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Mesoporous silica nanoparticles with bilayer coating of poly(acrylic acid-co-itaconic acid) and human serum albumin (HSA): A pH-sensitive carrier for gemcitabine delivery
, Article Materials Science and Engineering C ; Volume 61 , 2016 , Pages 782-790 ; 09284931 (ISSN) ; Mazaheri Tehrani, Z ; Sharif University of Technology
Abstract
Novel bilayer coated mesoporous silica nanoparticle (MCM-41) based on pH sensitive poly(acrylic acid-co-itaconic acid) and human serum albumin (HSA) was designed for controlled delivery of gemcitabine (anticancer drug) to cancer cells. The shell around the mesoporous silica has bilayer structure. Poly(acrylic acid-co-itaconic acid) was used as pH-sensitive inner shell and human serum albumin, HSA, was used as outer shell. The core-shell structure was formed due to electrostatic interaction between ammonium groups of modified MCM-41 and carboxylate groups of copolymer. Also, the albumin layer was wrapped around the copolymer coated nanoparticle by electrostatic interaction between ammonium...
Cytotoxicity and cell cycle effects of bare and poly(vinyl alcohol)-coated iron oxide nanoparticles in mouse fibroblasts
, Article Advanced Engineering Materials ; Volume 11, Issue 12 , 2009 , Pages B243-B250 ; 14381656 (ISSN) ; Simchi, A ; Vali, H ; Imani, M ; Shokrgozar, M. A ; Azadmanesh, K ; Azari, F ; Sharif University of Technology
Abstract
Super-paramagnetic iron oxide nanoparticles (SPIONs) are recognized as powerful biocompatible materials for use in various biomedical applications, such as drug delivery, magnetic-resonance imaging, cell/protein separation, hyperthermia and transfection. This study investigates the impact of high concentrations of SPIONs on cytotoxicity and cell-cycle effects. The interactions of surfacesaturated (via interactions with cell medium) bare SPIONs and those coated with poly(vinyl alcohol) (PVA) with adhesive mouse fibroblast cells (L929) are investigated using an MTT assay. The two SPION formulations are synthesized using a co-precipitation method. The bare and coated magnetic nanoparticles with...
The effects of geometrical parameters on force distributions and mechanics of carbon nanotubes: A critical study
, Article Communications in Nonlinear Science and Numerical Simulation ; Volume 14, Issue 12 , 2009 , Pages 4246-4263 ; 10075704 (ISSN) ; Motevalli, B ; Sharif University of Technology
Abstract
In this paper, using the continuum approximation together with Lennard-Jones potential, a new semi-analytical expression is given to evaluate the van der Waals interaction between two single-walled carbon nanotubes. Based on this expression, two new formulations are also proposed to model multi-walled carbon nanotubes. In the first one, the interactions between each pair of shells from the inner and outer tubes are summed up over all of the pairs, whereas in the second formulation, a set of correction factors are applied to convert the results of double-walled carbon nanotubes to the correlated multi-walled ones. With respect to the present formulations, extensive studies on the variations...
Switchable on/off drug release from gold nanoparticles-grafted dual light- and temperature-responsive hydrogel for controlled drug delivery
, Article Materials Science and Engineering C ; Volume 76 , 2017 , Pages 242-248 ; 09284931 (ISSN) ; Sadighi Bonabi, R ; Pourghazi, K ; Sharif University of Technology
Elsevier Ltd
2017
Abstract
A switchable dual light- and temperature-responsive drug carrier using gold nanoparticles (Au NPs)-grafted poly(dimethylacrylamide-co-acrylamide)/poly acrylic acid [P(DMA-co-AAm)/PAAc] hydrogel was prepared by free radical polymerization procedure using N,N-methylenebisacrylamide as cross-linker and ammonium persulfate as initiator. Initial P(DMA-co-AAm) hydrogel and uniformly-distributed stable Au NPs, prepared by reduction of hydrogen tetrachloroaureate (III) hydrate in the presence of trisodium citrate, were synthesized separately. Then, the prepared P(DMA-co-AAm) and Au NPs were added to an acrylic acid solution along with the cross-linker and initiator to prepare PAAc hydrogel within...
