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    Numerical simulation of cold and hot water injection into naturally fractured porous media using the extended–FEM and an equivalent continuum model

    , Article International Journal for Numerical and Analytical Methods in Geomechanics ; Volume 46, Issue 3 , 2022 , Pages 617-655 ; 03639061 (ISSN) Mortazavi, S. M. S ; Pirmoradi, P ; Khoei, A. R ; Sharif University of Technology
    John Wiley and Sons Ltd  2022
    Abstract
    In this paper, a computational technique is presented for the isothermal and non-isothermal water injection into naturally fractured oil reservoirs. A remarkable number of naturally fractured reservoirs contain relatively heavy oils that could not be extracted economically; hence, the thermal recovery methods are extensively used for such reservoirs. In this study, the effectiveness of hot water injection over cold (isothermal) water injection in oil production is quantified. The influence of long and short fractures and their alignments on oil recovery are discussed. To this end, a 2D model for two-phase fluid flow and heat transfer is presented. The medium is assumed to be partially... 

    A computational modelling study of excitation of neuronal cells with triboelectric nanogenerators

    , Article Scientific Reports ; Volume 12, Issue 1 , 2022 ; 20452322 (ISSN) Nazari Vanani, R ; Mohammadpour, R ; Asadian, E ; Rafii-Tabar, H ; Sasanpour, P ; Sharif University of Technology
    Nature Research  2022
    Abstract
    Neurological disorders and nerve injuries, such as spinal cord injury, stroke, and multiple sclerosis can result in the loss of muscle function. Electrical stimulation of the neuronal cells is the currently available clinical treatment in this regard. As an effective energy harvester, the triboelectric nanogenerators (TENG) can be used for self-powered neural/muscle stimulations because the output of the TENG provides stimulation pulses for nerves. In the present study, using a computational modelling approach, the effect of surface micropatterns on the electric field distribution, induced voltage and capacitance of the TENG structures have been investigated. By incorporating the effect of... 

    Monitoring multivariate profiles in multistage processes

    , Article Communications in Statistics: Simulation and Computation ; Volume 50, Issue 11 , 2021 , Pages 3436-3464 ; 03610918 (ISSN) Bahrami, H ; Akhavan Niaki, T ; Khedmati, M ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    Abstract
    In some quality control applications, processes consist of multiple components, stations or stages to finish the final products or the services. Some quality characteristics in each stage of these processes (called multistage processes) can be represented by a relationship between a response and one or more explanatory variables which is named as profile. In this paper, a general model is proposed for monitoring multivariate profiles in multistage processes. To this aim, the multivariate form of the U transformation approach is first used to remove the effect of the cascade property between the stages. Then, three control schemes are employed to monitor the parameters of multivariate simple... 

    Targeted pulmonary drug delivery in coronavirus disease (COVID-19) therapy: A patient-specific in silico study based on magnetic nanoparticles-coated microcarriers adhesion

    , Article International Journal of Pharmaceutics ; Volume 609 , 2021 ; 03785173 (ISSN) Ebrahimi, S ; Shamloo, A ; Alishiri, M ; Mozhdehbakhsh Mofrad, Y ; Akherati, F ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    Since the beginning of the COVID-19 pandemic, nearly most confirmed cases develop respiratory syndromes. Using targeted drug delivery by microcarriers is one of the most important noteworthy methods for delivering drugs to the involved bronchi. This study aims to investigate the performance of a drug delivery that applies microcarriers to each branch of the lung under the influence of a magnetic field. The results show that by changing the inlet velocity from constant to pulsatile, the drug delivery performance to the lungs increases by ∼31%. For transferring the microcarriers to the right side branches (LUL and LLL), placing the magnet at zero height and ∼30° angle yields the best outcome.... 

    Drug delivery performance of nanocarriers based on adhesion and interaction for abdominal aortic aneurysm treatment

    , Article International Journal of Pharmaceutics ; Volume 594 , 2021 ; 03785173 (ISSN) Ebrahimi, S ; Vatani, P ; Amani, A ; Shamloo, A ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    Targeted drug delivery using nanocarriers (NCs) is one of the novel techniques that has recently been used to improve drug delivery to the Abdominal aortic aneurysm (AAA) disease. The purpose of this study is to evaluate the surface density of NCs (SDNC) adhered via ligand-receptor binding to the inner wall of AAA. For this purpose, fluid–structure interaction (FSI) analysis was first performed for the patient-specific and ideal AAA models. Then, by injecting NCs into the aortic artery, the values of SDNC adhered to and interacted with AAA wall were obtained. Two types of NCs, liposomes, and solid particles in four different diameters, were used to investigate the effect of the diameter and... 

