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Drug delivery performance of nanocarriers based on adhesion and interaction for abdominal aortic aneurysm treatment
, Article International Journal of Pharmaceutics ; Volume 594 , 2021 ; 03785173 (ISSN) ; Vatani, P ; Amani, A ; Shamloo, A ; Sharif University of Technology
Elsevier B.V
2021
Abstract
Targeted drug delivery using nanocarriers (NCs) is one of the novel techniques that has recently been used to improve drug delivery to the Abdominal aortic aneurysm (AAA) disease. The purpose of this study is to evaluate the surface density of NCs (SDNC) adhered via ligand-receptor binding to the inner wall of AAA. For this purpose, fluid–structure interaction (FSI) analysis was first performed for the patient-specific and ideal AAA models. Then, by injecting NCs into the aortic artery, the values of SDNC adhered to and interacted with AAA wall were obtained. Two types of NCs, liposomes, and solid particles in four different diameters, were used to investigate the effect of the diameter and...
Targeted drug delivery of microbubble to arrest abdominal aortic aneurysm development: a simulation study towards optimized microbubble design
, Article Scientific Reports ; Volume 10, Issue 1 , 2020 ; Ebrahimi, S ; Amani, A ; Fallah, F ; Sharif University of Technology
Nature Research
2020
Abstract
Abdominal aortic aneurysm (AAA) is an irreversible bulge in the artery with higher prevalence among the elderlies. Increase of the aneurysm diameter by time is a fatal phenomenon which will lead to its sidewall rupture. Invasive surgical treatments are vital in preventing from AAA development. These approaches however have considerable side effects. Targeted drug delivery using microbubbles (MBs) has been recently employed to suppress the AAA growth. The present study is aimed to investigate the surface adhesion of different types of drug-containing MBs to the inner wall of AAA through ligand-receptor binding, using fluid-structure interaction (FSI) simulation by using a patient CT-scan...
Effect of material and population on the delivery of nanoparticles to an atherosclerotic plaque: a patient-specific in silico study
, Article Langmuir ; Volume 37, Issue 4 , 2021 , Pages 1551-1562 ; 07437463 (ISSN) ; Shamloo, A ; Barzegar, S ; Forouzandehmehr, M ; Sharif University of Technology
American Chemical Society
2021
Abstract
Coronary artery disease (CAD) is the prevalent reason of mortality all around the world. Targeting CAD, specifically atherosclerosis, with controlled delivery of micro and nanoparticles, as drug carriers, is a very proficient approach. In this work, a patient-specific and realistic model of an atherosclerotic plaque in the left anterior descending (LAD) artery was created by image-processing of CT-scan images and implementing a finite-element mesh. Next, a fluid-solid interaction simulation considering the physiological boundary conditions was conducted. By considering the simulated force fields and particle-particle interactions, the correlation between injected particles at each cardiac...
Particles focusing and separation by a novel inertial microfluidic device: divergent serpentine microchannel
, Article Industrial and Engineering Chemistry Research ; Volume 61, Issue 38 , 2022 , Pages 14324-14333 ; 08885885 (ISSN) ; Shamloo, A ; Vatani, P ; Ebrahimi, S ; Sharif University of Technology
American Chemical Society
2022
Abstract
Microfluidic experiments have found wide applications in medical sciences and engineering, such as cell separation and focusing. In the present study, focusing and separation of particles with different sizes and densities were investigated by designing inertial microfluidic devices. The microfluidic channel is designed by analyzing the induced forces on the particles. In the designing process, the objective was to focus and separate the particles in the shortest length of the channel with the lowest possible cycles and high efficiency. The simulation is then used for analyzing the two proposed geometries to evaluate their particle separation and focusing ability, named convergent and...
Designing a sustainable reverse supply chain network for COVID-19 vaccine waste under uncertainty
, Article Computers and Industrial Engineering ; Volume 174 , 2022 ; 03608352 (ISSN) ; Fallahi, A ; Varmazyar, M ; Fathi, M ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
The vast nationwide COVID-19 vaccination programs are implemented in many countries worldwide. Mass vaccination is causing a rapid increase in infectious and non-infectious vaccine wastes, potentially posing a severe threat if there is no well-organized management plan. This paper develops a mixed-integer mathematical programming model to design a COVID-19 vaccine waste reverse supply chain (CVWRSC) for the first time. The presented problem is based on minimizing the system's total cost and carbon emission. The uncertainty in the tendency rate of vaccination is considered, and a robust optimization approach is used to deal with it, where an interactive fuzzy approach converts the model into...
