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cytology
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Novel fluoridated silk fibroin/ TiO2 nanocomposite scaffolds for bone tissue engineering
, Article Materials Science and Engineering C ; Volume 82 , 2018 , Pages 265-276 ; 09284931 (ISSN) ; Madaah Hosseini, H. R ; Samadikuchaksaraei, A ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
It is known that Fluoride ions strongly affect bone mineralization and formation. In the present study, the engineered bone tissue scaffolds are fabricated using silk fibroin (SF) and flouridated TiO2 nanoparticles. TiO2 nanoparticles are modified by fluoride ions, and different levels (0, 5, 10, 15 and 20 wt%) of the fluoridated TiO2 nanoparticles (TiO2-F) were subsequently added to the SF matrix through phase separation method to prepare silk fibroin/flouridated TiO2 nanocomposite scaffolds (SF/TiO2-F). Phase structure, functional groups, morphology and mechanical properties of the obtained scaffolds were evaluated by X-ray diffraction method (XRD), Fourier transform infrared spectroscopy...
Design and simulation of a microfluidic device for acoustic cell separation
, Article Ultrasonics ; Volume 84 , March , 2018 , Pages 234-243 ; 0041624X (ISSN) ; Boodaghi, M ; Sharif University of Technology
Elsevier B.V
2018
Abstract
Experimental acoustic cell separation methods have been widely used to perform separation for different types of blood cells. However, numerical simulation of acoustic cell separation has not gained enough attention and needs further investigation since by using numerical methods, it is possible to optimize different parameters involved in the design of an acoustic device and calculate particle trajectories in a simple and low cost manner before spending time and effort for fabricating these devices. In this study, we present a comprehensive finite element-based simulation of acoustic separation of platelets, red blood cells and white blood cells, using standing surface acoustic waves...
Integrated system of multiple batches to evaluate the continuous performance of microbial cells in decolourization processes
, Article Journal of Environmental Chemical Engineering ; Volume 6, Issue 1 , February , 2018 , Pages 728-735 ; 22133437 (ISSN) ; Bagheri Lotfabad, T ; Heidarinasab, A ; Ebadipour, N ; Yaghmaei, S ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Azo dye degradation in wastewater treatment is a subject which has garnered the attention of many research studies. In this study, an innovative approach, namely, an integrated system of five batches (ISFB), was developed to investigate the capability of Saccharomyces cerevisiae ATCC 9763 for continuous degradation of methyl red as a representative azo dye. Toward this end, an expanded immobilized microbial bed (EIMB) reactor was established with a bed of encapsulated yeast cells in sodium alginate. EIMB reactor was run in two modes, single batch and ISFB. Moreover, durability of the microbial cells was evaluated by repeating the continuous decolourization eight sequential times in EIMB at...
Engineering of mature human induced pluripotent stem cell-derived cardiomyocytes using substrates with multiscale topography
, Article Advanced Functional Materials ; Volume 28, Issue 19 , 2018 ; 1616301X (ISSN) ; Garbern, J. C ; Behzadi, S ; Hill, M. J ; Tresback, J. S ; Heydari, T ; Ejtehadi, M. R ; Ahmed, N ; Copley, E ; Aghaverdi, H ; Lee, R. T ; Farokhzad, O. C ; Mahmoudi, M ; Sharif University of Technology
Wiley-VCH Verlag
2018
Abstract
Producing mature and functional cardiomyocytes (CMs) by in vitro differentiation of induced pluripotent stem cells (iPSCs) using only biochemical cues is challenging. To mimic the biophysical and biomechanical complexity of the native in vivo environment during the differentiation and maturation process, polydimethylsiloxane substrates with 3D topography at the micrometer and sub-micrometer levels are developed and used as cell-culture substrates. The results show that while cylindrical patterns on the substrates resembling mature CMs enhance the maturation of iPSC-derived CMs, sub-micrometer-level topographical features derived by imprinting primary human CMs further accelerate both the...
Construction of scaffolds composed of acellular cardiac extracellular matrix for myocardial tissue engineering
, Article Biologicals ; Volume 53 , 2018 , Pages 10-18 ; 10451056 (ISSN) ; Mashayekhan, S ; Ghanbari Asl, S ; Hajebrahimi, Z ; Sharif University of Technology
Academic Press
2018
Abstract
High rates of mortality and morbidity stemming from cardiovascular diseases unveil extreme limitations in current therapies despite enormous advances in medical and pharmaceutical sciences. Following myocardial infarction (MI), parts of myocardium undergo irreversible remodeling and is substituted by a scar tissue which eventually leads to heart failure (HF). To address this issue, cardiac patches have been utilized to initiate myocardial regeneration. In this study, a porous cardiac patch is fabricated using a mixture of decellularized myocardium extracellular matrix (ECM) and chitosan (CS). Results of rheological measurements, SEM, biodegradation test, and MTT assay showed that the...
