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Multifunctional 3D hierarchical bioactive green carbon-based nanocomposites
, Article ACS Sustainable Chemistry and Engineering ; Volume 9, Issue 26 , 2021 , Pages 8706-8720 ; 21680485 (ISSN) ; Bagherzadeh, M ; Ghadiri, A. M ; Kiani, M ; Fatahi, Y ; Tavakolizadeh, M ; Pourjavadi, A ; Jouyandeh, M ; Saeb, M. R ; Mozafari, M ; Shokouhimehr, M ; Varma, R. S ; Sharif University of Technology
American Chemical Society
2021
Abstract
Carbon-based nanocarriers such as multiwall carbon nanotubes (MWCNTs) and reduced graphene oxide (rGO) have shown promising delivery capabilities due to their low immunogenicity, superior internalization, and suitable cell penetration efficiency. Herein, a molecular engineering strategy is advanced for the one-pot synthesized rGO/MWCNT/Fe3O4/ZnO to enhance the stability of the nanocarrier in the biological matrix; green synthesized ZnO was responsible for water uptake and reduced cytotoxicity, while Fe3O4controlled the cellular internalization for gene delivery. Surface morphology of the ensuing nanocomposite was correlated with photocatalytic and gene delivery (CRISPR/Cas9) features. For...
Evaluation of antibacterial behavior of in situ grown CuO-GO nanocomposites
, Article Materials Today Communications ; Volume 28 , 2021 ; 23524928 (ISSN) ; Fattahi Nafchi Fatahi, R ; Sangpour, P ; Bagheri, M ; Rahimi, T ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
The growth of harmful microorganisms is a severe threat to human life. Nowadays, it is necessary to prepare antimicrobials materials with high biocompatibility properties. Hence, the use of nanomaterials and their nanocomposites has been proposed as a suitable way to obtain safe and potent antibacterial materials. Recently, several studies have been conducted on the antibacterial properties of metal oxide and graphene oxide (GO) nanomaterials individually. This study investigated the synergistic effect of GO and copper oxide (CuO) as a nanocomposite. CuO-GO nanocomposite containing 5%, 15%, 25%, 50%, and 75% of GO were synthesized to study antibacterial properties. X-ray diffraction (XRD)...
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus
, Article Chemistry and Physics of Lipids ; Volume 234 , 2021 ; 00093084 (ISSN) ; Keramati, M ; Azadi, A ; Afzali, E ; Shahbazi, R ; chiani, M ; Norouzian, D ; Bakhshandeh, H ; Sharif University of Technology
Elsevier Ireland Ltd
2021
Abstract
Niosomes, as a kind of drug delivery system, is widely used for the topical delivery of lipophilic drugs. Optimization of niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare an optimized niosomal formulation of simvastatin (nSIM), a lipophilic member of statins, through the experiment (Response Surface methodology). Optimized niosomes were characterized in size, polydispersity index (PDI), entrapment efficiency (EE), stability, releasing pattern, and antimicrobial activity. The different molar ratio of surfactant and cholesterol were applied to prepare various formulation of simvastatin loaded niosome. Mean particle size and size...
Evaluation of antibacterial behavior of in situ grown CuO-GO nanocomposites
, Article Materials Today Communications ; Volume 28 , 2021 ; 23524928 (ISSN) ; Fattahi Nafchi Fatahi, R ; Sangpour, P ; Bagheri, M ; Rahimi, T ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
The growth of harmful microorganisms is a severe threat to human life. Nowadays, it is necessary to prepare antimicrobials materials with high biocompatibility properties. Hence, the use of nanomaterials and their nanocomposites has been proposed as a suitable way to obtain safe and potent antibacterial materials. Recently, several studies have been conducted on the antibacterial properties of metal oxide and graphene oxide (GO) nanomaterials individually. This study investigated the synergistic effect of GO and copper oxide (CuO) as a nanocomposite. CuO-GO nanocomposite containing 5%, 15%, 25%, 50%, and 75% of GO were synthesized to study antibacterial properties. X-ray diffraction (XRD)...
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus
, Article Chemistry and Physics of Lipids ; Volume 234 , 2021 ; 00093084 (ISSN) ; Keramati, M ; Azadi, A ; Afzali, E ; Shahbazi, R ; chiani, M ; Norouzian, D ; Bakhshandeh, H ; Sharif University of Technology
Elsevier Ireland Ltd
2021
Abstract
Niosomes, as a kind of drug delivery system, is widely used for the topical delivery of lipophilic drugs. Optimization of niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare an optimized niosomal formulation of simvastatin (nSIM), a lipophilic member of statins, through the experiment (Response Surface methodology). Optimized niosomes were characterized in size, polydispersity index (PDI), entrapment efficiency (EE), stability, releasing pattern, and antimicrobial activity. The different molar ratio of surfactant and cholesterol were applied to prepare various formulation of simvastatin loaded niosome. Mean particle size and size...
Electrochemical and computational studies of bio-mimicked Ti3C2Tx MXene-based sensor with multivalent interface
, Article Journal of Colloid and Interface Science ; Volume 623 , 2022 , Pages 1063-1074 ; 00219797 (ISSN) ; Ashari Astani, N ; Atabay, M ; Naseri, N ; Esfandiar, A ; Reza Ejtehadi, M ; Sharif University of Technology
Academic Press Inc
2022
Abstract
Two-dimensional MXenes are the newly emerging family of nanomaterials with competitive performance for nano-device development. Surface functional groups and abundant binding sites make these materials ideal candidates for sensor applications. Herein, we report the successful fabrication of a MXene-based nano-bio device for capturing, sensing, and filtering the Escherichia coli (E. coli) bacteria. Mannose carbohydrate, which binds strongly to E.coli's fimH protein via glucan multivalent interactions, is used as the bio-receptor element. MXene's structure was engineered to guarantee efficient E. coli capturing without mannose detachment. Electrochemical impedance spectroscopy (EIS) and cyclic...