Deep federated learning-based privacy-preserving wind power forecasting
, Article IEEE Access ; Volume 11 , 2023 , Pages 39521-39530 ; 21693536 (ISSN) ; Talaei, M ; Sadipour, M ; Moradi Amani, A ; Jalili, M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2023
Abstract
Given the growing installed capacity, wind energy will exert a profound impact on the flexibility of modern energy systems. Wind power forecasting is a practical solution for dealing with the attributed variations and uncertainties, balancing supply and demand, and improving the reliability of the system. To achieve more accurate and generalizable forecast models, comprehensive data sets, supplied by multiple wind farms owing to their spatio-temporal dependencies, are required. In addition, data aggregation/collaboration across many wind farms scattered around a country is difficult, if not impossible, due to complex administrative processes, industry competition, and data privacy and...
Stability of Cantilevered Beams Subjected to Random Follower Forces
, M.Sc. Thesis Sharif University of Technology ; Haddadpour, Hassan (Supervisor)
Abstract
In Mechanical systems there is always possibility of statical and dynamical following force. These forces are generated due to aerodynamic pressure, temperature gradient, and jet thrusters. In unstabel systems, if the value of this force exceeds a certaim amount the system becomes unstable. This value is called as critical force. In order to analyse these systems, fisrt of all, the governing dynamic equations are obtained by using the Galerkin-Ritz method. Then, by utilising the modal analysis, these equation are uncoupled. And then, the Ito set of equations are derived. By utilising the Lyapanov method, Ito equations are transfered to another state. and using the fokker-planc equation the...
A System Dynamics Model to Find Optimal Policies for competition and Development of Online Question and Answer Knowledge Markets
, M.Sc. Thesis Sharif University of Technology ; Kianfar, Farhad (Supervisor)
Abstract
Knowledge markets where knowledge transactions take place are today see increasingly expansion by influences of the Internet and the importance of knowledge. A competitive space, thus, has been placed among different enterprises step in knowledge markets. With no exception to this general rule, one of these markets covers online question – answer knowledge market. Google Answers is a proposed website in this area which, although being of interest in recent decades, its activities ended in 2006 for several reasons. Significantly, these markets consist of many factors with interrelated effects on each other and this leads to complexity of systems. Therefore, in order to study these markets, it...
Dioxo and oxo-peroxo molybdenum(VI) complexes bearing salicylidene 2-picoloyl hydrazone: Structures and catalytic performances
, Article Polyhedron ; Volume 53 , 2013 , Pages 223-229 ; 02775387 (ISSN) ; Zare, M ; Amani, V ; Ellern, A ; Keith Woo, L ; Sharif University of Technology
2013
Abstract
Molybdenum complexes bearing a salicylidene 2-picoloyl hydrazone ligand have been synthesized and characterized. The salicylidene 2-picoloyl hydrazone ligand (H2sal-phz) was prepared by reaction of picoloyl hydrazine with salicylaldehyde. Reaction of H2sal-phz with MoO2(acac) 2 generates the dioxo molybdenum complex MoO2(sal-phz) (CH3OH). Treatment of MoO3 in the presence of H 2O2 with H2sal-phz produces the oxo-peroxo molybdenum(VI) complex MoO(O2)(sal-phz)(CH3OH). The new compounds were characterized by 1H NMR and IR spectroscopies, and elemental analysis. The complexes were also characterized by single crystal X-ray diffraction crystallography. The complexes were evaluated for epoxidation...
Data-driven model-free adaptive control of z-source inverters
, Article Sensors ; Volume 21, Issue 22 , 2021 ; 14248220 (ISSN) ; Ahmadi, A ; Mohammadi, S ; Moradi Amani , A ; Marzband, M ; Mohammadi Ivatloo, B ; Sharif University of Technology
MDPI
2021
Abstract
The universal paradigm shift towards green energy has accelerated the development of modern algorithms and technologies, among them converters such as Z-Source Inverters (ZSI) are playing an important role. ZSIs are single-stage inverters which are capable of performing both buck and boost operations through an impedance network that enables the shoot-through state. Despite all advantages, these inverters are associated with the non-minimum phase feature imposing heavy restrictions on their closed-loop response. Moreover, uncertainties such as parameter perturbation, unmodeled dynamics, and load disturbances may degrade their performance or even lead to instability, especially when...
