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targeted-drug-delivery
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ZnO-incorporated polyvinylidene fluoride/poly(ε-caprolactone) nanocomposite scaffold with controlled release of dexamethasone for bone tissue engineering
, Article Applied Physics A: Materials Science and Processing ; Volume 128, Issue 8 , 2022 ; 09478396 (ISSN) ; Mohammadi, M ; Mashayekhan, S ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Here we report on the development of a hybrid nanofibrous scaffold made from polyvinylidene fluoride (PVDF) nanofibers embedding zinc oxide nanorods (ZnOns), and poly(ε-caprolactone) (PCL) nanofibers incorporating dexamethasone (DEX)-loaded chitosan nanoparticles using dual-electrospinning method. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and tensile analysis were carried out for physiochemical characterization of the scaffolds, followed by DEX release profile. In addition, an MTT assay was conducted to assess the viability of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) on the hybrid nanofibrous scaffold....
Modeling of an ultrasound system in targeted drug delivery to abdominal aortic aneurysm: a patient-specificin silico study based on ligand-receptor binding
, Article IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control ; Volume 69, Issue 3 , 2022 , Pages 967-974 ; 08853010 (ISSN) ; Boroumand, A ; Ebrahimi, S ; Kalantarnia, F ; Maleki, S ; Moradi, H ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2022
Abstract
Targeted drug delivery methods have shown a significant impact on enhancing drug delivery efficiency and reducing drug side effects. While various stimuli have been used to promote the drug delivery process, applying ultrasound (US) waves to control drug particles through the human body, noninvasively, has drawn the scientist's attention. However, microcarriers delivery reaches the aneurysmal artery by US waves that exert volumetric forces on blood, and drug carriers, which can therefore affect blood flow patterns and movement pathways of drug carriers, have not yet been studied. In this study, we developed a 3-D patient-specific model of abdominal aortic aneurysm (AAA) to evaluate the...
Facile and tunable method for polymeric surface modification of magnetic nanoparticles via RAFT polymerization: Preparation, characterization, and drug release properties
, Article European Polymer Journal ; Volume 167 , 2022 ; 00143057 (ISSN) ; Pourjavadi, A ; Keshavarzi, N ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Herein, the facile and tunable technique for the preparation of novel multi-stimuli-responsive nanocomposites via RAFT polymerization for DOX delivery is reported. The influence of the molecular weight of pH- and thermo-sensitive poly (acrylic acid-co-NIPAM) (PNAx), as a macro-RAFT agent, on the nanocomposites size and drug release rate was investigated. The outcome of this study reveals that macro-RAFT agent with lower molecular weight can be attached to the surface of magnetic nanoparticles with higher content of polymeric layer than can macro-RAFT agent with higher molecular weight. Also, it was observed that the particle size, polymer grafting density, DOX loading capacity, and DOX...
In vitro study: synthesis and evaluation of Fe3O4/CQD magnetic/fluorescent nanocomposites for targeted drug delivery, MRI, and cancer cell labeling applications
, Article Langmuir ; Volume 38, Issue 12 , 2022 , Pages 3804-3816 ; 07437463 (ISSN) ; Ahmadi, R ; Heydari, M ; Rahimipour, M. R ; Molaei, M. J ; Unsworth, L ; Sharif University of Technology
American Chemical Society
2022
Abstract
In the present study, first, Fe3O4nanoparticles were functionalized using glutaric acid and then composited with CQDs. Doxorubicin (DOX) drug was loaded to evaluate the performance of the nanocomposite for targeted drug delivery applications. The XRD pattern confirmed the presence of characteristic peaks of CQDs and Fe3O4. In the FTIR spectrum, the presence of carboxyl functional groups on Fe3O4/CQDs was observed; DOX (positive charge) is loaded onto Fe3O4/CQDs (negative charge) by electrostatic absorption. FESEM and AFM images showed that the particle sizes of Fe3O4and CQDs were 23-75 and 1-3 nm, respectively. The hysteresis curves showed superparamagnetic properties for Fe3O4and Fe3O4/CQDs...
