Sharif Digital Repository

A sixteen node cylindrical super element is presented for evaluating the free vibration characteristics of a rotating laminated cylinder with conventional boundary conditions. It is shown that the natural frequencies are affected considerably when the centrifugal force is also taken into account. The vibration frequencies of rotating finite cylinder, obtained by conventional finite element are used to evaluate the accuracy of this approach. The special case of a stationary cylinder with zero spinning velocity is also considered as a check on this method. Results indicate only few number of cylindrical super elements are capable of predicting the natural frequency of the rotating cylinder... 

Functionally graded materials are advanced composite materials consisting two or more material ingredients that are engineered to have a continuous spatial variation of properties. There are a few analytical methods available to solve the governing equations of FGM made structures, confined to some specific and limited shapes, loadings and boundary conditions. Hence the numerical methods such as FEM are used to treat these materials. In previous studies the finite element method was used to solve thin walled FG structures like shells and plates by modification of the conventional shell and plate elements. Solving the thick walled FG structures confronts some difficulties. One of the methods... 

In this study, injectable PEG-based hydrogels containing Laponite particles with mechanical and structural properties close to the natural articular cartilage are introduced. The nanocomposites are fabricated by imide ring opening reactions utilizing synthesized copolymers containing PEG blocks and nanoclay through a two-step thermal poly-(amic acid) process. Butane diamine is used as nucleophilic reagent and hydrogels with interconnected pores with sizes in the range of 100–250 µm are prepared. Improved viscoelastic properties compared with the conventional PEG hydrogels are shown. Evaluation of cell viability utilizing human mesenchymal stem cells determines cytocompatibility of the... 

Microfluidic devices are beneficial in miniaturizing and multiplexing various cellular assays in a single platform. Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment. Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time. Effects of different strain magnitudes on the chondrogenic differentiation of adult stem cells have not been explored thoroughly. Here, a new multilayer microdevice is presented for the unidirectional compressive stimulation of cells in a three-dimensional cell culture. Numerical simulations were performed to evaluate and optimize the design. Results showed a... 

Open-pore titanium scaffolds were fabricated by sintering of compressed mixtures of TiH1.924 and urea. Spherical and irregular shaped space holders were used to investigate the effect of pore shape on cellular behavior. After removal of the space holder, the shape of the spacers was replicated to the pores. Average diameter of the pores was in the range of 300-600 lm. SEM images showed that titanium hydride resulted in higher surface roughness and larger micro porosities than pure titanium. In vitro evaluationswere carried out by using MTT assay, measuring alkaline phosphatase activity and alizarin red staining in flow perfusion bioreactor for cell culture. Observations revealed excellent... 

Stimuli responsive polymer hydrogels have sparked a considerable interest for biomedical applications. In this work, we present a novel injectable thermal responsive hydrogel based on mineral nanoclay (LAPONITE®), wool-derived fibrous protein (keratin), triblock copolymer (Pluronic), and chitosan biopolymer with potential applications for articular cartilage tissue engineering. Genipin was utilized as a natural crosslinker. The formation of polymer conjugates between the components is confirmed by FTIR and 1H NMR spectroscopy. The nanocomposite hydrogel contains interconnected pores within the hydrogel network and the size of the pores is found to reduce at higher crosslinking density and on... 

Large-scale simulation of spiking neural networks on hardware with a remarkable resemblance to their mathematical models is a key objective of the neuromorphic discipline. This issue is, however, considerably resource-intensive due to the presence of nonlinear terms in neuron models. This paper proposes a novel uniform piecewise linear segmentation approach for nonlinear function evaluations. Employing the proposed approach, we present a uniform-segmented adaptive exponential neuron model capable of accurately producing various responses exhibited by the original model and suitable for efficient large-scale implementation. In contrast to previous nonuniform-segmented neuron models, the... 

