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Colorimetric assay for exon 7 SMN1/SMN2 single nucleotide polymorphism using gold nanoprobes
, Article BioImpacts ; Volume 3, Issue 4 , 2013 , Pages 185-194 ; 22285652 (ISSN) ; Hormozi Nezhad, M. R ; Abadi, A ; Sanati, M. H ; Kazemi, B ; Sharif University of Technology
2013
Abstract
Introduction: Proximal spinal muscular atrophy (SMA) is one of the most significant neurodegenerative diseases amongst the autosomal-recessive genetic disorders which is caused by the absence of protein survival of motor neuron (SMN). A critical nucleotide difference in SMN2 compared to SMN1 gene leads to an inefficient protein. Hence, homozygous lack of SMN1 provides a progressive disease. Due to the high prevalence, up to now, several molecular diagnostic methods have been used which most of them are lengthy, expensive, and laborious. Methods: In the present study, we exploited a gold nanoprobe-based method for semi-quantitative SMN1 gene dosage analysis compared to SMN2. The assay was...
Colourimetric-based method for the diagnosis of spinal muscular atrophy using gold nanoprobes
, Article IET Nanobiotechnology ; Volume 9, Issue 1 , Feb , 2015 , Pages 5-10 ; 17518741 (ISSN) ; Hormozi Nezhad, M. R ; Abadi, A. R ; Sanati, M. H ; Kazemi, B ; Sharif University of Technology
Institution of Engineering and Technology
2015
Abstract
Although numerous molecular methods for spinal muscular atrophy (SMA) detection have been exploited, most of hem are laborious, time consuming and costly. Recently, gold nanoparticles (AuNPs) have attracted attention in the field of colourimetric bioanalysis, because AuNP aggregation can be tracked with the naked eye as well as ultraviolet-visible (UV-vis) peak analysis. Here, based on a non-cross linking platform, a colourimetric-based method was used to evaluate the capability of thiolated oligo-AuNPs (Au nanoprobes) to distinguish between normal individuals, carriers and those with SMA. In this platform, removal of the repulsive force of the Au nanoprobes using high salt concentration...
An Investigation on The Effect of Intermediate Deformation Between The Retrogression and Re Aging Process of 7xxx Series of Aluminum Alloys on The Mechanical Properties and Formability of These Alloys
, M.Sc. Thesis Sharif University of Technology ; Karimi Taheri, Ali (Supervisor) ; Kazeminejad, Mohsen (Supervisor)
Abstract
In this research it has been attempted to suggest a modified retrogression and re- aging heat treatment on the sheet of AA7075 alloy with a thickness of 2 mm. The main aim of the research is to reduce the required duration of RRA process while maintaining the value of the conventional tensile strength achieving by the RRA process. This was performed by adding an intermediate warm rolling deformation during the RRA process. The rolling temperature was 180 °C and the rolling reductions were 30%, 40%, 50%. Moreover, the temperature of 170°C was selected as the re-aging temperature, for which the aging time of 0.5, 1, 1.5, 2, and 2.5 hours were examined. This temperature and times were chosen to...
An efficient reconfigurable architecture by characterizing most frequent logic functions
, Article 25th International Conference on Field Programmable Logic and Applications, FPL 2015, 2 September 2015 through 4 September 2015 ; Sept , 2015 , Page(s): 1 - 6 ; 9780993428005 (ISBN) ; Khaleghi, B ; Asadi, H ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2015
Abstract
Generous flexibility of Look-Up Tables (LUTs) in implementing arbitrary functions comes with significant performance and area overheads compared with their Application-Specific Integrated Circuit (ASIC) equivalent. One approach to alleviate such overheads is to use less flexible logic elements capable to implement majority of logic functions. In this paper, we first investigate the most frequently used functions in standard benchmarks and then design a set of less-flexible but area-efficient logic cells, called Hard Logics (HL). Since higher input functions have diverse classes, we leverage Shannon decomposition to break them into smaller ones to either reduce the HL design space complexity...