Particles in coronary circulation: A review on modelling for drug carrier design
, Article Materials and Design ; Volume 216 , 2022 ; 02641275 (ISSN) ; Ghoytasi, I ; Shamloo, A ; Ghosi, S ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Atherosclerotic plaques and thrombosis are chronic inflammatory complications and the main manifestations of cardiovascular diseases (CVD), the leading cause of death globally. Achieving non/minimal-invasive therapeutic means for these implications in the coronary network is vital and has become an interdisciplinary concern. Accordingly, smart drug delivery systems, specifically based on micro- and nanoparticles, as a promising method to offer non/minimal-invasive therapeutic mechanisms are under active research. Notably, computational models enable us to study, design, and predict treatment strategies based on smart drug delivery systems with less time and cost compared with conventional...
Green metal-organic frameworks (MOFs) for biomedical applications
, Article Microporous and Mesoporous Materials ; Volume 335 , 2022 ; 13871811 (ISSN) ; Atarod, M ; Tavakolizadeh, M ; Asgari, S ; Rezaei, M ; Akhavan, O ; Pourjavadi, A ; Jouyandeh, M ; Lima, E. C ; Hamed Mashhadzadeh, A ; Ehsani, A ; Ahmadi, S ; Saeb, M. R ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Metal-organic frameworks (MOFs), known as highly ordered crystalline hybrid structures, are the products of coordination polymerization of transition metals and organic ligands. MOFs are best known for their extensive specific surface area, hierarchically porous and tailorable 1D, 2D, or 3D micro-and nanostructure, and acceptable biocompatibility. Because of the multiplicity of metallic and organic units used in MOFs synthesis, tailor-made MOFs can be synthesized to be served as building blocks of advanced biological materials and systems. Recently, synthesis of green MOFs has received much more attention for nanobiomedicine usage. We review herein synthesis and biomedical application of...
Droplet-based microfluidics in biomedical applications
, Article Biofabrication ; Volume 14, Issue 2 , 2022 ; 17585082 (ISSN) ; Besanjideh, M ; Nasiri, R ; Shamloo, A ; Nasrollahi, F ; De Barros, N. R ; Davoodi, E ; Erdem, A ; Mahmoodi, M ; Hosseini, V ; Montazerian, H ; Jahangiry, J ; Darabi, M.A ; Haghniaz, R ; Dokmeci, M.R ; Annabi, N ; Ahadian, S ; Khademhosseini, A ; Sharif University of Technology
IOP Publishing Ltd
2022
Abstract
Droplet-based microfluidic systems have been employed to manipulate discrete fluid volumes with immiscible phases. Creating the fluid droplets at microscale has led to a paradigm shift in mixing, sorting, encapsulation, sensing, and designing high throughput devices for biomedical applications. Droplet microfluidics has opened many opportunities in microparticle synthesis, molecular detection, diagnostics, drug delivery, and cell biology. In the present review, we first introduce standard methods for droplet generation (i.e. passive and active methods) and discuss the latest examples of emulsification and particle synthesis approaches enabled by microfluidic platforms. Then, the applications...
Gingerol/letrozole-loaded mesoporous silica nanoparticles for breast cancer therapy: In-silico and in-vitro studies
, Article Microporous and Mesoporous Materials ; Volume 337 , 2022 ; 13871811 (ISSN) ; Saremi Poor, A ; Khodarahmi, M ; Abdihaji, M ; Moammeri, A ; Jafari, S ; Salehi Moghaddam, Z ; Seif, M ; Moghtaderi, M ; Lalami, Z. A ; Heydari, M ; Adelnia, H ; Farasati Far, B ; Sharif University of Technology
Elsevier B.V
2022
Abstract
In this study, in-silico properties of Gingerol (Gin) and Letrozole (Let), as two potential anti-cancer drugs, were investigated and some significant ADME drawbacks were predicted. Accordingly, to address the drawbacks, mesoporous silica nanoparticles (MSNs) were prepared, functionalized with zinc, amine, and graphene oxide (GO) (MZNG), and employed for loading and delivery of the both to breast cancer cells in-vitro. Biophysical analysis showed that Let and Gin-loaded MZNGs have spherical structure with a mean diameter of ∼210 nm. The MZNGs provided high entrapment efficiency of Let and Gin with a pH-sensitive sustained release profile. The cytotoxicity assay demonstrated that loading of...
