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Curcumin-Loaded Starch Micro/Nano particles for biomedical application: the effects of preparation parameters on release profile
, Article Starch/Staerke ; Volume 71, Issue 5-6 , 2019 ; 00389056 (ISSN) ; Zahedifar, P ; Bagheri, R ; Solouk, A ; Sharif University of Technology
Wiley-VCH Verlag
2019
Abstract
Although curcumin is highly cytotoxic against cancer cells, its hydrophobicity and fast degradation at physiological pH limit its effective practical application. To prevent such limitations, inexpensive curcumin-loaded starch particles are synthesized in this research. Particles are prepared by water-in-oil (W/O) miniemulsion technique and an adsorption method is used for curcumin loading. Also, encapsulation efficiency (%EE) is improved by using pluronic F-127 in the drug solution. Particles are characterized, swelling studies are performed, and MTT assays against human adipose mesenchymal stem cells (hAMSCs) and MG-63 cells are utilized for investigations. Results indicate that...
Global stability of a deterministic model for HIV infection in vivo
, Article Chaos, Solitons and Fractals ; Volume 34, Issue 4 , 2007 , Pages 1225-1238 ; 09600779 (ISSN) ; Nasri, M ; Razvan, M. R ; Sharif University of Technology
2007
Abstract
A deterministic model for human immunodeficiency virus (denoted HIV) infection in the presence of combination therapy is considered. Global asymptotic stability of the disease-free equilibrium is discussed and the endemic equilibrium is also investigated. © 2006 Elsevier Ltd. All rights reserved
A systematic review of nano formulation of natural products for the treatment of inflammatory bowel disease: drug delivery and pharmacological targets
, Article DARU, Journal of Pharmaceutical Sciences ; 2018 ; 15608115 (ISSN) ; Bahramsoltani, R ; Marques, A. M ; Naseri, R ; Rahimi, R ; Haratipour, P ; Panah, A. I ; Farzaei, M. H ; Abdollahi, M ; Sharif University of Technology
Abstract
Inflammatory bowel diseases (IBD), which is classified into Crohn’s disease and ulcerative colitis, are among chronic gastrointestinal diseases with unknown pathogenesis. Diverse strategies have been applied for the treatment of this chronic disease. However, selective and site-specific routes of drug delivery to the inflamed location of the colon remain of high importance. Consequently, the application and effects of natural products in the form of nanoformulation and stimuli responsive nanoparticles as a novel strategy for the treatment of IBD are discussed in this review article. This approach may potentially overcome some complications that are associated with conventional means of colon...
Trunk muscles strength and endurance in chronic low back pain patients with and without clinical instability
, Article Journal of Back and Musculoskeletal Rehabilitation ; Volume 25, Issue 2 , 2012 , Pages 123-129 ; 10538127 (ISSN) ; Maroufi, N ; Ebrahimi, I ; Farahmand, F ; Parnianpour, M ; Sharif University of Technology
2012
Abstract
Objectives: Previous research has shown inconsistent findings regarding muscle endurance in chronic low back pain (CLBP). Questions also remain about muscle endurance in patients with clinical instability. The aim of this study was to investigate trunk muscles strength and endurance in CLBP patients with and without clinical instability. Methods: 32 CLBP patients (15 with and 17 without clinical instability) and 39 matched healthy subjects participated in this study. The standing extension test was performed to assess the strength and endurance of the lumbar extensors while recording their electromyographic activity. The patients' disability was evaluated using the Oswestry and Roland-Morris...
