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Total 121 records

    Co-delivery of letrozole and cyclophosphamide via folic acid-decorated nanoniosomes for breast cancer therapy: Synergic effect, augmentation of cytotoxicity, and apoptosis gene expression

    , Article Pharmaceuticals ; Volume 15, Issue 1 , 2022 ; 14248247 (ISSN) Sahrayi, H ; Hosseini, E ; Karimifard, S ; Khayam, N ; Meybodi, S. M ; Amiri, S ; Bourbour, M ; Far, B. F ; Akbarzadeh, I ; Bhia, M ; Hoskins, C ; Chaiyasut, C ; Sharif University of Technology
    MDPI  2022
    Abstract
    Breast cancer is one of the most prevalent causes of cancer mortality in women. In order to increase patient prognosis and survival rates, new technologies are urgently required to deliver therapeutics in a more effective and efficient manner. Niosome nanoparticles have been recently employed as therapeutic platforms capable of loading and carrying drugs within their core for both mono and combination therapy. Here, niosome-based nanoscale carriers were investigated as a targeted delivery system for breast cancer therapy. The platform developed consists of niosomes loaded with letrozole and cyclophosphamide (NLC) and surface-functionalized with a folic-acidtargeting moiety (NLCPFA). Drug... 
Total 121 records