    A perspective on electrostatics in gas-solid fluidized beds: Challenges and future research needs

    , Article 13th International Conference on Fluidized Bed Technology, CFB 2021, 10 May 2021 through 14 May 2021 ; 2021 , Pages 426-431 ; 9781771368506 (ISBN) Fotovat, F ; Bi, X. T ; Grace, J. R ; Sharif University of Technology
    GLAB Reactor and Fluidization Technologies  2021
    Abstract
    This paper provides a perspective on the current knowledge and potential areas of future research related to electrostatics in fluidized beds. Aspects addressed include characterization techniques, interplay between electrostatics and hydrodynamics, charge control methods, applications of tribo-electrostatic fluidization systems, and computational simulations which account for electrostatic forces, as well as other forces. This is a complex research field involving fluid mechanics, powders, and electrical physics. © 2021 CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology. All rights reserved  

    Seismic behavior of a dolphin-type berth subjected to liquefaction induced lateral spreading: 1g large scale shake table testing and numerical simulations

    , Article Soil Dynamics and Earthquake Engineering ; Volume 140 , 2021 ; 02677261 (ISSN) Kavand, A ; Haeri, S. M ; Raisianzadeh, J ; Sadeghi Meibodi, A ; Afzal Soltani, S ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    The effects of liquefaction induced lateral spreading on the piles of a dolphin-type berth were investigated using 1 g large scale shake table testing accompanied by numerical simulations. For this purpose, various aspects of the response of the soil and the pile group to lateral spreading were considered. The results indicated that large bending moments were induced in the piles during lateral spreading and the downslope piles of the group received greater bending moments than the upslope one. The monotonic components of bending moments in the piles were reasonably predicted by the displacement based numerical approach using p-y springs when they were properly tuned for strength reduction... 

    Interpretation of CPT in unsaturated sands under drained conditions: A numerical study

    , Article International Journal for Numerical and Analytical Methods in Geomechanics ; Volume 45, Issue 18 , 2021 , Pages 2732-2755 ; 03639061 (ISSN) Keshmiri, E ; Ahmadi, M. M ; Sharif University of Technology
    John Wiley and Sons Ltd  2021
    Abstract
    A finite difference-based numerical model simulating the cone penetration process in unsaturated sands is presented. Mohr–Coulomb model (MCM) with simple modifications and Sun model (SM) were implemented to capture the unsaturated sand behaviour. It was shown that the cone tip resistance values resulting from the two models were fairly comparable. Predicted cone tip resistance values in dry, saturated and unsaturated sands using MCM were validated by the results of field and calibration chamber tests. Sensitivity analyses were performed, and the influence of parameters including relative density, mean effective stress and apparent cohesion due to suction on the tip resistance was... 

    Examining the effect of simulation parameters on coal gasification in tapered fluidized bed reactor

    , Article Powder Technology ; Volume 388 , August , 2021 , Pages 505-516 ; 00325910 (ISSN) Khodabandehlou, R ; Askaripour, H ; Sharif University of Technology
    Elsevier B. V  2021
    Abstract
    The aim of this study is to assess the influence of oxygen-to-steam ratio, wall boundary conditions, coal feeding rate, and static bed height on the concentrations, heating values, and efficiencies of the product gas in a tapered fluidized bed reactor. Results show that lower and higher heating values slightly vary with increasing the oxygen-to-steam ratio in the range of 0.25–0.35. It is found that cold gas efficiency and carbon conversion efficiency goes up with increased ratio of oxygen to steam; however, both efficiencies decline as a result of increasing the coal feeding rate. As static bed height rises, lower and higher heating values diminish for tapered angle of 5°. For tapered angle... 

    On optimal proportions of structural member cross-sections to achieve best seismic performance using value based seismic design approach

    , Article Engineering Structures ; Volume 231 , 2021 ; 01410296 (ISSN) Mirfarhadi, S. A ; Estekanchi, H. E ; Sarcheshmehpour, M ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    The value-based seismic design framework is a new design method that efficiently balances the construction resources and the seismic consequences, through reliable evaluation of the building performance at an affordable computational cost. This paper employs the value-based design approach to optimize the cross-section proportions of the steel wide-flange members. An optimization problem is proposed within the framework of value-based design. Construction cost and seismic consequences are selected as the value components. Moreover, the minimum code requirements are formulated as the design constraints. FEMA-P58 framework is exploited for the prediction of the seismic consequences including... 