Magnetic nanoparticles-loaded PLA/PEG microspheres as drug carriers
, Article Journal of Biomedical Materials Research - Part A ; Vol. 103, issue. 5 , SEP , 2014 , p. 1893-1898 ; Shamshiri, S ; Sharif University of Technology
Abstract
Surface-modified magnetite (Fe3O4) nanoparticles with an average size of 22 nm were prepared. The nanoparticles had a saturation magnetization of 50.7 emu g-1. Then magnetite and drug-loaded microspheres of poly (lactic acid)/poly (ethylene glycol) were prepared at various compositions. The microspheres were spherical in shape and had smooth surface. The diameter size of the microspheres ranged between about 0.2 and 4 μm. Doxorubicin hydrochloride for cancer treatment was the drug that loaded into the microspheres. The prepared microspheres were characterized by FTIR, XRD, VSM, SEM and drug-release measurements. It was found that the drug cumulative release percentage was proportional to...
Magnetic micellar nanocarrier based on pH-sensitive PEG-PCL-PEG triblock copolymer: a potential carrier for hydrophobic anticancer drugs
, Article Journal of Nanoparticle Research ; Volume 20, Issue 10 , 2018 ; 13880764 (ISSN) ; Dastanpour, L ; Mazaheri Tehrani, Z ; Sharif University of Technology
Abstract
In this research, we report a magnetic pH-sensitive polymeric micelle designed for hydrophobic drug carrier in cancer treatment. This carrier was prepared by self-assembly of biodegradable triblock copolymer PEG-PCL-PEG coated on oleate-modified magnetic nanoparticles. The amphiphilic triblock copolymer was synthesized via reaction between the aldehyde group from the hydrophilic component with the amine group of the hydrophobic component. The resulting Schiff base linkage was sensitive to pH. The structure of nanocarrier was characterized by Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance spectroscopy (1H-NMR). Morphology and size of the magnetic...
Plant protein-based hydrophobic fine and ultrafine carrier particles in drug delivery systems
, Article Critical Reviews in Biotechnology ; Volume 38, Issue 1 , 2018 , Pages 47-67 ; 07388551 (ISSN) ; Mirshekari, H ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Baniasadi, F ; Sharifi Aghdam, M ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
Taylor and Francis Ltd
2018
Abstract
For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes. Zein is a water-insoluble protein from maize; Gliadin is a 70% alcohol-soluble...
The effect of hematocrit and nanoparticles diameter on hemodynamic parameters and drug delivery in abdominal aortic aneurysm with consideration of blood pulsatile flow
, Article Computer Methods and Programs in Biomedicine ; Volume 195 , October , 2020 ; Nasiri Sadr, A ; Kaffash, E ; Goudarzi, S ; Golab, E ; Karimipour, A ; Sharif University of Technology
Elsevier Ireland Ltd
2020
Abstract
Background and Objective: The present article has simulated to investigate the efficient hemodynamic parameters, the drug persistence, and drug distribution on an abdominal aortic aneurysm. Methods: Blood as a non-Newtonian fluid enters the artery acting as a real pulse waveform; its behavior is dependent on hematocrit and strain rate. In this simulation of computational fluid dynamic, magnetic nanoparticles of iron oxide which were in advance coated with the drug, are injected into the artery during a cardiac cycle. A two-phase model was applied to investigate the distribution of these carriers. Results: The results are presented for different hematocrits and the nanoparticle diameter. It...
