Sharif Digital Repository

Apathy is a stressor and debilitating common condition for both stroke survivors and their caregivers. However, its effects on the postural control of these patients have not yet been investigated. Improved postural stability through withdrawing attention from postural control by concurrent cognitive task (i.e. dual-task condition) has been reported previously, but the effect of apathy, as a confounding factor, remains unknown. This study aimed to examine the effects of apathy and dual-task condition on postural control of chronic stroke survivors from biomechanical and neurophysiological perspectives. Twenty non-apathetic stroke survivors, 20 apathetic stroke survivors, and 20 sex-, age-,... 

Background: Low back pain (LBP) is known as one of the most common workrelated musculoskeletal disorders. Spinal cumulative loads (CLs) during manual material handling (MMH) tasks are the main risk factors for LBP. However, there is no valid and reliable quantitative lifting analysis tool available for quantifying CLs among Iranian workers performing MMH tasks. Objective: This study aimed to investigate the validity and inter-rater reliability of a posture-matching load assessment tool (PLAT) for estimating the L5-S1 static cumulative compression (CC) and shear (CS) loads based on predictive regression equations. Material and Methods: This experimental study was conducted among six... 

Polylactic acid (PLA) scaffolds produced by the fused deposition modeling (FDM) method have biocompatibility, close Young's modulus to that of bone, and the ability to make complex shapes. However, PLA has some drawbacks like brittleness, inappropriate mechanical strength and hydrophobicity, and a low degradation rate. In this study, polyethylene glycol (PEG) (5 and 10 wt%) by solving method and titanium (Ti) particles (5 wt%) by two different methods were mixed with PLA to address the mentioned problems. Extruded filaments were investigated by X-ray diffraction (XRD), differential scanning calorimetry (DSC), and fourier transform infrared (FTIR). Surface morphology of the produced filaments... 

Multi-walled carbon nanotubes (MWCNTs) are one of the preferred candidates for reinforcing polymeric nanobiocomposites, such as acrylic bone type of cement. In this study, at first, bulk samples of the reinforced polymethylmethacrylate (PMMA) matrix were prepared with 0.1, 0.25, and 0.5 wt per wt% of MWCNTs by the casting method. Tensile and three-point bending tests were performed to determine the essential mechanical properties of bone cement, such as tensile and bending strengths. The tensile fracture surfaces were investigated by scanning electron microscopy (SEM). The commercial software (Abaqus) was used to conduct finite element analysis (FEA) by constructing a representative volume... 

Despite brilliant properties of glass ionomer cement (GIC), its weak mechanical property poses an obstacle for its use in medical applications. The present research aims to formulate hydroxyapatite/yttria-stabilized zirconia (HA/YSZ) in the composition of GIC to enhance mechanical properties and to improve fluoride release of GIC. HA/YSZ was synthesized via a sol-gel method and characterized by applying X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), X-ray photo-emission spectroscopy (XPS) and simultaneous thermal analysis (STA) along with transmission electron microscopy (TEM) methods. The synthesized nanocomposite was mixed with GIC at a fixed composition of 5.... 

The aim of this study was to use finite element analysis (FEA) to assess the influence of microthread design at the implant neck on stress distribution in the surrounding bone. A commercially available implant with 3.5 mm diameter and 10.5 mm length was selected and used as a model. For the purpose of designing the microthread implant model, microthreads were added to the implant neck in a computerized model. A force measuring 100 N was then applied to the entire surface of the abutment in the vertical direction. The results showed that in both models, stress was mainly concentrated at the cortical bone adjacent to the neck of the implant. Maximum stress values in the cortical bone... 

Fluid particle diffusion through blood flow within a capillary tube is an important phenomenon to understand, especially for studies in mass transport in the microcirculation as well as in solving technical issues involved in mixing in biomedical microdevices. In this paper, the spreading of tracer particles through up to 20% hematocrit blood, flowing in a capillary tube, was studied using a confocal micro-PTV system. We tracked hundreds of particles in high-hematocrit blood and measured the radial dispersion coefficient. Results yielded significant enhancement of the particle diffusion, due to a micron-scale flow-field generated by red blood cell motions. By increasing the flow rate, the... 

