Sharif Digital Repository

In recent years, monoclonal antibodies have gained attention as highly effective drugs for treating diseases, especially cancer. The high binding affinity between an antibody and its corresponding antigen is one of the key factors in triggering an effective immune response. Modeling binding affinity using machine learning is considered a promising and cost-effective computational approach; however, due to the lack of training data, the performance of these models is often poor and limited. In contrast, recent advances in geometric learning have demonstrated that incorporating the three-dimensional geometry of protein structures in the learning process can significantly impact 3D... 

It is important to provide an appropriate and economically method with technical and engineering considerations to stabilize excavated underground spaces. The necessity of this, especially for the construction of underground metro stations located in the cities which faces many problems, is more evident. In this research, it has been tried to introduce an optimal method according to the type of area for the construction of the underground station. In order to obtain stress and strain condition in structural elements and surface deformations due to different stages of excavating, numerical modeling in FLAC3D has been used. By examining the parameters that affect the sustainability of this... 

The purpose of Direction-of-arrival(DOA) estimation in MIMO communication networks is to find the direction of signals that are mixed together and mixed with noise by using an array of multiple receiving antennas. DOA estimation is an important issue in array signal processing. The traditional methods for DOA estimation try to solve this problem with mathematical algorithms. For example, some of these methods are based on parameter estimation; such as DOA estimation methods using maximum likelihood estimation methods. Some of other traditional methods are based on subspace decomposition; Like the famous MUSIC method. The traditional methods of DOA estimation usually have a drawback, and that... 

Pipe freezing has become well established in industry as a method of short-termisolation in order to carry out maintenance or repairs. It is often necessary to repair system components without plant shutdown or drainage of system having many piping structures which may have hazardous or expensive fluid. Therefore, a series of tests has been arranged to investigate the ice plug formation in two standard pipes with different diameter size. The freeze zone on the pipe has been created by means of an aluminum jacket which liquid nitrogen flows in it. In the tests the freezing time, amount of liquid nitrogen usage andthe pressure tolerance of ice plug have been determined. Moreover, the numerical... 

For increasing longevity of a structure, it is not enough to notice only to designing aspects. In operation phase of a construction, we can increase the level of service and longevity. Asset-based Organizations, in addition to design their new assets, should maintain them. Infrastructures, such as road, bridge, dam, and water network, are important because of social and economic aspects. So they need special attention. There are efficient models for infrastructure maintenance that consider infrastructure element information, such as condition rate, weight, dimensions, deterioration rate, and cost of maintenance as inputs and give planning for maintenance in future. This planning, involves a... 

In recent years, the area of research on micro flying robots has been developed due to the development in micro manufacturing technologies. Due to extra advantages of these flying robots, they are implemented in military and civilian missions such as identifying, espionage, aerial relays, traffic surveillance, rescue, aid, etc. Ability to fly in specified areas, without human injuries, low manufacturing and energy costs, easy and fast implementation, Easy Maintenance, etc, which are some advantages of these robots. We can control these robots manually by remote controllers (RC) or by Auto guidance systems. On the other hand, these robots are used in research laboratories for testing new... 

Range Profile (RP) is known as one of the most important tools for radar target recognition. The main problem with range profile for radar target recognition is its sensitivity to aspect angle. To overcome this problem, range profiles are assumed to have the same statistical characteristics in small frames of aspect angles or context dependent models such as HMM may be used. All methods presented, seems to have some shortcomings to offer a model based on physical circumstances of target maneuver. For example in such models, consecutive samples of RPs in an aspect frame are assumed to be statistically independent with the same distribution (IID). Here we propose dynamic system (DS) for... 

The present thesis aims at investigating the dynamic interaction of slosh and aeroelasticity in the fuel contained aero vehicles. The main approach in this research is to develop reduced order models for description of the coupled system. In this regard, boundary element method is used to develop slosh dynamic model. Axisymmetric boundary element method with non-symmetric boundary conditions is used to develop slosh dynamic model for axisymmetric containers. Zoning method is used to develop slosh dynamic model for the multi-baffled tanks and based on it, slosh equivalent mechanical model is developed for multi-baffled tanks. Finite element method along with modal technique is used to develop... 

