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Using smart core-shell polymer particles to improve efficiency of polymer flooding-modeling approach
, Article 75th European Association of Geoscientists and Engineers Conference and Exhibition 2013 Incorporating SPE EUROPEC 2013: Changing Frontiers ; 2013 , Pages 3496-3500 ; 9781629937915 (ISBN) ; Ramazani, A ; Sharif University of Technology
European Association of Geoscientists and Engineers, EAGE
2013
Abstract
Dissolution modeling of smart core-shell polymer particles (SPP) during polymer flooding is the main purpose of this study. The SPP is used to improve the efficiency of conventional polymer flooding. The smart title comes from selective dissolution of these core-shell particles in porous media, which is related to the hydrophobic-hydrophilic behavior of them. The core of the SPP is a hydrophilic high molecular weight polymer, which is covered by a protective shell layer of low molecular weight hydrophobic polymer. Reaching at the water-oil interface, these particles increases the viscosity of flooding water at neighborhood of the water-oil interface. Considering the analogy between drug...
Runtime Analysis of Self-adaptive Systems
, Ph.D. Dissertation Sharif University of Technology ; Movaghar, Ali (Supervisor) ; Sirjani, Marjan (Supervisor)
Abstract
Increasing the complexity of software systems, their ubiquitous presence in the human activities, and necessity to preserving the functional and nonfunctional requirements of the systems under an uncertain environment, increase the need for self-adaptive systems. A self-adaptive system changes its structure and behaviors in response to changes in its environment and the system itself. A key research challenge in the self-adaptive community is to guarantee that the system fulfills its requirements. This issue can be addressed by employing formal methods during the design of the software systems. However, the assurance techniques should be used during the execution of the system as well as the...
Theoretical Investigation of Quantum Optical Amplifiers in Quantum Communications
, M.Sc. Thesis Sharif University of Technology ; Bahrampour, Alireza (Supervisor) ; Bathaee, Marzieh Sadat (Co-Supervisor)
Abstract
Signal transmission of information on noiseless and lossy channels is an important issue in data transmission. Using the amplifier in the transmission channels is a good solution to help send information on longer channels. In classical communication, information can be coded in the amplitude or phase of the field and an amplifier is responsible for amplifying these parameters. If we consider the conditions ideal and ignore electrical noises, Classical mechanics does not impose any restrictions on the amplification of arbitrary classical signals. Instead, in quantum telecommunications the information encoded on the quadrature of the electromagnetic field are mounted on quantum states, such...
Design and Manufacturing of Gradient Cellular Tibial Stem for Total Knee Replacement
, M.Sc. Thesis Sharif University of Technology ; Farahmand, Farzam (Supervisor) ; Bahrami Nasab, Marjan (Co-Supervisor)
Abstract
Loosening of uncemented tibial component is one the most common causes of total knee prosthesis failure which is a result of short-term factors such as instability and incomplete osseointegration as well as long-term factors such as peri-prosthetic stress shielding and bone atrophy. Porous cellular structures for tibial stem have been considered as a solution to this problem. This project is aimed to achieve an optimal gradient porous cellular design of tibial stem that in addition to sufficient mechanical strength, provides a perfect osseointegration and prevents bone resorption by incorporating appropriate porosity size, small micro-motion and favorable stress distribution on bone. A...
Direct design of branched ducts
, Article Scientia Iranica ; Volume 16, Issue 2 B , 2009 , Pages 111-120 ; 10263098 (ISSN) ; Taiebi Rahni, M ; Ashrafizadeh, A ; Sharif University of Technology
2009
Abstract
A fully coupled formulation of thermo-fluid shape design problems has recently been developed in which the unknown nodal coordinates appear explicitly in the formulation of the problem. This "direct design" approach is, in principle, generally applicable and has been successfully applied in the context of potential and Euler flow models. This paper focuses on the direct design of ducts using the ideal flow model and may be considered as an addendum to the paper entitled "Direct Design of Ducts" [1]. However, a cell-vertex finite volume method is used and a different boundary condition implementation technique is applied, as compared to the method presented in the previous paper. The other...