    Numerical simulation of unsteady airflow in a nasal cavity for various sizes of maxillary sinus opening in a virtual endoscopic surgery

    , Article Respiratory Physiology and Neurobiology ; Volume 291 , 2021 ; 15699048 (ISSN) Moniripiri, M ; Amjadimanesh, H ; Faramarzi, M ; Sadrizadeh, S ; Abouali, O ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    Functional endoscopic sinus surgery (FESS) is performed to treat sinusitis when treatment with medication fails. In the present study, three different virtual maxillary sinus endoscopic surgeries were performed on a realistic 3-D computational model of the nasal cavity of an adult male under the supervision of a specialist. They included only uncinectomy, uncinectomy + 8mm Middle Meatal Antrostomy (MMA) and uncinectomy + 18 mm MMA. Simulations were performed for two human activity respiratory rates, including rest and moderate activities, and effects of different surgeries and respiratory rates on maxillary sinus were investigated. It was found that after endoscopic sinus surgery, the volume... 

    Experimental and CFD simulation of slurry flow in the annular flow path using two-fluid model

    , Article Journal of Petroleum Science and Engineering ; Volume 198 , 2021 ; 09204105 (ISSN) Movahedi, H ; Jamshidi, S ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    The current study is allocated to experimental evaluation of the multiphase flow of fine solid particles (FSPs) as well as comprehensive numerical study in an annular space under static, laminar, and turbulent flow conditions with consideration of the inner pipe eccentricity and rotation. The experimental investigation was carried out using an annular pipe flow loop. The numerical modeling and simulation of the multiphase flow in the annular space have been performed using the Euler-Euler approach. The unsteady-state multiphase model based on the kinetic theory of granular flow (KTGF) is developed to investigate the particulate flow characteristics in the annular space. Moreover, Standard... 

    On statistical learning of simplices: Unmixing problem revisited

    , Article Annals of Statistics ; Volume 49, Issue 3 , 2021 , Pages 1626-1655 ; 00905364 (ISSN) Najafi, A ; Ilchi, S ; Saberi, A. H ; Motahari, S. A ; Hossein Khalaj, B ; Rabiee, H. R ; Sharif University of Technology
    Institute of Mathematical Statistics  2021
    Abstract
    We study the sample complexity of learning a high-dimensional simplex from a set of points uniformly sampled from its interior. Learning of simplices is a long studied problem in computer science and has applications in computational biology and remote sensing, mostly under the name of “spectral unmixing.” We theoretically show that a sufficient sample complexity for reliable learning of a K-dimensional simplex up to a total-variation error of ε is O(Kε2 log Kε ), which yields a substantial improvement over existing bounds. Based on our new theoretical framework, we also propose a heuristic approach for the inference of simplices. Experimental results on synthetic and real-world datasets... 

    Numerical-probabilistic modeling of the liquefaction-induced free fields settlement

    , Article Soil Dynamics and Earthquake Engineering ; Volume 149 , 2021 ; 02677261 (ISSN) Sadeghi, H ; Pak, A ; Pakzad, A ; Ayoubi, P ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Liquefaction is a phenomenon through which saturated sandy soil loses its shear strength and turns into a liquefied state. One of the most detrimental consequences of liquefaction is the reconsolidation volumetric settlements after the earthquakes, which is due to the dissipation of excess pore pressure caused by earthquakes. Severe floods can follow these settlements in free fields such as grounds close to the sea or rivers. Several researchers studied this phenomenon using data obtained from experiments in the lab or observations in the fields. Previous works were mainly based on a limited number of experimental observations and considered loadings and boundary conditions that were... 

    Numerical study of stiff diaphragm walls used to improve the performance of rocking foundation systems

    , Article Journal of Earthquake Engineering ; Volume 25, Issue 13 , 2021 , Pages 2628-2650 ; 13632469 (ISSN) Sadjadi, M ; Fadaee, M ; Ghannad, M. A ; Jahankhah, H ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    Abstract
    This research explores the effectiveness of the use of stiff diaphragm walls next to a rocking foundation through numerical simulation. This improvement technique is used as a means to increase in subsoil peripheral confinement and reduce rocking-induced settlement. The numerical model was verified by the centrifuge test of rocking shallow foundations on clay under cyclic loading. A parametric study was conducted to explore the effect of three stiff wall shapes on the performance of a rocking system. The general conclusion of the parametric investigation is that the use of stiff diaphragm walls reduced the sinking-dominated settlement response of the rocking system. © 2019 Taylor & Francis... 