Scalable fabrication of tunable titanium nanotubes via sonoelectrochemical process for biomedical applications
, Article Ultrasonics Sonochemistry ; Volume 64 , June , 2020 ; Khataee, A ; Riahi, Z ; Shahin, K ; Asadnia, M ; Razmjou, A ; Hojjati Najafabadi, A ; Mei, C ; Orooji, Y ; Li, D ; Sharif University of Technology
Elsevier B. V
2020
Abstract
Titanium does not react well with the human tissues and due to its bio-inert nature the surface modification has yet to be well-studied. In this study, the sonoelectrochemical process has been carried out to generate TiO2 nanotube arrays on implantable Ti 6–4. All the prepared nanotubes fill with the vancomycin by immersion and electrophoresis method. Drug-releasing properties, antibacterial behavior, protein adsorption and cell attachment of drug-modified nanotubes are examined by UV–vis, flow cytometry, modified disc diffusion, BSA adsorption, and FESEM, respectively. The most uniform morphology, appropriate drug release, cell viability behavior and antibacterial properties can be achieved...
Stimuli-responsive chitosan as an advantageous platform for efficient delivery of bioactive agents
, Article Journal of Controlled Release ; Volume 317 , 2020 , Pages 216-231 ; Tavakolian, M ; Yazdani, H ; Frounchi, M ; van de Ven, T. G. M ; Maysinger, D ; Kakkar, A ; Sharif University of Technology
Elsevier B.V
2020
Abstract
Despite a diverse range of active pharmaceutical agents currently at our disposal, high morbidity rate diseases continue to pose a major health crisis globally. One of the important parameters in this regard is the controlled cargo delivery at desired sites. Among a variety of synthetic and natural macromolecular systems, chitosan, an abundant biopolymer, offers a platform for tailored architectures that could have high loading capacity of cargo, target and deliver. Stimuli directed accumulation of vehicles and drug release is an area of direct relevance to biomedical applications. In this review, we highlight essential characteristics of modified chitosan that present themselves for...
Turning toxic nanomaterials into a safe and bioactive nanocarrier for co-delivery of DOX/pCRISPR
, Article ACS Applied Bio Materials ; Volume 4, Issue 6 , 2021 , Pages 5336-5351 ; 25766422 (ISSN) ; Bagherzadeh, M ; Ghadiri, A. M ; Fatahi, Y ; Aldhaher, A ; Makvandi, P ; Dinarvand, R ; Jouyandeh, M ; Saeb, M. R ; Mozafari, M ; Shokouhimehr, M ; Hamblin, M. R ; Varma, R. S ; Sharif University of Technology
American Chemical Society
2021
Abstract
Hybrid bioactive inorganic-organic carbon-based nanocomposites of reduced graphene oxide (rGO) nanosheets enlarged with multi-walled carbon nanotubes (MWCNTs) were decorated to provide a suitable space forin situgrowth of CoNi2S4and green-synthesized ZnO nanoparticles. The ensuing nanocarrier supplied π-π interactions between the DOX drug and a stabilizing agent derived from leaf extracts on the surface of ZnO nanoparticles and hydrogen bonds; gene delivery of (p)CRISPR was also facilitated by chitosan and alginate renewable macromolecules. Also, these polymers can inhibit the potential interactions between the inorganic parts and cellular membranes to reduce the potential cytotoxicity....
Effect of material and population on the delivery of nanoparticles to an atherosclerotic plaque: a patient-specific in silico study
, Article Langmuir ; Volume 37, Issue 4 , 2021 , Pages 1551-1562 ; 07437463 (ISSN) ; Shamloo, A ; Barzegar, S ; Forouzandehmehr, M ; Sharif University of Technology
American Chemical Society
2021
Abstract
Coronary artery disease (CAD) is the prevalent reason of mortality all around the world. Targeting CAD, specifically atherosclerosis, with controlled delivery of micro and nanoparticles, as drug carriers, is a very proficient approach. In this work, a patient-specific and realistic model of an atherosclerotic plaque in the left anterior descending (LAD) artery was created by image-processing of CT-scan images and implementing a finite-element mesh. Next, a fluid-solid interaction simulation considering the physiological boundary conditions was conducted. By considering the simulated force fields and particle-particle interactions, the correlation between injected particles at each cardiac...
