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targeted-drug-delivery
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Turning toxic nanomaterials into a safe and bioactive nanocarrier for co-delivery of DOX/pCRISPR
, Article ACS Applied Bio Materials ; Volume 4, Issue 6 , 2021 , Pages 5336-5351 ; 25766422 (ISSN) ; Bagherzadeh, M ; Ghadiri, A. M ; Fatahi, Y ; Aldhaher, A ; Makvandi, P ; Dinarvand, R ; Jouyandeh, M ; Saeb, M. R ; Mozafari, M ; Shokouhimehr, M ; Hamblin, M. R ; Varma, R. S ; Sharif University of Technology
American Chemical Society
2021
Abstract
Hybrid bioactive inorganic-organic carbon-based nanocomposites of reduced graphene oxide (rGO) nanosheets enlarged with multi-walled carbon nanotubes (MWCNTs) were decorated to provide a suitable space forin situgrowth of CoNi2S4and green-synthesized ZnO nanoparticles. The ensuing nanocarrier supplied π-π interactions between the DOX drug and a stabilizing agent derived from leaf extracts on the surface of ZnO nanoparticles and hydrogen bonds; gene delivery of (p)CRISPR was also facilitated by chitosan and alginate renewable macromolecules. Also, these polymers can inhibit the potential interactions between the inorganic parts and cellular membranes to reduce the potential cytotoxicity....
ZnO-incorporated polyvinylidene fluoride/poly(ε-caprolactone) nanocomposite scaffold with controlled release of dexamethasone for bone tissue engineering
, Article Applied Physics A: Materials Science and Processing ; Volume 128, Issue 8 , 2022 ; 09478396 (ISSN) ; Mohammadi, M ; Mashayekhan, S ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Here we report on the development of a hybrid nanofibrous scaffold made from polyvinylidene fluoride (PVDF) nanofibers embedding zinc oxide nanorods (ZnOns), and poly(ε-caprolactone) (PCL) nanofibers incorporating dexamethasone (DEX)-loaded chitosan nanoparticles using dual-electrospinning method. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and tensile analysis were carried out for physiochemical characterization of the scaffolds, followed by DEX release profile. In addition, an MTT assay was conducted to assess the viability of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) on the hybrid nanofibrous scaffold....
Zn-rich (GaN)1−x(ZnO)x: a biomedical friend?
, Article New Journal of Chemistry ; Volume 45, Issue 8 , 2021 , Pages 4077-4089 ; 11440546 (ISSN) ; Rabiee, N ; Fatahi, Y ; Dinarvand, R ; Sharif University of Technology
Royal Society of Chemistry
2021
Abstract
A Zn-Rich (GaN)1−x(ZnO)xnanostructure was synthesized with the assistance of a high-gravity technique in order to reduce the reaction time and temperature. The synthesized inorganic nanomaterial has been applied in both drug and gene delivery systems, and as the first fully inorganic nanomaterial, it was investigated in a comprehensive cellular investigation as well. In order to increase the potential bioavailability, as well as the interactions with the pCRISPR, the nanomaterial was enriched with additional Zn ions. The nanomaterial and the final nanocarrier were characterized at each step before and after any biological analysisviaFESEM, AFM, TEM, FTIR and XRD. The polymer coated...