Loading...
Search for:
nonhuman
0.011 seconds
Total 314 records
Synthesis of green benzamide-decorated UiO-66-NH2 for biomedical applications
, Article Chemosphere ; Volume 299 , 2022 ; 00456535 (ISSN) ; Ghadiri, A. M ; Alinezhad, V ; Sedaghat, A ; Ahmadi, S ; Fatahi, Y ; Makvandi, P ; Saeb, M. R ; Bagherzadeh, M ; Asadnia, M ; Varma, R. S ; Lima, E. C ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Metal-organic frameworks (MOFs) biocompatible systems can host enzymes/bacteria/viruses. Herein we synthesized a series of fatty acid amide hydrolase (FAAH)-decorated UiO-66-NH2 based on Citrus tangerine leaf extract for drug delivery and biosensor applications. Five chemically manipulated FAAH-like benzamides were localized on the UiO-66-NH2 surface with physical interactions. Comprehensive cellular and molecular analyses were conducted on HEK-293, HeLa, HepG2, PC12, MCF-7, and HT-29 cell lines (cytotoxicity assessment after 24 and 48 h). MTT results proved above 95 and 50% relative cell viability in the absence and presence of the drug, respectively. A complete targeted drug-releasing...
Quantum dots against SARS-CoV-2: diagnostic and therapeutic potentials
, Article Journal of Chemical Technology and Biotechnology ; Volume 97, Issue 7 , 2022 , Pages 1640-1654 ; 02682575 (ISSN) ; Ahmadi, S ; Soufi, G. J ; Hekmatnia, A ; Khatami, M ; Fatahi, Y ; Iravani, S ; Varma, R. S ; Sharif University of Technology
John Wiley and Sons Ltd
2022
Abstract
The application of quantum dots (QDs) for detecting and treating various types of coronaviruses is very promising, as their low toxicity and high surface performance make them superior among other nanomaterials; in conjugation with fluorescent probes they are promising semiconductor nanomaterials for the detection of various cellular processes and viral infections. In view of the successful results for inhibiting SARS-CoV-2, functional QDs could serve eminent role in the growth of safe nanotherapy for the cure of viral infections in the near future; their large surface areas help bind numerous molecules post-synthetically. Functionalized QDs with high functionality, targeted selectivity,...
Bioactive hybrid metal-organic framework (MOF)-based nanosensors for optical detection of recombinant SARS-CoV-2 spike antigen
, Article Science of the Total Environment ; Volume 825 , 2022 ; 00489697 (ISSN) ; Fatahi, Y ; Ahmadi, S ; Abbariki, N ; Ojaghi, A ; Rabiee, M ; Radmanesh, F ; Dinarvand, R ; Bagherzadeh, M ; Mostafavi, E ; Ashrafizadeh, M ; Makvandi, P ; Lima, E. C ; Saeb, M. R ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Fast, efficient, and accurate detection of SARS-CoV-2 spike antigen is pivotal to control the spread and reduce the mortality of COVID-19. Nevertheless, the sensitivity of available nanobiosensors to detect recombinant SARS-CoV-2 spike antigen seems insufficient. As a proof-of-concept, MOF-5/CoNi2S4 is developed as a low-cost, safe, and bioactive hybrid nanostructure via the one-pot high-gravity protocol. Then, the porphyrin, H2TMP, was attached to the surface of the synthesized nanomaterial to increase the porosity for efficient detection of recombinant SARS-CoV-2 spike antigen. AFM results approved roughness in different ranges, including 0.54 to 0.74 μm and 0.78 to ≈0.80 μm, showing good...
Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment
, Article Journal of Hazardous Materials ; Volume 423 , 2022 ; 03043894 (ISSN) ; Fatahi, Y ; Asadnia, M ; Daneshgar, H ; Kiani, M ; Ghadiri, A. M ; Atarod, M ; Mashhadzadeh, A. H ; Akhavan, O ; Bagherzadeh, M ; Lima, E. C ; Saeb, M. R ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Green biomaterials play a crucial role in the diagnosis and treatment of diseases as well as health-related problem-solving. Typically, biocompatibility, biodegradability, and mechanical strength are requirements centered on biomaterial engineering. However, in-hospital therapeutics require an elaborated synthesis of hybrid and complex nanomaterials capable of mimicking cellular behavior. Accumulation of hazardous cations like K+ in the inner and middle ear may permanently damage the ear system. We synthesized nanoplatforms based on Allium noeanum to take the first steps in developing biological porous nanomembranes for hazardous cation detection in biological media. The...
Preparation and evaluation of bioactive and compatible starch based superabsorbent for oral drug delivery systems
, Article Journal of Drug Delivery Science and Technology ; Volume 23, Issue 5 , 2013 , Pages 511-517 ; 17732247 (ISSN) ; Ebrahimi, A. A ; Barzegar, S ; Sharif University of Technology
2013
Abstract
Novel types of highly swelling hydrogels (superabsorbent) were prepared by grafting crosslinked poly acrylic acid-co-2-hydroxyethylmetacrylate (PAA-co-HEMA) chains onto starch through a free radical polymerization method. The effect of grafting variables (i.e., concentration of methylenebisacrylamide (MBA), acrylic acid/2-hydroxy methymetacrylate (AA/HEMA) weight ratio, ammonium persulfate (APS), starch, neutralization percent, were systematically optimized to achieve a hydrogel with a maximum swelling capacity. The superabsorbent (SAP) formation was confirmed by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The controlled-release behavior of...
Silver nanoparticles with gelatin nanoshells: Photochemical facile green synthesis and their antimicrobial activity
, Article Journal of Nanoparticle Research ; Volume 13, Issue 10 , October , 2011 , Pages 4647-4658 ; 13880764 (ISSN) ; Soleyman, R ; Sharif University of Technology
2011
Abstract
In the current study, a facile green synthesis of silver-gelatin core-shell nanostructures (spherical, spherical/cubic hybrid, and cubic, DLS diameter: 4.1-6.9 nm) is reported via the wet chemical synthesis procedure. Sunlight-UV as an available reducing agent cause mild reduction of silver ions into the silver nanoparticles (Ag-NPs). Gelatin protein, as an effective capping/shaping agent, was used in the reaction to self-assemble silver nanostructures. The formation of silver nanostructures and their self-assembly pattern was confirmed by SEM, AFM, and TEM techniques. Further investigations were carried out using zeta-potential, UV-Vis, FTIR, GPC, and TGA/DTG/DTA data. The prepared Ag-NPs...
Biological activated carbon process for biotransformation of azo dye carmoisine by klebsiella spp
, Article Environmental Technology (United Kingdom) ; Volume 43, Issue 18 , 2022 , Pages 2713-2729 ; 09593330 (ISSN) ; Bagheri Lotfabad, T ; Heydarinasab, A ; Yaghmaei, S ; Mohseni, F. A ; Sharif University of Technology
Taylor and Francis Ltd
2022
Abstract
The feasibility of employing the biological activated carbon (BAC) process to debilitate azo dye Carmoisine by Klebsiella spp. was investigated. Plate assay revealed the capability of Klebsiella spp. for removal of Carmoisine via degradation. Kinetic parameters were measured for Carmoisine debilitation by Klebsiella spp. using the suspended anaerobic process. Two types of granular and rod-shaped activated carbon were used to form the biological beds in order to study the Carmoisine debilitation in batch processes. Scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM) were used to indicate the colonization and biofilm formation of bacteria grown on activated carbon...
