015 , Pages 482-489 ; 09284931 (ISSN) ; Akhavan, O ; Sadrnezhaad, S. K ; Ahadian, M. M ; Shirolkar, M. M ; Wang, H. Q ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Curcumin (as a natural reductant material) was utilized for green reduction and functionalization of chemically exfoliated graphene oxide (GO) sheets. The π-π attachment of the curcumin molecules onto the curcumin-reduced graphene oxide (rGO) sheets was confirmed by Raman and Fourier transform infrared spectroscopies. Zeta potential of the GO sheets decreased from about - 40 mV to - 20 mV, after the green reduction and functionalization. The probable cytotoxicity of the curcumin-rGO sheets was studied through their interactions with two human breast cancer cell lines (MDA-MB-231 and SKBR3 cell lines) and a normal cell line (mouse fibroblast L929 cell line). The curcumin-rGO sheet with...
Magnetite/dextran-functionalized graphene oxide nanosheets for in vivo positive contrast magnetic resonance imaging
, Article RSC Advances ; Volume 5, Issue 59 , May , 2015 , Pages 47529-47537 ; 20462069 (ISSN) ; Akhavan, O ; Tayyebi, A ; Rahighi, R ; Mohammadzadeh, M ; Saligheh Rad, H. R ; Sharif University of Technology
Royal Society of Chemistry
2015
Abstract
Superparamagnetic iron oxide (SPIO) nanomaterials are widely used as magnetic resonance imaging (MRI) contrast agents (CAs). These CAs significantly shorten transverse relaxation time (T2 ) and so decrease the intensity of the T2 -weighted MRI (negative contrast imaging). However, the partial-volume effect is known to be one of the problems in negative contrast MRI. In this work, SPIO nanoparticles were modified by dextran and graphene oxide (GO) nanosheets to achieve a positive contrast MRI with high intensity. This modification resulted in shortening the longitudinal relaxation time (T1 ) of the SPIO nanoparticles (in addition to the T2 shortening)....
ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells
, Article Materials Science and Engineering C ; Volume 46 , January , 2015 , Pages 394-399 ; 09284931 (ISSN) ; Akhavan, O ; Khoei, S ; Shokri, A. A ; Hajikarimi, Z ; Khansari, N ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Nanoparticles of high-Z elements exhibit stronger photoelectric effects than soft tissues under gamma irradiation. Hence, they can be used as effective radiosensitizers for increasing the efficiency of current radiotherapy. In this work, superparamagnetic zinc ferrite spinel (ZnFe2O4) nanoparticles were synthesized by a hydrothermal reaction method and used as radiosensitizers in cancer therapy. The magnetic nanoparticles showed fast separation from solutions (e.g., ~ 1 min for 2 mg mL- 1 of the nanoparticles in ethanol) by applying an external magnetic field (~ 1 T). The ZnFe2O4 nanoparticles were applied in an in vitro radiotherapy of lymph node carcinoma of prostate cells (as high...
Graphene oxide for rapid determination of testosterone in the presence of cetyltrimethylammonium bromide in urine and blood plasma of athletes
, Article Materials Science and Engineering C ; Volume 61 , 2016 , Pages 246-250 ; 09284931 (ISSN) ; Akhavan, O ; Ghaderi, E ; Hashemi, E ; Mortazavi, S. S ; Farmany, A ; Sharif University of Technology
Abstract
Electro-reduction behavior of testosterone at reduced graphene oxide/glassy carbon electrode (rGO/GCE) was studied. Cationic surfactant cetyltrimethylammonium bromide (CTAB) enhanced the reduction peak of testosterone. In borate buffer (pH 5.4) CTAB-testosterone showed a reduction peak at - 1.1 V (versus, Ag/AgCl). The increment of peak current obtained by deducting the reduction peak current of the CTAB-testosterone was rectilinear with testosterone concentration in the range of 2.0 to 210.0 nM, with a detection limit of 0.1 nM. The sensor was used for quantification of testosterone in biological fluids and drug
Apoptotic and anti-apoptotic genes transcripts patterns of graphene in mice
, Article Materials Science and Engineering C ; Volume 71 , 2017 , Pages 460-464 ; 09284931 (ISSN) ; Hashemi, E ; Akhavan, O ; Shamsara, M ; Hashemi, M ; Farmany, A ; Daliri Joupari, M ; Sharif University of Technology
Elsevier Ltd
2017
Abstract
Recent studies showed that a large amount of graphene oxide accumulated in kidney and liver when it injected intravenously. Evaluation of lethal and apoptosis gene expression in these tissues, which are under stress is very important. In this paper the in vivo dose-dependent effects of graphene oxide and reduced graphene oxide nanoplatelets on kidney and liver of mice were studied. Balb/C mice were treated by 20 mg/kg body weight of nanoplatelets. Molecular biology analysis showed that graphene nanoplatelets injected intravenously lead to overexpression of BAX gene in both kidney and liver tissues (P ≥ 0.01). In addition these nanoparticles significantly increase BCL2 gene expression in both...