Experimental Investigation and Theoretical Modelling of Swelling and Solution of Coated Polyacrylamide Particle in Porous Media
, M.Sc. Thesis Sharif University of Technology ; Ramazani Saadatabadi, Ahmad (Supervisor)
Abstract
The main purpose of this study is simulation of in-situ release of nano-size coated polymer particles at the water-oil interface during the polymer flooding. Reaching at the flooding interface, the hydrophobic coating starts dissolving into the oil phase. Subsequently, the hydrophilic core polymer starts diffusing back and simultaneously solves into the water phase and increase the in-situ viscosity of the flooding interface. Because of the in-situ release of the polymer and consequently the viscosity reduction of the injected fluid, the driving force for injection of the polymer as well as the amount of polymer used in flooding will reduce. In addition, smart coating can decrease the...
Improvement of polymer flooding using in-situ releasing of smart nano-scale coated polymer particles in porous media
, Article Energy Exploration and Exploitation ; Volume 30, Issue 6 , 2012 , Pages 915-940 ; 01445987 (ISSN) ; Ramazani, S. A. A ; Sadeghnejad, S ; Sharif University of Technology
2012
Abstract
The main purpose of this paper is modeling and simulation of in-situ releasing of smart nano-sized core-shell particles at the water-oil interface during polymer flooding. During the polymer flooding process, when these nano-particles reach the water-oil interface, migrate to the oil phase and the hydrophobic layer of them dissolves in this phase. After dissolution of this protective nano-sized layer, the hydrophilic core containing a water-soluble ultra high molecular weight polymer diffuses back into the water phase and with dissolving in this phase, dramatically increases viscosity of flooding water in the neighborhood of the water-oil interface. In this study, two different...
Hydrodynamic dispersion by electroosmotic flow of viscoelastic fluids within a slit microchannel
, Article Microfluidics and Nanofluidics ; Volume 22, Issue 1 , January , 2018 ; 16134982 (ISSN) ; Talebi, M ; Ashrafizadeh, S. N ; Sadeghi, A ; Sharif University of Technology
Springer Verlag
2018
Abstract
The biofluids being manipulated in lab-on-a-chip devices usually contain elastic macromolecules. Accordingly, for an accurate modeling of the relevant flow physics one should invoke viscoelastic constitutive equations. In this paper, attention is paid toward the hydrodynamic dispersion by the fully developed electroosmotic flow of PTT viscoelastic fluids in slit microchannels of low zeta potential. Adopting the Taylor–Aris approach, analytical solutions are derived for late-time solute concentration and effective dispersion coefficient. Finite element-based numerical simulations are also conducted to monitor the broadening of an analyte band from the moment of injection. Both approaches are...
Solute dispersion by electroosmotic flow through soft microchannels
, Article Sensors and Actuators, B: Chemical ; Volume 255, Part 3 , February , 2018 , Pages 3585-3600 ; 09254005 (ISSN) ; Khorami, A ; Ashrafizadeh, S. N ; Sadeghi, A ; Sharif University of Technology
Elsevier B.V
2018
Abstract
We study the hydrodynamic dispersion (HD) by electroosmotic flow in soft microchannels. Considering a fully developed flow in a slit microchannel of low surface potential and adopting the Taylor dispersion theory, we derive analytical solutions for the solute concentration field and the effective dispersion coefficient. We also conduct numerical analyses to broaden the paper's scope to high surface potentials and to specify a criterion for the validity of the Debye-Hückel linearization in soft microconduits as well as to investigate the broadening of an analyte band from the time of injection. It is demonstrated that the effective dispersion coefficient of a neutral solute band is generally...
