Sharif Digital Repository

Our bodies are made from billions of individual cells and DNA is the control central of each cell. In addition to linear DNAs, there are circular DNAs in nature. Circular DNAs cause new topological structures such as knots and catenanes. These topological structures form during biological proccesses such as replication. For example during replication, two daughter circular DNAs may link together and form catenanes. Anzymes named topoisomerases can simplify the topology of circular DNAs. Type 2 topoisomerases is used for simplification of catenanes. These anzymes do it with breaking a double-strand DNA and passing through another one. In comparison with DNAs, topoisomerases are very small and... 

In this thesis, we investigate the effects of topological constraints in catenanes composed of interlinked ring polymers on their size in a good solvent as well as on the location of their θ-point when the solvent quality is worsened. We mainly focus on poly[n]catenanes consisting of n ring polymers each of length m interlocked in a linear fashion. We study the scaling of the poly[n]catenane’s radius of gyration assuming that R ~ m^μ n^ν with µ = 16/25 and ν = 3/5 in a good solvent, with these values of µ and ν obtained by means of a Flory-like theory and further confirmed by numerical simulations. We show that individual rings within catenanes feature a surplus swelling due to the presence... 

Features with sculptured or free-form surfaces appear frequently in computer-aided design of parts common to aerospace, automotive, and die and mold industries. Because of their ability to machine complex features and to achieve good surface finish, ball-end tools are widely used in the finish milling process of sculptured parts. This research has been devoted to the modeling of cutter-workpiece engagement (CWE) boundaries, cutting forces, and stability prediction in ball-end finish milling process of sculptured parts. In the first step, a new analytical model taking into account the effect of surface curvatures was presented for three-axis and five-axis ball-end milling processes. In this... 

Investigation stability of chatter vibration is of great importance in machining processes. Finding frequency response function (FRF) at the tool tip is an effective method to predict stable machining regions. Commonly, the tool tip FRF is obtained using experimental modal analysis but this approach is often time consuming and requires expertise. In addition, changing tool or holder requires modal test which is a disadvantage, consequently modeling methods are of interest for researchers. Moreover, optimum design of machine tool is another benefit of modeling method. Also, in machining with flexible or micro tools in which experimental tests can not be performed, modeling methods would be... 

The introduction of Minimally Invasive Surgery (MIS) has deeply influenced modern surgery. Despite all the advantages for the patient, this method produces some limitations for the surgeon. Limitations such as reducing degrees of freedom resulting in the loss of dexterity, depriving surgeons of the depth perception and sense of touch lead to human errors due to fatigue and intense mental activity. Overcoming these limitations is the reason for robots entering the operating rooms. In this research a robot-assisted surgery system including two 5-DOF robots is utilized. The goal of this research is to model and simulate this system and also to design a bilateral controller to provide haptic... 

Lightweight cryptography is a new area in cryptography developed as a solution to the security requirements in pervasive, low cost and lightweight systems, such as RFID networks. Due to the pervasive nature of these systems, the users’ privacy is seriously threatened while severe restrictions are imposed on computational, memory and power resources. Therefore, the conventional design rules of cryptographic primitives and protocols are not accountable here and the designers have adopted innovative methods for lightweight designs. This makes the design of a lightweight primitive/protocol a very challenging and sensitive task which is not still reliable enough. Such a trust can not be made... 

Loosening and gap opening at the bone-implant interface depends on several physiological and mechanical factors such as bone remodeling, stress concentration, and variation in load transfer pathway. Since fracture of orthopedic material at the interface is one of the major failure mode of total joint implants, this study focused on the micromechanical behavior of the interface. Using a two-dimensional FE model, with pure compressive, tensile, and shearing forces applied on bone or cement, ratio of the stress at the interface to the applied stress has been calculated. Stress distribution was considered as a function of porosity,angle of bead contact to surface, as well as size of bead for two... 

New development in material fabrication resulted in functionally graded materials (FGM) with properties, can vary continuously based on the desired purpose. Vast applications of these materials attracted scientists to extend the researches in this area. One of the promising applications of these materials is in the optimized spherical and cylindrical pressure vessels. Optimization is usually based on the minimization of heat transfer and maximization of the strength of the vessel under pressure. In the present dissertation, spherical and cylindrical pressure vessels are designed and characteristics of the material distribution for certain pressure and temperature is developed. In this... 

Atomic force microscope (AFM) has a significant capability of imaging surface topography on an atomic scale. It is also widely used for Nanolithography in MEMS/NEMS (micro/nanoelectromechanical systems). Conventional AFMs consist of a cantilever with a sharp conical or pyramidal tip located at the free end of the cantilever that plays an important role in AFM measurements. Scanning across a surface, AFM interacts with the sample surface through its tip. Although the dynamic behavior of the AFM cantilever is complicated, the researchers have been interested in studying AFM dynamic behavior because it has a great influence on the surface imaging process. The imaging rate and contrast of... 