PLGA/TiO2 nanocomposite scaffolds for biomedical applications: Fabrication, photocatalytic, and antibacterial properties
, Article BioImpacts ; Volume 11, Issue 1 , 2021 , Pages 45-52 ; 22285652 (ISSN) ; Madaah Hosseini, H. R ; Nokhbedehghan, Z ; Samadikuchaksaraei, A ; Sharif University of Technology
Tabriz University of Medical Sciences
2021
Abstract
Introduction: Porous 3D scaffolds synthesized using biocompatible and biodegradable materials could provide suitable microenvironment and mechanical support for optimal cell growth and function. The effect of the scaffold porosity on the mechanical properties, as well as the TiO2 nanoparticles addition on the bioactivity, antimicrobial, photocatalytic, and cytotoxicity properties of scaffolds were investigated. Methods: In the present study, porous scaffolds consisting poly (lactide-co-glycolide) (PLGA) containing TiO2 nanoparticles were fabricated via air-liquid foaming technique, which is a novel method and has more advantages due to not using additives for nucleation compared to former...
Stimulus-specific adaptation decreases the coupling of spikes to LFP phase
, Article Frontiers in Neural Circuits ; Volume 13 , 2019 ; 16625110 (ISSN) ; Zarei, M ; Jahed, M ; Daliri, M. R ; Sharif University of Technology
Frontiers Media S.A
2019
Abstract
Stimulus repetition suppresses the neural activity in different sensory areas of the brain. This mechanism of so-called stimulus-specific adaptation (SSA) has been observed in both spiking activity and local field potential (LFP) responses. However, much remains to be known about the effect of SSA on the spike–LFP relation. In this study, we approached this issue by investigating the spike-phase coupling (SPC) in control and adapting paradigms. For the control paradigm, pure tones were presented in a random unbiased sequence. In the adapting paradigm, the same stimuli were presented in a random pattern but it was biased to an adapter stimulus. In fact, the adapter occupied 80% of the...
Chromatographic fingerprint analysis of secondary metabolites in citrus fruits peels using gas chromatography-mass spectrometry combined with advanced chemometric methods
, Article Journal of Chromatography A ; Volume 1251 , 2012 , Pages 176-187 ; 00219673 (ISSN) ; Jalali Heravi, M ; Sereshti, H ; Mani Varnosfaderani, A ; Sharif University of Technology
2012
Abstract
Multivariate curve resolution (MCR) and multivariate clustering methods along with other chemometric methods are proposed to improve the analysis of gas chromatography-mass spectrometry (GC-MS) fingerprints of secondary metabolites in citrus fruits peels. In this way, chromatographic problems such as baseline/background contribution, low S/N peaks, asymmetric peaks, retention time shifts, and co-elution (overlapped and embedded peaks) occurred during GC-MS analysis of chromatographic fingerprints are solved using the proposed strategy. In this study, first, informative GC-MS fingerprints of citrus secondary metabolites are generated and then, whole data sets are segmented to some...
Fuzzy C-means clustering for chromatographic fingerprints analysis: A gas chromatography-mass spectrometry case study
, Article Journal of Chromatography A ; Volume 1438 , 2016 , Pages 236-243 ; 00219673 (ISSN) ; Bazrafshan, A ; Sharif University of Technology
Elsevier
Abstract
Fuzzy C-means clustering (FCM) is proposed as a promising method for the clustering of chromatographic fingerprints of complex samples, such as essential oils. As an example, secondary metabolites of 14 citrus leaves samples are extracted and analyzed by gas chromatography-mass spectrometry (GC-MS). The obtained chromatographic fingerprints are divided to desired number of chromatographic regions. Owing to the fact that chromatographic problems, such as elution time shift and peak overlap can significantly affect the clustering results, therefore, each chromatographic region is analyzed using multivariate curve resolution-alternating least squares (MCR-ALS) to address these problems. Then,...
Chemometrics comparison of gas chromatography with mass spectrometry and comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry Daphnia magna metabolic profiles exposed to salinity
, Article Journal of Separation Science ; Volume 41, Issue 11 , 2018 , Pages 2368-2379 ; 16159306 (ISSN) ; Garreta Lara, E ; Campos, B ; Barata, C ; Lacorte, S ; Tauler, R ; Sharif University of Technology
Wiley-VCH Verlag
2018
Abstract
The performances of gas chromatography with mass spectrometry and of comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry are examined through the comparison of Daphnia magna metabolic profiles. Gas chromatography with mass spectrometry and comprehensive two-dimensional gas chromatography with mass spectrometry were used to compare the concentration changes of metabolites under saline conditions. In this regard, a chemometric strategy based on wavelet compression and multivariate curve resolution–alternating least squares is used to compare the performances of gas chromatography with mass spectrometry and comprehensive two-dimensional gas chromatography with...