Multifunctional tetracycline-loaded silica-coated core-shell magnetic nanoparticles: antibacterial, antibiofilm, and cytotoxic activities
, Article ACS Applied Bio Materials ; Volume 5, Issue 4 , 2022 , Pages 1731-1743 ; 25766422 (ISSN) ; Eshrati Yeganeh, F ; Yousefi, M ; Baniyaghoob, S ; Farasati Far, B ; Akbarzadeh, I ; Bigham, A ; Ashrafizadeh, M ; Rabiee, N ; Makvandi, P ; Saeb, M. R ; Sharif University of Technology
American Chemical Society
2022
Abstract
In the current study, the physicochemical and biological properties of tetracycline-loaded core-shell nanoparticles (Tet/Ni0.5Co0.5Fe2O4/SiO2 and Tet/CoFe2O4/SiO2) were investigated. The antibacterial activity of nanoparticles alone and in combination with tetracycline was investigated against a number of Gram-positive and Gram-negative bacteria for determining minimum inhibitory concentration (MIC) values. The MIC of Tet/Ni0.5Co0.5Fe2O4/SiO2 nanoparticles turned out to be significantly higher than that of Tet/CoFe2O4/SiO2 nanoparticles. Furthermore, Tet/Ni0.5Co0.5Fe2O4/SiO2 nanoparticles exhibited potent antibiofilm activity against pathogenic bacteria compared to Tet/CoFe2O4/SiO2...
Detection of dopamine receptors using nanoscale dendrimer for potential application in targeted delivery and whole-body imaging: synthesis and in vivo organ distribution
, Article ACS Applied Bio Materials ; Volume 5, Issue 4 , 2022 , Pages 1744-1755 ; 25766422 (ISSN) ; Aminzadeh Jahromi, N ; Ali, V ; Ebrahimpour, A ; Salehian, E ; Shafiee Ardestani, M ; Seyedhamzeh, M ; Ahmadi, S ; Sharifi, E ; Ashrafizadeh, M ; Rabiee, N ; Makvandi, P ; Sharif University of Technology
American Chemical Society
2022
Abstract
Dopamine is one of the most important neurotransmitters released by neurons in the central nervous system, and a variety of neurological illnesses and mental disorders are associated with impairments in the secretion and functionality of dopamine. Dopamine, depending on the type of receptors, can act as a stimulant or an inhibitor. In this study, dendrimer-conjugated dopamine was utilized as a chelating agent for Technetium-99m to investigate the organ distribution of this compound in vivo using the single-photon emission computed tomography (SPECT) technique. For this purpose, dendrimers were synthesized using polyethylene glycol diacid and citric acid precursors, and dopamine was...
The association of clinicopathological characterizations of colorectal cancer with membrane-bound mucins genes and LncRNAs
, Article Pathology Research and Practice ; Volume 233 , 2022 ; 03440338 (ISSN) ; Entezari, M ; Rejali, L ; Nazemalhosseini-Mojarad, E ; Maghsoudloo, M ; Asadzadeh Aghdaei, H ; Zali, M. R ; Hushmandi, K ; Rabiee, N ; Makvandi, P ; Ashrafizadeh, M ; Hashemi, M ; Sharif University of Technology
Elsevier GmbH
2022
Abstract
Background: Colorectal cancer (CRC) is one of the most common malignancies in the world and has a high mortality rate. It is believed that dysfunction in the expression of mucins and aberrant expression of some lncRNAs are associated with the occurrence and development of CRC. Therefore, the aim of the present study was to investigate the expression of MUC15, MUC16, MUC20, PCAT1, CCAT1 and HOTAIR genes in colorectal cancer and its relationship with clinicopathological variables. Materials and methods: This research was prospective case-control study. Tumors from CRC patients were collected from the Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. RNA...
Folic acid-adorned curcumin-loaded iron oxide nanoparticles for cervical cancer
, Article ACS Applied Bio Materials ; Volume 5, Issue 3 , 2022 , Pages 1305-1318 ; 25766422 (ISSN) ; Azarian, M ; Heydari Sheikh Hossein, H ; Abdolvahabi, Z ; Mohammadi Abgarmi, Z ; Moradi, A ; Mousavi, S. M ; Ashrafizadeh, M ; Makvandi, P ; Saeb, M. R ; Rabiee, N ; Sharif University of Technology
American Chemical Society
2022
Abstract
Cancer is a deadly disease that has long plagued humans and has become more prevalent in recent years. The common treatment modalities for this disease have always faced many problems and complications, and this has led to the discovery of strategies for cancer diagnosis and treatment. The use of magnetic nanoparticles in the past two decades has had a significant impact on this. One of the objectives of the present study is to introduce the special properties of these nanoparticles and how they are structured to load and transport drugs to tumors. In this study, iron oxide (Fe3O4) nanoparticles with 6 nm sizes were coated with hyperbranched polyglycerol (HPG) and folic acid (FA). The...