A robust and low-power near-threshold SRAM in 10-nm FinFET technology
, Article Analog Integrated Circuits and Signal Processing ; Volume 94, Issue 3 , 2018 , Pages 497-506 ; 09251030 (ISSN) ; Moaiyeri, M. H ; Hessabi, S ; Sharif University of Technology
Springer New York LLC
2018
Abstract
This paper presents a robust and low-power single-ended robust 11T near-threshold SRAM cell in 10-nm FinFET technology. The proposed cell eliminates write disturbance and enhances write performance by disconnecting the path between cross-coupled inverters during the write operation. FinFETs suffer from width quantization, and SRAM performance is highly dependent to transistors sizing. The proposed structure with minimum sized tri-gate FinFETs operates without failure under major process variations. In addition, read disturbance is reduced by isolating the storage nodes during the read operations. To reduce power consumption this cell uses only one bit-line for both read and write operations....
Atorvastatin treatment softens human red blood cells: an optical tweezers study
, Article Biomedical Optics Express ; Volume 9, Issue 3 , 2018 ; 21567085 (ISSN) ; Babaei, M ; Azadbakht, A ; Pazoki Toroudi, H ; Mashaghi, A ; Moosavi Movahedi, A. A ; Seyed Reihani, .N ; Sharif University of Technology
OSA - The Optical Society
2018
Abstract
Optical tweezers are proven indispensable single-cell micro-manipulation and mechanical phenotyping tools. In this study, we have used optical tweezers for measuring the viscoelastic properties of human red blood cells (RBCs). Comparison of the viscoelastic features of the healthy fresh and atorvastatin treated cells revealed that the drug softens the cells. Using a simple modeling approach, we proposed a molecular model that explains the drug-induced softening of the RBC membrane. Our results suggest that direct interactions between the drug and cytoskeletal components underlie the drug-induced softening of the cells. © 2018 Optical Society of America
Improving MLC PCM performance through relaxed write and read for intermediate resistance levels
, Article ACM Transactions on Architecture and Code Optimization ; Volume 15, Issue 1 , 2018 ; 15443566 (ISSN) ; Jalili, M ; Sarbazi Azad, H ; Sharif University of Technology
Association for Computing Machinery
2018
Abstract
Phase Change Memory (PCM) is one of the most promising candidates to be used at the main memory level of the memory hierarchy due to poor scalability, considerable leakage power, and high cost/bit of DRAM. PCM is a new resistive memory that is capable of storing data based on resistance values. The wide resistance range of PCM allows for storing multiple bits per cell (MLC) rather than a single bit per cell (SLC). Unfortunately, higher density of MLC PCM comes at the expense of longer read/write latency, higher soft error rate, higher energy consumption, and earlier wearout compared to the SLC PCM. Some studies suggest removing the most error-prone level to mitigate soft error and write...
Characterization of nanostructured biodegradable Zn-Mn alloy synthesized by mechanical alloying
, Article Journal of Alloys and Compounds ; Volume 735 , 2018 , Pages 1319-1327 ; 09258388 (ISSN) ; Khaleghpanah, S ; Sheibani, S ; Khakbiz, M ; Zakeri, A ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
In this study, nanostructured biodegradable pure Zn, Zn-4 wt. % Mn and Zn-24 wt % Mn alloys were produced by 20 h mechanical alloying and consequent cold pressing and sintering. Structural evolutions were investigated using the X-ray diffraction technique. Also, the microstructure was characterized by scanning electron microscopy. The effects of alloy composition on density, mechanical properties, corrosion behavior in Hank's solution, cell viability and cell attachment were investigated. Crystallite size of the synthesized alloys after 20 h of milling reached to less than 40 nm and remained less than 80 nm after consolidation and sintering for 1 h. Alloys contain MnZn13 as second phase...
