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    Alterations of the electroencephalogram sub-bands amplitude during focal seizures in the pilocarpine model of epilepsy

    , Article Physiology and Pharmacology ; Volume 16, Issue 1 , 2012 , Pages 11-20 ; 17350581 (ISSN) Motaghi, S ; Niknazar, M ; Sayyah, M ; babapour, V ; Vahdat, B. V ; Shamsollahi, M. B ; Sharif University of Technology
    Introduction: Temporal lobe epilepsy (TLE) is the most common and drug resistant epilepsy in adults. Due to behavioral, morphologic and electrographic similarities, pilocarpine model of epilepsy best resembles TLE. This study was aimed at determination of the changes in electroencephalogram (EEG) sub-bands amplitude during focal seizures in the pilocarpine model of epilepsy. Analysis of these changes might help detection of a pre-seizure state before an oncoming seizure. Methods: Rats were treated by scopolamine (1mg/kg, s.c) to prevent cholinergic effects. After 30 min, pilocarpine (380 mg/kg, i.p) was administered to induce status epilepticus (SE) and 2 hours after SE, diazepam (20 mg/kg,... 

    A Boolean network control algorithm guided by forward dynamic programming

    , Article PLoS ONE ; Volume 14, Issue 5 , 2019 ; 19326203 (ISSN) Moradi, M ; Goliaei, S ; Foroughmand Araabi, M. H ; Sharif University of Technology
    Public Library of Science  2019
    Control problem in a biological system is the problem of finding an interventional policy for changing the state of the biological system from an undesirable state, e.g. disease, into a desirable healthy state. Boolean networks are utilized as a mathematical model for gene regulatory networks. This paper provides an algorithm to solve the control problem in Boolean networks. The proposed algorithm is implemented and applied on two biological systems: T-cell receptor network and Drosophila melanogaster network. Results show that the proposed algorithm works faster in solving the control problem over these networks, while having similar accuracy, in comparison to previous exact methods. Source... 

    Correlation between concentrations of chlorophyll-a and satellite derived climatic factors in the Persian Gulf

    , Article Marine Pollution Bulletin ; Volume 161, Part A , December , 2020 Moradi, M ; Moradi, N ; Sharif University of Technology
    Elsevier Ltd  2020
    Monthly mean satellite derived Chl-a, aerosols, wind, SST, PAR, and turbidity datasets were used to investigate the possible factors regulating phytoplankton variability in the Persian Gulf. The spatial correlation analysis revealed two distinct regions of SST and PAR, and a relatively uniform spatial correlation pattern of the other parameters. The cross correlation between aeolian dusts and Chl-a was significantly positive with 1–3 months offset. The pattern of spatial correlation between Chl-a and SST was positive in the shallow regions without time lag, and was negative with time offset of 3–5 months in deeper regions. The cross correlation between Chl-a and north-ward winds were... 

    Optimal robust control of drug delivery in cancer chemotherapy: A comparison between three control approaches

    , Article Computer Methods and Programs in Biomedicine ; Volume 112, Issue 1 , 2013 , Pages 69-83 ; 01692607 (ISSN) Moradi, H ; Vossoughi, G ; Salarieh, H ; Sharif University of Technology
    During the drug delivery process in chemotherapy, both of the cancer cells and normal healthy cells may be killed. In this paper, three mathematical cell-kill models including log-kill hypothesis, Norton-Simon hypothesis and Emax hypothesis are considered. Three control approaches including optimal linear regulation, nonlinear optimal control based on variation of extremals and H∞-robust control based on μ-synthesis are developed. An appropriate cost function is defined such that the amount of required drug is minimized while the tumor volume is reduced. For the first time, performance of the system is investigated and compared for three control strategies; applied on three nonlinear models... 

    Phytoremediation of stable Cs from solutions by Calendula alata, Amaranthus chlorostachys and Chenopodium album

    , Article Ecotoxicology and Environmental Safety ; Volume 74, Issue 7 , October , 2011 , Pages 2036-2039 ; 01476513 (ISSN) Moogouei, R ; Borghei, M ; Arjmandi, R ; Sharif University of Technology
    Uptake rate of 133Cs, at three different concentrations of CsCl, by Calendula alata, Amaranthus chlorostachys and Chenopodium album plants grown outdoors was studied. These plants grow abundantly in semi-arid regions and their varieties exist in many parts of the world. When exposed to lowest Cs concentration 68 percent Cs was remediated by Chenopodium album. 133Cs accumulation in shoots of Amaranthus chlorostachys reached its highest value of 2146.2mgkg -1 at a 133Cs supply level of 3.95mgl -1 of feed solution. The highest concentration ratio value was 4.89 for Amaranthus chlorostachys, whereas for the other tests it ranged from 0.74 to 3.33. Furthermore uptake of 133Cs by all three species... 