Analysis of the bio-environmental advantages using two types of activated carbon at a petro-chemical water treatment plant
, Article 18th International Congress of Chemical and Process Engineering, CHISA 2008, Prague, 24 August 2008 through 28 August 2008 ; 2008 ; Mansouri, M ; Badry, N
2008
Abstract
Activated carbon powder was analyzed at one of the petro-chemical units in Iran, to determine the usefulness of this material in waste water treatment. Two types of commercial activated carbon powder were used giving different results, attributed to different constituents. For every experiment, 4 kg of activated carbon was used in the pilot plant column. Analysis results on the effect of parameters, e.g., inlet volumetric flow rate of waste water and activated carbon structure, on the plant performance were presented. This is an abstract of a paper presented at the 18th International Congress of Chemical and Process Engineering (Prague, Czech Republic 8/24-28/2008)
Higher-order energy balance method for a series of nonlinear oscillatory systems
, Article Asian-European Journal of Mathematics ; Volume 6, Issue 4 , December , 2013 ; 17935571 (ISSN) ; Safaie, N ; Ahmadpour, M. A ; Askari, H ; Sharif University of Technology
2013
Abstract
The aim of this paper is to use higher-order energy balance method as a novel solution procedure for investigation the nonlinear oscillation of various systems. The method is associated with collocation method and employed for a group of nonlinear problems including pure cubic nonlinearity, fractional elastic force and duffing harmonic terms. Obtained results are evaluated by comparing with the classical balance method and also the exact solutions computed numerically. It is shown our solution procedure achieves more accurate results versus the classical solution and higher agreement are observed between the newer solutions and the exact ones for the systems. Effect of initial conditions in...
Using goal programming for transportation planning decisions problem in imprecise environment
, Article Australian Journal of Basic and Applied Sciences ; Volume 6, Issue 2 , 2012 , Pages 57-65 ; 19918178 (ISSN) ; Chitgar, S ; Sharif University of Technology
2012
Abstract
In this paper, we present a fuzzy goal programming model for Transportation Planning Decisions (TPD) problem. In real-world applications of the transportation planning decisions problems with multi-objective, input data or related parameters are majority vague/fuzzy. It is hard for decision maker(s) to determine the goal value of each objective precisely as the goal values are imprecise. We consider three methods in the research for solving TPD problem under fuzziness, first method is interactive fuzzy goal programming (IFGP), that this approach aim minimizing the worst upper bound to determine an reasonable solution which is end to the best lower bound of each objective function. Second...
Function Simulation and Performance Evaluation of an Underground Multi-Storey Car Park Ventilation Systems under Normal Condition
, M.Sc. Thesis Sharif University of Technology ; Farhanieh, Bijan (Supervisor)
Abstract
Because of increase in use of cars in recent years, demands for parking spaces have also dramatically grown. To resolve this issue construction of multi-storey underground car parks has sharply increased. Due to the high level of contaminants emitted by cars in parking lots and also the continuous presence of humen within them, the control of pollution level and parking indoor air quality is a vital matter. Type of ventilation systems including modern and conventional used for ventilating parking lots and also exhaust and supply vents locations are the most important factors affecting contaminants distribution. Thus investigation the performance of the conventional and modern ventilation...
Performance Evaluation of H-ZSM-5 Catalyst Improved With Boron in Methanol to Propylene Process
, M.Sc. Thesis Sharif University of Technology ; Khorasheh, Farhad (Supervisor)
Abstract
Propylene is one of the key material in petrochemical industries. In recent years, as propylene demand increases, development of new methods alongside traditional ways in production of propylene seems essential. The production of propylene from methanol using zeolitic catalysts is as one of this new methods. This method in recent years has got attention. H-ZSM-5 zeolite is one of the best catalysts appropriate for this process. However, rapid deactivation is the main problem this catalyst at the present time. Therefore, more research in order to increase stability and lifetime has been performed. The uses of promoters are as one of the simplest improvement methods of H-ZSM-5 zeolite....
Effects of different operating parameters on the particle size of silver chloride nanoparticles prepared in a spinning disk reactor
, Article Applied Physics A: Materials Science and Processing ; Volume 120, Issue 1 , July , 2015 , Pages 105-113 ; 09478396 (ISSN) ; Davarpanah, M ; Ahmadpour, A ; Sharif University of Technology
Springer Verlag
2015
Abstract
The aim of this research was to present an experimental method for large-scale production of silver chloride nanoparticles using spinning disk reactor. Silver nitrate and sodium chloride were used as the reactants, and the protecting agent was gelatin. The experiments were carried out in a continuous mode by injecting the reactants onto the surface of the spinning disk, where a chemical precipitation reaction took place to form AgCl particles. The effects of various operating variables, including supersaturation, disk rotational speed, reactants flow rate, disk diameter, and excess ions, on the particle size of products were investigated. In addition, the AgCl nanoparticles were...
