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azimzadeh-sani--mahnaz
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Preparation and Investigation of Electrochemical Sensors for Determination of Pharmaceutical and Biological Compunds Based on Glassy Carbon Electrode Modified with Polypyrrole/Carbon Nanotube Composite
, M.Sc. Thesis Sharif University of Technology ; Shahrokhian, Saeed (Supervisor)
Abstract
In the recent years, conductive polymers are widely used in the design and construction of chemical and biological sensors.The polypyrrole due to features such as good thermal and chemical stability, ease of synthesis and better conductivity than other conductive polymers, atracts much attention. In order to modification of electrode surface,adhesiveand thin polymer films can be electropolymerized in the presence of organic or inorganic dopants on the surface of metal or carbon surfaces in aqueous or organic solutions. On the other hand carbon nanotubes by owing unique properties such as chemical stability and high electrical conductivity are good choice for electrod surface modification....
An Efficient Architecture for A Simplified Dalvik Processor
, M.Sc. Thesis Sharif University of Technology ; Goudarzi, Maziar (Supervisor)
Abstract
Google Inc. states that, 400 million Android-powered devices have been activated and used by people until 2012. This rapid growth of Android operating system in mobile phones and other electronic devices makes it very important to improve the efficiency of this Operating System. Dalvik is the underlying virtual machine (VM) in Android that executes Android-based applications, and hence, its performance directly affects Android-powered devices. De-virtualization is a technique to improve performance of VMs. In this method, VM’s instructions (bytecode) are natively and directly executed by hardware. In addition, de-virtualization technique eliminates the software interpretation/translation...
Production of drug Loaded Microgels Using Microfluidic
, M.Sc. Thesis Sharif University of Technology ; Saadatmand, Maryam (Supervisor) ; Eskandari, Mahnaz (Supervisor)
Abstract
Microfluidic systems have the ability to produce microgels with uniform size distribution and spherical shape due to the laminar flow and better control of the flow rates. Spherical microgels with same size can be used as high-potential carriers for drug release. An important challenge in the production of these drug-carrying microgels is the simultaneous process of drug loading into microgels and their production. The overall goal of this project was to produce drug-carrying microgels with uniform size distribution that show controlled drug release. To achieve this goal, various factors such as the type of polymer, the type of drug, the volume ratio of the polymer and the drug and the...
Performance analysis of android underlying virtual machine in mobile phones
, Article IEEE International Conference on Consumer Electronics - Berlin, ICCE-Berlin ; 2012 , Pages 292-295 ; 21666814 (ISSN) ; 9781467315470 (ISBN) ; Sameki, M ; Goudarzi, M ; Sharif University of Technology
2012
Abstract
In recent years, Android is widely used in cell phones. Dalvik is the virtual machine which is embedded inside the Android operating system, and executes the Android-based applications. Thus, improving efficiency of the Dalvik virtual machine plays an important role in optimizing performance of android-based mobile phones. In this paper, we present a comprehensive analysis of the Dalvik bytecodes and their frequency of use in common Android applications and use the results to determine the most frequently used bytecodes in Dalvik virtual machine to identify best targets for improvement. Our analysis showed that over 82% of total execution time of our Android benchmarks is spent by only 5...
GAG positioning on IL-1RI; A mechanism regulated by dual effect of glycosylation
, Article Glycobiology ; Volume 29, Issue 11 , 2019 , Pages 803-812 ; 14602423 (ISSN) ; Ejtehadi, M. R ; Sharif University of Technology
NLM (Medline)
2019
Abstract
IL-1RI is the signaling receptor for the IL-1 family of cytokines that are involved in establishment of the innate and acquired immune systems. Glycosylated extracellular (EC) domain of the IL-1RI binds to agonist such as IL-1β or antagonist ligands and the accessory protein to form the functional signaling complex. Dynamics and ligand binding of the IL-1RI is influenced by presence of the glycosaminoglycans (GAGs) of the EC matrix. Here a combination of molecular dockings and molecular dynamics simulations of the unglycosylated, partially N-glycosylated and fully N-glycosylated IL-1RI EC domain in the apo, GAG-bound and IL-1β-bound states were carried out to explain the co-occurring...
