Sharif Digital Repository

Microfluidic cell culture platforms are ideal candidates for modeling the native tumor microenvironment because they can precisely reconstruct in vivo cellular behavior. Moreover, mathematical modeling of tumor growth can pave the way toward description and prediction of growth pattern as well as improving cancer treatment. In this study, a modified mathematical model based on concentration distribution is applied to tumor growth in both conventional static culture and dynamic microfluidic cell culture systems. Apoptosis and necrosis mechanisms are considered as the main inhibitory factors in the model, while tumor growth rate and nutrient consumption rate are modified in both quiescent and... 

In this study, a novel pseudo-three-dimensional model is developed to find out both fluid and solid temperature distributions in multi-stream plate fin heat exchangers. In this simulation algorithm, heat exchangers can be in either parallel flow or cross flow configuration. The model considerations include: heat leakage of cap plates and side plates, conduction throughout the solid matrix of the heat exchanger, variable physical properties, and inlet mass flow rate maldistribution. Using the computational code, the effects of different factors such as: the number of layers, mass flow variation, inlet mass flow rate maldistribution, and stacking pattern on the thermal performance of the heat... 

In this paper, a comprehensive three-dimensional model of photovoltaic thermal system integrated with phase change material (PVT/PCM) is developed and simulated. The effect of some key parameters using parametric analysis on performance of PVT/PCM system with water as working fluid is investigated. Parameters considered in this study include the properties of PCM (i.e. melting temperature, enthalpy of fusion and thermal conductivity), solar radiation and mass flow rate. The parametric analysis ranges are selected according to the properties of the most of available PCMs on the market, which shows the practical application of the numerical research. Furthermore, a three-dimensional model of... 

In this work, a mathematical model was developed to simulate the urinary concentration mechanism. A 3-D geometry was derived based on the detail physiological pictures of rat kidney. The approximate region of each tubule was obtained from the volume distribution of structures based on Walter Pfaller's monograph and Layton's region-based model. Mass and momentum balances were applied to solve for the change in solutes concentration and osmolality. The osmolality of short and long descending nephrons at the end of the outer medulla was obtained to be 530 mOsmol/kgH2O and 802 mOsmol/kgH2O, respectively, which were in acceptable agreement with experimental data. The fluid osmolality of the short... 

The aim of this paper is to consider the ability of endurance time (ET) method to estimate the seismic response of fixed offshore platforms at various excitation levels. In this way, various sources of nonlinear behaviour and challenging issues in the ET approach are included in the three-dimensional model of a real jacket platform utilising the finite element method. In addition to common-designed, over-designed and under-designed cases of this platform have been investigated to examine the effects of the structural characteristics on the ET response. To consider the accuracy and reliability of this approach, results of the ET method are compared with results of nonlinear time history... 

Machining of ceramics often involves many challenges due to their high hardness, brittleness, and low-thermal conductivity. Laser Assisted Machining (LAM) is a promising technology for improving the machinability of hard-to-cut materials. In this work, the effect of laser heating in the LAM process on Slip Cast Fused Silica (SCFS) ceramics is investigated by conducting a numerical thermal analysis of laser effects on material behavior. A transient three-dimensional heat transfer analysis for Laser Assisted Turning (LAT) of SCFS is performed using finite-element method. Temperature distributions in SCFS cylindrical specimens are obtained. Moreover, the influence of laser parameters, such as... 

The aim of this paper is to consider the ability of endurance time (ET) method to estimate the seismic response of fixed offshore platforms at various excitation levels. In this way, various sources of nonlinear behaviour and challenging issues in the ET approach are included in the three-dimensional model of a real jacket platform utilising the finite element method. In addition to common-designed, over-designed and under-designed cases of this platform have been investigated to examine the effects of the structural characteristics on the ET response. To consider the accuracy and reliability of this approach, results of the ET method are compared with results of nonlinear time history... 

Machining of ceramics often involves many challenges due to their high hardness, brittleness, and low-thermal conductivity. Laser Assisted Machining (LAM) is a promising technology for improving the machinability of hard-to-cut materials. In this work, the effect of laser heating in the LAM process on Slip Cast Fused Silica (SCFS) ceramics is investigated by conducting a numerical thermal analysis of laser effects on material behavior. A transient three-dimensional heat transfer analysis for Laser Assisted Turning (LAT) of SCFS is performed using finite-element method. Temperature distributions in SCFS cylindrical specimens are obtained. Moreover, the influence of laser parameters, such as... 