Antioxidant nanomaterials in advanced diagnoses and treatments of ischemia reperfusion injuries
, Article Journal of Materials Chemistry B ; Volume 5, Issue 48 , 2017 , Pages 9452-9476 ; 20507518 (ISSN) ; Habibey, R ; Hajmiresmail, S. J ; Latifi, S ; Pazoki Toroudi, H ; Akhavan, O ; Sharif University of Technology
Royal Society of Chemistry
2017
Abstract
Organ ischemia with inadequate oxygen supply followed by reperfusion (which initiates a complex of inflammatory responses and oxidative stress) occurs in different clinical conditions and surgical procedures including stroke, myocardial infarction, limb ischemia, renal failure, organ transplantation, free-tissue-transfer, cardiopulmonary bypass, and vascular surgery. Even though pharmacological treatments protect against experimental ischemia reperfusion (I/R) injury, there has not been enough success in their application for patient benefits. The main hurdles in the treatment of I/R injury are the lack of diagnosis tools for understanding the complicated chains of I/R-induced signaling...
Multifunctional core-shell nanoplatforms (gold@graphene oxide) with mediated NIR thermal therapy to promote miRNA delivery
, Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 14, Issue 6 , 2018 , Pages 1891-1903 ; 15499634 (ISSN) ; Akhavan, O ; Adeli, M ; Razzazan, S ; Dinarvand, R ; Zanganeh, S ; Soleimani, M ; Dinarvand, M ; Atyabi, F ; Sharif University of Technology
Elsevier Inc
2018
Abstract
Recent insights into the nanomedicine have revealed that nanoplatforms enhance the efficacy of carrier in therapeutic applications. Here, multifunctional nanoplatforms were utilized in miRNA-101 delivery and NIR thermal therapy to induce apoptosis in breast cancer cells. Au nanorods (NRs) or nanospheres (NSs) covered with graphene oxide (GO) were prepared and functionalized with polyethylene glycol as a stabilizer and poly-L-arginine (P-L-Arg) as a targeting agent. In nanoplatforms, coupling Au@GO prepared stable structures with higher NIR reactivity. P-L-Arg substantially enhanced the cellular uptake and gene retardation of stuffs coated by them. However, rod-shape nanoplatforms indicated...
