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An Efficient Architecture for A Simplified Dalvik Processor
, M.Sc. Thesis Sharif University of Technology ; Goudarzi, Maziar (Supervisor)
Abstract
Google Inc. states that, 400 million Android-powered devices have been activated and used by people until 2012. This rapid growth of Android operating system in mobile phones and other electronic devices makes it very important to improve the efficiency of this Operating System. Dalvik is the underlying virtual machine (VM) in Android that executes Android-based applications, and hence, its performance directly affects Android-powered devices. De-virtualization is a technique to improve performance of VMs. In this method, VM’s instructions (bytecode) are natively and directly executed by hardware. In addition, de-virtualization technique eliminates the software interpretation/translation...
Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles
, Article Nanomedicine ; Volume 18, Issue 3 , 2023 , Pages 279-302 ; 17435889 (ISSN) ; Mousazadeh, M ; Taji, S ; Bahmani, A ; Khashayar, P ; Azimzadeh, M ; Mostafavi, E ; Sharif University of Technology
Newlands Press Ltd
2023
Abstract
AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug-dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and...
Performance analysis of android underlying virtual machine in mobile phones
, Article IEEE International Conference on Consumer Electronics - Berlin, ICCE-Berlin ; 2012 , Pages 292-295 ; 21666814 (ISSN) ; 9781467315470 (ISBN) ; Sameki, M ; Goudarzi, M ; Sharif University of Technology
2012
Abstract
In recent years, Android is widely used in cell phones. Dalvik is the virtual machine which is embedded inside the Android operating system, and executes the Android-based applications. Thus, improving efficiency of the Dalvik virtual machine plays an important role in optimizing performance of android-based mobile phones. In this paper, we present a comprehensive analysis of the Dalvik bytecodes and their frequency of use in common Android applications and use the results to determine the most frequently used bytecodes in Dalvik virtual machine to identify best targets for improvement. Our analysis showed that over 82% of total execution time of our Android benchmarks is spent by only 5...
GAG positioning on IL-1RI; A mechanism regulated by dual effect of glycosylation
, Article Glycobiology ; Volume 29, Issue 11 , 2019 , Pages 803-812 ; 14602423 (ISSN) ; Ejtehadi, M. R ; Sharif University of Technology
NLM (Medline)
2019
Abstract
IL-1RI is the signaling receptor for the IL-1 family of cytokines that are involved in establishment of the innate and acquired immune systems. Glycosylated extracellular (EC) domain of the IL-1RI binds to agonist such as IL-1β or antagonist ligands and the accessory protein to form the functional signaling complex. Dynamics and ligand binding of the IL-1RI is influenced by presence of the glycosaminoglycans (GAGs) of the EC matrix. Here a combination of molecular dockings and molecular dynamics simulations of the unglycosylated, partially N-glycosylated and fully N-glycosylated IL-1RI EC domain in the apo, GAG-bound and IL-1β-bound states were carried out to explain the co-occurring...
Glycan-mediated functional assembly of IL-1RI: structural insights into completion of the current description for immune response
, Article Journal of Biomolecular Structure and Dynamics ; 2020 ; Ejtehadi, M. R ; Sharif University of Technology
Taylor and Francis Ltd
2020
Abstract
Interleukin 1 Receptor type I (IL-1RI) is a multi-domain transmembrane receptor that triggers the inflammatory response. Understanding its detailed mechanism of action is crucial for treating immune disorders. IL-1RI is activated upon formation of its functional assembly that occurs by binding of the IL-1 cytokine and the accessory protein (Il-1RAcP) to it. X-ray crystallography, small-Angle X-ray Scattering and molecular dynamics simulation studies showed that IL-1RI adopts two types of ‘compact’ and ‘extended’ conformational states in its dynamical pattern. Furthermore, glycosylation has shown to play a critical role in its activation process. Here, classical and accelerated atomistic...