Synthesis, properties and biomedical applications of carbon-based quantum dots: an updated review
, Article Biomedicine and Pharmacotherapy ; Volume 87 , 2017 , Pages 209-222 ; 07533322 (ISSN) ; Negahdari, B ; Eatemadi, A ; Sharif University of Technology
Elsevier Masson SAS
2017
Abstract
Carbon-based quantum dots (CQDs) are a newly developed class of carbon nano-materials that have attracted much interest and attention as promising competitors to already available semiconductor quantum dots owing to their un-comparable and unique properties. In addition, controllability of CQDs unique physiochemical properties is as a result of their surface passivation and functionalization. This is an update article (between 2013 and 2016) on the recent progress, characteristics and synthesis methods of CQDs and different advantages in varieties of applications. © 2017 Elsevier Masson SAS
کلیدواژه های تکراریCurcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats
, Article Biomedicine and Pharmacotherapy ; Volume 108 , 2018 , Pages 1244-1252 ; 07533322 (ISSN) ; Ashrafi Hafez, A ; Abdorahim, M ; Abdollahifar, M. A ; Shabani, R ; Peirovi, H ; Simchi, A ; Ashtari, K ; Sharif University of Technology
Abstract
Background: The aim of this study was to investigate the neurotoxic effects of Fe3O4 magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model. Methods: We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (Fe3O4 magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of Fe3O4 magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential. Further, to prove Fe3O4 magnetic- CurNPs results in superior therapeutic effects, and also, the mitochondrial membrane potential collapse, mitochondrial complex II activity, reactive oxygen species generation,...
Multi-model robust control of depth of hypnosis
, Article Biomedical Signal Processing and Control ; Volume 40 , 2018 , Pages 443-453 ; 17468094 (ISSN) ; Hosseinzadeh, M ; Dumont, G. A ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
This paper presents a multi-model robust control scheme to control the depth of hypnosis during intravenous administration of propofol. The objective of the proposed control scheme is to provide an adequate drug administration regime for propofol to avoid overdosing and underdosing of patients. The proposed scheme is designed to withstand the patient's inherent drug response variability, to achieve good output disturbance and sensor noise rejection, and to attain a good set point response. A comprehensive simulation study of 44 patients is presented to assess the performance of the proposed control scheme. © 2017 Elsevier Ltd
Doxorubicin-conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy
, Article Journal of Drug Targeting ; Volume 26, Issue 3 , 2018 , Pages 267-277 ; 1061186X (ISSN) ; Eskandani, M ; Johari Ahar, M ; Nemati, A ; Akbari, H ; Davaran, S ; Omidi, Y ; Sharif University of Technology
Taylor and Francis Ltd
2018
Abstract
Nanoscaled quantum dots (QDs), with unique optical properties have been used for the development of theranostics. Here, InP/ZnS QDs were synthesised and functionalised with folate (QD-FA), D-glucosamine (QD-GA) or both (QD-FA-GA). The bi-functionalised QDs were further conjugated with doxorubicin (QD-FA-GA-DOX). Optimum Indium to fatty acid (In:MA) ratio was 1:3.5. Transmission electron microscopy (TEM) micrographs revealed spherical morphology for the QDs (11 nm). Energy-dispersive spectroscopy (EDS) spectrum confirmed the chemical composition of the QDs. MTT analysis in the OVCAR-3 cells treated with bare QDs, QD-FA, QD-GA, QD-FA-GA and QD-FA-GA-DOX (0.2 mg/mL of QDs) after 24 h indicated...