Bioactive hybrid metal-organic framework (MOF)-based nanosensors for optical detection of recombinant SARS-CoV-2 spike antigen
, Article Science of the Total Environment ; Volume 825 , 2022 ; 00489697 (ISSN) ; Fatahi, Y ; Ahmadi, S ; Abbariki, N ; Ojaghi, A ; Rabiee, M ; Radmanesh, F ; Dinarvand, R ; Bagherzadeh, M ; Mostafavi, E ; Ashrafizadeh, M ; Makvandi, P ; Lima, E. C ; Saeb, M. R ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Fast, efficient, and accurate detection of SARS-CoV-2 spike antigen is pivotal to control the spread and reduce the mortality of COVID-19. Nevertheless, the sensitivity of available nanobiosensors to detect recombinant SARS-CoV-2 spike antigen seems insufficient. As a proof-of-concept, MOF-5/CoNi2S4 is developed as a low-cost, safe, and bioactive hybrid nanostructure via the one-pot high-gravity protocol. Then, the porphyrin, H2TMP, was attached to the surface of the synthesized nanomaterial to increase the porosity for efficient detection of recombinant SARS-CoV-2 spike antigen. AFM results approved roughness in different ranges, including 0.54 to 0.74 μm and 0.78 to ≈0.80 μm, showing good...
CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin
, Article Chemosphere ; Volume 306 , 2022 ; 00456535 (ISSN) ; Akhavan, O ; Fatahi, Y ; Ghadiri, A. M ; Kiani, M ; Makvandi, P ; Rabiee, M ; Nicknam, M. H ; Saeb, M. R ; Varma, R. S ; Ashrafizadeh, M ; Nazarzadeh Zare, E ; Sharifi, E ; Lima, E. C ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Overexpression of proteins/antigens and other gene-related sequences in the bodies could lead to significant mutations and refractory diseases. Detection and identification of assorted trace concentrations of such proteins/antigens and/or gene-related sequences remain challenging, affecting different pathogens and making viruses stronger. Correspondingly, coronavirus (SARS-CoV-2) mutations/alterations and spread could lead to overexpression of ssDNA and the related antigens in the population and brisk activity in gene-editing technologies in the treatment/detection may lead to the presence of pCRISPR in the blood. Therefore, the detection and evaluation of their trace concentrations are of...
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance
, Article Expert Opinion on Drug Delivery ; Volume 19, Issue 4 , 2022 , Pages 355-382 ; 17425247 (ISSN) ; Saebfar, H ; Gholami, M.H ; Hushmandi, K ; Zabolian, A ; Bikarannejad, P ; Hashemi, M ; Daneshi, S ; Mirzaei, S ; Sharifi, E ; Kumar, A.P ; Khan, H ; Heydari Sheikh Hossein, H ; Vosough, M ; Rabiee, N ; Kumar Thakur, V ; Makvandi, P ; Mishra, Y. K ; Tay, F. R ; Wang, Y ; Zarrabi, A ; Orive, G ; Mostafavi, E ; Sharif University of Technology
Taylor and Francis Ltd
2022
Abstract
Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting its cytotoxicity in cancer. Areas covered: The favorable characteristics of GO nanocomposites, preparation method, and application in cancer therapy are described. Then, DOX resistance in cancer, GO-mediated photothermal therapy, and DOX delivery for cancer suppression are described. Preparation of stimuli-responsive GO nanocomposites, surface functionalization, hybrid nanoparticles, and theranostic applications are emphasized in DOX chemotherapy. Expert opinion: GO...