Glycan-mediated functional assembly of IL-1RI: structural insights into completion of the current description for immune response
, Article Journal of Biomolecular Structure and Dynamics ; Volume 40, Issue 6 , 2022 , Pages 2575-2585 ; 07391102 (ISSN) ; Ejtehadi, M. R ; Sharif University of Technology
Taylor and Francis Ltd
2022
Abstract
Interleukin 1 Receptor type I (IL-1RI) is a multi-domain transmembrane receptor that triggers the inflammatory response. Understanding its detailed mechanism of action is crucial for treating immune disorders. IL-1RI is activated upon formation of its functional assembly that occurs by binding of the IL-1 cytokine and the accessory protein (Il-1RAcP) to it. X-ray crystallography, small-Angle X-ray Scattering and molecular dynamics simulation studies showed that IL-1RI adopts two types of ‘compact’ and ‘extended’ conformational states in its dynamical pattern. Furthermore, glycosylation has shown to play a critical role in its activation process. Here, classical and accelerated atomistic...
Preparation and Investigation of Electrochemical Sensors for Determination of Pharmaceutical and Biological Compunds Based on Glassy Carbon Electrode Modified with Polypyrrole/Carbon Nanotube Composite
, M.Sc. Thesis Sharif University of Technology ; Shahrokhian, Saeed (Supervisor)
Abstract
In the recent years, conductive polymers are widely used in the design and construction of chemical and biological sensors.The polypyrrole due to features such as good thermal and chemical stability, ease of synthesis and better conductivity than other conductive polymers, atracts much attention. In order to modification of electrode surface,adhesiveand thin polymer films can be electropolymerized in the presence of organic or inorganic dopants on the surface of metal or carbon surfaces in aqueous or organic solutions. On the other hand carbon nanotubes by owing unique properties such as chemical stability and high electrical conductivity are good choice for electrod surface modification....
Gold nanorods for drug and gene delivery: An overview of recent advancements
, Article Pharmaceutics ; Volume 14, Issue 3 , 2022 ; 19994923 (ISSN) ; Mousazadeh, M ; Taji, S ; Bahmani, A ; Zarepour, A ; Zarrabi, A ; Sharifi, E ; Azimzadeh, M ; Sharif University of Technology
MDPI
2022
Abstract
Over the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to their several advantageous. However, rod-shaped gold nanoparticles, or gold nanorods (GNRs), have some more unique physical, optical, and chemical properties, making them proper candidates for biomedical applications including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. Most of their therapeutic applications are based on their ability for tunable heat generation upon exposure to near-infrared (NIR) radiation, which is helpful in both...
A Practical Examination of the Antibacterial and Absorption Effect of Bioceramic Apatite-Coated TiO2 as a Modified Nanophotocatalyst
, M.Sc. Thesis Sharif University of Technology ; Gholami, Mohammad Reza (Supervisor) ; Haghighi, Saeed (Co-Advisor)
Abstract
Ag / AgCl /TiO2 , 2 Ap / Ag / AgCl /TiO , 2 AgI /TiO and 2 Ap / AgI /TiO were prepared by the deposition-precipitation method on 2TiO (P25) nanoparticles and their photocatalyctic activities have been investigated under visible light and dark environments. Cationic surfactant plus 2 PVPI (topical solution and dry powder) as an iodine ion source and nonionic surfactant plus KI as an iodide ion source were used to prepar 2 AgI /TiO . In less than 30 minutes, 2 AgI /TiO which has been resulted from combination of cationic surfactant and 2 PVPI showed high efficiency on Escherichia coli under visible light when small quantities of it is used . However, AgCl sample prepared with cationic...
Elucidating the Roles of Interlukin I Receptor Type II (lL-1Rll) in the Regulation of Human Immune System, Atomistic Molecular Dynamics Simulation
, M.Sc. Thesis Sharif University of Technology ; Ejtehadi, Mohammad Reza (Supervisor) ; Azimzadeh Irani, Maryam (Co-Supervisor)
Abstract
IL-1 family of cytokines plays a critical role in the regulation of immune response.These cytokines transfer the signals to the target cells through binding to the IL-1 receptors.Interleukin 1 Receptor Type II (IL-1RII) is the decoy receptor of the IL-1 cytokines. IL-1RII is homologous to the signaling Interleukin 1 Receptor Type I (IL1RI) in its extracellular region and can bind to the same cytokines with higher affinity and the same accessory protein. It down-regulates the signaling and suppresses the downstream pathways due to the lack of the intracellular Toll-Interleukin Receptor (TIR) domain. IL-1RII is decorated by carbohydrate units in-vivo. Dynamics and ligand binding of receptors...