Superparamagnetic iron oxide nanoparticles with rigid cross-linked polyethylene glycol fumarate coating for application in imaging and drug delivery
, Article Journal of Physical Chemistry C ; Volume 113, Issue 19 , 2009 , Pages 8124-8131 ; 19327447 (ISSN) ; Simchi, A ; Imani, M ; Hafeli, U. O ; Sharif University of Technology
2009
Abstract
Superparamagnetic iron oxide nanoparticles with proper surface coatings are increasingly being evaluated for clinical applications such as hyperthermia, drug delivery, magnetic resonance imaging, transfection, and cell/protein separation. To enhance the applicability of magnetic nanoparticles, two main problems must be overcome. First, as the drug coats the particle surface, a significant portion of it is quickly released upon injection (burst effect). Therefore, only small amounts of the drug reach the specific site after, for example, magnetic drug targeting. Second, once the surface-derivatized nanoparticles are inside the cells, the coating is likely digested, leaving the bare particles...
Rigorous silica solubility estimation in superheated steam: Smart modeling and comparative study
, Article Environmental Progress and Sustainable Energy ; Volume 38, Issue 4 , 2019 ; 19447442 (ISSN) ; Shokrollahi, A ; Esmaeili Jaghdan, Z ; Ghazanfari, M. H ; Sharif University of Technology
John Wiley and Sons Inc
2019
Abstract
One of the main issues of wastewater treatment is the silica deposition in steam turbines. Evaporation of silica with the steam in adequate concentration is one of the main sources of scale formation in steam turbines. In this study, the authors introduce the utilization of a genetic-based approach—gene expression programming (GEP)—for solubility prognostication of the silica in superheated steam of boilers with respect to water silica content and pressure. The result of GEP mathematical approach is a new algebraic formula to achieve our goals. Developed model predicts the silica solubility in the range of 0.8–22.1 MPa and 1–500 mg/kg for pressure and boiler water silica content,...
Mathematical modeling of drug release from biodegradable polymeric microneedles
, Article Bio-Design and Manufacturing ; Volume 2, Issue 2 , 2019 , Pages 96-107 ; 20965524 (ISSN) ; Rabiee, M ; Rafizadeh, M ; Rabiee, N ; Shamsabadi, A. S ; Bagherzadeh, M ; Salarian, R ; Tahriri, M ; Tayebi, L ; Sharif University of Technology
Springer
2019
Abstract
Transdermal drug delivery systems have overcome many limitations of other drug administration routes, such as injection pain and first-pass metabolism following oral route, although transdermal drug delivery systems are limited to drugs with low molecular weight. Hence, new emerging technology allowing high molecular weight drug delivery across the skin—known as ‘microneedles’—has been developed, which creates microchannels that facilitate drug delivery. In this report, drug-loaded degradable conic microneedles are modeled to characterize the degradation rate and drug release profile. Since a lot of data are available for polylactic acid-co-glycolic acid (PLGA) degradation in the literature,...
Poly(glycidyl methacrylate)-coated magnetic graphene oxide as a highly efficient nanocarrier: Preparation, characterization, and targeted DOX delivery
, Article New Journal of Chemistry ; Volume 43, Issue 47 , 2019 , Pages 18647-18656 ; 11440546 (ISSN) ; Kohestanian, M ; Yaghoubi, M ; Sharif University of Technology
Royal Society of Chemistry
2019
Abstract
Herein, we report the preparation of novel magnetic graphene oxide (GO) grafted with brush polymer via surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization and its application as a nanocarrier for magnetic- and pH-triggered delivery of doxorubicin anticancer drug. The RAFT agent, DDMAT, was firstly attached to the surface of magnetic GO nanosheets. The DDMAT-functionalized magnetic GO nanosheets were then used to polymerize glycidyl methacrylate (GMA) using an SI-RAFT method. Afterwards, the epoxy rings of the PGMA chains were opened with hydrazine (N2H4) moieties. The resulting nanocomposite was used as a drug carrier for doxorubicin (DOX) as an...