    Biocompatibility, osseointegration, antibacterial and mechanical properties of nanocrystalline Ti-Cu alloy as a new orthopedic material

    , Article Colloids and Surfaces B: Biointerfaces ; Volume 189 , May , 2020 Moniri Javadhesari, S ; Alipour, S ; Akbarpour, M. R ; Sharif University of Technology
    Elsevier B.V  2020
    The demands for high-performance biomaterials are driving the development of new metallic alloys with improved mechanical and biological responses. In this study, a nanocrystalline Ti-Cu intermetallic alloy was prepared by a powder metallurgy route, and its application as an orthopedic material was evaluated by the microstructural, mechanical, corrosion, antibacterial, cytotoxicity and osseointegration examinations. Microstructural characterization revealed the formation of TiCu and Ti2Cu3 as major phases with 23 nm grain size in the structure of the alloy. The synthesized alloy exhibited ultra-high hardness of 10 GPa, acceptable toughness of 8.14 MPam1/2, a ∼98 % anti-bacterial rate against... 

    A comparative study of wound dressings loaded with silver sulfadiazine and silver nanoparticles: In vitro and in vivo evaluation

    , Article International Journal of Pharmaceutics ; Volume 564 , 2019 , Pages 350-358 ; 03785173 (ISSN) Mohseni, M ; Shamloo, A ; Aghababaie, Z ; Afjoul, H ; Abdi, S ; Moravvej, H ; Vossoughi, M ; Sharif University of Technology
    Elsevier B.V  2019
    In the current study, two series of antimicrobial dressings conjugated with silver sulfadiazine (SSD) and silver nanoparticles (AgNPs) were developed and evaluated for chronic wound healing. Highly porous polycaprolactone (PCL)/polyvinyl alcohol (PVA) nanofibers were loaded with different concentrations of SSD or AgNPs and compared comprehensively in vitro and in vivo. SSD and AgNPs indicated a strong and equal antimicrobial activity against S. aureus. However, SSD had more toxicity against fibroblast cells over one week in vitro culture. An in vivo model of wound healing on male Wistar rats was developed with a full thickness wound. All the wound dressings indicated enough flexibility and... 

    Combinational therapy of lithium and human neural stem cells in rat spinal cord contusion model

    , Article Journal of Cellular Physiology ; Volume 234, Issue 11 , 2019 , Pages 20742-20754 ; 00219541 (ISSN) Mohammadshirazi, A ; Sadrosadat, H ; Jaberi, R ; Zareikheirabadi, M ; Mirsadeghi, S ; Naghdabadi, Z ; Ghaneezabadi, M ; Fardmanesh, M ; Baharvand, H ; Kiani, S ; Sharif University of Technology
    Wiley-Liss Inc  2019
    A large number of treatment approaches have been used for spinal cord injury improvement, a medically incurable disorder, and subsequently stem cell transplantation appears to be a promising strategy. The main objective of this study is to ascertain whether combinational therapy of human neural stem cells (hNSCs) together with lithium chloride improves cell survival, proliferation, and differentiation in a rat spinal contusion model, or not. Contusive spinal cord injury was implemented on Wistar male rats. Experimental groups comprised of: control, hNSCs transplanted, lithium chloride (Li), and hNSCs and lithium chloride (hNSCs + Li). In every experimental group, locomotor activity score and... 

    Light harvesting and photocurrent generation by nanostructured photoelectrodes sensitized with a photosynthetic pigment: A new application for microalgae

    , Article Bioresource Technology ; Volume 163 , July , 2014 , Pages 1-5 ; ISSN: 09608524 Mohammadpour, R ; Janfaza, S ; Abbaspour Aghdam, F ; Sharif University of Technology
    Here in this study, successful conversion of visible light into electricity has been achieved through utilizing microalgal pigments as a sensitizer of nanostructured photo-electrode of dye-sensitized solar cells (DSSCs). For the first time, photosynthetic pigments extracted from microalgae grown in wastewater is employed to imitate photosynthesis process in bio-molecule-sensitized solar cells. Two designs of photoanode were employed: 10μm nanoparticular TiO2 electrode and 20μm long self-ordered, vertically oriented nanotube arrays of titanium dioxide films. Microalgal photosynthetic pigments are loaded on nanostructured electrodes and their photovoltaic performances have been investigated.... 

