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Fabrication of Allograft-derived Scaffold by 3D Bioprinting for Craniofacial Defect
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor)
Abstract
Craniofacial bone defects without scarring are a major clinical issue. These critical defects, which can be caused by infection or fracture, cannot be repaired without surgery. The main goal of skull repair is to protect vulnerable structures such as the brain, or it can be due to the improvement of jaw function and beauty. Tissue engineering can offer a new generation solution. The purpose of this study was to construct and characterise a degradable polymer/ bioceramic composite scaffold with allograft powder used in the craniofacial bone. The complexities of the extracellular matrix of humans can be simulated using 3D bioprinting.In this study, tricalcium silicate (TCS) was first...
3D-printing-assisted synthesis of paclitaxel-loaded niosomes functionalized by cross-linked gelatin/alginate composite: Large-scale synthesis and in-vitro anti-cancer evaluation
, Article International Journal of Biological Macromolecules ; Volume 242 , 2023 ; 01418130 (ISSN) ; Mirzaei Chegeni, M ; Bidaki, A ; Zaer, M ; Abolhassani, H ; Seyedi, S. A ; Nabipoorashrafi, S. A ; Ashrafnia Menarbazari, A ; Moeinzadeh, A ; Farmani, A. R ; Tavakkoli Yaraki, M ; Sharif University of Technology
Elsevier B.V
2023
Abstract
Breast cancer is one of the most lethal cancers, especially in women. Despite many efforts, side effects of anti-cancer drugs and metastasis are still the main challenges in breast cancer treatment. Recently, advanced technologies such as 3D-printing and nanotechnology have created new horizons in cancer treatment. In this work, we report an advanced drug delivery system based on 3D-printed gelatin-alginate scaffolds containing paclitaxel-loaded niosomes (Nio-PTX@GT-AL). The morphology, drug release, degradation, cellular uptake, flow cytometry, cell cytotoxicity, migration, gene expression, and caspase activity of scaffolds, and control samples (Nio-PTX, and Free-PTX) were investigated....