Poly(glycidyl methacrylate)-coated magnetic graphene oxide as a highly efficient nanocarrier: Preparation, characterization, and targeted DOX delivery
, Article New Journal of Chemistry ; Volume 43, Issue 47 , 2019 , Pages 18647-18656 ; 11440546 (ISSN) ; Kohestanian, M ; Yaghoubi, M ; Sharif University of Technology
Royal Society of Chemistry
2019
Abstract
Herein, we report the preparation of novel magnetic graphene oxide (GO) grafted with brush polymer via surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization and its application as a nanocarrier for magnetic- and pH-triggered delivery of doxorubicin anticancer drug. The RAFT agent, DDMAT, was firstly attached to the surface of magnetic GO nanosheets. The DDMAT-functionalized magnetic GO nanosheets were then used to polymerize glycidyl methacrylate (GMA) using an SI-RAFT method. Afterwards, the epoxy rings of the PGMA chains were opened with hydrazine (N2H4) moieties. The resulting nanocomposite was used as a drug carrier for doxorubicin (DOX) as an...
Niosomal delivery of simvastatin to MDA-MB-231 cancer cells
, Article Drug Development and Industrial Pharmacy ; Volume 46, Issue 9 , 2020 , Pages 1535-1549 ; Saremi Poor, A ; Yaghmaei, S ; Norouzian, D ; Noorbazargan, H ; Saffar, S ; Ahangari Cohan, R ; Bakhshandeh, H ; Sharif University of Technology
Taylor and Francis Ltd
2020
Abstract
Objective: The objective of this study was to use nano-niosomal formulations to deliver simvastatin as a poor-water soluble drug into breast cancer cells. Significance: Our study focused on the problem associated with poor water-soluble drugs which have significant biological activity in vivo. Methods: Different niosomal formulations of simvastatin were prepared and characterized in terms of morphology, size, encapsulation efficiency (EE), and release kinetic. Antiproliferative activity and the mechanism were assessed by quantitative real-time PCR and flow cytometry. Moreover, confocal microscopy was employed to analyze the cell uptake of simvastatin loaded niosomes to the cancerous cells....
Nano mesoporous silica for cancer treatment: ROS-responsive and redox-responsive carriers
, Article Journal of Drug Delivery Science and Technology ; Volume 57 , 2020 ; Abdekhodaie, M. J ; Behroozi, F ; Mehrvar, M ; Sharif University of Technology
Editions de Sante
2020
Abstract
Reactive oxygen species ROS and redox agents are two features of cancer medium, which could be used through responsive drug delivery systems for cancer treatment. Furthermore, mesoporous silica nanoparticles (MSNs) have special characteristics to use them in ROS-responsive and redox-responsive carriers. To shed light on this issue, we propose two drug delivery systems: 1) responsive to hydrogen peroxide (a ROS component) and 2) responsive to dithiothreitol (a redox agent). The proposed carriers are composed of 4 parts: MSNs, responsive agent (selenocystine for ROS-responsive and dithiodipropionic for the redox-responsive carrier), hyaluronic acid as the coating and targeting agent, and the...
Ferrofluid droplet manipulation using an adjustable alternating magnetic field
, Article Sensors and Actuators, A: Physical ; Volume 301 , 2020 ; Favakeh, A ; Sedighi, E ; Shafii, M. B ; Sharif University of Technology
Elsevier B.V
2020
Abstract
Magnetically actuated droplet manipulation offers a promising tool for biomedical and engineering applications, such as drug delivery, biochemistry, sample handling in lab-on-chip devices and tissue engineering. In this study, characteristics of an adjustable alternating magnetic field generated by a magnetic coil for droplet manipulation was investigated which enables more control on droplet transport, and it can be considered as a suitable alternative for moving magnets or an array of micro-coils. By adjusting the magnetic flux density, the duty cycle and applied magnetic frequency, the manipulation of water-based ferrofluid droplets with a bio-compatible surfactant for different volumes...