Synthesis and characterization of metal dithiocarbamate derivatives of 3-((pyridin-2-yl)methylamino)propanenitrile: Crystal structure of [3-((pyridin-2-yl)methylamino)propanenitrile dithiocarbamato] nickel(II)
, Article Polyhedron ; Volume 102 , 2015 , Pages 643-648 ; 02775387 (ISSN) ; Torabi, S ; Amani, V ; Notash, B ; Saidi, M. R ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Four metal dithiocarbamate complexes (Zn, Ni, Hg and Sn) based on an amine containing pyridyl and nitrile groups, 3-((pyridin-2-yl)methylamino)propanenitrile, were prepared and characterized by their elemental analysis, spectroscopic data (such as IR, 1H and 13C NMR), TGA analysis and X-ray crystallography of the Ni(II) complex. The presence of a band in the 1000 cm-1 region in the IR spectra, without any splitting, confirms the symmetrical bidentate bonding mode of the dithiocarbamate ligand. Also, the short thioureide C=N distance in the X-ray analysis of the Ni complex confirms the delocalization of π electrons over the S2CN moiety and strong double bond character between the carbon and...
Experimental study on viscosity of spinel-type manganese ferrite nanofluid in attendance of magnetic field
, Article Journal of Magnetism and Magnetic Materials ; Volume 428 , 2017 , Pages 457-463 ; 03048853 (ISSN) ; Amani, P ; Kasaeian, A ; Mahian, O ; Kasaeian, F ; Wongwises, S ; Sharif University of Technology
2017
Abstract
In this paper, an experimental evaluation on the viscosity of water-based manganese ferrite nanofluid with and without magnetic field with 100, 200, 300, and 400 G intensities has been conducted. The Brookfield DV-I PRIME viscometer is implemented to measure the MnFe2O4/water nanofluid viscosity and to evaluate the influence of different volume concentrations (from 0.25% to 3%) and various temperatures (from 20 to 60 °C) on the viscosity. According to the measurements, viscosity incrementally increases with the augmentation of nanoparticles concentration while it remarkably decreases at higher temperatures under absence and attendance of magnetic field. The maximum viscosity ratio of 1.14 is...
Buckling behavior of composite triangular plates
, Article International Journal of GEOMATE ; Volume 2, Issue 2 , 2012 , Pages 253-260 ; 21862982 (ISSN) ; Heydarnia, E ; Amani, P ; Sharif University of Technology
GEOMATE International Society
2012
Abstract
This paper is to do a brief research on the buckling behavior of composite triangular plates with various edge boundary conditions and in-plane loads. It may be regarded as a right and simple numerical method for the analysis of composite triangular thin plate using the natural Area coordinates. Previous studies on the solution of triangular plates with different boundary conditions were mostly based on the Rayleigh-Ritz principle which is performed in the Cartesian coordinate. In this method, the energy functional of a general triangular plate is derived and the Rayleigh-Ritz method is utilized to derive the governing eigenvalue equation for the buckling problem. The geometry is presented...
A three-winding coupled-inductor high step-up boost converter with an active-clamp circuit
, Article 12th Power Electronics, Drive Systems, and Technologies Conference, PEDSTC 2021, 2 February 2021 through 4 February 2021 ; 2021 ; 9780738111971 (ISBN) ; Beiranvand, R ; Zolghadri, M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2021
Abstract
A new high step-up boost converter with an active clamp circuit to eliminate voltage spike caused by leakage inductor is introduced in this paper. The introduced power converter has a high voltage gain for variable input voltage from 48V to 80V. Since both main and auxiliary switches turn on with zero voltage switching (ZVS) and all the diodes turn off under zero current switching (ZCS) condition, switching losses and EMI noises are strongly degraded. Therefore, the converter's efficiency is improved significantly. Simulation results show a 96.4% peak efficiency and 95.4% average efficiency. The proposed topology is suitable for low-input-voltage and low-output power applications such as...
