Sharif Digital Repository

The oxidation-reduction (redox) responsive micelle system is based on a diselenide-containing triblock copolymer, poly(ε-caprolactone)-bis(diselenide-methoxy poly(ethylene glycol)/poly(ethylene glycol)-folate) [PCL-(SeSe-mPEG/PEG-FA)2]. Resulting in the development of tumor-targeted delivery for hydrophobic anticancer drugs. The diselenide bond, as redox-sensitive linkage, was designed, so it is located at the hydrophilic/hydrophobic hinge to allow complete micelles collapse and efficient drug release, in redox environments. The amphiphilic block copolymers self-assembled into micelles at concentrations above the critical micelle concentration (CMC) in an aqueous environment. Dynamic light... 

In the world today, biological materials widely used are which requires proper packaging, the types of enzymes are used in various industries: food, pharmaceutical, cosmetics. Shelf Life of enzymes Limited and affected by internal and external factors a maximum of one year. Internal factors include water activity, pH, microbial flora, oxidation-reduction potential, chemistry and biochemistry products, product formulation, additives and the reaction with package. External factors such as relative humidity, light, gas atmosphere within the package, the storage conditions and temperature. Water activity and relative humidity are important factors in spoilage. Avoid drying, lipid reaction,... 

DNA Microarray is the state-of-the-art technology in analyzing gene expression data. It has made it possible to measure expression levels of thousand of genes simultaneously. Microarray classification has been widely used in effective diagnosis of cancers and some other biological diseases. But the most challenging issue is the intense asymmetry between the dimensionality of genes and tissue samples which can wreck the classification performance. This dissertation will focus on gene selection and reduction solutions and presents a novel classification scheme which uses both gene selection and dimension reduction in its different stages. We have improved one of the recently proposed topology... 

Since the classical continuum theory fails to deal with the problems associated with defects, stress concentrators, and relevant deformation phenomena in solids, alternative approaches that can detect the atomistic nature of materials' fracture are required. The deficiency of the capture the size effect which yields delusively high values for some components of the stress field right on the edge of the stress concentrators, and its weakness in describing the complex interaction between small inhomogeneities, cracks and the like when they are only a few nanometers apart, are among some of the disadvantages of the classical approach. In recent years, however, atomistic methods are emerging to... 

Aluminum Bronzes have many applications in marine environments. These alloys suffer from both hot cracking and cold cracking. In order to overcome the hot cracking and cold cracking, Semisolid Stir Joining method and a proper thermal cycle was used respectively. Effects of temperature, stirring rate, and tool type were investigated in Semisolid Stir joining method. In this method, butt joint design was used in order to place specimens, and the specimens were heated up to specific temperatures (920, 925, 930°C). A stirrer (Cylindrical and Grooved tool) with three rotational speeds (800, 1200, 1600 RPM) was introduced into the stir weld seam. Welded specimens were cooled to the 900°C... 

The low female labor force participation rate in the Iranian labor market relative to the global average and even to countries that do not differ significantly from the socio-economic characteristics of our country is one of the important questions of the Iranian labor market. In this study, we seek to answer the question of whether the economic participation rate of married women will increase if the gender gaps in wages, job findings and job losses among women and men are eliminated in the Iranian labor market. To answer this question using household expenditure and income data and labor force data, we show that between the two categories of occupations, in terms of the share of women's...