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3D calculation of absorbed dose for 131I-targeted radiotherapy: A monte carlo study
, Article Radiation Protection Dosimetry ; Volume 150, Issue 3 , October , 2012 , Pages 298-305 ; 01448420 (ISSN) ; Sarkar, S ; Abbaspour Tehrani Fard, A ; Ay, M. R ; Khosravi, H. R ; Loudos, G ; Sharif University of Technology
2012
Abstract
Various methods, such as those developed by the Medical Internal Radiation Dosimetry (MIRD) Committee of the Society of Nuclear Medicine or employing dose point kernels, have been applied to the radiation dosimetry of 131I radionuclide therapy. However, studies have not shown a strong relationship between tumour absorbed dose and its overall therapeutic response, probably due in part to inaccuracies in activity and dose estimation. In the current study, the GATE Monte Carlo computer code was used to facilitate voxel-level radiation dosimetry for organ activities measured in an . 131I-treated thyroid cancer patient. This approach allows incorporation of the size, shape and composition of...