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Modeling of an ultrasound system in targeted drug delivery to abdominal aortic aneurysm: a patient-specificin silico study based on ligand-receptor binding
, Article IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control ; Volume 69, Issue 3 , 2022 , Pages 967-974 ; 08853010 (ISSN) ; Boroumand, A ; Ebrahimi, S ; Kalantarnia, F ; Maleki, S ; Moradi, H ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2022
Abstract
Targeted drug delivery methods have shown a significant impact on enhancing drug delivery efficiency and reducing drug side effects. While various stimuli have been used to promote the drug delivery process, applying ultrasound (US) waves to control drug particles through the human body, noninvasively, has drawn the scientist's attention. However, microcarriers delivery reaches the aneurysmal artery by US waves that exert volumetric forces on blood, and drug carriers, which can therefore affect blood flow patterns and movement pathways of drug carriers, have not yet been studied. In this study, we developed a 3-D patient-specific model of abdominal aortic aneurysm (AAA) to evaluate the...
Investigation of coronary artery tortuosity with atherosclerosis: A study on predicting plaque rupture and progression
, Article International Journal of Mechanical Sciences ; Volume 223 , 2022 ; 00207403 (ISSN) ; Fallah, F ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
This study investigated the effects of different patterns of coronary artery tortuosity (CAT) on the stress concentration of the plaques and the blood flow pattern inside an atherosclerotic artery to predict the risk of plaque rupture and progression. Four different loadings of the coronary artery, including pulsatile blood pressure as well as one-end twist around the artery axis at blood pressures of 74, 100, and 120 mmHg were considered. No study has addressed bent and twist buckling of an atherosclerotic artery considering pulsatile flow (for bent buckling), fluid-solid interaction, and different geometrical parameters of the plaque. The results showed that C-shape tortuosity under...
Engineered Biomimetic Membranes for Organ-on-a-Chip
, Article ACS Biomaterials Science and Engineering ; Volume 8, Issue 12 , 2022 , Pages 5038-5059 ; 23739878 (ISSN) ; Rasouli, F ; Jahangiri, S ; Ahmadi, S ; Rabiee, N ; Ramezani Farani, M ; Akhavan, O ; Asadnia, M ; Fatahi, Y ; Hong, S ; Lee, J ; Lee, J ; Hahn, S. K ; Sharif University of Technology
American Chemical Society
2022
Abstract
Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the physiochemical environment of a specific organ in the body. Among various components of OOC systems, biomimetic membranes have been regarded as one of the most important key components to develop controllable biomimetic bioanalysis systems. Here, we review the preparation and characterization of biomimetic membranes in comparison with the features of the extracellular matrix. After that, we review and discuss the latest applications of engineered biomimetic membranes to fabricate various organs on a chip, such as liver, kidney, intestine, lung, skin, heart, vasculature and blood vessels, brain, and multiorgans with...
Investigation of the different parameters contributing to bubble sticking inside physiological bifurcations
, Article Medical and Biological Engineering and Computing ; Volume 60, Issue 2 , 2022 , Pages 599-618 ; 01400118 (ISSN) ; Saidi, M. S ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Gas embolotherapy (GE) is a developing medical method which can be utilized either as an autonomous therapeutic method to treat vascularized solid tumors, or it can be combined with other medical procedures—such as high-intensity focused ultrasound—to improve their efficiency. This paper is dedicated to investigating the different parameters which influence bubble lodging inside human vasculature via 2D-modeling of bubble dynamics in arteries’ and arterioles’ bifurcations which are potential sticking positions. Values used in the simulations are in accordance with the non-dimensional physiological numbers. It is found out that inlet pressure plays a decisive role in bubble lodging; the lower...