Glycan-mediated functional assembly of IL-1RI: structural insights into completion of the current description for immune response
, Article Journal of Biomolecular Structure and Dynamics ; 2020 ; Ejtehadi, M. R ; Sharif University of Technology
Taylor and Francis Ltd
2020
Abstract
Interleukin 1 Receptor type I (IL-1RI) is a multi-domain transmembrane receptor that triggers the inflammatory response. Understanding its detailed mechanism of action is crucial for treating immune disorders. IL-1RI is activated upon formation of its functional assembly that occurs by binding of the IL-1 cytokine and the accessory protein (Il-1RAcP) to it. X-ray crystallography, small-Angle X-ray Scattering and molecular dynamics simulation studies showed that IL-1RI adopts two types of ‘compact’ and ‘extended’ conformational states in its dynamical pattern. Furthermore, glycosylation has shown to play a critical role in its activation process. Here, classical and accelerated atomistic...
Glycan-mediated functional assembly of IL-1RI: structural insights into completion of the current description for immune response
, Article Journal of Biomolecular Structure and Dynamics ; Volume 40, Issue 6 , 2022 , Pages 2575-2585 ; 07391102 (ISSN) ; Ejtehadi, M. R ; Sharif University of Technology
Taylor and Francis Ltd
2022
Abstract
Interleukin 1 Receptor type I (IL-1RI) is a multi-domain transmembrane receptor that triggers the inflammatory response. Understanding its detailed mechanism of action is crucial for treating immune disorders. IL-1RI is activated upon formation of its functional assembly that occurs by binding of the IL-1 cytokine and the accessory protein (Il-1RAcP) to it. X-ray crystallography, small-Angle X-ray Scattering and molecular dynamics simulation studies showed that IL-1RI adopts two types of ‘compact’ and ‘extended’ conformational states in its dynamical pattern. Furthermore, glycosylation has shown to play a critical role in its activation process. Here, classical and accelerated atomistic...
Design and Fabrication of Microfluidic System to Produce Microgel for Drug Delivery Application
, M.Sc. Thesis Sharif University of Technology ; Bastani, Dariush (Supervisor) ; Saadatmand, Maryam (Supervisor) ; Eskandari, Mahnaz (Supervisor)
Abstract
Due to the increasing need of use of drugs and insufficient efficiency of conventional methods, drug delivery systems has gathered a lot of interests. There are different systems existing for controlled drug delivery, among which is implementation of hydrogel microparticles (microgels) as carriers with high potential. The most important factor in these systems is size distribution of drug-carrying microgels and a narrow size distribution leads to a controlled and suitable release. Due to unique characteristics of microfluidic systems, significant focus has been placed on them nowadays for production of microgels with suitable morphology and narrow size distribution. Therefore, in this study...
A Practical Examination of the Antibacterial and Absorption Effect of Bioceramic Apatite-Coated TiO2 as a Modified Nanophotocatalyst
, M.Sc. Thesis Sharif University of Technology ; Gholami, Mohammad Reza (Supervisor) ; Haghighi, Saeed (Co-Advisor)
Abstract
Ag / AgCl /TiO2 , 2 Ap / Ag / AgCl /TiO , 2 AgI /TiO and 2 Ap / AgI /TiO were prepared by the deposition-precipitation method on 2TiO (P25) nanoparticles and their photocatalyctic activities have been investigated under visible light and dark environments. Cationic surfactant plus 2 PVPI (topical solution and dry powder) as an iodine ion source and nonionic surfactant plus KI as an iodide ion source were used to prepar 2 AgI /TiO . In less than 30 minutes, 2 AgI /TiO which has been resulted from combination of cationic surfactant and 2 PVPI showed high efficiency on Escherichia coli under visible light when small quantities of it is used . However, AgCl sample prepared with cationic...
