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    Gene Selection and Reduction in DNA Microarrays to Improve Classification Accuracy of Cancerous Samples

    , M.Sc. Thesis Sharif University of Technology Baharvand Irannia, Zohreh (Author) ; Rabiee, Hamid Reza (Supervisor)
    Abstract
    DNA Microarray is the state-of-the-art technology in analyzing gene expression data. It has made it possible to measure expression levels of thousand of genes simultaneously. Microarray classification has been widely used in effective diagnosis of cancers and some other biological diseases. But the most challenging issue is the intense asymmetry between the dimensionality of genes and tissue samples which can wreck the classification performance. This dissertation will focus on gene selection and reduction solutions and presents a novel classification scheme which uses both gene selection and dimension reduction in its different stages. We have improved one of the recently proposed topology... 

    ANMR: aging-aware adaptive N-modular redundancy for homogeneous multicore embedded processors

    , Article Journal of Parallel and Distributed Computing ; Volume 109 , 2017 , Pages 29-41 ; 07437315 (ISSN) Baharvand, F ; Miremadi, S. G ; Sharif University of Technology
    2017
    Abstract
    Advances in semiconductor technology have made integration of multiple processing cores into one single die a promising trend towards increasing processing performance, lowering power consumption, and increasing reliability for embedded systems. Multicore processors, due to their intrinsic redundancies, are good choices for critical embedded systems for which the reliability is a crucial component. In this paper, an aging-aware adaptive fault tolerance method for DVFS-enabled multicore processors is presented. The analytical results show 3 to 6 order of magnitude increase in reliability of the system without addition of cores or redundant software. By using an aging-aware approach, the... 

    LEXACT: low energy n-modular redundancy using approximate computing for real-time multicore processors

    , Article IEEE Transactions on Emerging Topics in Computing ; 2017 ; 21686750 (ISSN) Baharvand, F ; Ghassem Miremadi, S ; Sharif University of Technology
    2017
    Abstract
    Multicore processors are becoming popular in safety-critical applications. A series of these applications comprises of kernels where inexact computations may produce results within the boundary of sufficient quality though, for which the reliability should stay at the maximum possible level. Intrinsic core-level redundancy in multicore processors can be leveraged to achieve the desired reliability level in form of N-modular redundancy (NMR). While NMR provides a proactive means of reliability for critical systems, it has two main drawbacks: Increase in the area and energy consumption that are both limiting factors in the embedded systems. This paper presents a software-based method to... 

    LEXACT: low energy n-modular redundancy using approximate computing for real-time multicore processors

    , Article IEEE Transactions on Emerging Topics in Computing ; Volume 8, Issue 2 , 2020 , Pages 431-441 Baharvand, F ; Miremadi, S. G ; Sharif University of Technology
    IEEE Computer Society  2020
    Abstract
    Multicore processors are becoming popular in safety-critical applications. A series of these applications comprises of kernels where inexact computations may produce results within the boundary of sufficient quality though, for which the reliability should stay at the maximum possible level. Intrinsic core-level redundancy in multicore processors can be leveraged to achieve the desired reliability level in form of N-modular redundancy (NMR). While NMR provides a proactive means of reliability for critical systems, it has two main drawbacks: Increase in the area and energy consumption that are both limiting factors in the embedded systems. This paper presents a software-based method to... 

    Hydrazine-modified starch coated magnetic nanoparticles as an effective pH-responsive nanocarrier for doxorubicin delivery

    , Article Journal of Industrial and Engineering Chemistry ; Volume 39 , 2016 , Pages 203-209 ; 1226086X (ISSN) Zohreh, N ; Hosseini, S. H ; Pourjavadi, A ; Sharif University of Technology
    Korean Society of Industrial Engineering Chemistry  2016
    Abstract
    A novel, magnetic nanocarrier was successfully synthesized through a facile and economical producer in which Fe3O4 magnetic nanoparticles were coated by starch-g-poly (methyl methacrylate-co-PEG-acrylamide). The surface of nanocarrier was then modified by hydrazine to preparation of a pH-responsive carrier. The resulted nanocarrier was applied for delivery of doxorubicin (DOX) as an effective anti-cancer drug. DOX was reacted with hydrazine linkage on the surface of nanocarrier to form hydrazone bond. Due to the presence of numerous hydrazine groups on the surface of magnetic nanocarrier large amounts of DOX was loaded onto the carrier (327 mg g−1). © 2016 The Korean Society of Industrial... 