There are numerous ways available to achieve low temperatures that cryocoolers might be among the most important of them. In the meantime, the pulse tube refrigerator has a special place due to its simple geometry and not be using any moving parts. This simple property make the pulse tube refrigerator one of the most popular methods to achieve low temperatures. Nowadays, a pulse tube refrigerator is used for cooling in the range of 4 to 123 Kelvin in two form of one-stage and two-stage and up to an approximate power of 1 KW. Today, due to the temperature and the amount of power required for cooling, as well as the time it takes to reach that temperature, this chiller is used in medical,... 

During the last few years, the study of urban environment structures is considered as a research field of interest in remote sensing. In satellite observations of the earth's surface, continuous imaging in terms of time and space has caused the remote sensing technique to be proposed as a useful and efficient tool for the analysis of urban areas. Obtaining quantitative spatial information from the urban environment in fields such as determining the height of buildings plays an essential role in urban planning, monitoring damage to buildings, establishing communication bases and digital cities. During the last two decades, the use of Tomosar approach in order to reconstruct the structures of... 

In this thesis we consider the effect of random locations of users in the capacity analysis of SIR-based power control systems and comparison to the strength-based systems, for the first time. Unlike previous works we do not consider a simple deterministic uniform model for the analysis. We provide simulations and analytical solutions for calculating the interference statistics, based on which, we not only calculate the interference statistics, but also study the effect of locating a user in every location in the network coverage area and its share in the interference. We also calculate each cell’s share in every statistics of the interference. In this thesis, based on the common assumption... 

In synthetic aperture radar (SAR) satellites, the nadir echo is defined as the backscattered signal from the point directly below the satellite on the earth surface. If the timing of the radar is such that the nadir echo arrives at the receiver while the receiver is turned on for receiving the desired signal, it could damage the receiver or disrupt the resulting SAR image, unless it is suppressed enough by proper design of antenna radiation pattern. In current SAR satellites, ”avoiding” this phenomenon is associated with two problems: 1) limiting the swath width, 2) imposing stringent restrictions on the selection of pulse repeatition frequency (PRF). Therefore, ”suppressing” the nadir echo,... 

Localization of radio sources has various applications in civil and military communications. Some of important localization methods consist of Angle of Arrival (AoA) estimation of the illuminated signals from the interested sources. Between various Direction Finding (DF) methods, subspace based methods are of special importance, because of their high resolution and accuracy. And from beginning of invention, because of new challenges, have been focus of numerous researches. In this thesis, first we explain the most important subspace based DF methods called MUSIC and root-MUSIC. Then a novel modification for root-MUSIC is introduced. In our new method the computational complexity of... 

In order to study the interaction of sloshing and structural vibrations of baffled tanks a reduced order model based on modal analysis of structure model and boundary element method for fluids motion is developed. For this purpose the governing equations of elastic structure and incompressible flow used to derive simple models to simulate both fields. Using the modal analysis technique the structural motions are applied to the fluid model and on the other hand by using boundary element method the fluid loads are applied to the structural model. Based on this formulation a code is developed which is applicable to an arbitrary elastic tank with arbitrary arrangement of baffles. Results... 

The aim of this article is ancestral control of a set of 3-wheel robots with non-holonomics dynamics for hunting and covering around moving target. Robots have mass and inertia and the wheels' mass have been considered in the dynamics of robots. The output of controller is wheel's torque and front wheel's steering torque. Moving target dynamics has been considered in a way that it is escaping from invader and the target has holonomics dynamic. To derive the equation of motion, Kane's dynamics procedure has been used. Robots are equipped to sensors for distance assessment, vision angle assessment and also signal receiver antenna. To estimate relative position and variables of other robots'... 

These days, according to increasing requirement to the applications of clean rooms in industries in and within the developing industry of computer, positive indicators that show a real need to a compere comprehensive study and research about the Clean rooms, in oder to predict the distribution and dispersal of the particles. Correct determination of indoor airflow and particle concentration distribution results in new standard development for Clean rooms. As computational fluid dynamics has become a powerful tool for indoor airflow studies, in this research, influence of effective parameters on the flow and concentration distribution in clean rooms has been...