Elucidating the Roles of Interlukin I Receptor Type II (lL-1Rll) in the Regulation of Human Immune System, Atomistic Molecular Dynamics Simulation
, M.Sc. Thesis Sharif University of Technology ; Ejtehadi, Mohammad Reza (Supervisor) ; Azimzadeh Irani, Maryam (Co-Supervisor)
Abstract
IL-1 family of cytokines plays a critical role in the regulation of immune response.These cytokines transfer the signals to the target cells through binding to the IL-1 receptors.Interleukin 1 Receptor Type II (IL-1RII) is the decoy receptor of the IL-1 cytokines. IL-1RII is homologous to the signaling Interleukin 1 Receptor Type I (IL1RI) in its extracellular region and can bind to the same cytokines with higher affinity and the same accessory protein. It down-regulates the signaling and suppresses the downstream pathways due to the lack of the intracellular Toll-Interleukin Receptor (TIR) domain. IL-1RII is decorated by carbohydrate units in-vivo. Dynamics and ligand binding of receptors...
Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles
, Article Nanomedicine ; Volume 18, Issue 3 , 2023 , Pages 279-302 ; 17435889 (ISSN) ; Mousazadeh, M ; Taji, S ; Bahmani, A ; Khashayar, P ; Azimzadeh, M ; Mostafavi, E ; Sharif University of Technology
Newlands Press Ltd
2023
Abstract
AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug-dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and...
History based unsupervised data oriented parsing
, Article International Conference Recent Advances in Natural Language Processing, RANLP ; September , 2013 , Pages 453-459 ; 13138502 (ISSN) ; Ghasem Sani, G ; Sharif University of Technology
2013
Abstract
Grammar induction is a basic step in natural language processing. Based on the volume of information that is used by different methods, we can distinguish three types of grammar induction method: supervised, unsupervised, and semi-supervised. Supervised and semisupervised methods require large tree banks, which may not currently exist for many languages. Accordingly, many researchers have focused on unsupervised methods. Unsupervised Data Oriented Parsing (UDOP) is currently the state of the art in unsupervised grammar induction. In this paper, we show that the performance of UDOP in free word order languages such as Persian is inferior to that of fixed order languages such as English. We...
Continuous size-based focusing and bifurcating microparticle streams using a negative dielectrophoretic system
, Article Microfluidics and Nanofluidics ; Volume 14, Issue 1-2 , 2013 , Pages 265-276 ; 16134982 (ISSN) ; Saidi, M. S ; Sadeghi, A ; Sani, M
2013
Abstract
Dielectrophoresis (DEP) is an electrokinetic phenomenon which is used for manipulating micro- and nanoparticles in micron-sized devices with high sensitivity. In recent years, electrode-based DEP by patterning narrow oblique electrodes in microchannels has been used for particle manipulation. In this theoretic study, a microchannel with triangular electrodes is presented and a detailed comparison with oblique electrodes is made. For each shape, the behavior of particles is compared for three different configurations of applied voltages. Electric field, resultant DEP force, and particle trajectories for configurations are computed by means of Rayan native code. The separation efficiency of...
A lagged implicit segregated data reconstruction procedure to treat open boundaries
, Article Journal of Computational Physics ; Volume 229, Issue 14 , July , 2010 , Pages 5418-5431 ; 00219991 (ISSN) ; Saidi, M. S ; Sharif University of Technology
2010
Abstract
The problem of treating open boundaries is still a challenging one. Applying fully developed condition is constrained to long enough domains. Without having enough physical evidence about what happens on boundaries, the domain extent could not be shortened and computational costs could not be reduced. From the advent of free (open) boundary conditions, they were confined to mixed finite element procedures. Recent works have extended their application to coupled finite volume solvers based on the shape function data reconstruction. A wider class of flow solvers available, however, rely on the segregated procedure where the velocity components and pressure are solved in succession. Moreover,...
Rayan: A polyhedral grid co-located incompressible finite volume solver (Part I: Basic design features)
, Article Scientia Iranica ; Volume 17, Issue 6 B , NOVEMBER-DECEMBE , 2010 , Pages 443-455 ; 10263098 (ISSN) ; Saidi, M. S ; Sharif University of Technology
2010
Abstract
In this work, basic design features of Rayan are documented. One of the new design features presented in this work is the way Rayan handles polyhedral grids. Grid definition is combined with the definition of the structure of the sparse coefficient matrix, thereby releasing a considerable part of the memory used by the grid to store otherwise required faces belonging to the cell part of the connectivity description. The key idea is to use a uniform way for creating the structure of the coefficient matrix from the grid connectivity description and to access that data when computing the elements of the coefficient matrix. This saving requires many modifications to the computational algorithm...