    Numerical study to evaluate the important parameters affecting the hydrodynamic performance of manta ray's in flapping motion

    , Article Applied Ocean Research ; Volume 109 , 2021 ; 01411187 (ISSN) Safari, H ; Abbaspour, M ; Darbandi, M ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Manta ray swimming or bio-inspiration propulsion system, as a special type of marine propulsion system, is used for submersible vehicles that require high-speed maneuverability and stability, such as glider and AUV. In a manta ray swimming, the thrust force is generated by a couple of undulation and oscillation of wing, so that the direction of undulation wave and oscillation is upright and perpendicular to the direction of thrust force, respectively. It is possible to combine these two movement modes (flapping motion) on the three-dimensional model without considering the effects of wing twisting and flexibility to simplify and better understand the physical behaviors or special study of... 

    Dynamic analysis of mud loss during overbalanced drilling operation: An experimental study

    , Article Journal of Petroleum Science and Engineering ; Volume 196 , 2021 ; 09204105 (ISSN) Shad, S ; Salmanpour, S ; Zamani, H ; Zivar, D ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    Mud filtration happens during an overbalanced drilling operation that causes mud invasion into pores and fractures. The productivity of a formation is significantly affected by the invasion of the mud into the near-wellbore area during the mud loss process. A considerable number of studies have evaluated mud filtration statically; however, a few studies have considered the dynamic behavior of a mud loss process during overbalanced drilling, which results in the inadequate prediction of the mud loss volume and inflicted damage to the formation. In this study, a near-wellbore simulation system (NeWSS) was designed to evaluate the dynamic mud loss behavior using dimensionless parameters and... 

    Convective-reactive transport of dissolved CO2 in fractured-geological formations

    , Article International Journal of Greenhouse Gas Control ; Volume 109 , 2021 ; 17505836 (ISSN) Shafabakhsh, P ; Ataie Ashtiani, B ; Simmons, C. T ; Younes, A ; Fahs, M ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Carbon dioxide (CO2) storage in geologic formations is an attractive means of reducing greenhouse gas emissions. The main processes controlling the migration of CO2 in geological formations are related to convective mixing and geochemical reactions. The effects of heterogeneity on these coupled processes have been widely discussed in the literature. Recently, special attention has been devoted to fractured geological formations that can be found in several storage reservoirs. However, existing studies on the effect of fractures on the fate of CO2 neglect the key processes of geochemical reactions. This work aims at addressing this gap. Based on numerical simulations of a hypothetical... 

    Using distance on the Riemannian manifold to compare representations in brain and in models

    , Article NeuroImage ; Volume 239 , 2021 ; 10538119 (ISSN) Shahbazi, M ; Shirali, A ; Aghajan, H ; Nili, H ; Sharif University of Technology
    Academic Press Inc  2021
    Abstract
    Representational similarity analysis (RSA) summarizes activity patterns for a set of experimental conditions into a matrix composed of pairwise comparisons between activity patterns. Two examples of such matrices are the condition-by-condition inner product and correlation matrix. These representational matrices reside on the manifold of positive semidefinite matrices, called the Riemannian manifold. We hypothesize that representational similarities would be more accurately quantified by considering the underlying manifold of the representational matrices. Thus, we introduce the distance on the Riemannian manifold as a metric for comparing representations. Analyzing simulated and real fMRI... 

    Nanoscale characterization of the biomolecular corona by cryo-electron microscopy, cryo-electron tomography, and image simulation

    , Article Nature Communications ; Volume 12, Issue 1 , 2021 ; 20411723 (ISSN) Sheibani, S ; Basu, K ; Farnudi, A ; Ashkarran, A ; Ichikawa, M ; Presley, J. F ; Bui, K. H ; Ejtehadi, M. R ; Vali, H ; Mahmoudi, M ; Sharif University of Technology
    Nature Research  2021
    Abstract
    The biological identity of nanoparticles (NPs) is established by their interactions with a wide range of biomolecules around their surfaces after exposure to biological media. Understanding the true nature of the biomolecular corona (BC) in its native state is, therefore, essential for its safe and efficient application in clinical settings. The fundamental challenge is to visualize the biomolecules within the corona and their relationship/association to the surface of the NPs. Using a synergistic application of cryo-electron microscopy, cryo-electron tomography, and three-dimensional reconstruction, we revealed the unique morphological details of the biomolecules and their...