Range of motion (ROM) of the thoracic spine has implications in patient discrimination for diagnostic purposes and in biomechanical models for predictions of spinal loads. Few previous studies have reported quite different thoracic ROMs. Total (T1-T12), lower (T5-T12) and upper (T1-T5) thoracic, lumbar (T12-S1), pelvis, and entire trunk (T1) ROMs were measured using an inertial tracking device as asymptomatic subjects flexed forward from their neutral upright position to full forward flexion. Correlations between body height and the ROMs were conducted. An effect of measurement errors of the trunk flexion (T1) on the model-predicted spinal loads was investigated. Mean of peak voluntary total... 

It is known that Fluoride ions strongly affect bone mineralization and formation. In the present study, the engineered bone tissue scaffolds are fabricated using silk fibroin (SF) and flouridated TiO2 nanoparticles. TiO2 nanoparticles are modified by fluoride ions, and different levels (0, 5, 10, 15 and 20 wt%) of the fluoridated TiO2 nanoparticles (TiO2-F) were subsequently added to the SF matrix through phase separation method to prepare silk fibroin/flouridated TiO2 nanocomposite scaffolds (SF/TiO2-F). Phase structure, functional groups, morphology and mechanical properties of the obtained scaffolds were evaluated by X-ray diffraction method (XRD), Fourier transform infrared spectroscopy... 

Natural compounds containing polysaccharide ingredients have been employed as candidates for treatment of skin tissue. Herein, for the first time, electrospinning setup was proposed to fabricate an efficient composite nanofibrous structure of Beta vulgaris (obtained from Beet [Chenopodiaceae or Amaranthaceae]) belonged to polysaccharides and an elastic polymer named nylon 66 for skin tissue engineering. Both prepared scaffolds including noncomposite and composite types were studied by Scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, mechanical assay, and contact angle. Scanning electron microscope examinations have approved the uniform and homogeneous... 

Small diameter vascular grafts (<6 mm) are highly demanded for patients suffering from severe occluded arteries to be used as a bypass or substituted conduit. Fabricating a graft with appropriate structural, mechanical and cell growth properties which has simultaneously anti-thrombogenic trait is a challenge nowadays. Here, we proposed a bilayer heparinized vascular graft that can mimic the structural and mechanical characteristics close to those of the native coronary artery by combining electrospinning and freeze drying methods. In this study, the inner layer was made by co-electrospinning of synthetic polymer, poly-caprolactone (PCL) and the natural polymer, gelatin (Gel). Also, heparin... 

Small diameter vascular grafts (<6 mm) are highly demanded for patients suffering from severe occluded arteries to be used as a bypass or substituted conduit. Fabricating a graft with appropriate structural, mechanical and cell growth properties which has simultaneously anti-thrombogenic trait is a challenge nowadays. Here, we proposed a bilayer heparinized vascular graft that can mimic the structural and mechanical characteristics close to those of the native coronary artery by combining electrospinning and freeze drying methods. In this study, the inner layer was made by co-electrospinning of synthetic polymer, poly-caprolactone (PCL) and the natural polymer, gelatin (Gel). Also, heparin... 

We produced bifurcated bone-like shape memory implant (BL-SMI) with desirable tooth-root fixation capability by compact-sintering of TiH2–Ni-urea mixture. The primary constituents of the porous product were Ni and Ti. We could adjust the pores' shape, size, and interconnectivity for favorite bone ingrowth by using urea as a space holder. Without urea, we obtained an average porosity of 0.30, and a mean void size of 100 μm. With 70 vol % urea, we got 62% interconnected pores of 400 μm average size. Aging allowed us to tune the austenite-martensite transformation temperatures towards the needed body tissue arouse. Differential scanning calorimetry measured the transformation temperatures.... 

