Sharif Digital Repository

Obstruction of left anterior descending artery (LAD) due to the thrombosis or atherosclerotic plaques is the leading cause of death worldwide. Targeted delivery of drugs through micro- and nanoparticles is a very promising approach for developing new strategies in clot-busting or treating restenosis. In this work, we modelled the blood flow characteristics in a patient-specific reconstructed LAD artery by the fluid–solid interaction method and based on physiological boundary conditions. Next, we provided a Lagrangian description of micro- and nanoparticles dynamics in the blood flow considering their Brownian motion and the particle–particle interactions. Our results state that the number of... 

A sequential implicit numerical method based on discrete-fracture model and the Galerkin Finite Element method, for time-dependent coupled fluid flow and geomechanics problems in fractured subsurface formations is presented. Discrete-fracture model has been used to explicitly represent the fracture network inside porous media. The Galerkin Finite Element method with adaptive unstructured gridding is implemented to numerically solve the spatially three-dimensional and time-dependent problem. The presented method is validated with previously obtained solutions. Two problems are numerically solved by applying the presented methodology in a three-dimensional fractured petroleum reservoir under... 

Recent advances in the field of microfabrication have made the application of high-throughput microfluidics feasible. Mixing which is an essential part of any miniaturized standalone system remains the key challenge. This paper proposes a geometrically simple micromixer for efficient mixing for high-throughput microfluidic devices. The proposed micromixer utilizes a curved microchannel (spiral microchannel) to induce chaotic advection and enhance the mixing process. It is shown that the spiral microchannel is more efficient in comparison to a straight microchannel, mixing wise. The pressure drop in the spiral microchannel is only slightly higher than that in the straight microchannel. It is... 

In this paper, a new computational technique is presented based on the eXtended Finite Element Method (X-FEM) in pressure-sensitive plasticity of powder compaction considering frictional contact. In X-FEM, the need for mesh adaption to discontinuity interface is neglected and the process is accomplished by partitioning the domain with some triangular sub-elements whose Gauss points are used for integration of the domain of the elements. The technique is applied by employing additional functions, which are added to approximate the displacement field of the elements located on the interface. The double-surface cap plasticity model is employed within the X-FEM framework in numerical simulation... 

In this paper, the eXtended Finite Element Method (X-FEM) is developed in pressure-sensitive plasticity of powder compaction process. In X-FEM, the need for mesh adaption to discontinuity interface is neglected and the process is accomplished by employing additional functions, which are added to approximate the displacement field of the elements located on the interface. The double-surface cap plasticity model is employed within the X-FEM framework in numerical simulation of powder material. The plasticity model includes a failure surface and an elliptical cap, which closes the open space between the failure surface and hydrostatic axis. The moving cap expands in the stress space according...