Margination and adhesion of micro- and nanoparticles in the coronary circulation: A step towards optimised drug carrier design
, Article Biomechanics and Modeling in Mechanobiology ; Volume 17, Issue 1 , 2018 , Pages 205-221 ; 16177959 (ISSN) ; Shamloo, A ; Sharif University of Technology
Springer Verlag
2018
Abstract
Obstruction of left anterior descending artery (LAD) due to the thrombosis or atherosclerotic plaques is the leading cause of death worldwide. Targeted delivery of drugs through micro- and nanoparticles is a very promising approach for developing new strategies in clot-busting or treating restenosis. In this work, we modelled the blood flow characteristics in a patient-specific reconstructed LAD artery by the fluid–solid interaction method and based on physiological boundary conditions. Next, we provided a Lagrangian description of micro- and nanoparticles dynamics in the blood flow considering their Brownian motion and the particle–particle interactions. Our results state that the number of...
Three-dimensional simulation of urine concentrating mechanism in a functional unit of rat outer medulla. I. Model structure and base case results
, Article Mathematical Biosciences ; Vol. 258 , 2014 , pp. 44-56 ; ISSN: 00255564 ; Saidi, M. S ; Saadatmand, M ; Banazadeh, M. H ; Firoozabadi, B ; Sharif University of Technology
Abstract
The urine formation and excretion system have long been of interest for mathematicians and physiologists to elucidate the obscurities within the process happens in renal tissue. In this study, a novel three-dimensional approach is utilized for modeling the urine concentrating mechanism in rat renal outer medulla which is essentially focused on demonstrating the significance of tubule's architecture revealed in anatomic studies and physiological literature. Since nephrons and vasculatures work interdependently through a highly structured arrangement in outer medulla which is dominated by vascular bundles, a detailed functional unit is proposed based on this specific configuration....
Pulsatile blood flow in total cavopulmonary connection: a comparison between Y-shaped and T-shaped geometry
, Article Medical and Biological Engineering and Computing ; Volume 55, Issue 2 , 2017 , Pages 213-224 ; 01400118 (ISSN) ; Firoozabadi, B ; Saidi, M. S ; Monjezi, M ; Navabi Shirazi, M. A ; Malakan Rad, E ; Sharif University of Technology
Springer Verlag
2017
Abstract
Single-ventricle anomaly is a hereditary heart disease that is characterized by anatomical malformations. The main consequence of this malformation is desaturated blood flow, which without proper treatment increases the risk of death. The classical treatment is based on a three-stage palliative procedure which should begin from the first few days of patient’s life. The final stage is known as Fontan procedure, in which inferior vena cava is directly connected to pulmonary arteries without going through the ventricle. This connection is called total cavopulmonary connection (TCPC). After surgery, the single ventricle supplies adequate and saturated systemic blood flow to the body; however,...
Controlling differentiation of stem cells for developing personalized organ-on-chip platforms
, Article Advanced Healthcare Materials ; Volume 7, Issue 2 , 2018 ; 21922640 (ISSN) ; Jafari, P ; Sheikh Hassani, M ; Heidary Araghi, B ; Mohammadi, M. H ; Ghafari, A. M ; Hassanpour Tamrin, S ; Pezeshgi Modarres, H ; Rezaei Kolahchi, A ; Ahadian, S ; Sanati Nezhad, A ; Sharif University of Technology
Wiley-VCH Verlag
2018
Abstract
Organ-on-chip (OOC) platforms have attracted attentions of pharmaceutical companies as powerful tools for screening of existing drugs and development of new drug candidates. OOCs have primarily used human cell lines or primary cells to develop biomimetic tissue models. However, the ability of human stem cells in unlimited self-renewal and differentiation into multiple lineages has made them attractive for OOCs. The microfluidic technology has enabled precise control of stem cell differentiation using soluble factors, biophysical cues, and electromagnetic signals. This study discusses different tissue- and organ-on-chip platforms (i.e., skin, brain, blood–brain barrier, bone marrow, heart,...
