Search for: unclassified-drug
0.008 seconds
Total 291 records

    Synthesis of new 2-aryl-4-chloro-3-hydroxy-1H-indole-5,7-dicarbaldehydes via Vilsmeier-Haack reaction

    , Article Journal of Heterocyclic Chemistry ; Volume 47, Issue 2 , 2010 , Pages 463-467 ; 0022152X (ISSN) Eftekhari Sis, B ; Zirak, M ; Akbari, A ; Hashemi, M. M ; Sharif University of Technology
    (Chemical Equation Presented) New 2-aryl-4-chloro-3-hydroxy-1H-indole-5,7- dicarbaldehydes were synthesized in three steps from acetophenone derivatives. By oxidation of acetophenones to aryl glyoxals using selenium dioxide and condensation with acetylacetone in the presence of ammonium acetate in water 3-acetyl-5-aryl-4-hydroxy-2-methyl-1H-pyrrols were obtained. 2-Aryl-4-chloro-3-hydroxy-1H-indole-5,7-dicarbaldehydes were synthesized via Vilsmeier-Haack reaction of pyrrole derivatives in moderate yields  

    Tailoring dicobalt pacman complexes of schiff-base calixpyrroles towards dioxygen reduction catalysis

    , Article Chemical Communications ; Volume 46, Issue 5 , 2010 , Pages 710-712 ; 13597345 (ISSN) Askarizadeh, E ; Bani Yaghoob, S ; Boghaei, D. M ; Slawin, A. M. Z ; Love, J. B ; Sharif University of Technology
    By modifying the mouth of a macrocyclic dicobalt Pacman complex, it is possible to both isolate new bridging-superoxo and hydroxyl complexes and to tune the reactivity of this system towards catalytic four-electron reduction of dioxygen to water  

    Feasibility of using bulk metallic glass for self-expandable stent applications

    , Article Journal of Biomedical Materials Research - Part B Applied Biomaterials ; Volume 105, Issue 7 , 2017 , Pages 1874-1882 ; 15524973 (ISSN) Praveen Kumar, G ; Jafary Zadeh, M ; Tavakoli, R ; Cui, F ; Sharif University of Technology
    Self-expandable stents are widely used to restore blood flow in a diseased artery segment by keeping the artery open after angioplasty. Despite the prevalent use of conventional crystalline metallic alloys, for example, nitinol, to construct self-expandable stents, new biomaterials such as bulk metallic glasses (BMGs) are being actively pursued to improve stent performance. Here, we conducted a series of analyses including finite element analysis and molecular dynamics simulations to investigate the feasibility of using a prototypical Zr-based BMG for self-expandable stent applications. We model stent crimping of several designs for different percutaneous applications. Our results indicate... 

    Regioselective diversification of 2,1-borazaronaphthalenes: unlocking isosteric space via C-H activation

    , Article Journal of Organic Chemistry ; Volume 82, Issue 15 , 2017 , Pages 8072-8084 ; 00223263 (ISSN) Davies, G. H. M ; Jouffroy, M ; Sherafat, F ; Saeednia, B ; Howshall, C ; Molander, G. A ; Sharif University of Technology
    Methods for the regioselective C-H borylation and subsequent cross-coupling of the 2,1-borazaronaphthalene core are reported. Azaborines are dependent on B-N/C=C isosterism when employed in strategies for developing diverse heterocyclic scaffolds. Although 2,1-borazaronaphthalene is closely related to naphthalene in terms of structure, the argument is made that the former has electronic similarities to indole. Based on that premise, iridium-mediated C-H activation has enabled facile installation of a versatile, nucleophilic coupling handle at a previously inaccessible site of 2,1-borazaronaphthalenes. A variety of substituted 2,1-borazaronaphthalene cores can be successfully borylated and... 

    A copper-catalyzed synthesis of functionalized quinazolines from isocyanides and aniline tri- and dichloroacetonitrile adducts through intramolecular C-H activation

    , Article Synlett ; Volume 28, Issue 12 , 2017 , Pages 1441-1444 ; 09365214 (ISSN) Nematpour, M ; Rezaee, E ; Tabatabai, S. A ; Jahani, M ; Sharif University of Technology
    A novel class of substituted quinazolines were prepared in good yields by a one-pot three-component reaction of isocyanides with adducts of anilines and tri- or dichloroacetonitrile, followed by intramolecular C-H activation, catalyzed by copper(I) iodide with l -proline as a ligand in acetonitrile at room temperature. © 2017 Georg Thieme Verlag Stuttgart .New York-Synlett  

