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    Recent advances in porphyrin-based nanocomposites for effective targeted imaging and therapy

    , Article Biomaterials ; Volume 232 , 2020 Rabiee, N ; Tavakkoli Yaraki, M ; Mokhtari Garakani, S ; Mokhtari Garakani, S ; Ahmadi, S ; Lajevardi, A ; Bagherzadeh, M ; Rabiee, M ; Tayebi, L ; Tahriri, M ; Hamblin, M. R ; Sharif University of Technology
    Elsevier Ltd  2020
    Abstract
    Porphyrins are organic compounds that continue to attract much theoretical interest, and have been called the “pigments of life”. They have a wide role in photodynamic and sonodynamic therapy, along with uses in magnetic resonance, fluorescence and photoacoustic imaging. There is a vast range of porphyrins that have been isolated or designed, but few of them have real clinical applications. Due to the hydrophobic properties of porphyrins, and their tendency to aggregate by stacking of the planar molecules they are difficult to work with in aqueous media. Therefore encapsulating them in nanoparticles (NPs) or attachment to various delivery vehicles have been used to improve delivery...