Background and Objective: Blood flow variation during cardiac cycle is the main mechanism of atherosclerotic development which is dependent on. Methods: The present work mainly tends to investigate stenosis effect in dynamic curvature of coronary artery. This paper presents numerical investigations on wall shear stress profiles in three-dimensional pulsatile flow through curved stenotic coronary arteries for both static and dynamic model. In order to do so, three-dimensional models related to the curved arteries with two degrees of stenosis (30% and 50%). Results: Lower amount of wall shear stress is found near the inner wall of artery distal to the plaque region (stenosis) and in both... 

Horizontal ground heat exchangers (GHEs) have a lower cost in comparison to vertical ones; however, they require more land area. For the sake of reducing the required land area for horizontal GHEs, flat-panel GHEs have been recently introduced. In this piece of research, a 3-D numerical model has been developed to predict the thermal performance of flat-panel GHEs. In this study, at first, the thermal performance of a flat-panel GHE has been compared with that of linear horizontal ones. The results demonstrate that the flat-panel GHE has a better thermal performance of about 27% in comparison to an arrangement of linear GHEs with a value of 0.5 m for pipe spacing. In the second part of this... 

A three-dimensional model has been developed to describe the multiphase release of macromolecular drugs encapsulated in a hydrogel. The heterogeneity of network mesh size was considered by assigning varying diffusion coefficients to the network lattices randomly. Using a stochastic approach, the random nature of diffusion of drug molecules was captured within the network. The simplest form of distribution containing two diffusion coefficients was tested. To generate the drug release profiles for experimental validation under the limitation of computational cost, a simple scaling relationship was employed. Unlike the single-diffusivity model, the dual-diffusivity model showed good agreement... 

In the study, the daily and monthly performance of a photovoltaic thermal system integrated with phase change material is investigated in Shanghai, China. A three-dimensional model of photovoltaic thermal system integrated with phase change material system is developed and numerically simulated. Water is considered as working fluid, and the fluid flow regime is laminar and incompressible. Both quasi-steady and transient models are compared together, and the transient model is selected because of its higher accuracy. Validation analysis is performed on the numerical model to show the reasonable agreement of current research compared to some other research. After obtaining the suitable... 

This paper describes a three-dimensional (3D) finite-element (FE) model developed to assess the seismic behaviour of a novel prefabricated beam-to-beam connection termed a double-bolted flush end-plate beam (DBFEB) splice connection under cyclic loading. The seismic response was analysed and evaluated in terms of the hysteretic behaviour, rigidity, resistance degradation, ductility, energy dissipation capacity and equivalent damping coefficient. It is shown that the required performance can be achieved by controlling the end-plate thickness as well as the bolt grade and diameter; these parameters were therefore chosen as the key geometric variables investigated here for parametric study.... 

Compact heat exchangers are among the vital components used in various industries. In this study, a general framework has been developed with a multi-scale point of view for three-dimensional simulation of multi-stream plate-fin heat exchangers. The most important features in the MSPFHEs simulation, such as phase change phenomena, multi-component mixtures, multiple streams, transversal, lateral and longitudinal conduction, non-uniformity of inlet flow, variable fluid properties, and heat leakage are simultaneously considered in this model. The modular form of the model structure has facilitated layer-by-layer simulation of cross flow heat exchangers as well as parallel flow ones. Our model... 

In this study, coupled Generative Adversarial and Auto-Encoder neural networks have been used to reconstruct realizations of three-dimensional porous media. The gradient-descent-based optimization method is used for training and stabilizing the neural networks. The multi-scale reconstruction has been conducted for both sandstone and carbonate samples from an Iranian oilfield. The sandstone contains inter and intra-grain porosity. The generative adversarial network predicts the inter-grain pores and the auto-encoder provides the generative adversarial network result with intra-grain pores (micro-porosity). Different matching criteria, including porosity, permeability, auto-correlation... 

Mechanized tunneling method using Tunnel Boring Machine (TBM) is being extensively employed in urban areas, especially when excavation takes place underneath the groundwater table. In this study, three-dimensional coupled Finite Element Analyses (FEA) have been performed to investigate the interaction mechanism between mechanized twin tunnels construction of Shiraz metro (line 2) and groundwater. Firstly, two soil constitutive models (Mohr-Coulomb and Modified Cam-Clay model) of Shiraz lean clay are validated against drained triaxial compression test data. Varying the permeability of the grout layer within the specified range, the base numerical model is then calibrated by the field data of... 

In this paper, a three-dimensional steady state incompressible turbulent air flow is considered in a large single room. The buoyancy affected turbulent air flow is numerically simulated by solving governing equations. The turbulence modeling includes both κ - ε and zero-equation models and their results are compared to the experimental data. The paper reviews several aspects, such as displacement of radiator system performance, temperature and flow field distribution and comfort conditions. The results show that the best temperature distribution and comfort condition are obtained when the radiator is installed under the window and its height is equal to or greater than that of the window. ©...