An Efficient Reconfigurable Architecture Based on Most Frequent Logic Functions
, M.Sc. Thesis Sharif University of Technology ; Asadi, Hossein (Supervisor)
Abstract
Reconfigurable devices are a popular platform invarious computational fields due to having high performance and flexibility and low non-recurring engineering cost. Generous flexibility of Look-up Tables (LUTs) in implementing arbitrary functions comes withsignificant area and performance overheads as compared with their Application Specific Integrated Circuit (ASIC) equivalent. One approach to alleviate such overheads is to use less flexible logic elements capable to implement majority of logic functions. In this thesis, we first investigate the most frequently used functions in standard benchmarks and then design a set of less-flexible but area-efficient logic cells, called Hard Logics...
Effect of sintering temperature and siliconcarbide fraction on density, mechanical properties and fracture mode of alumina-silicon carbide micro/nanocomposites
, Article Materials and Design ; Volume 37 , May , 2012 , Pages 251-255 ; 02641275 (ISSN) ; Baharvandi, H ; Abdizadeh, H ; Purasad, J ; Fathi, A ; Ahmadi, H ; Sharif University of Technology
2012
Abstract
In this study Al2O3-SiC micro/nanocomposites have been fabricated by mixing alumina nanopowders and silicon carbide micro/nanopowders, followed by hot pressing at 1550, 1600, 1650 and 1700°C. The density, mechanical properties and fracture mode of Al2O3-SiC composites containing different volume fractions (2.5%, 5%, 7.5%, 10% and 15%) of micro/nanoscale SiC particles were investigated and compared with those of alumina. The relative density of composites could reach values very close to theoretical density, especially after sintering at 1700°C. However, relative density declined by increasing the SiC fraction at the same sintering temperature. The flexural strength of composites was best for...
Electrokinetic mixing at high zeta potentials: Ionic size effects on cross stream diffusion
, Article Journal of Colloid and Interface Science ; Volume 442 , 2015 , Pages 8-14 ; 00219797 (ISSN) ; Sadeghi, A ; Saidi, M. H ; Sharif University of Technology
Academic Press Inc
2015
Abstract
The electrokinetic phenomena at high zeta potentials may show several unique features which are not normally observed. One of these features is the ionic size (steric) effect associated with the solutions of high ionic concentration. In the present work, attention is given to the influences of finite ionic size on the cross stream diffusion process in an electrokinetically actuated Y-shaped micromixer. The method consists of a finite difference based numerical approach for non-uniform grid which is applied to the dimensionless form of the governing equations, including the modified Poisson-Boltzmann equation. The results reveal that, neglecting the ionic size at high zeta potentials gives...
Steric effects on electrokinetic flow of non-linear biofluids
, Article Colloids and Surfaces A: Physicochemical and Engineering Aspects ; Volume 484 , 2015 , Pages 394-401 ; 09277757 (ISSN) ; Sadeghi, A ; Saidi, M. H ; Sharif University of Technology
Elsevier
2015
Abstract
Some of electrokinetic-based biomicrofluidic devices work at zeta potentials that are sufficiently high for ionic size (steric) effects to show up. In the present effort, consideration is given to the steric effects on the hydrodynamics of electroosmotic flow in a rectangular microchannel. The distinction between this research and the previous ones is that we account for non-linear rheology of the fluids encountered in biomicrofluidic systems by means of the power-law viscosity model. The method of analysis consists of a finite-difference-based numerical procedure for a non-uniform distribution of grid points, which is applied to the dimensionless form of the governing equations including...
A depthwise averaging solution for cross-stream diffusion in a Y-micromixer by considering thick electrical double layers and nonlinear rheology
, Article Microfluidics and Nanofluidics ; Volume 19, Issue 6 , 2015 , Pages 1297-1308 ; 16134982 (ISSN) ; Sadeghi, A ; Saidi, M. H ; Sharif University of Technology
Springer Verlag
2015
Abstract
Both nonlinear rheology and finite EDL thickness effects on the mixing process in an electroosmotically actuated Y-sensor are being investigated in this paper, utilizing a depthwise averaging method based on the Taylor dispersion theory. The fluid rheological behavior is assumed to obey the power-law viscosity model. Analytical solutions are obtained assuming a large channel width to depth ratio for which a 1-D profile can efficiently describe the velocity distribution. Full numerical simulations are also performed to determine the applicability range of the analytical model, revealing that it is able to provide accurate results for channel aspect ratios of ten and higher and quite...