Simulation of low density lipoprotein (LDL) permeation into multilayer coronary arterial wall: interactive effects of wall shear stress and fluid-structure interaction in hypertension
, Article Journal of Biomechanics ; Volume 67 , 2018 , Pages 114-122 ; 00219290 (ISSN) ; Nikmaneshi, M. R ; Firoozabadi, B ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Due to increased atherosclerosis-caused mortality, identification of its genesis and development is of great importance. Although, key factors of the origin of the disease is still unknown, it is widely believed that cholesterol particle penetration and accumulation in arterial wall is mainly responsible for further wall thickening and decreased rate of blood flow during a gradual progression. To date, various effective components are recognized whose simultaneous consideration would lead to a more accurate approximation of Low Density Lipoprotein (LDL) distribution within the wall. In this research, a multilayer Fluid-Structure Interaction (FSI) model is studied to simulate the penetration...
In silico study of patient-specific magnetic drug targeting for a coronary LAD atherosclerotic plaque
, Article International Journal of Pharmaceutics ; Volume 559 , 2019 , Pages 113-129 ; 03785173 (ISSN) ; Amani, A ; Forouzandehmehr, M ; Ghoytasi, I ; Sharif University of Technology
Elsevier B.V
2019
Abstract
Coronary artery disease is the first cause of death across the world. Targeted delivery of therapeutics through controlled release of micro- and nano-particles remains a very capable approach to develop new strategies in treating restenosis and atherosclerotic plaques. In this research, to produce the arterial geometry, an image-processing was done using CT-scan images of a LAD coronary artery. After implementing the finite element mesh, the Fluid-Structure Interaction (FSI) simulation based on physiological boundary conditions was performed. Next, a Lagrangian description of particles dynamics in a non-Newtonian blood flow considering momentum equation of motion for each particle and the...
The effect of hematocrit and nanoparticles diameter on hemodynamic parameters and drug delivery in abdominal aortic aneurysm with consideration of blood pulsatile flow
, Article Computer Methods and Programs in Biomedicine ; Volume 195 , October , 2020 ; Nasiri Sadr, A ; Kaffash, E ; Goudarzi, S ; Golab, E ; Karimipour, A ; Sharif University of Technology
Elsevier Ireland Ltd
2020
Abstract
Background and Objective: The present article has simulated to investigate the efficient hemodynamic parameters, the drug persistence, and drug distribution on an abdominal aortic aneurysm. Methods: Blood as a non-Newtonian fluid enters the artery acting as a real pulse waveform; its behavior is dependent on hematocrit and strain rate. In this simulation of computational fluid dynamic, magnetic nanoparticles of iron oxide which were in advance coated with the drug, are injected into the artery during a cardiac cycle. A two-phase model was applied to investigate the distribution of these carriers. Results: The results are presented for different hematocrits and the nanoparticle diameter. It...
Spatiotemporal registration and fusion of transthoracic echocardiography and volumetric coronary artery tree
, Article International Journal of Computer Assisted Radiology and Surgery ; Volume 16, Issue 9 , 2021 , Pages 1493-1505 ; 18616410 (ISSN) ; Behnam, H ; Fatemizadeh, E ; Faghihi Langroudi, T ; Bayat, F ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2021
Abstract
Purpose: Cardiac multimodal image fusion can offer an image with various types of information in a single image. Many coronary stenosis, which are anatomically clear, are not functionally significant. The treatment of such kind of stenosis can cause irreversible effects on the patient. Thus, choosing the best treatment planning depend on anatomical and functional information is very beneficial. Methods: An algorithm for the fusion of coronary computed tomography angiography (CCTA) as an anatomical and transthoracic echocardiography (TTE) as a functional modality is presented. CCTA and TTE are temporally registered using manifold learning. A pattern search optimization algorithm, using...
