Loading...
Search for:
atherosclerosis
0.007 seconds
Total 28 records
Simulation of low density lipoprotein (LDL) permeation into multilayer coronary arterial wall: interactive effects of wall shear stress and fluid-structure interaction in hypertension
, Article Journal of Biomechanics ; Volume 67 , 2018 , Pages 114-122 ; 00219290 (ISSN) ; Nikmaneshi, M. R ; Firoozabadi, B ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Due to increased atherosclerosis-caused mortality, identification of its genesis and development is of great importance. Although, key factors of the origin of the disease is still unknown, it is widely believed that cholesterol particle penetration and accumulation in arterial wall is mainly responsible for further wall thickening and decreased rate of blood flow during a gradual progression. To date, various effective components are recognized whose simultaneous consideration would lead to a more accurate approximation of Low Density Lipoprotein (LDL) distribution within the wall. In this research, a multilayer Fluid-Structure Interaction (FSI) model is studied to simulate the penetration...
Atheroprone sites of coronary artery bifurcation: Effect of heart motion on hemodynamics-dependent monocytes deposition
, Article Computers in Biology and Medicine ; Volume 133 , 2021 ; 00104825 (ISSN) ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
Atherosclerosis as a common cardiovascular disease is a result of both adverse hemodynamics conditions and monocyte deposition within coronary arteries. It is known that the adhesion of monocytes on the arterial wall and their interaction with the vascular surface are one of the main parameters in the initiation and progression of atherosclerosis. In this work, hemodynamic parameters and monocyte deposition have been investigated in a 3D computational model of the Left Anterior Descending coronary artery (LAD) and its first diagonal branch (D1) under the heart motion. A one-way Lagrangian approach is performed to trace the monocyte particles under different blood flow regimes and heart motion...
Investigation of coronary artery tortuosity with atherosclerosis: A study on predicting plaque rupture and progression
, Article International Journal of Mechanical Sciences ; Volume 223 , 2022 ; 00207403 (ISSN) ; Fallah, F ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
This study investigated the effects of different patterns of coronary artery tortuosity (CAT) on the stress concentration of the plaques and the blood flow pattern inside an atherosclerotic artery to predict the risk of plaque rupture and progression. Four different loadings of the coronary artery, including pulsatile blood pressure as well as one-end twist around the artery axis at blood pressures of 74, 100, and 120 mmHg were considered. No study has addressed bent and twist buckling of an atherosclerotic artery considering pulsatile flow (for bent buckling), fluid-solid interaction, and different geometrical parameters of the plaque. The results showed that C-shape tortuosity under...
Computational investigation of stenosis in curvature of coronary artery within both dynamic and static models
, Article Computer Methods and Programs in Biomedicine ; Volume 185 , 2020 ; Momeni Larimi, M ; Hassanzadeh Afrouzi, H ; Moshfegh, A ; Toghraie, D ; Javadzadegan, A ; Rostami, S ; Sharif University of Technology
Elsevier Ireland Ltd
2020
Abstract
Background and Objective: Blood flow variation during cardiac cycle is the main mechanism of atherosclerotic development which is dependent on. Methods: The present work mainly tends to investigate stenosis effect in dynamic curvature of coronary artery. This paper presents numerical investigations on wall shear stress profiles in three-dimensional pulsatile flow through curved stenotic coronary arteries for both static and dynamic model. In order to do so, three-dimensional models related to the curved arteries with two degrees of stenosis (30% and 50%). Results: Lower amount of wall shear stress is found near the inner wall of artery distal to the plaque region (stenosis) and in both...
Thickness as an important parameter in designing vascular grafts
, Article 2014 21st Iranian Conference on Biomedical Engineering, ICBME 2014 ; Nov , 2014 , p. 40-43 ; Shamloo, A ; Samani, S. A ; Dodel, M ; Sharif University of Technology
Abstract
The main goal of this study is to investigate the role of vascular graft thickness in wall stress gradient in anastomosis region. Atherosclerosis is a common heart disease causes high mortality rates every year. The gold standard treatment of atherosclerosis is replacing with autologous vein extracted from patient's body. Since proper autologous vein is limited, researchers have made efforts to achieve compliance engineered blood vessels. Mechanical stress has great effect on both smooth muscle cells and endothelial cells and it is considered as a stimulus in plaque formation. In this study, we evaluate the role of thickness in wall stress of anastomosis region. For this purpose, two...
A simple model of intimal thickening-effects of hypertension
, Article 2012 19th Iranian Conference of Biomedical Engineering, ICBME 2012 ; 2012 , Pages 276-281 ; 9781467331302 (ISBN) ; Saidi, M. S ; Firoozabadi, D ; Sharif University of Technology
2012
Abstract
A vast amount of death in the world has been attributed to atherosclerosis. This disease causes plaque formation and finally lack of blood supply to an organ. The prominent aim of this study is proposing an accurate and simple model to investigate the process of arterial wall thickening. In order to investigate LDL (low density lipoprotein) accumulation in arterial wall which is considered the first stage of atherosclerosis, a four layer model for arterial wall consisting of endothelium, intima, IEL and media is presented. All layers are treated as homogenous porous media. The four-layer arterial wall model is the most powerful and reliable tool for modeling LDL transport within arterial...
A multiscale approach for determining the morphology of endothelial cells at a coronary artery
, Article International Journal for Numerical Methods in Biomedical Engineering ; Volume 33, Issue 12 , 2017 ; 20407939 (ISSN) ; Saidi, M. S ; Firoozabadi, B ; Sharif University of Technology
Abstract
The morphology of endothelial cells (ECs) may be an indication for determining atheroprone sites. Until now, there has been no clinical imaging technique to visualize the morphology of ECs in the arteries. The present study introduces a computational technique for determining the morphology of ECs. This technique is a multiscale simulation consisting of the artery scale and the cell scale. The artery scale is a fluid-structure interaction simulation. The input for the artery scale is the geometry of the coronary artery, that is, the dynamic curvature of the artery due to the cardiac motion, blood flow, blood pressure, heart rate, and the mechanical properties of the blood and the arterial...
Simulation of low density lipoprotein (LDL) permeation into multilayer coronary arterial wall: interactive effects of wall shear stress and fluid-structure interaction in hypertension
, Article Journal of Biomechanics ; 2017 ; 00219290 (ISSN) ; Nikmaneshi, M. R ; Firoozabadi, B ; Sharif University of Technology
Abstract
Due to increased atherosclerosis-caused mortality, identification of its genesis and development is of great importance. Although, key factors of the origin of the disease is still unknown, it is widely believed that cholesterol particle penetration and accumulation in arterial wall is mainly responsible for further wall thickening and decreased rate of blood flow during a gradual progression. To date, various effective components are recognized whose simultaneous consideration would lead to a more accurate approximation of Low Density Lipoprotein (LDL) distribution within the wall. In this research, a multilayer Fluid-Structure Interaction (FSI) model is studied to simulate the penetration...