How the possibility of a fight-back strategy affects the consequences of a sanctions regime
, Article Journal of International Studies ; Volume 13, Issue 3 , 2020 , Pages 264-279 ; Maleki, A ; Yazdi, A. H ; Sharif University of Technology
Centre of Sociological Research
2020
Abstract
Sanctions imposed by a country against another country are considered as a foreign policy tool. Many studies have investigated different aspects of sanctions including the efficacy of sanctions to alter the target country’s behaviour. However, the effects of a potential fight-back strategy adopted by a target country have been discussed rarely. In this paper, the outcomes of a possible fight-back strategy are simulated using game theoretical analysis. To find the matching state of game theory and sanction regimes, we have conducted a critical and systematic review of 12 sanctions, from 1950 to 2012. The results show that the capability of a target country to implement fight-back strategies...
Quantum corrections in the drift-diffusion model
, Article Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers ; Volume 46, Issue 11 , 2007 , Pages 7247-7250 ; 00214922 (ISSN) ; Faez, R ; Sadoghi Yazdi, H ; Sharif University of Technology
2007
Abstract
Based on the solution of the Wigner-Boltzmann (WB) equation, quantum correction in the drift-diffusion (DD) model is proposed. The new model, which is a form of the quantum DD model, can show quantum phenomena such as tunneling and quantum repulsion. To evaluate the proposed model, potential barrier and potential wells are simulated. Simulation results show the electron tunneling through and repulsion from the potential barrier. © 2007 The Japan Society of Applied Physics
Pereparation, Characterization and Photocatalytic Application of Some Polyoxometalates in Degradation of Oraganic Pollutants
, M.Sc. Thesis Sharif University of Technology ; Rahman Setayesh, Shahrbanoo (Supervisor)
Abstract
In this project photocatalysts TiO2, H3PW12O40, H3PMo6W6O40, H3PW12O40 / TiO2, H3PMo6W6O40 / TiO2, K2.5H0.5PW12O40, Cs2.5H0.5PW12O40, (NH4) 2.5H0.5PW12O40 and H3PW12O40 / M-TiO2 that M = La , Ce, Cr, Fe, Co were characterized by techniques DRS, FT-IR, BET, 31P NMR, SEM and XRD. The results of SEM and XRD particle size and page crystalline nanoscale catalysts, with size less than 40nm, respectively. FT-IR analysis confirmed the structure of heteropolyacid was produced. DRS analysis of the degradation reactions during wavelenght longer upheld. Degradation of methylene blue and pollutants such as Tinopal CBS-x to the polyoxometalates keggin is homogeneous and composite titanium dioxide two...
Experimental investigation and theoretical prediction of extrudate swell using conformational rheological models
, Article International Polymer Processing ; Volume 27, Issue 4 , 2012 , Pages 478-485 ; 0930777X (ISSN) ; Ahmad Ramazani, S. A ; Amoli, H. H ; Kamyabi, A ; Sharif University of Technology
Hanser
2012
Abstract
In this study the extrudate swell of polymer solutions is estimated using the microstructure of polymer molecules. When a flexible polymer chain goes through a narrow die shear stress exerting on the chain will cause the polymer chain to be stretched along the flow direction. After emerging from die all external stresses vanish immediately and the chains tend to recover their previous state due to elastic recovery. This phenomenon will results in a gradual increase in extrudate diameter and this is used as the key idea for estimating swell ratio. A Giesekus based conformational model was used in order to predict polymer chains microstructure everywhere in the domain. The resulting PDE set...
Size-dependent bistability of an electrostatically actuated arch NEMS based on strain gradient theory?
, Article Journal of Physics D: Applied Physics ; Volume 48, Issue 24 , May , 2015 ; 00223727 (ISSN) ; Pishkenari, H. N ; Yazdi, M. R. H ; Miandoab, E. M ; Sharif University of Technology
Institute of Physics Publishing
2015
Abstract
This paper deals with the investigation of the size-dependent nature of nonlinear dynamics, in a doubly clamped shallow nano-arch actuated by spatially distributed electrostatic force. We employ strain gradient theory together with the Euler-Bernoulli and shallow arch assumptions in order to derive the nonlinear partial differential equation governing the transverse motion of the arch with mid-plane stretching effects. Using the Galerkin projection method, we derive the lumped single degree of freedom model which is then used for the study of the size effects on the nonlinear snap-through and pull-in instabilities of the arch nano-electro-mechanicalsystem (NEMS). Moreover, using strain...