Alginate-based multifunctional films incorporated with sulfur quantum dots for active packaging applications
, Article Colloids and Surfaces B: Biointerfaces ; Volume 215 , 2022 ; 09277765 (ISSN) ; Priyadarshi, R ; Rhim, J. W ; Lotfali, E ; Bagheri, R ; Pircheraghi, G ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Sulfur quantum dots (SQDs) were fabricated using a facile hydrothermal method and used for the preparation of functional food packaging film and compared the properties with other sulfur-based fillers like elemental sulfur (ES) and sulfur nanoparticles (SNP). The SQDs have an average size of 5.3 nm and were very stable in aqueous suspension. Unlike other sulfur-based fillers, the SQD showed high antioxidant, antibacterial and antifungal activity, but no cytotoxicity was found for L929 mouse fibroblasts even after long-term exposure of 48 h. When sulfur-based fillers were added to the alginate film, SQD was more evenly dispersed in the polymer matrix than SNP and ES. The addition of SQD to...
Electrospun Ag-decorated reduced GO-graft-chitosan composite nanofibers with visible light photocatalytic activity for antibacterial performance
, Article Chemosphere ; Volume 299 , 2022 ; 00456535 (ISSN) ; Mohammadi Ziarani, G ; Badiei, A ; Setayeshmehr, M ; Kiani, M ; Pourjavadi, A ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
The treatment of water contaminated by bacteria is becoming a necessity. The nanomaterials possessing both intrinsic antibacterial properties and photocatalytic activity are excellent candidates for water disinfection. The powdered form of nanomaterials can be aggregated while embedding the nanomaterials into the NFs can overcome the limitation and enhance the photocatalytic activity and transition from UV-light to visiblelight. Here, graphene oxide (GO) was synthesized, grafted to chitosan, and decorated with silver nanoparticles (Ag NPs) to produce Ag-decorated reduced GO-graft-Chitosan (AGC) NPs. The blends of polyacrylonitrile (PAN) and AGC NPs were prepared in various concentrations of...
Amoxicillin-loaded multilayer pullulan-based nanofibers maintain long-term antibacterial properties with tunable release profile for topical skin delivery applications
, Article International Journal of Biological Macromolecules ; Volume 215 , 2022 , Pages 413-423 ; 01418130 (ISSN) ; Asgari, S ; Guerra, P. R ; Chamorro, C. I ; Ilchenco, O ; Piqueras, S ; Fossum, M ; Boisen, A ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Unique physiochemical and biological properties of nanofibers along with the choice of a wide variety of materials for both fabrication and tunable release patterns make nanofibers an ideal option for drug delivery. Loading antibacterial agents into nanofibers has attracted great deal of attention. Whilst there are several studies focusing on applying new generations of antibacterial materials, antibiotics are still the gold standard in clinical applications. Therefore, we aimed at introducing antibiotic-loaded nanofiber substrates with potential for topical skin delivery applications, reduced consumption of antibiotics and increased storage time. We applied Amoxicillin (AMX) as a model drug...
Carboxymethyl cellulose-based functional film integrated with chitosan-based carbon quantum dots for active food packaging applications
, Article Progress in Organic Coatings ; Volume 166 , 2022 ; 03009440 (ISSN) ; Rhim, J. W ; Bagheri, R ; Pircheraghi, G ; Lotfali, E ; Sharif University of Technology
Elsevier B.V
2022
Abstract
A chitosan-based carbon quantum dots (CQDs) with multifunctional properties were synthesized using a hydrothermal process. The CQDs were spherical with an average size of 7.8 ± 2.4 nm. The CQD showed strong antioxidant activity, potent antibacterial activity against E. coli and L. monocytogenes, and antifungal activity against A. niger and P. chrysogenum. In addition, the prepared CQD showed negligible cytotoxicity against L929 cells even at a concentration of 500 μg/mL. Carboxymethyl cellulose (CMC)-based functional films were fabricated by adding various amounts of CQD. The CQDs were evenly dispersed in the polymer matrix to form a highly transparent UV-blocking film. The addition of CQD...
Development of HAp/GO/Ag coating on 316 LVM implant for medical applications
, Article Journal of the Mechanical Behavior of Biomedical Materials ; Volume 126 , 2022 ; 17516161 (ISSN) ; Izanloo, S ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
In this study, antibacterial activity, biocompatibility, and corrosion resistance of 316 LVM implants were improved using the development of HAp/GO/Ag nanocomposite coatings by the dip-coating method. The XRD and FTIR results confirmed the synthesis of HAp/GO/Ag nanocomposites. HAp/Ag nanoparticles (68 nm) bound to epoxy, hydroxyl, and carboxyl functional groups on GO sheets (size of GO sheets varies from 255 to 1480 nm) by electrostatic interaction. FESEM images showed that HAp/GO/Ag coatings had higher density and fewer micro-cracks than pure HAp coatings. In addition, HAp/GO/Ag coatings showed optimized nano-hardness (4.5 GPa) and elasticity modulus (123 GPa). The results of...