Iran in transition
, Article The Lancet ; Volume 393, Issue 10184 , 2019 , Pages 1984-2005 ; 01406736 (ISSN) ; Farzadfar, F ; Kelishadi, R ; Rashidian, A ; Rouhani, O. M ; Ahmadnia, S ; Ahmadvand, A ; Arabi, M ; Ardalan, A ; Arhami, M ; Azizi, M. H ; Bahadori, M ; Baumgartner, J ; Beheshtian, A ; Djalalinia, S ; Doshmangir, L ; Haghdoost, A. A ; Haghshenas, R ; Hosseinpoor, A. R ; Islami, F ; Kamangar, F ; Khalili, D ; Madani, K ; Masoumi Asl, H ; Mazyaki, A ; Mirchi, A ; Moradi, E ; Nayernouri, T ; Niemeier, D ; Houshang Omidvari, A ; Peykari, N ; Pishgar, F ; Qorbani, M ; Rahimi, K ; Rahimi Movaghar, A ; Ramezani Tehrani, F ; Rezaei, N ; Shahraz, S ; Takian, A ; Tootee, A ; Ezzati, M ; Jamshidi, H. R ; Larijani, B ; Majdzadeh, R ; Malekzadeh, R ; Sharif University of Technology
Lancet Publishing Group
2019
Abstract
Being the second-largest country in the Middle East, Iran has a long history of civilisation during which several dynasties have been overthrown and established and health-related structures have been reorganised. Iran has had the replacement of traditional practices with modern medical treatments, emergence of multiple pioneer scientists and physicians with great contributions to the advancement of science, environmental and ecological changes in addition to large-scale natural disasters, epidemics of multiple communicable diseases, and the shift towards non-communicable diseases in recent decades. Given the lessons learnt from political instabilities in the past centuries and the...
Global trends of hand and wrist trauma: A systematic analysis of fracture and digit amputation using the Global Burden of Disease 2017 Study
, Article Injury Prevention ; 2020 ; Massenburg, B.B ; Morrison, S.D ; Chang, J ; Friedrich, J.B ; Abady, G.G ; Alahdab, F ; Alipour, V ; Arabloo, J ; Asaad, M ; Banach, M ; Bijani, A ; Borzì, A.M ; Briko, N.I ; Castle, C.D ; Cho, D.Y ; Chung, M.T ; Daryani, A ; Demoz, G.T ; Dingels, Z.V ; Do, H.T ; Fischer, F ; Fox, J.T ; Fukumoto, T ; Gebre, A.K ; Gebremichael, B ; Haagsma, J.A ; Haj-Mirzaian, A ; Handiso, D.W ; Hay, S.I ; Hoang, C.L ; Irvani, S.S.N ; Jozwiak, J.J ; Kalhor, R ; Kasaeian, A ; Khader, Y.S ; Khalilov, R ; Khan, E.A ; Khundkar, R ; Kisa, S ; Kisa, A ; Liu, Z ; Majdan, M ; Manafi, N ; Manafi, A ; Manda, A.-L ; Meretoja, T.J ; Miller, T.R ; Mohammadian Hafshejani, A ; Mohammadpourhodki, R ; Mohseni Bandpei, M.A ; Mokdad, A.H ; Naimzada, M.D ; Ndwandwe, D.E ; Nguyen, C.T ; Nguyen, H.L.T ; Olagunju, A.T ; Olagunju, T.O ; Pham, H.Q ; Pribadi, D.R.A ; Rabiee, N ; Ramezanzadeh, K ; Ranganathan, K ; Roberts, N.L.S ; Roever, L ; Safari, S ; Samy, A.M ; Sanchez Riera, L ; Shahabi, S ; Smarandache, C.-G ; Sylte, D.O ; Tesfay, B.E ; Tran, B.X ; Ullah, I ; Vahedi, P ; Vahedian Azimi, A ; Vos, T ; Woldeyes, D. H ; Wondmieneh, A. B ; Zhang, Z. J ; James, S. L ; Sharif University of Technology
BMJ Publishing Group
2020
Abstract
Background: As global rates of mortality decrease, rates of non-fatal injury have increased, particularly in low Socio-demographic Index (SDI) nations. We hypothesised this global pattern of non-fatal injury would be demonstrated in regard to bony hand and wrist trauma over the 27-year study period. Methods: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 was used to estimate prevalence, age-standardised incidence and years lived with disability for hand trauma in 195 countries from 1990 to 2017. Individual injuries included hand and wrist fractures, thumb amputations and non-thumb digit amputations. Results: The global incidence of hand trauma has only modestly...
HEROHE Challenge: Predicting HER2 status in breast cancer from hematoxylin–eosin whole-slide imaging
, Article Journal of Imaging ; Volume 8, Issue 8 , 2022 ; 2313433X (ISSN) ; Vale, J ; Feng, M ; Xu, K ; Wang, Y ; Della Mea, V ; La Barbera, D ; Montahaei, E ; Baghshah, M ; Turzynski, A ; Gildenblat, J ; Klaiman, E ; Hong, Y ; Aresta, G ; Araújo, T ; Aguiar, P ; Eloy, C ; Polónia, A ; Sharif University of Technology
MDPI
2022
Abstract
Breast cancer is the most common malignancy in women worldwide, and is responsible for more than half a million deaths each year. The appropriate therapy depends on the evaluation of the expression of various biomarkers, such as the human epidermal growth factor receptor 2 (HER2) transmembrane protein, through specialized techniques, such as immunohistochemistry or in situ hybridization. In this work, we present the HER2 on hematoxylin and eosin (HEROHE) challenge, a parallel event of the 16th European Congress on Digital Pathology, which aimed to predict the HER2 status in breast cancer based only on hematoxylin–eosin-stained tissue samples, thus avoiding specialized techniques. The...
