Sharif Digital Repository

A novel thermo responsive decorated system is designed by coating Fe3O4 magnetic nanoparticles with conjugated Pluronic-ATPEG copolymer incorporated into the PEG-PMDA Hydrogel for drug delivery to the cartilage tissue. Grafted copolymer was synthesized by reaction between carboxylated Pluronic and amino terminated Poly ethylene glycol (ATPEG) and confirmed by FTIR and NMR analysis. The magnetic nanoparticles were modified with the produced copolymer and characterized by TEM, HRTEM, XRD, DLS, and VSM. A typical product has 13 nm magnetic core and 105 nm hydrodynamic diameter with narrow size distribution. DLS results showed that there was an increase in size by increasing temperature from 25℃... 

Increasing the complexity of software systems, their ubiquitous presence in the human activities, and necessity to preserving the functional and nonfunctional requirements of the systems under an uncertain environment, increase the need for self-adaptive systems. A self-adaptive system changes its structure and behaviors in response to changes in its environment and the system itself. A key research challenge in the self-adaptive community is to guarantee that the system fulfills its requirements. This issue can be addressed by employing formal methods during the design of the software systems. However, the assurance techniques should be used during the execution of the system as well as the... 

Signal transmission of information on noiseless and lossy channels is an important issue in data transmission. Using the amplifier in the transmission channels is a good solution to help send information on longer channels. In classical communication, information can be coded in the amplitude or phase of the field and an amplifier is responsible for amplifying these parameters. If we consider the conditions ideal and ignore electrical noises, Classical mechanics does not impose any restrictions on the amplification of arbitrary classical signals. Instead, in quantum telecommunications the information encoded on the quadrature of the electromagnetic field are mounted on quantum states, such... 

Loosening of uncemented tibial component is one the most common causes of total knee prosthesis failure which is a result of short-term factors such as instability and incomplete osseointegration as well as long-term factors such as peri-prosthetic stress shielding and bone atrophy. Porous cellular structures for tibial stem have been considered as a solution to this problem. This project is aimed to achieve an optimal gradient porous cellular design of tibial stem that in addition to sufficient mechanical strength, provides a perfect osseointegration and prevents bone resorption by incorporating appropriate porosity size, small micro-motion and favorable stress distribution on bone. A...