    Kinetic study of navy blue photocatalytic degradation over Ag3PO4/BiPO4@MIL-88B(Fe)@g-C3N4 core@shell nanocomposite under visible light irradiation

    , Article New Journal of Chemistry ; Volume 41, Issue 18 , 2017 , Pages 10390-10396 ; 11440546 (ISSN) Gholizadeh Khasevani, S ; Mohaghegh, N ; Gholami, M. R ; Sharif University of Technology
    Royal Society of Chemistry  2017
    Herein, a novel quaternary Ag3PO4/BiPO4@MIL-88B(Fe)@g-C3N4 (AB@MIL-88B(Fe)@g-CN) nanocomposite with a core@shell structure is successfully fabricated in two simple steps. The prepared samples are characterized via various techniques. The photocatalytic activity of the prepared samples is evaluated by the degradation of navy Acid Blue 92 (AB92) dye as an organic pollutant under visible light irradiation. Highly enhanced photocatalytic efficiency is observed for the quaternary AB@MIL-88B(Fe)@g-CN nanocomposite compared to that for the other samples. The experimental results indicate that the photocatalytic activity enhancement is mainly attributed to the strong visible light absorption and... 

    Preparation and characterization of starch-based composite films reinforced by cellulose nanofibers

    , Article International Journal of Biological Macromolecules ; Volume 116 , 2018 , Pages 272-280 ; 01418130 (ISSN) Fazeli, M ; Keley, M ; Biazar, E ; Sharif University of Technology
    Elsevier B.V  2018
    The current study deals with the preparation and characterization of polysaccharide-based biocomposite films acquired by the incorporation of cellulose nanofiber within glycerol plasticized matrix formed by starch. The application of starch-based films is limited due to highly hydrophilic nature and poor mechanical properties. These problems are solved by forming a nanocomposite of thermoplastic starch (TPS) as matrix and cellulose nanofiber (CNF) as reinforcement. CNF is successfully prepared from short henequen fibers which consist of almost 60% cellulose by a chemo-mechanical process. TPS/CNF composite films are prepared by the polymer solution casting method, and their characterizations... 

    Permeability mapping of gelatin methacryloyl hydrogels

    , Article Acta Biomaterialia ; Volume 77 , 2018 , Pages 38-47 ; 17427061 (ISSN) Miri, A. K ; Goodarzi Hosseinabadi, H ; Cecen, B ; Hassan, S ; Shrike Zhang, Y ; Sharif University of Technology
    We report the development of an efficient, customized spherical indentation-based testing method to systematically estimate the hydraulic permeability of gelatin methacryloyl (GelMA) hydrogels fabricated in a wide range of mass concentrations and photocrosslinking conditions. Numerical simulations and Biot's theory of poroelasticity were implemented to calibrate our experimental data. We correlated elastic moduli and permeability coefficients with different GelMA concentrations and crosslinking densities. Our model could also predict drug release rates from the GelMA hydrogels and diffusion of biomolecules into the three-dimensional GelMA hydrogels. The results potentially provide a design... 

    Visible-enhanced photocatalytic performance of CuWO4/WO3 hetero-structures: Incorporation of plasmonic Ag nanostructures

    , Article New Journal of Chemistry ; Volume 42, Issue 13 , 2018 , Pages 11109-11116 ; 11440546 (ISSN) Salimi, R ; Sabbagh Alvani, A. A ; Naseri, N ; Du, S. F ; Poelman, D ; Sharif University of Technology
    Royal Society of Chemistry  2018
    A new plasmonic Ag hybridized CuWO4/WO3 heterostructure was successfully synthesized via a ligand-assisted sol gel method. The as-prepared plasmonic nanohybrid was thoroughly characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), UV-visible spectroscopy, photoluminescence (PL) spectrometry, X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, Brunauer-Emmett-Teller (BET) surface area analysis and electrochemical impedance spectroscopy (EIS). Moreover, the photocatalytic activity was evaluated by photo-degradation of methylene blue (MB) under visible light irradiation. The results indicate that the as-prepared plasmonic Ag-CuWO4/WO3 nanohybrid (compared to pure... 