Cationic graphene oxide nanoplatform mediates miR-101 delivery to promote apoptosis by regulating autophagy and stress
, Article International journal of nanomedicine ; Volume 13 , 2018 , Pages 5865-5886 ; 11782013 (ISSN) ; Akhavan, O ; Mottaghitalab, F ; Adeli, M ; Dinarvand, R ; Razzazan, S ; Arefian, E ; Soleimani, M ; Atyabi, F ; Sharif University of Technology
NLM (Medline)
2018
Abstract
Introduction: MicroRNA-101 (miR-101) is an intense cancer suppressor with special algorithm to target a wide range of pathways and genes which indicates the ability to regulate apoptosis, cellular stress, metastasis, autophagy, and tumor growth. Silencing of some genes such as Stathmin1 with miR-101 can be interpreted as apoptotic accelerator and autophagy suppressor. It is hypothesized that hybrid microRNA (miRNA) delivery structures based on cationized graphene oxide (GO) could take superiority of targeting and photothermal therapy to suppress the cancer cells
Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling
, Article Scientific Reports ; Volume 9, Issue 1 , 2019 ; 20452322 (ISSN) ; Habibey, R ; Shokri, F ; Hajmiresmail, S. J ; Akhavan, O ; Mashaghi, A ; Pazoki Toroudi, H ; Sharif University of Technology
Nature Publishing Group
2019
Abstract
Ischemic cerebral stroke is a major cause of death and morbidity. Currently, no neuroprotective agents have been shown to impact the clinical outcomes in cerebral stroke cases. Here, we report therapeutic effects of Se nanoparticles on ischemic stroke in a murine model. Anti-transferrin receptor monoclonal antibody (OX26)-PEGylated Se nanoparticles (OX26-PEG-Se NPs) were designed and synthesized and their neuroprotective effects were measured using in vitro and in vivo approaches. We demonstrate that administration of the biodegradable nanoparticles leads to resolution of brain edema, protection of axons in hippocampus region, and myelination of hippocampal area after cerebral ischemic...
Graphene aerogel nanoparticles for in-situ loading/pH sensitive releasing anticancer drugs
, Article Colloids and Surfaces B: Biointerfaces ; Volume 186 , 2020 ; Akhavan, O ; Raoufi, M ; Varshochian, R ; Hosseini Motlagh, N. S ; Atyabi, F ; Sharif University of Technology
Elsevier B.V
2020
Abstract
Free polymer graphene aerogel nanoparticles (GA NPs) were synthesized by using reduction/aggregation of graphene oxide (GO) sheets in the presence of vitamin C (as a biocompatible reductant agent) at a low temperature (40 °C), followed by an effective sonication. Synthesis of GA NPs in doxorubicin hydrochloride (DOX)-containing solution results in the simultaneous synthesis and drug loading with higher performance (than that of the separately synthesized and loaded samples). To investigate the mechanism of loading and the capability of GA NPs in the loading of other drug structures, two groups of ionized (DOX, Amikacin sulfate and, D-glucosamine hydrochloride) and non-ionized (Paclitaxel...
Graphene oxide negatively regulates cell cycle in embryonic fibroblast cells
, Article International Journal of Nanomedicine ; Volume 15 , 2020 , Pages 6201-6209 ; Akhavan, O ; Shamsara, M ; Ansari Majd, S ; Sanati, M. H ; Daliri Joupari, M ; Farmany, A ; Sharif University of Technology
Dove Medical Press Ltd
2020
Abstract
Background: Unique properties of graphene and its derivatives make them attractive in the field of nanomedicine. However, the mass application of graphene might lead to side effects, which has not been properly addressed in previous studies, especially with regard to its effect on the cell cycle. Methods: The effect of two concentrations (100 and 200 μg/mL) of nano-and microsized graphene oxide (nGO and mGO) on apoptosis, cell cycle, and ROS generation was studied. The effect of both sizes on viability and genotoxicity of the embryonic fibroblast cell cycle was evaluated. MTT and flow cytometry were applied to evaluate the effects of graphene oxide (GO) nanosheets on viability of cells....
Prevascularized micro-/nano-sized spheroid/bead aggregates for vascular tissue engineering
, Article Nano-Micro Letters ; Volume 13, Issue 1 , 2021 ; 23116706 (ISSN) ; Nasrollahi Boroujeni, N ; Jahangiri, S ; Rabiee, N ; Rabiee, M ; Makvandi, P ; Akhavan, O ; Varma, R. S ; Sharif University of Technology
Springer Science and Business Media B.V
2021
Abstract
Efficient strategies to promote microvascularization in vascular tissue engineering, a central priority in regenerative medicine, are still scarce; nano- and micro-sized aggregates and spheres or beads harboring primitive microvascular beds are promising methods in vascular tissue engineering. Capillaries are the smallest type and in numerous blood vessels, which are distributed densely in cardiovascular system. To mimic this microvascular network, specific cell components and proangiogenic factors are required. Herein, advanced biofabrication methods in microvascular engineering, including extrusion-based and droplet-based bioprinting, Kenzan, and biogripper approaches, are deliberated with...