Dose-dependent effects of nanoscale graphene oxide on reproduction capability of mammals
, Article Carbon ; Volume 95 , December , 2015 , Pages 309-317 ; 00086223 (ISSN) ; Ghaderi, E ; Hashemi, E ; Akbari, E ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
In vivo dose-dependent effects of nanoscale graphene oxide (NGO) sheets on reproduction capability of Balb/C mice were investigated. Biodistribution study of the NGO sheets (intravenously injected into male mice at dose of ∼2000 μg/mL or 4 mg/kg of body weight) showed a high graphene uptake in testis. Hence, in vivo effects of the NGO sheets on important characteristics of spermatozoa (including their viability, morphology, kinetics, DNA damage and chromosomal aberration) were evaluated. Significant in vivo effects was found at the injected concentrations ≥200 μg/mL after (e.g., ∼45% reduction in sperm viability and motility at 2000 μg/mL). Observation of remarkable DNA fragmentations and...
Accelerated differentiation of neural stem cells into neurons on ginseng-reduced graphene oxide sheets
, Article Carbon ; Volume 66 , January , 2014 , Pages 395-406 ; Ghaderi, E ; Abouei, E ; Hatamie, S ; Ghasemi, E ; Sharif University of Technology
2014
Abstract
Asian red ginseng was used for green reduction of chemically exfoliated graphene oxide (GO) into reduced graphene oxide (rGO). The reduction level and electrical conductivity of the ginseng-rGO sheets were comparable to those of hydrazine-rGO ones. Reduction by ginseng resulted in repairing the sp 2 graphitic structure of the rGO, while hydrazine-rGO showed more defects and/or smaller aromatic domains. The ginseng-rGO sheets presented a better stability against aggregation than the hydrazine-rGO ones in an aqueous suspension. Whilst the hydrophobic hydrazine-rGO films exhibited no toxicity against human neural stem cells (hNSCs), the hydrophilic GO and ginseng-rGO films (as more...
Contested framings and policy controversies: Analysing biosafety policy-making in Iran
, Article Science and Public Policy ; Volume 40, Issue 5 , 2013 , Pages 616-627 ; 03023427 (ISSN) ; Millstone, E ; Sharif University of Technology
2013
Abstract
Vigorous debates have taken place within and between many countries about regulatory policy regimes covering the assessment and approval of genetically modified (GM) crops. In Iran, a very vigorous and hotly contested policy debate concerning legislation covering GM crops occurred between 2004 and 2009, but it was confined within government circles with almost no public discussion. This paper analyses the Iranian policy-making process in the period 2006-9. It explains how and why a stalemate arose in disputes between ministries and departments. The chosen analytical framework draws mainly on the regulation of technological risks and the analysis of public policy-making. It deploys the...
On the possible volumes of μ-way latin trades
, Article Aequationes Mathematicae ; Volume 63, Issue 3 , 2002 , Pages 303-320 ; 00019054 (ISSN) ; Billington, E. J ; Bryant, D. E ; Mahmoodian, E. S ; Sharif University of Technology
Birkhauser Verlag Basel
2002
Abstract
A μ-way latin trade of volume s is a set of μ partial latin rectangles (of inconsequential size) containing exactly the same s filled cells, such that if cell (i, j) is filled, it contains a different entry in each of the μ partial latin rectangles, and such that row i in each of the μ partial latin rectangles contains, set-wise, the same symbols and column j, likewise. In this paper we show that all μ-way latin trades with sufficiently large volumes exist, and state some theorems on the non-existence of μ-way latin trades of certain volumes. We also find the set of possible volumes (that is, the volume spectrum) of μ-way latin trades for μ = 4 and 5. (The case μ = 2 was dealt with by Fu,...