Healthy and diseasedin vitromodels of vascular systems
, Article Lab on a Chip ; Volume 21, Issue 4 , 2021 , Pages 641-659 ; 14730197 (ISSN) ; Mallone, A ; Nasrollahi, F ; Ostrovidov, S ; Nasiri, R ; Mahmoodi, M ; Haghniaz, R ; Baidya, A ; Salek, M. M ; Darabi, M. A ; Orive, G ; Shamloo, A ; Dokmeci, M. R ; Ahadian, S ; Khademhosseini, A ; Sharif University of Technology
Royal Society of Chemistry
2021
Abstract
Irregular hemodynamics affects the progression of various vascular diseases, such atherosclerosis or aneurysms. Despite the extensive hemodynamics studies on animal models, the inter-species differences between humans and animals hamper the translation of such findings. Recent advances in vascular tissue engineering and the suitability ofin vitromodels for interim analysis have increased the use ofin vitrohuman vascular tissue models. Although the effect of flow on endothelial cell (EC) pathophysiology and EC-flow interactions have been vastly studied in two-dimensional systems, they cannot be used to understand the effect of other micro- and macro-environmental parameters associated with...
Effect of material and population on the delivery of nanoparticles to an atherosclerotic plaque: a patient-specific in silico study
, Article Langmuir ; Volume 37, Issue 4 , 2021 , Pages 1551-1562 ; 07437463 (ISSN) ; Shamloo, A ; Barzegar, S ; Forouzandehmehr, M ; Sharif University of Technology
American Chemical Society
2021
Abstract
Coronary artery disease (CAD) is the prevalent reason of mortality all around the world. Targeting CAD, specifically atherosclerosis, with controlled delivery of micro and nanoparticles, as drug carriers, is a very proficient approach. In this work, a patient-specific and realistic model of an atherosclerotic plaque in the left anterior descending (LAD) artery was created by image-processing of CT-scan images and implementing a finite-element mesh. Next, a fluid-solid interaction simulation considering the physiological boundary conditions was conducted. By considering the simulated force fields and particle-particle interactions, the correlation between injected particles at each cardiac...
Targeted drug delivery of magnetic microbubble for abdominal aortic aneurysm: an in silico study
, Article Biomechanics and Modeling in Mechanobiology ; Volume 21, Issue 2 , 2022 , Pages 735-753 ; 16177959 (ISSN) ; Ebrahimi, S ; Ghorbani, G ; Alishiri, M ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Targeted drug delivery (TDD) to abdominal aortic aneurysm (AAA) using a controlled and efficient approach has recently been a significant challenge. In this study, by using magnetic microbubbles (MMBs) under a magnetic field, we investigated the MMBs performance in TDD to AAA based on the amount of surface density of MMBs (SDMM) adhered to the AAA lumen. The results showed that among the types of MMBs studied in the presence of the magnetic field, micromarkers are the best type of microbubble with a −50 % increase in SDMM adhered to the critical area of AAA. The results show that applying a magnetic field causes the amount of SDMM adhered to the whole area of AAA to increase −1.54 times...
Aortic dissection is determined by specific shape and hemodynamic interactions
, Article Annals of Biomedical Engineering ; Volume 50, Issue 12 , 2022 , Pages 1771-1786 ; 00906964 (ISSN) ; Marlevi, D ; Bruse, J. L ; Nezami, F. R ; Moradi, H ; Fortunato, R. N ; Maiti, S ; Billaud, M ; Edelman, E. R ; Gleason, T. G ; Sharif University of Technology
Springer
2022
Abstract
The aim of this study was to determine whether specific three-dimensional aortic shape features, extracted via statistical shape analysis (SSA), correlate with the development of thoracic ascending aortic dissection (TAAD) risk and associated aortic hemodynamics. Thirty-one patients followed prospectively with ascending thoracic aortic aneurysm (ATAA), who either did (12 patients) or did not (19 patients) develop TAAD, were included in the study, with aortic arch geometries extracted from computed tomographic angiography (CTA) imaging. Arch geometries were analyzed with SSA, and unsupervised and supervised (linked to dissection outcome) shape features were extracted with principal component...