Segmentation of aerial images has been a challenging task in recent years. This paper introduces a simple and efficient method for segmentation and classification of aerial images based on a pixel-level classification. To this end, we use the Gabor texture features in HSV color space as our best experienced features for aerial images segmentation and classification. We test different classifiers including KNN, SVM and a classifier based on sparse representation. Comparison of our proposed method with a sample of segmentation pre-process based classification methods shows that our pixel-wise approach results in higher accuracy results with lower computation time  

Pore facies analysis plays an important role in the classification of reservoir rocks and reservoir simulation studies. The current study proposes a two-step approach for pore facies characterization in the carbonate reservoirs with an example from the Kangan and Dalan formations in the South Pars gas field. In the first step, pore facieswere determined based on Mercury Injection Capillary Pressure (MICP) data in corporation with the Hierarchical Clustering Analysis (HCA) method. Each pore facies represents a specific type of pore geometry indicating the interaction between the primary rock fabric and its diagenetic overprints. In the next step, polynomial meta-models were established based... 

Bone Tissue Engineering (BTE) composed of three main parts: scaffold, cells and signaling factors. Several materials and composites are suggested as a scaffold for BTE. Biocompatibility is one of the most important property of a BTE scaffold. In this work synthesis of a novel nanocomposite including layered double hydroxides (LDH) and gelatin is carried out and its biological properties were studied. The co-precipitation (pH=11) method was used to prepare the LDH powder, using calcium nitrate, Magesium nitrate and aluminum nitrate salts as starting materials. The resulted precipitates were dried. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron... 

Endothelial cell migration is a crucial step in the process of new blood vessel formation - a necessary process to maintain cell viability inside thick tissue constructs. Here, we report a new method for maintaining cell viability and inducing cell migration using a perfused microfluidic platform based on collagen gel and a gradient hydrogel sheet. Due to the helpful role of the extracellular matrix components in cell viability, we developed a hydrogel sheet from decellularized tissue (DT) of the bovine heart and chitosan (CS). The results showed that hydrogel sheets with an optimum weight ratio of CS/DT = 2 possess a porosity of around 75%, a mechanical strength of 23 kPa, and display cell... 

In this paper, we report on the design and analysis of filters and lenses realized by an array of metallic posts integrated in a parallel-plate waveguide (PPWG). The design methodology of these components is inferred from the modal analysis of a spoof surface plasmonic waveguide composed of metallic posts arranged in a 1D periodic structure inside PPWG. Samples of the proposed devices are analyzed using a full-wave analysis method and their performance is assessed. We show that the mentioned structure can be used to realize all-metallic band-pass filters and lenses for mm-wave and terahertz applications  

Gain-boosted cascode amplifiers are good choices for power optimiied high-speed amplifiers. In this paper, after a comprehensive study on the pole-zero locus and time response, a generic and perfect model is developed for these amplifiers. By the help of this novel modeling method, the optimum parameters for the feedback or auxiliary amplifier are determined, in order to eliminate the well-known slow timing component in the step response and obtain the minimum achievable senling time. The required circuit conditions as well as a straightforward design procedure for realizing the results of the analytic analysis are presented, finally. © 2003 IEEE  

This study investigated the behavior of ferrofluids containing superparamagnetic iron oxide nanoparticles (SPION) of various compositions for potential applications in drug delivery and imaging. To ensure biocompatibility, the interaction of these SPION with two cell lines (adhesive and suspended) was also investigated using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) assay. The cell lines studied were primary mouse connective tissue cells (adhesive) and human leukemia cells (suspended). SPION were synthesized with a co-precipitation method under different stirring rates and NaOH molarities. The SPION demonstrated a range of magnetic saturations due to their... 

We consider a production system with a single product and two classes of customers. Customers are segmented into two classes: 1) loyal and 2) occasional. Each class has a different shortage cost for the system. The demand of the customer classes is assumed to be stochastic and price sensitive, and distributed as a Poisson process. The objective is to determine the inventory rationing as well as pricing policies in order to maximise the profit function of the system. We formulate the problem as a Markov decision problem and characterise the optimal policies for pricing and inventory rationing. The joint pricing and rationing threshold policy is shown to be optimal. The performance of the... 

Performance of polymer electrolyte membrane fuel cells (PEMFC) at high current densities is limited to transport reactants and products. Furthermore, large amounts of water are generated and may be condensed due to the low temperature of the PEMFC. Development of a two-phase flow model is necessary in order to predict water flooding and its effects on the PEMFC performance. In this paper, a multiphase mixture model (M2) is used, accurately, to model two-phase transport in porous media of a PEMFC. The cathode side, which includes channel, gas diffusion layer (GDL), microporous layer (MPL), and catalyst layer (CL), is considered as the computational domain. A multidomain approach has been used...