Neuro-Skins: Dynamics, plasticity and effect of neuron type and cell size on their response
, Article Neural Processing Letters ; 2018 , Pages 1-23 ; 13704621 (ISSN) ; Shafiei Dizaji, M ; Sharif University of Technology
Springer New York LLC
2018
Abstract
We are introducing a new type of membrane, called neuro-skin or neuro-membrane. It is comprised of neurons embedded in a plastic membrane. The skin is smart and adaptive and is capable of providing desirable response to inputs intelligently. This way, the neuro-skin can be considered as a new type of neural network with adaptivity and learning capabilities. However, in this paper, only the response of neuro-skins to a dynamic input is studied. The membrane is modelled by nonlinear dynamic finite elements. Each finite element is considered as a cell of the neuro-skin which has a neuron. The neuron is the intelligent nucleus of the element. So, the finite elements are called finite...
A microfabricated platform for the study of chondrogenesis under different compressive loads
, Article Journal of the Mechanical Behavior of Biomedical Materials ; Volume 78 , 2018 , Pages 404-413 ; 17516161 (ISSN) ; Jahanbakhsh, A ; Saidi, M. S ; Bonakdar, S ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Microfluidic devices are beneficial in miniaturizing and multiplexing various cellular assays in a single platform. Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment. Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time. Effects of different strain magnitudes on the chondrogenic differentiation of adult stem cells have not been explored thoroughly. Here, a new multilayer microdevice is presented for the unidirectional compressive stimulation of cells in a three-dimensional cell culture. Numerical simulations were performed to evaluate and optimize the design. Results showed a...
Alumina feeding system changes in aluminum electrochemical cell with d18 technology for energy efficiency (Case study: Almahdi-hormozal aluminum smelter)
, Article 147th Annual Meeting and Exhibition of the Minerals, Metals and Materials Society, TMS 2018, 11 March 2018 through 15 March 2018 ; Volume Part F12 , 2018 , Pages 721-728 ; 23671181 (ISSN); 9783319725253 (ISBN) ; Samimi, A ; Baharvand, B ; Sharif University of Technology
Springer International Publishing
2018
Abstract
Aluminum reduction cells have benefited from point feeding technology for a long time, but there are still smelters which are using the old technology of center break and center feed system. Due to several factors this system is no longer approved and there have been a few attempts worldwide to upgrade these cells so as to implement the newer technology by applying mechanical and automation changes. In this paper we will present an attempt which was made in order to retrofit a so-called center break cell to point feeder cell. The results show that this project has decreased the energy consumption and anode effect frequency. Furthermore, there has been a significant increase in current...
Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing
, Article Advanced Drug Delivery Reviews ; Volume 123 , 2018 , Pages 33-64 ; 0169409X (ISSN) ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Sahandi Zangabad, K ; Ghamarypour, A ; Aref, A. R ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
Elsevier B.V
2018
Abstract
According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally...
Fully-coupled mathematical modeling of actomyosin-cytosolic two-phase flow in a highly deformable moving Keratocyte cell
, Article Journal of Biomechanics ; Volume 67 , January , 2018 , Pages 37-45 ; 00219290 (ISSN) ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Interaction between intracellular dynamics and extracellular matrix (ECM) generally occurred into very thin fragment of moving cell, namely lamellipodia, enables all movable cells to crawl on ECM. In fast-moving cells such as fish Keratocytes, Lamellipodia including most cell area finds a fan-like shape during migration, with a variety of aspect ratio function of fish type. In this work, our purpose is to present a novel and more complete two-dimensional continuum mathematical model of actomyosin-cytosolic two-phase flow of a self-deforming Keratocyte with circular spreaded to steady fan-like shape. In the new approach, in addition to the two-phase flow of the F-actin and cytosol, the...
A portable culture chamber for studying the effects of hydrostatic pressure on cellular monolayers
, Article Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science ; 2018 ; 09544062 (ISSN) ; Saidi, M ; Mosadegh, B ; Firoozabadi, B ; Sharif University of Technology
SAGE Publications Ltd
2018
Abstract
Hydrostatic pressure is one of the most fundamental and common mechanical stimuli in the body, playing a critical role in the homeostasis of all organ systems. Kidney function is affected by high blood pressure, namely hypertension, by the increased pressure acting on the glomerular capillary walls. This general effect of hypertension is diagnosed as a chronic disease, but underlying mechanistic causes are still not well understood. This paper reports a portable and adaptive device for studying the effects of hydrostatic pressure on a monolayer of cells. The fabricated device fits within a conventional incubation system and microscope. The effects of various pressures and durations were...