Metabolomic biomarkers in the diagnosis of non-alcoholic fatty liver disease
, Article Hepatitis Monthly ; Volume 19, Issue 9 , 2019 ; 1735143X (ISSN) ; Ghafourpour, M ; Rezaei Farimani, A ; Gholami, A ; Nobakht Motlagh Ghoochani, B. F ; Sharif University of Technology
Kowsar Medical Publishing Company
2019
Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is the most abundant chronic liver disorder, because racial and ethnic differences may influence prevalence and severity of NAFLD. Objectives: This metabolomic study was conducted to identify the metabolic biomarkers and determine the mechanism of progress of NAFLD in Iranian patients. Methods: Serum samples were collected from 75 participants (37 healthy controls and 38 patients with NAFLD) after an overnight fast. The metabolome of all samples were determined by nuclear magnetic resonance (NMR) and were compared by multivariate statistical analysis. Results: Totally, 19 metabolomic biomarkers were identified by NMR. Compared to healthy...
Evaluation of anti-cancer and anti-metastatic effects of folate-PEGylated niosomes for co-delivery of letrozole and ascorbic acid on breast cancer cells
, Article Molecular Systems Design and Engineering ; Volume 7, Issue 9 , 2022 , Pages 1102-1118 ; 20589689 (ISSN) ; Khayam, N ; Noorbazargan, H ; Tavakkoli Yaraki, M ; Asghari Lalami, Z ; Akbarzadeh, I ; Eshrati Yeganeh, F ; Dolatabadi, A ; Mirzaei Rad, F ; Tan, Y. N ; Sharif University of Technology
Royal Society of Chemistry
2022
Abstract
Fighting with cancer requires the delivery of different therapeutics to the target cancerous cells by taking advantage of the synergistic effects of complementary medicine. Herein, we present a folate-PEGylated niosome as an efficient nanocarrier for targeted co-delivery of hydrophobic letrozole (L) and hydrophilic ascorbic acid (A) to breast cancer cells. The formulation of the niosomal nanocarrier was optimized by varying the ratio of cholesterol and surfactants to maximize the drug loading and minimize the size of nanocarriers. The optimum drug carriers were further functionalized with folate-PEG molecules to enhance the efficiency of drug delivery to the breast cancer cells and prevent...
A hybrid deep model for automatic arrhythmia classification based on LSTM recurrent networks
, Article 15th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2020, 1 June 2020 through 3 June 2020 ; 2020 ; Amini, A ; Baghshah, M. S ; Khodajou Chokami, H ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2020
Abstract
Electrocardiogram (ECG) recording of electrical heart activities has a vital diagnostic role in heart diseases. We propose to tackle the problem of arrhythmia detection from ECG signals totally by a deep model that does not need any hand-designed feature or heuristic segmentation (e.g., ad-hoc R-peak detection). In this work, we first segment ECG signals by detecting R-peaks automatically via a convolutional network, including dilated convolutions and residual connections. Next, all beats are aligned around their R-peaks as the most informative section of the heartbeat in detecting arrhythmia. After that, a deep learning model, including both dilated convolution layers and a Long-Short Term...
Atheroprone sites of coronary artery bifurcation: Effect of heart motion on hemodynamics-dependent monocytes deposition
, Article Computers in Biology and Medicine ; Volume 133 , 2021 ; 00104825 (ISSN) ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
Atherosclerosis as a common cardiovascular disease is a result of both adverse hemodynamics conditions and monocyte deposition within coronary arteries. It is known that the adhesion of monocytes on the arterial wall and their interaction with the vascular surface are one of the main parameters in the initiation and progression of atherosclerosis. In this work, hemodynamic parameters and monocyte deposition have been investigated in a 3D computational model of the Left Anterior Descending coronary artery (LAD) and its first diagonal branch (D1) under the heart motion. A one-way Lagrangian approach is performed to trace the monocyte particles under different blood flow regimes and heart motion...