Co-movement between inflation and nominal interest in response to an interest rate shock, dubbed neo-fisherianism, has been the subject of contentious debate since the advent of non-inflationary ZLB environment. We design an economic model rich with banking features to understand the economic responses to permanent and long-term interest rate shocks. We find that responses to a permanent positive interest rate shock depend on the monetary authorities’ speculation of the new long-term inflation rate, with the most probable outcome being a permanent increase in inflation. Responses to a long-term positive interest rate shock depict an increase and then decrease in inflation. We also discover... 

FE simulations have been widely used to investigate the response of the brain tissue in various circumstances. The accuracy of the material models critically affects the results of the numerical simulation. However, despite the numerous studies aiming for the material modeling of the brain, there is still divergence between the results reported in the literature. A part of this discrepancy is due to the inherent difference between samples. Nonetheless, another part of it is resulted from the differences between testing protocols used by researchers. In some protocols multiple mechanical tests are performed on each sample. Enough recovery time should be considered between consecutive test... 

Micro electromechanical systems (MEMS) such as sensors and actuators are gaining more popularity in recent years. These systems have different application in automation, medicine and other industries. Mechanical structures are governed by electrical systems in MEMS devices and this is one of the challenges of MEMS studies. Usually these systems made by one deformable beam or plate over a fixed substrate. Due to applied voltage between substrate and deformable plate or beam, the deformable plate deflects toward the fixed substrate. The voltage at which the system becomes unstableis called pull-in voltage. Pull-in voltage is the most important characteristics of MEMS beyond which pull-in takes... 

In this thesis, the influence of nonideal boundary conditions on the vibration of a functionally graded beam excited by a moving oscillator on Pasternak-type viscoelastic foundation has been investigated. The beam has simply-supported boundary conditions and is assumed that the right-hand-side boundary conditions allows for small deflection, moment and axial force. The beam property gradient is assumed to be in the thickness direction and varies according to the power law distribution. The Hamilton's principle is utilized to obtain the governing equations of motion under the assumptions of Euler-Bernoulli beam theory. The equations of motion of the beam are solved using an... 

Epistemic logic gets its start with the recognition of the systematic properties of epistemic concepts. These properties make epistemic concepts amenable for formal study, and become our tools to present logical models for them.“Certainty” is one of these epistemic concepts for which no comprehensive logical model has been presented so far.
Among the logical models that have been presented for “Certainty”, there are two main models which are more comprehensive than the others and all the other models may be extendable to one of them. In this thesis, these two main logical models that have been proposed for the concept of certainty are introduced and described from a philosophical... 

Due to special characteristics, nowadays functionally graded materials are of great interest of researchers. Continuous change of properties in these materials,decreases undesirable phenomena such as stresscon centration. On the other hand knowing vibration parameters of structures such as natural frequencies, to avoid damage, is important. So far, many researches have been devoted to vibration analysis of structures, such as beams.In this dissertation, free vibration analysis of FGM beams, are investigated, using RKPM, a meshlesh method. The system of equations of motion is derived using Lagrange’s method under the assumption of Euler-Bernoulli beam theory. Buckling analysis of FGM beams... 

The ossicular chain of the human middle ear has a key role in sound conduction since it transfers vibrations from the tympanic membrane to the cochlea, connecting the outer and the inner part of the hearing organ. This study reports firstly a description of the main anatomical features of the middle ear to introduce a detailed survey of its biomechanics,focused on model development, with a collection of geometric, inertial and mechanical/material parameters. The joint issues are particularly discussed from the perspective of developing a model of the middle ear both explanatory and predictive. Such a survey underlines the remarkable dispersion of ... 

After Alzheimer and brain attack, the most common neurological disorder is epilepsy, which often involves seizures. In two-thirds of patients with epilepsy, the seizures can be controlled by antiepileptic drugs, and about 8% of patients can use epilepsy surgery; but unfortunately there is no acceptable treatment for the other 25% of these patients. Therefore preventing from epilepsy losses is a very important topic.
The gold standard for the diagnosis of the epilepsy is EEG monitoring. In this method, electrodes are placed on the scalp. Electrodes are uncomfortable to wear, and cause invasion to the patient, hence long-term monitoring and home monitoring is not feasible. In some... 

The purpose of this project is the analysis of free and forced vibrations of sandwich panels under moving loads. In order to analyze the problem, sandwich panels are modeled as composite square plates. By using third order shear deformation theory, equations of motion are derived. Equations of motion with six different boundary conditions are solved utilizing generalized differential quadrature method. Natural frequencies are obtained for simple cases reported in the literature.In addition, a sandwich panel under moving load with simply supported boundary conditions is analyzed and time series response of the middle point is obtained. The time series response is also studied parametrically... 

One of the main problems in human health, both in advanced societies and in growing societies, is a variety of cancers, one of which is brain tumor. One of the non-invasive methods of treating tumors is the use of ultrasound.HIFU (High Intensity Focused Ultrasound) therapy method is known as one of the most advanced surgical techniques in tumor ablation therapy. HIFU are produced and concentrated by powerful transducers. The two main mechanisms in HIFU are mechanical and thermal mechanisms, and the effects of these two mechanisms appear as thermal effects and cavitation. The fundamental mechanism in the HIFU is to absorb ultrasonic waves and to convert them into heat.The purpose of this...