    Biodiesel production from Spirulina microalgae feedstock using direct transesterification near supercritical methanol condition

    , Article Bioresource Technology ; Volume 239 , 2017 , Pages 378-386 ; 09608524 (ISSN) Mohamadzadeh Shirazi, H ; Karimi Sabet, J ; Ghotbi, C ; Sharif University of Technology
    Elsevier Ltd  2017
    Microalgae as a candidate for production of biodiesel, possesses a hard cell wall that prevents intracellular lipids leaving out from the cells. Direct or in situ supercritical transesterification has the potential for destruction of microalgae hard cell wall and conversion of extracted lipids to biodiesel that consequently reduces the total energy consumption. Response surface methodology combined with central composite design was applied to investigate process parameters including: Temperature, Time, Methanol-to-dry algae, Hexane-to-dry algae, and Moisture content. Thirty-two experiments were designed and performed in a batch reactor, and biodiesel efficiency between 0.44% and 99.32% was... 

    Prevalence of influenza a infection in the middle-east: a systematic review and meta-analysis

    , Article Clinical Respiratory Journal ; Volume 12, Issue 5 , 2018 , Pages 1787-1801 ; 17526981 (ISSN) Moghoofei, M ; Monavari, H. R ; Mostafaei, S ; Hadifar, S ; Ghasemi, A ; Babaei, F ; Kavosi, H ; Tavakoli, A ; Javanmard, D ; Esghaei, M ; Khodabandehlou, N ; Sharif University of Technology
    Blackwell Publishing Ltd  2018
    Objective: This systematic review and meta-analysis was performed to determine the prevalence rate of influenza virus from different parts of Middle East region, and present an overall relative frequency (RF) for this region. Methods: The authors performed a systematic literature review from several reliable databases such as PubMed, ISI Web of Science and Scopus during 2000–2016. Furthermore, the keywords of this research were ‘Influenza’, ‘Subtype’, ‘Seroprevalence’, ‘Incidence’, ‘Seroepidemiology’, ‘H1N1’, ‘H3N2’, ‘H5N1’, ‘H9N2’, ‘Middle-East’ and ‘Meta-analysis’. The reported data were selected according to inclusion and exclusion criteria. Results: The authors selected 71 studies out of... 

    Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

    , Article Advanced Drug Delivery Reviews ; Volume 123 , 2018 , Pages 33-64 ; 0169409X (ISSN) Mofazzal Jahromi, M. A ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Sahandi Zangabad, K ; Ghamarypour, A ; Aref, A. R ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
    Elsevier B.V  2018
    According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally... 

    RMet: An automated R based software for analyzing GC-MS and GC×GC-MS untargeted metabolomic data

    , Article Chemometrics and Intelligent Laboratory Systems ; Volume 194 , 2019 ; 01697439 (ISSN) Moayedpour, S ; Parastar, H ; Sharif University of Technology
    Elsevier B.V  2019
    Gas chromatography-mass spectrometry (GC-MS) and comprehensive two-dimensional gas chromatography-mass spectrometry (GC×GC-MS) are powerful techniques for measurement of all metabolites in complex metabolic samples. However, analyzing GC-MS and especially GC×GC-MS metabolomic data is a major challenge to the researchers in the field of metabolomics mainly due to the complexity and large data size. In this regard, an automated R based software entitled RMet has been developed to overcome the challenges in the metabolomic analysis workflow of GC-MS and GC×GC-MS data sets. Additionally, it is able to facilitate the complex process of extracting reliable and useful biological information from... 

    Preparation and optimization of ciprofloxacin encapsulated niosomes: A new approach for enhanced antibacterial activity, biofilm inhibition and reduced antibiotic resistance in ciprofloxacin-resistant methicillin-resistance Staphylococcus aureus

    , Article Bioorganic Chemistry ; Volume 103 , October , 2020 Mirzaie, A ; Peirovi, N ; Akbarzadeh, I ; Moghtaderi, M ; Heidari, F ; Yeganeh, F. E ; Noorbazargan, H ; Mirzazadeh, S ; Bakhtiari, R ; Sharif University of Technology
    Academic Press Inc  2020
    Ciprofloxacin is an alternative to vancomycin for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The objective of this study was to optimization of niosomes encapsulated ciprofloxacin and evaluate their antibacterial and anti-biofilm efficacies against ciprofloxacin-resistant methicillin-resistant S. aureus (CR-MRSA) strains. Formulation of niosomes encapsulated ciprofloxacin were optimized by changing the proportions of Tween 60, Span 60, and cholesterol. The optimized ciprofloxacin encapsulated niosomal formulations based on Span 60 and Tween 60 were prepared and characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM) and... 

    Plant hormones as signals in arbuscular mycorrhizal symbiosis

    , Article Critical Reviews in Biotechnology ; Vol. 34, issue. 2 , 2014 , p. 123-133 Miransari, M ; Abrishamchi, A ; Khoshbakht, K ; Niknam, V ; Sharif University of Technology
    Arbuscular mycorrhizal (AM) fungi are non-specific symbionts developing mutual and beneficial symbiosis with most terrestrial plants. Because of the obligatory nature of the symbiosis, the presence of the host plant during the onset and proceeding of symbiosis is necessary. However, AM fungal spores are able to germinate in the absence of the host plant. The fungi detect the presence of the host plant through some signal communications. Among the signal molecules, which can affect mycorrhizal symbiosis are plant hormones, which may positively or adversely affect the symbiosis. In this review article, some of the most recent findings regarding the signaling effects of plant hormones, on... 