Coordinated multivoxel coding beyond univariate effects is not likely to be observable in fMRI data
, Article NeuroImage ; Volume 247 , 2022 ; 10538119 (ISSN) ; Abbaszadeh, M ; Ghazizadeh, A ; Sharif University of Technology
Academic Press Inc
2022
Abstract
Simultaneous recording of activity across brain regions can contain additional information compared to regional recordings done in isolation. In particular, multivariate pattern analysis (MVPA) across voxels has been interpreted as evidence for distributed coding of cognitive or sensorimotor processes beyond what can be gleaned from a collection of univariate effects (UVE) using functional magnetic resonance imaging (fMRI). Here, we argue that regardless of patterns revealed, conventional MVPA is merely a decoding tool with increased sensitivity arising from considering a large number of ‘weak classifiers’ (i.e., single voxels) in higher dimensions. We propose instead that ‘real’ multivoxel...
Targeted nanomedicines for the treatment of bone disease and regeneration
, Article Medicinal Research Reviews ; Volume 41, Issue 3 , 2021 , Pages 1221-1254 ; 01986325 (ISSN) ; Zandi, N ; Mazaheri, M ; Luther, G. A ; Ghovvati, M ; Akbarzadeh, A ; Annabi, N ; Sharif University of Technology
John Wiley and Sons Inc
2021
Abstract
Targeted delivery by either passive or active targeting of therapeutics to the bone is an attractive treatment for various bone related diseases such as osteoporosis, osteosarcoma, multiple myeloma, and metastatic bone tumors. Engineering novel drug delivery carriers can increase therapeutic efficacy and minimize the risk of side effects. Developmnet of nanocarrier delivery systems is an interesting field of ongoing studies with opportunities to provide more effective therapies. In addition, preclinical nanomedicine research can open new opportunities for preclinical bone-targeted drug delivery; nevertheless, further research is needed to progress these therapies towards clinical...
Advances in skin regeneration: application of electrospun scaffolds
, Article Advanced Healthcare Materials ; Volume 4, Issue 8 , 2015 , Pages 1114-1133 ; 21922640 (ISSN) ; Boroujeni, S. M ; Omidvarkordshouli, N ; Soleimani, M ; Sharif University of Technology
Wiley-VCH Verlag
2015
Abstract
The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin...
Fungal bioleaching of e-waste utilizing molasses as the carbon source in a bubble column bioreactor
, Article Journal of Environmental Management ; Volume 307 , 2022 ; 03014797 (ISSN) ; Arshadi, M ; Yaghmaei, S ; Sharif University of Technology
Academic Press
2022
Abstract
Mobile phones are known as the most widely used electronic instruments, and an enormous number of discarded mobile phones are generated. The present work used a pure culture of Penicillium simplicissimum in a bubble column bioreactor to extract Cu and Ni from mobile phone printed circuit boards (MPPCBs) waste. Molasses was used as an efficient carbon source to enhance bioleaching efficiency and increase the cost benefits. The adaptation phase was done at Erlenmeyer flasks to reach 40 g/L of MPPCBs powder. The most significant parameters, including the mass of MPPCBs powder, aeration, molasses concentration, and their interaction, were optimized in order to leach the maximum possible Cu and...