Controlling surface statistical properties using bias voltage: Atomic force microscopy and stochastic analysis
, Article Physical Review B - Condensed Matter and Materials Physics ; Volume 71, Issue 15 , 2005 ; 10980121 (ISSN) ; Jafari, G. R ; Akhavan, O ; Moshfegh, A. Z ; Rahimi Tabar, M. R ; Sharif University of Technology
2005
Abstract
The effect of bias voltages on the statistical properties of rough surfaces has been studied using atomic force microscopy technique and its stochastic analysis. We have characterized the complexity of the height fluctuation of a rough surface by the stochastic parameters such as roughness exponent, level crossing, and drift and diffusion coefficients as a function of the applied bias voltage. It is shown that these statistical as well as microstructural parameters can also explain the macroscopic property of a surface. Furthermore, the tip convolution effect on the stochastic parameters has been examined. © 2005 The American Physical Society
DNA-decorated graphene nanomesh for detection of chemical vapors
, Article Applied Physics Letters ; Volume 103, Issue 18 , 2013 ; 00036951 (ISSN) ; Kybert, N. J ; Dattoli, E. N ; Hee Han, G ; Lerner, M. B ; Akhavan, O ; Irajizad, A ; Charlie Johnson, A. T ; Sharif University of Technology
2013
Abstract
The promise of graphene for use as a vapor sensor motivated exploration of the vapor responses of graphene nanomesh (GNM) functionalized with single stranded DNA. Devices detected different vapor types, including carboxylic acids, aldehydes, organophosphates, and explosives. As-fabricated GNM field effect transistors (FETs) had larger vapor responses than standard graphene FETs due to the effect of oxidized edges and lattice defects. DNA-GNM devices discriminated between homologous species with detection limits of a few parts per million, with fast response and recovery. Responses varied significantly when the base sequence of the DNA was changed, making the sensor class an intriguing...
Photo-destruction of cancer cells by NIR irradiation and graphene nano-sheets
, Article Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011, 13 June 2011 through 16 June 2011, Boston, MA ; Volume 3 , 2011 , Pages 236-239 ; 9781439871386 (ISBN) ; Mohajerzadeh, S ; Janmaleki, M ; Akhavan, O ; Azimi, S ; Clean Technology and Sustainable Industries Organization (CTSI); European Patent Office; Greenberg Traurig; Innovation and Materials Science Institute; Jackson Walker L.L.P ; Sharif University of Technology
2011
Abstract
The photo-thermal therapy using nano-materials has attracted great attention as an efficient strategy for the next generation of cancer treatments. Recently, photo-thermal therapy based on nano-materials that can be activated by a skin-penetrating NIR (Near Infra Red) irradiation has been suggested as a noninvasive, harmless, and highly efficient therapeutic technique. Graphene nano-layers synthesized by a bio-compatible method, with reduced toxicity, will be a suitable candidate for the photo-thermal therapeutic agent. A significant amount of heat is generated upon excitation with near-infrared light (NIR, 700-1100nm) which is transparent to biological species including skins. In this...
Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide
, Article Nanoscale ; Volume 7, Issue 19 , Apr , 2015 , Pages 8978-8994 ; 20403364 (ISSN) ; Raheb, J ; Akhavan, O ; Arjmand, S ; Mashinchian, O ; Rahman, M ; Abdolahad, M ; Serpooshan, V ; Laurent, S ; Mahmoudi, M ; Sharif University of Technology
Royal Society of Chemistry
2015
Abstract
The hard corona, the protein shell that is strongly attached to the surface of nano-objects in biological fluids, is recognized as the first layer that interacts with biological objects (e.g., cells and tissues). The decoration of the hard corona (i.e., the type, amount, and conformation of the attached proteins) can define the biological fate of the nanomaterial. Recent developments have revealed that corona decoration strongly depends on the type of disease in human patients from which the plasma is obtained as a protein source for corona formation (referred to as the 'personalized protein corona'). In this study, we demonstrate that graphene oxide (GO) sheets can trigger different...