Processing and properties of nanofibrous bacterial cellulose-containing polymer composites: a review of recent advances for biomedical applications
, Article Polymer Reviews ; Volume 60, Issue 1 , 2020 , Pages 144-170 ; Mahmoodi, A ; Mahmoudi, N ; Zandi, N ; Simchi, A ; Sharif University of Technology
Taylor and Francis Inc
2020
Abstract
Bacterial cellulose (BC) is an extracellular natural polymer produced by many microorganisms and its properties could be tailored via specific fabrication methods and culture conditions. There is a growing interest in BC derived materials due to the main features of BC such as porous fibrous structure, high crystallinity, impressive physico-mechanical properties, and high water content. However, pristine BC lacks some features, limiting its practical use in varied applications. Thus, fabrication of BC composites has been attempted to overcome these constraints. This review article overviews most recent advance in the development of BC composites and their potential in biomedicine including...
Synthesizing efficacious genistein in conjugation with superparamagnetic Fe3O4 decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma
, Article Biomaterials Research ; Volume 24, Issue 1 , 2020 ; Mohammadi, M. R ; Malekzadeh, K ; Sharif University of Technology
BioMed Central Ltd
2020
Abstract
Background: Genistein (C15H10O5) is a soy isoflavone with anti-cancer properties such as inhibition of cell growth, proliferation and tumor invasion, but effective dosage against hematopoietic malignant cells was not in non-toxic range. This property cause to impede its usage as chemotherapeutic agent. Therefore, this hypothesis raised that synthesizing biocompatible nanoparticle could assist to prevail this struggle. Methods: Genistein covalently attached on Fe3O4 nanoparticles decorated with carboxymethylated chitosan to fabricate Fe3O4-CMC-genistein in alkaline circumstance. This obtained nanoparticles were evaluated by TEM, DLS, FTIR, XRD and VSM and its anti-cancer effect by growth rate...
Niosome-encapsulated tobramycin reduced antibiotic resistance and enhanced antibacterial activity against multidrug-resistant clinical strains of Pseudomonas aeruginosa
, Article Journal of Biomedical Materials Research - Part A ; 2020 ; Abolhassani Targhi, A ; Shamsi, F ; Heidari, F ; Salehi Moghadam, Z ; Mirzaie, A ; Behdad, R ; Moghtaderi, M ; Akbarzadeh, I ; Sharif University of Technology
John Wiley and Sons Inc
2020
Abstract
In the current study, niosome-encapsulated tobramycin based on Span 60 and Tween 60 was synthesized and its biological efficacies including anti-bacterial, anti-efflux, and anti-biofilm activities were investigated against multidrug resistant (MDR) clinical strains of Pseudomonas aeruginosa. The niosomal formulations were characterized using scanning electron microscopy, transmission electron microscopy, and dynamic light scattering measurement. The encapsulation efficiency was found to be 69.54% ±; 0.67. The prepared niosomal formulations had a high storage stability to 60 days with small changes in size and drug entrapment, which indicates that it is a suitable candidate for pharmaceutical...
Synthesis of micelles based on chitosan functionalized with gold nanorods as a light sensitive drug delivery vehicle
, Article International Journal of Biological Macromolecules ; Volume 149 , 2020 , Pages 809-818 ; Bagherifard, M ; Doroudian, M ; Sharif University of Technology
Elsevier B.V
2020
Abstract
This study aims to design photo-triggered micelles by using a natural base polymer. Chitosan was functionalized with thiourea, and in the next step, it was modified by grafting poly(L-lactide), poly(N-isopropylacrylamide), and poly(acrylamide) in determined ratio to form thermo-sensitive micelles. The sulfur content of chitosan@thiourea was measured about 2%. Grafting of polymers on chitosan was characterized by FT-IR and NMR techniques. The critical micellar concentration was measured by using photo luminescence spectroscopy. The size and surface morphology experiments revealed that average size of micelles is about 14 nm, and the length and width of GNRs are about 65 and 19 nm,...