Sharif Digital Repository

Based on the importance of DNA/RNA binding proteins in different cellular processes, finding binding sites of them play crucial role in many applications, like designing drug/vaccine, designing protein, and cancer control. Many studies target this issue and try to improve the prediction accuracy with three strategies: complex neural-network structures, various types of inputs, and ML methods to extract input features. But due to the growing volume of sequences, these methods face serious processing challenges. So, this paper presents KDeep, based on CNN-LSTM and the primary form of DNA/RNA sequences as input. As the key feature improving the prediction accuracy, we propose a new encoding... 

In the last decade, Intrusion Detection Systems has attracted attention due to their importance in network security, but still they've shortcomings. Generating a lot of low level alerts is the main problem. Many of these alerts are actually false positives. One suggested solution is Alert Correlation Analysis. Because of false positives alert correlation techniques are not able to build accurate scenarios, but the accuracy of alerts can be verified with the aid of the information logged in the host systems. In this dissertation after surveying the current alert correlation techniques, a model will be introduced to effectively verify the generated alerts and to apply correlation techniques to... 

In this research, synthesis of new heterogeneous catalysts has been studied. These catalysts were prepared in three different areas of the synthesis of coordination polymers and metal-organic frameworks, supported palladium nanoparticles on these polymers, and production of metal oxide nanoparticles. At first, metal organic frameworks of cobalt and manganese transition metals were synthesized through hydrothermal method. In order to prepare these frameworks, 1,4-benzenedicarboxylic acid (terephthalic acid) and 2-amino-1,4-benzenedicarboxylic acid ligands were utilized as spacer ligands. X-ray analysis indicated that the structure of polymers is composed of secondary building units (SBUs) of... 

The properties of metamaterials can be tailored through modification of their microstructures geometry. In this regard, a vast range of metamaterials have been designed. Auxetic metamaterials are a novel class of materials exhibiting the interesting characteristic of negative Poisson’s ratio. Theoretically, auxetic metamaterials have improved mechanical properties such as shear modulus and fracture toughness. The design and modeling of auxetic metamaterials is not completed yet. In order to exploit the interesting properties of auxetic metamaterials, their potential applications have been investigated in medical, sports, automobile and defense industries, so far. In the present work, the... 

Speech synthesis and its applications have been very attractive recently. The main purpose of this technique is to produce a speech signal with natural characteristics of human speech like prosody and emotion. Among all existing methods for speech synthesis, statistical parametric speech synthesis methods are more promising because ofhigher flexibility in comparison to other methods. One of the applications of speech synthesis is speech to speech translation. In these systems, the generated voice in target language should have the same characteristics as the input voice in source language. The main purpose of this research is to review and evaluate the cross lingual speaker adaptation... 

Surface piercing propellers are particular type of supercavitating propellers that are commonly used for High-speed vessels. Most studies on this type of propellers has been investigating the hydrodynamic forces. But in recent years with increase in SPPs diameter used in vessels, structural analysis of this type of propellers is considered. For this purpose, studies on the stresses exerted on the propeller structures under load is done with the help of Hydro elastic methods. In this type of analysis, structura of propeller is intended to be flexible and Displacements under pressure checked and Tensions resulting from it are studied.
The present Thesis using ANSYS software to analyze a... 

The increasing demand for autonomous vehicles and reliable communication protocols and hardware interfaces, such as CAN bus and USB, underscores the necessity for stable clock sources that maintain a low temperature coefficient (TC) over wide temperature ranges. This demand is particularly emphasized in applications such as wearables, network sensors, downhole devices, WSNs, and IoT, where long-lasting battery life and frequency-stable clock sources over a broad temperature range (e.g. -20 °C to 100 °C) are crucial. Traditionally, variations in frequency caused by temperature have been mitigated by employing off-chip components like crystals or ceramic based oscillators, but this approach... 

Pricing plays an important and essential role in the profit and income of companies. The importance of pricing is not only related to its role in the company's profitability, but it also changes the customer's understanding and loyalty towards the company and can create the company's reputation or destroy it. Determining the right price will increase product sales and increase customer loyalty and create a competitive advantage for the company. One of the most important and influential variables in product pricing is the amount of demand. The main challenge of companies for product pricing is the uncertainty in their demand. In order to deal with this problem, data-driven pricing is used.... 

Low back pain is the most prevalence musculoskeletal pain that people experience in their life. Some cases of low back pain are called non-specific. These are cases for which the reason of pain is not well defined. The aim of this study is to propose a simple approach to diagnose and cluster low back pain patients which helps clinicians to evaluate patients by an affordable and simple tool. In this study, data are collected in two steps using Inertial Sensors. Inertial Sensors consist of a 3-axis gyroscope and a 3-axis accelerometer which represent the kinematic parameters of lumbar movement. In the first step, we examine 24 healthy and 28 patients with low back pain and in the second, 84... 

There are numerous ways available to achieve low temperatures that cryocoolers might be among the most important of them. In the meantime, the pulse tube refrigerator has a special place due to its simple geometry and not be using any moving parts. This simple property make the pulse tube refrigerator one of the most popular methods to achieve low temperatures. Nowadays, a pulse tube refrigerator is used for cooling in the range of 4 to 123 Kelvin in two form of one-stage and two-stage and up to an approximate power of 1 KW. Today, due to the temperature and the amount of power required for cooling, as well as the time it takes to reach that temperature, this chiller is used in medical,... 

The idea of "vacuum energy" with definition of the "Aether" has many historical backgrounds from Aristotelian philosophy to 19th century and the advent of quantum vacuum. Some assert vacuum which is defined as "pure void" and others have got contrary viewpoints. It can be said that the history of vacuum is as old as history of physics. With the advent of quantum mechanics, vacuum has taken a specific definition. Vacuum from vision of quantum mechanics describes that vacuum is the minimum possible energy state, because if the energy of "quantum vacuum state" became zero, Heisenberg uncertainty principle would be violated. The important consequence of quantum mechanics will be in apparent... 

Fusion surgery or fixation of vertebrae in the spine is used to treat scoliosis, fractures, infections, tumors, spinal cord injuries, and disc herniation. In this type of surgery, two or more vertebrae are connected by special screws called pedicle screws to eliminate movement between the vertebrae. Given the serious risks of spinal fusion surgery, if the slightest mistake is made at the entry point or angle of the screw inside the vertebrae, the risk of spinal cord injury is very high, which is one of the complications of fusion surgery. Therefore, in order to increase the accuracy of screw placement, patient-specific template guides are used as drill guides in this operation. For this...