Emerging phospholipid nanobiomaterials for biomedical applications to lab-on-a-chip, drug delivery, and cellular engineering
, Article ACS Applied Bio Materials ; 2021 ; 25766422 (ISSN) ; Rabiee, N ; Ahmadi, S ; Jahangiri, S ; Sajadi, S. M ; Akhavan, O ; Saeb, M. R ; Kwon, W ; Kim, M ; Hahn, S. K ; Sharif University of Technology
American Chemical Society
2021
Abstract
The design of advanced nanobiomaterials to improve analytical accuracy and therapeutic efficacy has become an important prerequisite for the development of innovative nanomedicines. Recently, phospholipid nanobiomaterials including 2-methacryloyloxyethyl phosphorylcholine (MPC) have attracted great attention with remarkable characteristics such as resistance to nonspecific protein adsorption and cell adhesion for various biomedical applications. Despite many recent reports, there is a lack of comprehensive review on the phospholipid nanobiomaterials from synthesis to diagnostic and therapeutic applications. Here, we review the synthesis and characterization of phospholipid nanobiomaterials...
A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discovery
, Article Chemical Biology and Drug Design ; Volume 100, Issue 5 , 2022 , Pages 699-721 ; 17470277 (ISSN) ; Taghavi Shahraki, B ; Rameh, F ; Nazarabi, M ; Fatahi, Y ; Akhavan, O ; Rabiee, M ; Mostafavi, E ; Lima, E. C ; Saeb, M. R ; Rabiee, N ; Sharif University of Technology
John Wiley and Sons Inc
2022
Abstract
Application of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development of unprecedented drugs. The expensive and time-consuming process of traditional drug discovery is no longer feasible, for nowadays the identification of potential drug candidates is much easier for therapeutic targets through elaborate in silico approaches,...
Reduced polydopamine coated graphene for delivery of Hset1 antisense as A photothermal and gene therapy of breast cancer
, Article Journal of Drug Delivery Science and Technology ; Volume 73 , 2022 ; 17732247 (ISSN) ; Tekie, F. S. M ; Ayazi, H ; Ranjbar, S ; Varshochian, R ; Rad-Malelkshahi, M ; Akhavan, O ; Dinarvand, R ; Sharif University of Technology
Editions de Sante
2022
Abstract
Breast cancer is the most prevalent type of cancer in women; hence, many researches have been focused on developing effective treatment protocols. In this study, a novel nanocarrier was fabricated for gene and photothermal combination cancer therapy by conjugating histone methyltransferase complex subunit SET1 (hSET1) on reduced polydopamine coated graphene oxide nanosheets (rGO-PDA). The rGO-PDA nanocarriers provide higher near-infrared absorption and further integrating with hSET1 antisense as an anticancer gene that down-regulates the amount of hSET1 overexpressed and suppresses the proliferation of cancer cells. The nanoplatform was prepared by polymerizing of dopamine, a mussel adhesive...
Immobilization of modular peptides on graphene cocktail for differentiation of human mesenchymal stem cells to hepatic-like cells
, Article Frontiers in Chemistry ; Volume 10 , 2022 ; 22962646 (ISSN) ; Hashemi, E ; Akhavan, O ; Khezri, J ; Rezaei, A ; Zamani Amir Zakria, J ; Siadat, S. D ; Sahebghadam Lotfi, A ; Farmany, A ; Sharif University of Technology
Frontiers Media S.A
2022
Abstract
In this study, two novel biomimetic modular peptide motifs based on the alpha-2 subunit of type IV collagen (CO4A2) were designed and immobilized on a graphene platform to imitate integrin and heparan sulfate- (HS-) binding proteins. The in silico study was used to design 9-mer K[KGDRGD]AG and 10-mer KK[SGDRGD]AG for testing designed Integrin-Binding Peptide (dIBP) and HS-Binding Peptide (dHBP). The virtual docking technique was used to optimize the peptide motifs and their relevant receptors. Molecular dynamic (MD) simulation was used to evaluate the stability of peptide-receptor complexes. The effect of the platform on the differentiation of human mesenchymal stem cells (hMSCs) to...