A unified approach for detection of induced epileptic seizures in rats using ECoG signals
, Article Epilepsy and Behavior ; Volume 27, Issue 2 , 2013 , Pages 355-364 ; 15255050 (ISSN) ; Mousavi, S. R ; Motaghi, S ; Dehghani, A ; Vosoughi Vahdat, B ; Shamsollahi, M. B ; Sayyah, M ; Noorbakhsh, S. M ; Sharif University of Technology
2013
Abstract
Objective: Epileptic seizure detection is a key step for epilepsy assessment. In this work, using the pentylenetetrazole (PTZ) model, seizures were induced in rats, and ECoG signals in interictal, preictal, ictal, and postictal periods were recorded. The recorded ECoG signals were then analyzed to detect epileptic seizures in the epileptic rats. Methods: Two different approaches were considered in this work: thresholding and classification. In the thresholding approach, a feature is calculated in consecutive windows, and the resulted index is tracked over time and compared with a threshold. The moment the index crosses the threshold is considered as the moment of seizure onset. In the...
Application of a dissimilarity index of EEG and its sub-bands on prediction of induced epileptic seizures from rat's EEG signals
, Article IRBM ; Volume 33, Issue 5-6 , December , 2012 , Pages 298-307 ; 19590318 (ISSN) ; Mousavi, S. R ; Shamsollahi, M. B ; Vosoughi Vahdat, B ; Sayyah, M ; Motaghi, S ; Dehghani, A ; Noorbakhsh, S. M ; Sharif University of Technology
2012
Abstract
Objective: Epileptic seizures are defined as manifest of excessive and hyper-synchronous activity of neurons in the cerebral cortex that cause frequent malfunction of the human central nervous system. Therefore, finding precursors and predictors of epileptic seizure is of utmost clinical relevance to reduce the epileptic seizure induced nervous system malfunction consequences. Researchers for this purpose may even guide us to a deep understanding of the seizure generating mechanisms. The goal of this paper is to predict epileptic seizures in epileptic rats. Methods: Seizures were induced in rats using pentylenetetrazole (PTZ) model. EEG signals in interictal, preictal, ictal and postictal...
Biomechanical response of intact, degenerated and repaired intervertebral discs under impact loading – Ex-vivo and In-Silico investigation
, Article Journal of Biomechanics ; Volume 70 , March , 2018 , Pages 26-32 ; 00219290 (ISSN) ; Wang, J. L ; Parnianpour, M ; El-Rich, M ; Khalaf, K ; Sharif University of Technology
Elsevier Ltd
2018
Abstract
Understanding the effect of impact loading on the mechanical response of the intervertebral disc (IVD) is valuable for investigating injury mechanisms and devising effective therapeutic modalities. This study used 24 porcine thoracic motion segments to characterize the mechanical response of intact (N = 8), degenerated (Trypsin-denatured, N = 8), and repaired (Genepin-treated, N = 8) IVDs subject to impact loading. A meta-model analysis of poroelastic finite element simulations was used in combination with ex-vivo creep and impact tests to extract the material properties. Forward analyses using updated specimen-specific FE models were performed to evaluate the effect of impact duration. The...
Microfluidic-based droplets for advanced regenerative medicine: current challenges and future trends
, Article Biosensors ; Volume 12, Issue 1 , 2022 ; 20796374 (ISSN) ; Heirani Tabasi, A ; Ghorbani, S ; Eyni, H ; Razavi Bazaz, S ; Khayati, M ; Gheidari, F ; Moradpour, K ; Kehtari, M ; Ahmadi Tafti, S.M ; Ahmadi Tafti, S. H ; Warkiani, M. E ; Sharif University of Technology
MDPI
2022
Abstract
Microfluidics is a promising approach for the facile and large-scale fabrication of monodispersed droplets for various applications in biomedicine. This technology has demonstrated great potential to address the limitations of regenerative medicine. Microfluidics provides safe, accurate, reliable, and cost-effective methods for encapsulating different stem cells, gametes, biomaterials, biomolecules, reagents, genes, and nanoparticles inside picoliter-sized droplets or droplet-derived microgels for different applications. Moreover, microenvironments made using such droplets can mimic niches of stem cells for cell therapy purposes, simulate native extracellular matrix (ECM) for tissue...