Heuristic search by guided enforced hill climbing in fast forward automated planning
, Article Journal of Scientific and Industrial Research ; Volume 68, Issue 4 , 2009 , Pages 278-284 ; 00224456 (ISSN) ; Ghasem Sani, G ; Sharif University of Technology
2009
Abstract
Enforced hill climbing (EHC), a heuristicaa search method, has been frequently used in a number of AI planning systems. This paper presents a new form of EHC, guided enforced hill climbing (GEHC), to enhance EHC efficiency. Main feature in GEHC is an adaptive ordering function. GEHC has shown a significant improvement in EHC efficiency, especially when applied to larger problems
A set of particle locating algorithms not requiring face belonging to cell connectivity data
, Article Journal of Computational Physics ; Volume 228, Issue 19 , 2009 , Pages 7357-7367 ; 00219991 (ISSN) ; Saidi, M. S ; Sharif University of Technology
2009
Abstract
Existing efficient directed particle locating (host determination) algorithms rely on the face belonging to cell relationship (F2C) to find the next cell on the search path and the cell in which the target is located. Recently, finite volume methods have been devised which do not need F2C. Therefore, existing search algorithms are not directly applicable (unless F2C is included). F2C is a major memory burden in grid description. If the memory benefit from these finite volume methods are desirable new search algorithms should be devised. In this work two new algorithms (line of sight and closest cell) are proposed which do not need F2C. They are based on the structure of the sparse...
Incremental learning of planning operators in stochastic domains
, Article 33rd Conference on Current Trends in Theory and Practice of Computer Science, SOFSEM 2007, Harrachov, 20 January 2007 through 26 January 2007 ; Volume 4362 LNCS , 2007 , Pages 644-655 ; 03029743 (ISSN); 9783540695066 (ISBN) ; Ghassem Sani, G ; Sharif University of Technology
Springer Verlag
2007
Abstract
In this work we assume that there is an agent in an unknown environment (domain). This agent has some predefined actions and it can perceive its current state in the environment completely. The mission of this agent is to fulfill the tasks (goals) that are often assigned to it as fast as it can. Acting has lots of cost, and usually planning and simulating the environment can reduce this cost. In this paper we address a new approach for incremental induction of probabilistic planning operators, from this environment while the agent tries to reach to its current goals. It should be noted that there have been some works related to incremental induction of deterministic planning operators and...
LHTNDT: Learn HTN method preconditions using decision tree
, Article ICINCO 2008 - 5th International Conference on Informatics in Control, Automation and Robotics, Funchal, Madeira, 11 May 2008 through 15 May 2008 ; Volume ICSO , January , 2008 , Pages 60-65 ; 9789898111319 (ISBN); 9789898111302 (ISBN) ; Ghassem Sani, G ; Sharif University of Technology
2008
Abstract
In this paper, we describe LHTNDT, an algorithm that learns the preconditions of HTN methods by examining plan traces produced by another planner. LHTNDT extracts conditions for applying methods by using decision tree based algorithm. It considers the state of relevant domain objects in both current and goal states. Redundant training samples are removed using graph isomorphism. Our experiments, LHTNDT converged. It can learn most of preconditions correctly and quickly. 80% of our test problems were solved by preconditions extracted by 3/4 of plan traces needed for full convergence
History-based inside-outside algorithm
, Article Frontiers in Artificial Intelligence and Applications ; Volume 141 , 2006 , Pages 558-562 ; 09226389 (ISSN) ; 9781586036423 (ISBN) ; Ghassem Sani, G ; Sharif University of Technology
2006
Abstract
Grammar induction is one of the most important research areas of the natural language processing. The lack of a large Treebank, which is required in supervised grammar induction, in some natural languages such as Persian encouraged us to focus on unsupervised methods. We have found the Inside-Outside algorithm, introduced by Lari and Young, as a suitable platform to work on, and augmented IO with a history notion. The result is an improved unsupervised grammar induction method called History-based IO (HIO). Applying HIO to two very divergent natural languages (i.e., English and Persian) indicates that inducing more conditioned grammars improves the quality of the resultant grammar. Besides,...