Numerical study of the effect of hemodynamic variables on LDL concentration through the single layer of the Left Anterior Descending coronary artery (LAD) under the heart pulse
, Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 236, Issue 7 , 2022 , Pages 994-1008 ; 09544119 (ISSN) ; Seyedhossein, S. S ; Firoozabadi, B ; MomeniLarimi, M ; Sharif University of Technology
SAGE Publications Ltd
2022
Abstract
Heart attack is one of the most common causes of death in the world. Coronary artery disease is the most recognized cause of heart attack whose onset and progression have been attributed to low-density lipoprotein (LDL) passing through the wall of the artery. In this paper, hemodynamic variables as well as the concentration of LDL through the coronary porous artery at the Left Anterior Descending coronary artery (LAD), and its first diagonal branch (D1) under the heart motion investigated using computational simulation. The geometry that has been studied in this paper is the first bifurcation of Left Anterior Descending (LAD) that has been placed on a perimeter of hypothetical sphere...
Advances in tannic acid-incorporated biomaterials: Infection treatment, regenerative medicine, cancer therapy, and biosensing
, Article Chemical Engineering Journal ; Volume 432 , 2022 ; 13858947 (ISSN) ; Rahimkhoei, V ; Abasian, P ; Delfi, M ; Naderi, J ; Ghomi, M ; Dabbagh Moghaddam, F ; Waqar, T ; Nuri Ertas, Y ; Sharifi, S ; Rabiee, N ; Ersoy, S ; Maleki, A ; Nazarzadeh Zare, E ; Sharifi, E ; Jabbari, E ; Makvandi, P ; Akbari, A ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Polyphenol-based materials have attracted wide-spread interest from academic and industrial communities because of their unique structure and physicochemical properties. Tannic acid (TA), as a polyphenolic phytochemical with high level of galloyl groups, interacts with various substances (proteins, polysaccharides, and metals) through several modes including hydrogen bonding, hydrophobic and electrostatic interactions. Such hybrid or hybrid-like systems allow the preparation of various advanced materials with promising applications in medicine. In this review, we highlight the recent advances of TA-incorporated materials in medical applications including drug delivery, tissue engineering,...
Exploring cellular interactions of liposomes using protein corona fingerprints and physicochemical properties
, Article ACS Nano ; Volume 10, Issue 3 , 2016 , Pages 3723-3737 ; 19360851 (ISSN) ; Palchetti, S ; Pozzi, D ; Hormozi Nezhad, M. R ; Baldelli Bombelli, F ; Caracciolo, G ; Mahmoudi, M ; Sharif University of Technology
American Chemical Society
Abstract
To control liposomes fate and transport upon contact with biofluids, it is essential to consider several parameters affecting the synthetic and biological identity of liposomes, as well as liposome-protein corona (PC) aspects. As a powerful tool in this data mining adventure, quantitative structure-activity relationship (QSAR) approach is used to correlate physicochemical properties of liposomes and their PC fingerprints to multiple quantified biological responses. In the present study, the relationship between cellular interactions of a set of structurally diverse liposomal formulations and their physicochemical and PC properties has been investigated via linear and nonlinear QSAR models....
Some natural hypomethylating agents in food, water and environment are against distribution and risks of COVID-19 pandemic: Results of a big-data research
, Article Avicenna Journal of Phytomedicine ; Volume 12, Issue 3 , 2022 , Pages 309-324 ; 22287930 (ISSN) ; Izadi, M ; Talebpour, A ; Sharif University of Technology
Mashhad University of Medical Sciences
2022
Abstract
Objective: This study analyzes the effects of lifestyle, nutrition, and diets on the status and risks of apparent (symptomatic) COVID-19 infection in Iranian families. Materials and Methods: A relatively extensive questionnaire survey was conducted on more than 20,000 Iranian families (residing in more than 1000 different urban and rural areas in the Islamic Republic of Iran) to collect the big data of COVID-19 and develop a lifestyle dataset. The collected big data included the records of lifestyle effects (e.g. nutrition, water consumption resources, physical exercise, smoking, age, gender, health and disease factors, etc.) on the status of COVID-19 infection in families (i.e. residents of...