Customizing nano-chitosan for sustainable drug delivery
, Article Journal of Controlled Release ; Volume 350 , 2022 , Pages 175-192 ; 01683659 (ISSN) ; Vahidi, O ; Moghbeli, M ; Ahmadi, S ; Asadnia, M ; Akhavan, O ; Seidi, F ; Rabiee, M ; Saeb, M. R ; Webster, T. J ; Varma, R. S ; Sharifi, E ; Zarrabi, A ; Rabiee, N ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in...
Forced and free vibrational analysis of viscoelastic nanotubes conveying fluid subjected to moving load in hygro-thermo-magnetic environments with surface effects
, Article Archives of Civil and Mechanical Engineering ; Volume 22, Issue 4 , 2022 ; 16449665 (ISSN) ; Alibeigloo, A ; Borjalilou, V ; Koochakianfard, O ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Forced and free vibrational analyses of viscoelastic nanotubes containing fluid under a moving load in complex environments incorporating surface effects are conducted based on the nonlocal strain gradient theory and the Rayleigh beam model. To model the internal nanoflow, the slip boundary condition is employed. Adopting the Galerkin discretization approach, the reduced-order dynamic model of the system is acquired. Analytical and numerical methods are exploited to determine the dynamic response of the system. The impacts of geometry, scale parameter ratio, Knudsen number, fluid velocity, rotary inertia parameter, viscoelastic parameter, surface residual stress, surface elastic modulus, and...
Folic acid-adorned curcumin-loaded iron oxide nanoparticles for cervical cancer
, Article ACS Applied Bio Materials ; Volume 5, Issue 3 , 2022 , Pages 1305-1318 ; 25766422 (ISSN) ; Azarian, M ; Heydari Sheikh Hossein, H ; Abdolvahabi, Z ; Mohammadi Abgarmi, Z ; Moradi, A ; Mousavi, S. M ; Ashrafizadeh, M ; Makvandi, P ; Saeb, M. R ; Rabiee, N ; Sharif University of Technology
American Chemical Society
2022
Abstract
Cancer is a deadly disease that has long plagued humans and has become more prevalent in recent years. The common treatment modalities for this disease have always faced many problems and complications, and this has led to the discovery of strategies for cancer diagnosis and treatment. The use of magnetic nanoparticles in the past two decades has had a significant impact on this. One of the objectives of the present study is to introduce the special properties of these nanoparticles and how they are structured to load and transport drugs to tumors. In this study, iron oxide (Fe3O4) nanoparticles with 6 nm sizes were coated with hyperbranched polyglycerol (HPG) and folic acid (FA). The...
Targeted drug delivery of magnetic microbubble for abdominal aortic aneurysm: an in silico study
, Article Biomechanics and Modeling in Mechanobiology ; Volume 21, Issue 2 , 2022 , Pages 735-753 ; 16177959 (ISSN) ; Ebrahimi, S ; Ghorbani, G ; Alishiri, M ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Targeted drug delivery (TDD) to abdominal aortic aneurysm (AAA) using a controlled and efficient approach has recently been a significant challenge. In this study, by using magnetic microbubbles (MMBs) under a magnetic field, we investigated the MMBs performance in TDD to AAA based on the amount of surface density of MMBs (SDMM) adhered to the AAA lumen. The results showed that among the types of MMBs studied in the presence of the magnetic field, micromarkers are the best type of microbubble with a −50 % increase in SDMM adhered to the critical area of AAA. The results show that applying a magnetic field causes the amount of SDMM adhered to the whole area of AAA to increase −1.54 times...