The three-way intersection problem for latin squares
, Article Discrete Mathematics ; Volume 243, Issue 1-3 , 2002 , Pages 1-19 ; 0012365X (ISSN) ; Billington, E. J ; Bryant, D. E ; Mahmoodian, E. S ; Sharif University of Technology
2002
Abstract
The set of integers k for which there exist three latin squares of order n having precisely k cells identical, with their remaining n2 -k cells different in all three latin squares, denoted by I3[n], is determined here for all orders n. In particular, it is shown that I3[n] = {0,.,n2 -15}U [n2 - 12,n2-9,n2], for n ≫8. ©2002 Eisevier Science B.V. All rights reserved
Integration of spatial fuzzy clustering with level set for segmentation of 2-D angiogram
, Article IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet", 8 December 2014 through 10 December 2014 ; December , 2015 , Pages 309-314 ; 9781479940844 (ISBN) ; Zahedi, E ; Fatemizadeh, E ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2015
Abstract
Coronary angiography is a vital instrument to detect the prevailing of vascular diseases, and accurate vascular segmentation acts a crucial role for proper quantitative analysis of the vascular tree morphological features. Level set methods are popular for segmenting the coronary arteries, but their performance is related to suitable start-up and optimum setting of regulating parameters, essentially done manually. This research presents a novel fuzzy level set procedure with the objective of segmentation of the coronary artery tree in 2-D X-ray angiography as automatically. It is clever to clearly develop from the early segmentation with spatial fuzzy grouping. The adjusting parameters of...
Deep relative attributes
, Article 13th Asian Conference on Computer Vision, ACCV 2016, 20 November 2016 through 24 November 2016 ; Volume 10115 LNCS , 2017 , Pages 118-133 ; 03029743 (ISSN); 9783319541921 (ISBN) ; Noury, E ; Adeli, E ; Sharif University of Technology
Springer Verlag
2017
Abstract
Visual attributes are great means of describing images or scenes, in a way both humans and computers understand. In order to establish a correspondence between images and to be able to compare the strength of each property between images, relative attributes were introduced. However, since their introduction, hand-crafted and engineered features were used to learn increasingly complex models for the problem of relative attributes. This limits the applicability of those methods for more realistic cases. We introduce a deep neural network architecture for the task of relative attribute prediction. A convolutional neural network (ConvNet) is adopted to learn the features by including an...
A public code for astrometric microlensing with contour integration
, Article Monthly Notices of the Royal Astronomical Society ; Volume 505, Issue 1 , 2021 , Pages 126-135 ; 00358711 (ISSN) ; Khalouei, E ; Bachelet, E ; Sharif University of Technology
Oxford University Press
2021
Abstract
We present the first public code for the calculation of the astrometric centroid shift occurring during microlensing events. The computation is based on the contour integration scheme and covers single and binary lensing of finite sources with arbitrary limb darkening profiles. This allows for general detailed investigations of the impact of finite source size in astrometric binary microlensing. The new code is embedded in version 3.0 of vbbinarylensing, which offers a powerful computational tool for extensive studies of microlensing data from current surveys and future space missions. © 2021 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society
Toward electrically tunable, lithography-free, ultra-thin color filters covering the whole visible spectrum
, Article Scientific Reports ; Volume 8, Issue 1 , 2018 ; 20452322 (ISSN) ; Serebryannikov, A. E ; Khavasi, A ; Vandenbosch, G. A. E ; Ozbay, E ; Sharif University of Technology
Nature Publishing Group
2018
Abstract
The possibility of real-time tuning of optical devices has attracted a lot of interest over the last decade. At the same time, coming up with simple lithography-free structures has always been a challenge in the design of large-area compatible devices. In this work, we present the concept and the sample design of an electrically tunable, lithography-free, ultra-thin transmission-mode color filter, the spectrum of which continuously covers the whole visible region. A simple Metal-Insulator-Metal (MIM) cavity configuration is used. It is shown that using the electro-optic dielectric material of 4-dimethyl-amino-N-methyl-4-stilbazoliumtosylate (DAST) as the dielectric layer in this...
A novel method for modeling the magnetizing yoke
, Article Electromagnetics ; Volume 30, Issue 3 , 2010 , Pages 297-308 ; 02726343 (ISSN) ; Norouzi, E
2010
Abstract
Magnetic flux leakage is the most widely used method for oil and gas pipeline non destructive testing. The saturation level of the sample under test has a significant effect on its efficiency; therefore, the magnetizing yoke requires an elaborate design. The finite element method is the conventional approach used for this purpose, but it is very time consuming. In this article, a neuro-fuzzy method is presented to model the behavior of the magnetizing yoke. Modeling a few different designs with the finite element method and using the results for training the neuro-fuzzy model eradicates the necessity of modeling a huge number of designs with the finite element method. The acquired...