Loading...
Search for:
drug-interactions
0.009 seconds
Total 23 records
Thermo- and pH-sensitive dendrosomes as bi-phase drug delivery systems
, Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 9, Issue 8 , 2013 , Pages 1203-1213 ; 15499634 (ISSN) ; Fard, A. K ; Abedi, F ; Chegeni, B. K ; Bani, F ; Sharif University of Technology
2013
Abstract
Fully supramolecular dendrosomes (FSD) as bi-phase drug delivery systems are reported in this work. For preparation of FSD, amphiphilic linear-dendritic supramolecular systems (ALDSS) have been synthesized by host-guest interactions between hyperbranched polyglycerol having β-cyclodextrin core and bi-chain polycaprolactone (BPCL) with a fluorescine focal point. Self-assembly of ALDSS in aqueous solutions led to FSD. They were able to encapsulate paclitaxel with a high loading capacity. The dendrosome-based drug delivery systems were highly sensitive to pH and temperature. They were stable at 20-37. °C and pH7-8, but dissociated and released drug at temperatures lower than 20. °C or higher...
Safe Personalized Treatment Recommendation System for Multimorbidity
, M.Sc. Thesis Sharif University of Technology ; Habibi, Jafar (Supervisor)
Abstract
Multimorbidity in an individual is a typical and increasing condition and a major challenge in healthcare. The goal of treatment recommendation for such patients is to decide the most effective combination of treatments. Doctors typically prescribe medication based on their intuition and experience. However, due to knowledge gaps or unintended biases, often times these clinical decisions can be sub-optimal. Broad adoption and usage of electronic health records (EHRs) in the last decade has opened up a great opportunity to leverage healthcare data to improve clinical decisions.In this approach we use EHR and drug-drug interaction (DDI) information to prescribe medications. We use multiple...
Microfluidic-based multi-organ platforms for drug discovery
, Article Micromachines ; Volume 7, Issue 9 , 2016 ; 2072666X (ISSN) ; Khadem Mohtaram, N ; Pezeshgi Modarres, H ; Mohammadi, M. H ; Geraili, A ; Jafari, P ; Akbari, M ; Sanati Nezhad, A ; Sharif University of Technology
MDPI AG
Abstract
Development of predictive multi-organ models before implementing costly clinical trials is central for screening the toxicity, efficacy, and side effects of new therapeutic agents. Despite significant efforts that have been recently made to develop biomimetic in vitro tissue models, the clinical application of such platforms is still far from reality. Recent advances in physiologically-based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling, micro- and nanotechnology, and in silico modeling have enabled single- and multi-organ platforms for investigation of new chemical agents and tissue-tissue interactions. This review provides an overview of the principles of designing...