A new high step-up interleaved LLC converter
, Article 12th Power Electronics, Drive Systems, and Technologies Conference, PEDSTC 2021, 2 February 2021 through 4 February 2021 ; 2021 ; 9780738111971 (ISBN) ; Beiranvand, R ; Zolghadri, M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2021
Abstract
In this study, a new LLC resonant converter for high-voltage high-power applications is introduced. The introduced power converter is a two-phase interleaved full-bridge based that uses a transformer with secondary and tertiary windings to obtain higher output voltage. Zero voltage switching (ZVS) at MOSFETs turn on and zero current switching (ZCS) for all the output diodes at turn off are achieved for a wide range of input voltage (100 V-200 V) and output power (200 W-1500 W) variations. Simulation results show a 95% peak efficiency. © 2021 IEEE
Treatment of wastewatercontaining carbohydrates usingpichia saitoi culture
, Article International Journal of Engineering, Transactions B: Applications ; Volume 17, Issue 3 , 2004 , Pages 209-218 ; 1728-144X (ISSN) ; Yaghmaei, S ; Maghsoodi, V ; Sharif University of Technology
National Research Center of Medical Sciences
2004
Abstract
Treatment of wastewater containing carbohydrates by Pichia saitoi growing on beet molasses was investigated in a well-mixed continuous tank as an alternative to bulking control. The yeast strain that used in this work was isolated from non-alcoholic beverage industrial wastewater, with a view on TOC removal compared with other strains in previous study.In this research the isolated yeast showed high COD and TOC removal at three hydraulic retention times, HRT= 48, 24 and 18 hours.Maximum COD and TOC reductions were obtained at HRT=48 hours, which were 96% and 88%, respectively.The influent COD and TOC were 2500 and 148 mg/1, respectively.The pH maintained for synthetic wastewater was about...
A lightweight mutual authentication scheme for vanets between vehicles and RSUs
, Article ISeCure ; Volume 15, Issue 3 , 2023 , Pages 77-89 ; 20082045 (ISSN) ; Mohajeri, J ; Salmasizadeh, M ; Sharif University of Technology
Iranian Society of Cryptology
2023
Abstract
Vehicular Ad-hoc Networks (VANETs) have emerged as part of Intelligent Transportation Systems (ITS), offering the potential to enhance passenger and driver safety, as well as driving conditions. However, VANETs face significant security challenges and various attacks due to their wireless nature and operation in free space. Mutual authentication between vehicles and RSUs is one of the most, if not the most, critical security requirements in VANETs. In this process, maintaining resource authenticity, data authenticity and preserving users’ privacy, are key concerns. This paper proposes a pseudonym-based authentication scheme for VANETs, built upon existing approaches. The proposed scheme not...
Quantum Modeling of Dynamic Ride-sharing Problem: Development of Quantum Solution Methodologies
, M.Sc. Thesis Sharif University of Technology ; Eshghi, Kourosh (Supervisor)
Abstract
Mathematical modeling and the subsequent development of optimization algorithms for problems have been the core focus of operations research scientists. However, the challenges of solving complex models within an acceptable time frame have consistently fostered creativity in this field. Quantum computing has been proposed as an alternative to binary computing for several decades. In recent years, scientists and researchers in operations research have paid significant attention to utilizing and integrating this logic with optimization. Specifically, quantum variants of many optimization algorithms have been developed; however, more focus needs to be placed on modeling optimization problems...
Optimization of catalytic activity of sulfated titania for efficient synthesis of isoamyl acetate by response surface methodology
, Article Monatshefte fur Chemie ; Volume 146, Issue 12 , December , 2015 , Pages 1949-1957 ; 00269247 (ISSN) ; Sadehvand, M ; Azad, A ; Dekamin, M. G ; Jalali Heravi, M ; Mollahosseini, A ; Amani, M ; Tadjarodi, A ; Sharif University of Technology
Springer-Verlag Wien
2015
Abstract
TiO2 nanoparticles were synthesized by sol-gel method using titanium tetraisopropoxide. Sulfate ions were introduced on the titania by impregnation method using sulfuric acid as precursor of sulfate ions. Fourier transform infrared and energy-dispersive X-ray spectroscopy, X-ray fluorescence as well as X-ray diffraction, scanning electron microscopy, and BET methods were used for the characterization of the obtained nanoparticles. The esterification of isoamyl alcohol with acetic acid was investigated to prove the catalytic activity of the TiO2 nanoparticles under solvent-free conditions. Response surface methodology was applied to optimize the effect of some parameters such as the molar...
A rapid and convenient synthesis of gem-bis(dithiocarbamate) derivatives from primary aliphatic amines, carbon disulfide, and aromatic aldehydes using boron trifluoride-diethyl etherate
, Article Tetrahedron Letters ; Vol. 55, Issue. 25 , 2014 , Pages 3572-3575 ; ISSN: 00404039 ; Ghiyaei, A. G. G ; Notash, B ; Shayegan, M. H ; Amani, V ; Sharif University of Technology
2014
Abstract
An efficient route for the synthesis of gem-bis(dithiocarbamate) derivatives is developed using dithiocarbamic acid salts generated from primary aliphatic amines and CS2. The method offers high yields, employs mild reaction conditions, and demonstrates excellent functional group compatibility. The structures of the products were confirmed spectroscopically and by X-ray analysis