Sharif Digital Repository

This paper presents a case study and numerical simulations of a corner of a deep excavation in Tehran supported by soldier piles and ground anchors. This study focuses on the differences between 2D and 3D numerical modelling in estimating the wall deflection at the corner locations of the excavation. Furthermore, the performance of modelling with Mohr–Coulomb constitutive law was compared with the result of a hardening soil model. The modelling procedure was calibrated against a full-scale instrumented tieback wall at Texas A&M University and the monitoring data of the excavation project. The results indicated that the hardening soil model yields reasonable predictions of wall deflection in... 

Binding of the SARS-CoV-2 S-glycoprotein to cell receptors is vital for the entry of the virus into cells and subsequent infection. ACE2 is the main cell receptor for SARS-CoV-2, which can attach to the C-terminal receptor-binding domain (RBD) of the SARS-CoV-2 S-glycoprotein. The GRP78 receptor plays an anchoring role, which attaches to the RBD and increases the chance of other RBDs binding to ACE2. Although high levels of reactive oxygen and nitrogen species (RONS) are produced during viral infections, it is not clear how they affect the RBD structure and its binding to ACE2 and GRP78. In this research, we apply molecular dynamics simulations to study the effect of oxidation of the highly... 

This study aims to investigate the nonlinear dynamic characteristics of annular cylinders coupled with a fluid medium to identify the effective parameters on stability margins at different rotation speeds. To achieve this, stability and nonlinear vibrations of rotating cylindrical shells containing incompressible annular fluid are considered. The fluid medium is bounded by a rigid external cylinder. Sanders–Koiter kinematic assumptions are utilized to determine the geometrically nonlinear structural equations of motion. These equations are then used to investigate finite amplitude vibrations of various fluid-loaded shells at different states. A penalty approach is introduced by using...