Classification of abnormalities in mammograms by new asymmetric fractal features
, Article Biocybernetics and Biomedical Engineering ; Volume 36, Issue 1 , 2016 , Pages 56-65 ; 02085216 (ISSN) ; Ahmadi Noubari, H ; Fatemizadeh, E ; Khalili, M ; Sharif University of Technology
PWN-Polish Scientific Publishers
2016
Abstract
In this paper we use fractal method for detection and diagnosis of abnormalities in mammograms. We have used 168 images that were carefully selected by a radiologist and their abnormalities were also confirmed by biopsy. These images included asymmetric lesions, architectural distortion, normal tissue and mass lesion where in case of mass lesion they included circumscribed benign, ill-defined and spiculated malignant masses. At first, by using wavelet transform and piecewise linear coefficient mapping, image enhancement were done. Secondly detection of lesions was done by fractal method as a ROI. Since in investigation of breast cancer, it is important that fibroglandular tissues in both...
Modeling and control of HIV by computational intelligence techniques
, Article IFMBE Proceedings, 30 April 2010 through 2 May 2010, College Park, MD ; Volume 32 IFMBE , April , 2010 , Pages 192-195 ; 16800737 (ISSN) ; 9783642149979 (ISBN) ; Sharif University of Technology
2010
Abstract
The paper aims at proposing a controller through two-layer neural networks (NN) in order to control CD4 amount in HIV + Patients. In the same direction, initially a new mathematical model by using of two-layer neural networks (NN) was designed. Medical information of 300 HIV + Patients who were being treated in the Iranian Research Center for HIV/AIDS (IRCHA), Imam Khomeini Hospital, Tehran, was used to design this model. Highly active antiretroviral therapy (HAART) medical method is a significant method that was used in this study. It is worthy to say that CD4 amount declining leads to immune system deficiency and it is considered as one of AIDS main symptoms. Output of this mathematic...
Real-time simulation of the nonlinear visco-elastic deformations of soft tissues
, Article International Journal of Computer Assisted Radiology and Surgery ; Volume 6, Issue 3 , 2011 , Pages 297-307 ; 18616410 (ISSN) ; Farahmand, F ; Sharif University of Technology
Abstract
Purpose: Mass-spring-damper (MSD) models are often used for real-time surgery simulation due to their fast response and fairly realistic deformation replication. An improved real time simulation model of soft tissue deformation due to a laparoscopic surgical indenter was developed and tested. Method: The mechanical realization of conventional MSD models was improved using nonlinear springs and nodal dampers, while their high computational efficiency was maintained using an adapted implicit integration algorithm. New practical algorithms for model parameter tuning, collision detection, and simulation were incorporated. Results: The model was able to replicate complex biological soft tissue...
Properties of functional brain networks correlate frequency of psychogenic non-epileptic seizures
, Article Frontiers in Human Neuroscience ; Issue DEC , 2012 ; 16625161 (ISSN) ; Joudaki, A ; Jalili, M ; Rossetti, A. O ; Frackowiak, R. S ; Knyazeva, M. G ; Sharif University of Technology
Frontiers Media S. A
2012
Abstract
Abnormalities in the topology of brain networks may be an important feature and etiological factor for psychogenic non-epileptic seizures (PNES). To explore this possibility, we applied a graph theoretical approach to functional networks based on resting state EEGs from 13 PNES patients and 13 age- and gender-matched controls. The networks were extracted from Laplacian-transformed time-series by a cross-correlation method. PNES patients showed close to normal local and global connectivity and small-world structure, estimated with clustering coefficient, modularity, global efficiency, and small-worldness metrics, respectively. Yet the number of PNES attacks per month correlated with a...
WLFS: Weighted label fusion learning framework for glioma tumor segmentation in brain MRI
, Article Biomedical Signal Processing and Control ; Volume 68 , 2021 ; 17468094 (ISSN) ; Jamzad, M ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
Glioma is a common type of tumor that develops in the brain. Due to many differences in the shape and appearance, accurate segmentation of glioma for identifying all parts of the tumor and its surrounding tissues in cancer detection is a challenging task in cancer detection. In recent researches, the combination of atlas-based segmentation and machine learning methods have presented superior performance over other automatic brain MRI segmentation algorithms. To overcome the side effects of limited existing information on atlas-based segmentation, and the long training and the time consuming phase of learning methods, we proposed a semi-supervised learning framework by introducing a...