    Improvement of size-based particle separation throughput in slanted spiral microchannel by modifying outlet geometry

    , Article Electrophoresis ; Volume 41, Issue 5-6 , February , 2020 , Pages 353-359 Mihandoust, A ; Maleki Jirsaraei, N ; Rouhani, S ; Safi, S ; Alizadeh, M ; Sharif University of Technology
    Wiley-VCH Verlag  2020
    The inertial microfluidic technique, as a powerful new tool for accurate cell/particle separation based on the hydrodynamic phenomenon, has drawn considerable interest in recent years. Despite numerous microfluidic techniques of particle separation, there are few articles in the literature on separation techniques addressing external outlet geometry to increase the throughput efficiency and purity. In this work, we report on a spiral inertial microfluidic device with high efficiency (>98%). Herein, we demonstrate how changing the outlet geometry can improve the particle separation throughput. We present a complete separation of 4 and 6 μm from 10 μm particles potentially applicable to... 

    Supramolecular polycaprolactone nanocomposite based on functionalized hydroxyapatite

    , Article Journal of Bioactive and Compatible Polymers ; Volume 27, Issue 5 , January , 2012 , Pages 467-480 ; 08839115 (ISSN) Mehmanchi, M ; Shokrollahi, P ; Atai, M ; Omidian, H ; Bagheri, R ; Sharif University of Technology
    SAGE  2012
    Arms bearing ureido-pyrimidinone functional groups with self-association capability (through quadruple hydrogen bonds) were successfully grafted onto hydroxyapatite nanoparticles. The supramolecularly modified nanoparticles (nHApUPy) exhibited enhanced colloidal stability compared to the original hydroxyapatite nanoparticles and were uniformly dispersed in supramolecular polycaprolactone in PCL(UPy)2/HApUPy nanocomposites at different filler loadings. The combined atomic force microscopy, mechanical, and rheological analyses confirmed a high degree of compatibility of HApUPy nanoparticles with the polymer matrix. The temperature dependence of the supramolecular structure in PCL(UPy)2/HApUPy... 

    Nanomedicine applications in orthopedic medicine: State of the art

    , Article International Journal of Nanomedicine ; Volume 10 , 2015 , Pages 6039-6054 ; 11769114 (ISSN) Mazaheri, M ; Eslahi, N ; Ordikhani, F ; Tamjid, E ; Simchi, A ; Sharif University of Technology
    Dove Medical Press Ltd  2015
    The technological and clinical need for orthopedic replacement materials has led to significant advances in the field of nanomedicine, which embraces the breadth of nanotechnology from pharmacological agents and surface modification through to regulation and toxicology. A variety of nanostructures with unique chemical, physical, and biological properties have been engineered to improve the functionality and reliability of implantable medical devices. However, mimicking living bone tissue is still a challenge. The scope of this review is to highlight the most recent accomplishments and trends in designing nanomaterials and their applications in orthopedics with an outline on future directions... 

    A simple and efficient total synthesis of (±)-danshexinkun A, a bioactive diterpenoid from Salvia miltiorrhiza

    , Article Tetrahedron Letters ; Volume 51, Issue 3 , 2010 , Pages 540-542 ; 00404039 (ISSN) Matloubi Moghaddam, F ; Moridi Farimani, M ; Sharif University of Technology
    An efficient 12-step route for the synthesis of the diterpenoid quinone (±)-danshexinkun A in 23% overall yield from the corresponding highly substituted stilbene using a photocyclization strategy is described  

    Chemical constituents of dichloromethane extract of cultivated Satureja khuzistanica

    , Article Evidence-based Complementary and Alternative Medicine ; Volume 4, Issue 1 , 2007 , Pages 95-98 ; 1741427X (ISSN) Matloubi Moghaddam, F ; Farimani, M. M ; Salahvarzi, S ; Amin, G ; Sharif University of Technology
    Four compounds β-sitosterol, β-sitosterol-3-O-β-D- glucopyranoside, ursolic acid and 4′,5,6-trihydroxy-3′,7- dimethoxyflavone were characterized from the dichloromethane extract of the aerial parts of Satureja khuzistanica (Lamiaceae), a native medicinal plant growing in Iran, on the basis of spectral analysis and comparing with the data in literature. The natural occurrence of these compounds can be conclusive for the chemotaxonomic characterization of the genus Satureja. © 2006 The Author(s)