    A new and facile synthesis of thieno[2,3-b]indole derivatives via condensation of isocyanide and indolin-2-thiones

    , Article Synlett ; Issue 7 , 2009 , Pages 1047-1050 ; 09365214 (ISSN) Matloubi Moghaddam, F ; Saeidian, H ; Mirjafary, Z ; Taheri, S ; Kheirjou, S ; Sharif University of Technology
    A new one-pot synthesis of thieno[2,3-b]indole ring systems is described. Condensation of cyclohexyl isocyanide with indolin-2-thiones yielded 3-cyclohexyaminomethylene-indolin-2-thiones, which upon reaction with α-halocarbonyl compounds produced the title compounds. © Georg Thieme Verlag Stuttgart  

    Diastereo- and enantioselective synthesis of α,β-disubstituted γ-nisalkoxycarbonyl sulfonates

    , Article Synlett ; Issue 17 , 2009 , Pages 2872-2874 ; 09365214 (ISSN) Enders, D ; Saeidian, H ; Mirjafary, Z ; Iffland, D ; Raabe, G ; Runsink, J ; Sharif University of Technology
    The asymmetric synthesis of ,-disubstituted -bisalkoxycarbonyl sulfonates is reported. The synthesis is based on the Michael addition of a lithiated enantiopure sulfonate bearing a cheap chiral sugar auxiliary to Knoevenagel acceptors. The reaction proceeds with high asymmetric inductions (ds=69-96%) and good yields (62-79%). The absolute configuration was determined by X-ray crystal-structure analysis  

    Catalyst-free Friedel-Crafts alkylation of naphthols with nitrostyrenes in the presence of water

    , Article Tetrahedron Letters ; Volume 50, Issue 13 , 2009 , Pages 1441-1443 ; 00404039 (ISSN) Ziyaei Halimehjani, A ; Aryanasab, F ; Saidi, M. R ; Sharif University of Technology
    Accelerated Michael-type Friedel-Crafts alkylation of naphthols with nitrostyrenes in the presence of water is reported. The procedure is simple, catalyst-free, and affords good yields of the products. © 2009 Elsevier Ltd. All rights reserved  

    Origin of apparent light-enhanced and negative capacitance in perovskite solar cells

    , Article Nature Communications ; Volume 10, Issue 1 , 2019 ; 20411723 (ISSN) Ebadi, F ; Taghavinia, N ; Mohammadpour, R ; Hagfeldt, A ; Tress, W ; Sharif University of Technology
    Nature Publishing Group  2019
    So-called negative capacitance seems to remain an obscure feature in the analysis of the frequency-dependent impedance of perovskite solar cells. It belongs to one of the puzzling peculiarities arising from the mixed ionic-electronic conductivity of this class of semiconductor. Here we show that apparently high capacitances in general (positive and negative) are not related to any capacitive feature in the sense of a corresponding charge accumulation. Instead, they are a natural consequence of slow transients mainly in forward current of the diode upon ion displacement when changing voltage. The transient current leads to a positive or negative ‘capacitance’ dependent on the sign of its... 

    Enhancement mitochondrial apoptosis in breast cancer cells by paclitaxel-triphenylphosphonium conjugate in DNA aptamer modified nanoparticles

    , Article Journal of Drug Delivery Science and Technology ; Volume 54 , 2019 ; 17732247 (ISSN) Esfandyari Manesh, M ; Mohammadi, A ; Atyabi, F ; Ebrahimi, S. M ; Shahmoradi, E ; Amini, M ; Mirzaie, Z. H ; Ghahremani, M. H ; Dinarvand, R ; Sharif University of Technology
    Editions de Sante  2019
    Mitochondria is a major regulator of inducing tumor apoptosis and it is as a prime target for chemotherapy. Anticancers need to access specific tumor cells and also pass through different barriers such as outer and inner membranes of mitochondria. Targeted accumulation of paclitaxel (PTX) within the mitochondria was achieved by direct conjugation of PTX with triphenylphosphonium (TPP) as a mitochondrial membrane-permeable cation. PTX-TPP prodrug was synthesized by pH-sensitive ester bond between the hydroxyl function of PTX and the carboxylic function of TPP. This ester bond is only cleaved by the mitochondrial aldehyde dehydrogenase. Prodrug was loaded in the albumin nanoparticles by... 

    Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations

    , Article Journal of Microencapsulation ; Volume 36, Issue 8 , 2019 , Pages 715-727 ; 02652048 (ISSN) Rafati, N ; Zarrabi, A ; Caldera, F ; Trotta, F ; Ghias, N ; Sharif University of Technology
    Taylor and Francis Ltd  2019
    Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer. Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy... 