Ultra-Dense 5G small cell deployment for fiber and wireless backhaul-aware infrastructures
, Article IEEE Transactions on Vehicular Technology ; 2018 ; 00189545 (ISSN) ; Beyranvand, H ; Salehi, J. A ; Maier, M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2018
Abstract
In this paper, we study the cell planning problem for a two-tier cellular network containing two types of base stations (BSs)— i.e. with fiber backhaul, referred to as wired BSs (W-BSs), and BSs with wireless backhaul, referred to as unwired-BSs (U-BSs). In-band full-duplex wireless communications is used to connect U-BSs and W-BSs. We propose an algorithm to determine the minimum number of W-BSs and U-BSs to satisfy given cell and capacity coverage constraints. Furthermore, we apply our proposed non-dominated sorting genetic algorithm II (NSGA-II) to solve the joint cell and backhaul planning problem to minimize the cost of planning, while maximizing the coverage simultaneously....
Experimental investigation on asphaltene biodegradability using microorganism: cell surface properties’ approach
, Article Journal of Petroleum Exploration and Production Technology ; 2018 ; 21900558 (ISSN) ; Ayatollahi, S ; Sharif University of Technology
Springer Verlag
2018
Abstract
Asphaltene precipitation is known to be responsible for serious challenges in oil industry such as wellbore damage, oil flow reduction, and plugging of transportation lines. The traditional methods to remove asphaltene deposition are mostly based on chemical solvent. One of the recent proposed green and cost–effect remedial methods is the application of microorganisms capable of consuming the heavy hydrocarbon chains. The cell surface hydrophobicity among others effectively manipulates the efficiency of the microorganism for asphaltene degradation. Besides, surface active agents would affect the microorganism adhesion and cell surface properties, and alters its hydrophobicity. Investigating...
Natural compounds for skin tissue engineering by electrospinning of nylon-Beta vulgaris
, Article ASAIO Journal ; Volume 64, Issue 2 , 2018 , Pages 261-269 ; 10582916 (ISSN) ; Mahmoudifard, M ; Kehtari, M ; Babaie, A ; Hamedi, S ; Mirzaei, S ; Soleimani, M ; Hosseinzadeh, S ; Sharif University of Technology
Lippincott Williams and Wilkins
2018
Abstract
Natural compounds containing polysaccharide ingredients have been employed as candidates for treatment of skin tissue. Herein, for the first time, electrospinning setup was proposed to fabricate an efficient composite nanofibrous structure of Beta vulgaris (obtained from Beet [Chenopodiaceae or Amaranthaceae]) belonged to polysaccharides and an elastic polymer named nylon 66 for skin tissue engineering. Both prepared scaffolds including noncomposite and composite types were studied by Scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, mechanical assay, and contact angle. Scanning electron microscope examinations have approved the uniform and homogeneous...
Express read in MLC phase change memories
, Article ACM Transactions on Design Automation of Electronic Systems ; Volume 23, Issue 3 , February , 2018 ; 10844309 (ISSN) ; Sarbazi Azad, H ; Sharif University of Technology
Association for Computing Machinery
2018
Abstract
In the era of big data, the capability of computer systems must be enhanced to support 2.5 quintillion byte/day data delivery. Among the components of a computer system, main memory has a great impact on overall system performance. DRAM technology has been used over the past four decades to build main memories. However, the scalability of DRAM technology has faced serious challenges. To keep pace with the ever-increasing demand for larger main memory, some new alternative technologies have been introduced. Phase change memory (PCM) is considered as one of such technologies for substituting DRAM. PCM offers some noteworthy properties such as low static power consumption, nonvolatility, and...
Application of hyperelastic models in mechanical properties prediction of mouse oocyte and embryo cells at large deformations
, Article Scientia Iranica ; Volume 25, Issue 2B , March , 2018 , Pages 700-710 ; 10263098 (ISSN) ; Ahmadian, M. T ; Alizadeh, A ; Tarighi, S ; Sharif University of Technology
Sharif University of Technology
2018
Abstract
Biological cell studies have many applications in biology, cell manipulation, and diagnosis of diseases such as cancer and malaria. In this study, Inverse Finite Element Method (IFEM) combined with Levenberg-Marquardt optimization algorithm has been used to extract and characterize material properties of mouse oocyte and embryo cells at large deformations. Then, the simulation results have been validated using data from experimental works. In this study, it is assumed that cell material is hyperelastic, isotropic, homogenous, and axisymmetric. For inverse analysis, FEM model of cell injection experiment implemented in Abaqus software has been coupled with Levenberg-Marquardt optimization...