Excessive loads on the human spine is recognized as a risk factor for back injuries/pain. Various lifting analysis tools such as musculoskeletal models, regression equations and NIOSH (National Institute for Occupational Safety and Health) lifting equation (NLE) have been proposed to evaluate and mitigate associated risks during manual material handling activities. Present study aims to compare predicted spinal loads from 5 different lifting analysis tools as well as to critically evaluate the NIOSH recommended weight limit (RWL). Spinal loads were estimated under different symmetric/asymmetric lifting tasks in which hand-load mass at each task was set based on RWL from NLE. Estimated... 

The relative vulnerability of spinal motion segments to different loading combinations remains unknown. The meta-analysis described here using the results of a validated L2-L3 nonlinear viscoelastic finite element model was designed to investigate the critical loading and its effect on the internal mechanics of the human lumbar spine. A Box-Behnken experimental design was used to design the magnitude of seven independent variables associated with loads, rotations and velocity of motion. Subsequently, an optimization method was used to find the primary and secondary variables that influence spine mechanical output related to facet forces, disc pressure, ligament forces, annulus matrix... 

The performance of cellular solids in biomedical applications relies strongly on a detailed understanding of the effects of pore topology on mechanical properties. This study aims at characterizing the failure mechanism of scaffolds based on nodal connectivity (number of struts that meet in joints) and geometry of the pores. Plastic models of scaffolds having the same relative density but different cubic and trigonal unit cells were designed and then fabricated via three dimensional (3-D) printing. Unit cells were repeated in different arrangements in 3-D space. An in-situ imaging technique was utilized to study the progressive deformation of the scaffold models. Different nodal... 

A detailed 3D anatomical model of the patellofemoral joint was developed to study the tracking, force, contact and stability characteristics of the joint. The quadriceps was considered to include six components represented by 15 force vectors. The patellar tendon was modeled using four bundles of viscoelastic tensile elements. Each of the lateral and medial retinaculum was modeled by a three-bundle nonlinear spring. The femur and patella were considered as rigid bodies with their articular cartilage layers represented by an isotropic viscoelastic material. The geometrical and tracking data needed for model simulation, as well as validation of its results, were obtained from an in vivo... 

Image based registration of rigid objects has been frequently addressed in the literature to obtain an object's motion parameters. In this paper, a new approach of joint segmentation-rigid registration, within the variational framework of the phase field approximation of the Mumford-Shah's functional, is proposed. The defined functional consists of two Mumford-Shah equations, extracting the discontinuity set of the reference and target images due to a rigid spatial transformation. Multiscale minimization of the proposed functional after finite element discretization provided a sub-pixel, robust algorithm for edge extraction as well as edge based rigid registration. The implementation... 

Muscle force partitioning methods and musculoskeletal system simplifications are key modeling issues that can alter outcomes, and thus change conclusions and recommendations addressed to health and safety professionals. A critical modeling concern is the use of single-joint equilibrium to estimate muscle forces and joint loads in a multi-joint system, an unjustified simplification made by most lumbar spine biomechanical models. In the context of common occupational tasks, an EMG-assisted optimization method (EMGAO) is modified in this study to simultaneously account for the equilibrium at all lumbar joints (M-EMGAO). The results of this improved approach were compared to those of its... 

Abstract: In recent years, temporary skin grafts (TSG) based on natural biopolymers modified with carbon nanostructures have received considerable attention for wound healing. Developments are required to improve physico-mechanical properties of these materials to match to natural skins. Additionally, in-deep pre-clinical examinations are necessary to ensure biological performance and toxicity effect in vivo. In the present work, we show superior acute-wound healing effect of graphene oxide nanosheets embedded in ultrafine biopolymer fibers (60 nm) on adult male rats. Nano-fibrous chitosan-based skin grafts crosslinked by Genepin with physico-mechanical properties close to natural skins were...