Fluid particle diffusion through high-hematocrit blood flow within a capillary tube
, Article Journal of Biomechanics ; Volume 44, Issue 1 , Jan , 2011 , Pages 170-175 ; 00219290 (ISSN) ; Ishikawa, T ; Matsuki, N ; Jafar Abdekhodaie, M ; Imai, Y ; Ueno, H ; Yamaguchi, T ; Sharif University of Technology
2011
Abstract
Fluid particle diffusion through blood flow within a capillary tube is an important phenomenon to understand, especially for studies in mass transport in the microcirculation as well as in solving technical issues involved in mixing in biomedical microdevices. In this paper, the spreading of tracer particles through up to 20% hematocrit blood, flowing in a capillary tube, was studied using a confocal micro-PTV system. We tracked hundreds of particles in high-hematocrit blood and measured the radial dispersion coefficient. Results yielded significant enhancement of the particle diffusion, due to a micron-scale flow-field generated by red blood cell motions. By increasing the flow rate, the...
Integrative Utilization of Microenvironments, Biomaterials and Computational Techniques for Advanced Tissue Engineering
, Article Journal of Biotechnology ; Volume 212 , 2015 , Pages 71-89 ; 01681656 (ISSN) ; Mohammadaliha, N ; Mohseni, M ; Sharif University of Technology
Elsevier
2015
Abstract
This review aims to propose the integrative implementation of microfluidic devices, biomaterials, and computational methods that can lead to a significant progress in tissue engineering and regenerative medicine researches. Simultaneous implementation of multiple techniques can be very helpful in addressing biological processes. Providing controllable biochemical and biomechanical cues within artificial extracellular matrix similar to in vivo conditions is crucial in tissue engineering and regenerative medicine researches. Microfluidic devices provide precise spatial and temporal control over cell microenvironment. Moreover, generation of accurate and controllable spatial and temporal...
Multiphysics flow modeling and in vitro toxicity of iron oxide nanoparticles coated with poly(vinyl alcohol)
, Article Journal of Physical Chemistry C ; Volume 113, Issue 6 , 2009 , Pages 2322-2331 ; 19327447 (ISSN) ; Shokrgozar, M. A ; Simchi, A ; Imani, M ; Milani, A. S ; Stroeve, P ; Vali, H ; Häfeli, U. O ; Bonakdar, S ; Sharif University of Technology
2009
Abstract
This study investigated the behavior of ferrofluids containing superparamagnetic iron oxide nanoparticles (SPION) of various compositions for potential applications in drug delivery and imaging. To ensure biocompatibility, the interaction of these SPION with two cell lines (adhesive and suspended) was also investigated using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) assay. The cell lines studied were primary mouse connective tissue cells (adhesive) and human leukemia cells (suspended). SPION were synthesized with a co-precipitation method under different stirring rates and NaOH molarities. The SPION demonstrated a range of magnetic saturations due to their...
Automatic segmentation, detection, and diagnosis of abdominal aortic aneurysm (AAA) using convolutional neural networks and hough circles algorithm
, Article Cardiovascular Engineering and Technology ; Volume 10, Issue 3 , 2019 , Pages 490-499 ; 1869408X (ISSN) ; Mohammadi, M ; Dehlaghi, V ; Ahmadi, A ; Sharif University of Technology
Springer New York LLC
2019
Abstract
Purpose: An abdominal aortic aneurysm (AAA) is known as a cardiovascular disease involving localized deformation (swelling or enlargement) of aorta occurring between the renal and iliac arteries. AAA would jeopardize patients’ lives due to its rupturing risk, so prompt recognition and diagnosis of this disorder is vital. Although computed tomography angiography (CTA) is the preferred imaging modality used by radiologist for diagnosing AAA, computed tomography (CT) images can be used too. In the recent decade, there has been several methods suggested by experts in order to find a precise automated way to diagnose AAA without human intervention base on CT and CTA images. Despite great...