    Recent advancements in aptamer-bioconjugates: Sharpening stones for breast and prostate cancers targeting

    , Article Journal of Drug Delivery Science and Technology ; Volume 53 , 2019 ; 17732247 (ISSN) Maghsoudi, S ; Shahraki, B. T ; Rabiee, N ; Afshari, R ; Fatahi, Y ; Dinarvand, R ; Ahmadi, S ; Bagherzadeh, M ; Rabiee, M ; Tahriri, M ; Tayebi, L ; Sharif University of Technology
    Editions de Sante  2019
    Breast and prostate cancers are common types of cancers with various strategies, such as chemotherapy and radiotherapy, for their therapy. Since these methods have undesired side effects and poor target affinity, neoteric strategies—known as aptamer-based smart drug delivery systems (SDDSs)—have been developed in recent years to overcome the obstacles of current treatment, and investigated for a clinical trial. The high affinity and versatility of aptamers for binding to the corresponding targets make them highly noticeable agents in the drug delivery domains. In addition to their exceptional benefits, aptamers are able to overcome tumor resistance because of their high selectivity and low... 

    Design and fabrication of a two-phase diamond nanoparticle aided fast PCR device

    , Article Analytica Chimica Acta ; Volume 1068 , 2019 , Pages 28-40 ; 00032670 (ISSN) Madadelahi, M ; Ghazimirsaeed, E ; Shamloo, A ; Sharif University of Technology
    Elsevier B.V  2019
    Polymerase Chain Reaction (PCR) is an important and prevalent technique in biotechnology because of its crucial role in cloning DNA fragments and diagnostic applications. In the present study, a high-throughput two-phase PCR device is designed and fabricated which utilizes a serpentine microchannel together with a spiral structure. The former is for the droplet-generation and mixing and the latter is for the thermal cycling process. Moreover, the effect of diamond nanoparticles (diamondNP) on the performance of PCR is also investigated while using commercial PCR devices and the fabricated PCR device designed in this study. Using numerical simulation, it is shown that within the simple and... 

    Stimulus-responsive polymeric nanogels as smart drug delivery systems

    , Article Acta Biomaterialia ; Volume 92 , 2019 , Pages 1-18 ; 17427061 (ISSN) Hajebi, S ; Rabiee, N ; Bagherzadeh, M ; Ahmadi, S ; Rabiee, M ; Roghani Mamaqani, H ; Tahriri, M ; Tayebi, L ; Hamblin, M. R ; Sharif University of Technology
    Acta Materialia Inc  2019
    Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light and redox, thus resulting in the controlled release of loaded drugs. This “smart” targeting ability prevents drug accumulation in... 

    Double network hydrogel of sodium alginate/polyacrylamide cross-linked with POSS: Swelling, dye removal and mechanical properties

    , Article International Journal of Biological Macromolecules ; Volume 129 , 2019 , Pages 187-197 ; 01418130 (ISSN) Bahrami, Z ; Akbari, A ; Eftekhari Sis, B ; Sharif University of Technology
    Elsevier B.V  2019
    In this work, for the first time, we presented a novel design strategy to fabricate a new type of Octa-aminopropyl polyhedral oligomeric silsesquioxane hydrochloride salt (OA-POSS)-based Alg/PAAm DN gels, consisting of PAAm gel as the first chemical network and Alg/OA-POSS gel as the second chemical-physical network. Incorporation of OA-POSS nanoparticles with various feed ratio into the second network not only led to form strong coordination interactions but also in comparison to the other Alg/PAAm gels demonstrated superior mechanical properties. pH, temperature, contact time and salt effects parameters were studied on the swelling and dye removal properties of the synthesized DN hybrid... 

    AntAngioCOOL: computational detection of anti-angiogenic peptides

    , Article Journal of Translational Medicine ; Volume 17, Issue 1 , 2019 ; 14795876 (ISSN) Zahiri, J ; Khorsand, B ; Yousefi, A. A ; Kargar, M. J ; Shirali Hossein Zade, R ; Mahdevar, G ; Sharif University of Technology
    BioMed Central Ltd  2019
    Background: Angiogenesis inhibition research is a cutting edge area in angiogenesis-dependent disease therapy, especially in cancer therapy. Recently, studies on anti-angiogenic peptides have provided promising results in the field of cancer treatment. Methods: A non-redundant dataset of 135 anti-angiogenic peptides (positive instances) and 135 non anti-angiogenic peptides (negative instances) was used in this study. Also, 20% of each class were selected to construct an independent test dataset (see Additional files 1, 2). We proposed an effective machine learning based R package (AntAngioCOOL) to predict anti-angiogenic peptides. We have examined more than 200 different classifiers to build...