    Study Optimum Conditions and Proper Packaging of Amylase

    , M.Sc. Thesis Sharif University of Technology Baharvand, Mina (Author) ; Roosta Azad, Reza (Supervisor)
    Abstract
    In the world today, biological materials widely used are which requires proper packaging, the types of enzymes are used in various industries: food, pharmaceutical, cosmetics. Shelf Life of enzymes Limited and affected by internal and external factors a maximum of one year. Internal factors include water activity, pH, microbial flora, oxidation-reduction potential, chemistry and biochemistry products, product formulation, additives and the reaction with package. External factors such as relative humidity, light, gas atmosphere within the package, the storage conditions and temperature. Water activity and relative humidity are important factors in spoilage. Avoid drying, lipid reaction,... 

    Synthesis & Properties of Nd-doped Glass-ceramics in the SiO2-CaO-MgO System from Sol-gel Method Used as Solid Lasers

    , M.Sc. Thesis Sharif University of Technology Eslami, Masoud (Author) ; Hamnabard, Zohreh (Supervisor) ; Nemati, Ali (Supervisor)
    Abstract
    In this study, SiO2-CaO-MgO galsses and glass-ceramic powder doped with Nd3+ were synthesized with sol-gel method. Tetraethylorthosilicate (TEOS), Ca(NO3)2.4H2O, Mg(NO3)2.6H2O, Nd(NO3)3.6H2O, ethanol, distilled water, and HNO3 were used as starting materials. The synthesized powder’s properties were examined with STA, XRD, DRS, PL, FTIR and SEM analysis. From XRD patterns of glass samples, the role of dopant was introduced as intermediate oxide in glass matrix. The XRD patterns of glass-ceramic samples indicated that the bredigite and akermanite crystals were formed in glass matrix. The band gap energy of samples were calculated from DRS analysis and were seen with increasing the dopant... 

    Cross-linked poly (dimethylaminoethyl acrylamide) coated magnetic nanoparticles: a high loaded, retrievable, and stable basic catalyst for the synthesis of benzopyranes in water

    , Article RSC Advances ; Vol. 4, issue. 91 , 2014 , p. 50047-50055 Zohreh, N ; Hosseini, S. H ; Pourjavadi, A ; Bennett, C ; Sharif University of Technology
    2014
    Abstract
    A novel heterogeneous catalyst has been synthesized based on the distillation-precipitation-polymerization of methyl acrylate onto modified magnetic nanoparticles followed by the amidation of the methyl ester groups using N,N-dimethylethylenediamine. The resulting poly(dimethylaminoethyl acrylamide) coated magnetic nanoparticles (MNP@PDMA) catalyst was characterized using an array of sophisticated analytical techniques, including FT-IR, TGA, SEM, TEM, CHN, vibrating sample magnetometer (VSM), and XRD analysis. The resulting heterogeneous base catalyst allowed the performance of a domino Knoevenagel condensation/Michael addition/cycloaddition reaction toward the synthesis of... 

    Magnetic nanoparticles entrapped in the cross-linked poly(imidazole/imidazolium) immobilized Cu(ii): An effective heterogeneous copper catalyst

    , Article RSC Advances ; Volume 4, Issue 87 , 2014 , Pages 46418-46426 ; ISSN: 20462069 Pourjavadi, A ; Hosseini, S. H ; Zohreh, N ; Bennett, C ; Sharif University of Technology
    2014
    Abstract
    Anchoring of copper sulfate in layered poly(imidazole-imidazolium) coated magnetic nanoparticles provided a highly stable, active, reusable, high loading, and green catalyst for the click synthesis of 1,2,3-triazoles via a one-pot cycloaddition of alkyl halide, azide, and alkyne (Cu-A3C). The catalyst was characterized by FTIR, TGA, TEM, SEM, XRD, EDAX, VSM and AAS. High selectivity, broad diversity of alkyl/benzyl bromide/chloride and alkyl/aryl terminal alkynes, and good to excellent yields of products were obtained using 0.7 mol% catalyst. The catalyst was readily recovered and reused up to 6 times without significant loss of activity  

    Alumina feeding system changes in aluminum electrochemical cell with d18 technology for energy efficiency (Case study: Almahdi-hormozal aluminum smelter)

    , Article 147th Annual Meeting and Exhibition of the Minerals, Metals and Materials Society, TMS 2018, 11 March 2018 through 15 March 2018 ; Volume Part F12 , 2018 , Pages 721-728 ; 23671181 (ISSN); 9783319725253 (ISBN) Siahooei, M. A ; Samimi, A ; Baharvand, B ; Sharif University of Technology
    Springer International Publishing  2018
    Abstract
    Aluminum reduction cells have benefited from point feeding technology for a long time, but there are still smelters which are using the old technology of center break and center feed system. Due to several factors this system is no longer approved and there have been a few attempts worldwide to upgrade these cells so as to implement the newer technology by applying mechanical and automation changes. In this paper we will present an attempt which was made in order to retrofit a so-called center break cell to point feeder cell. The results show that this project has decreased the energy consumption and anode effect frequency. Furthermore, there has been a significant increase in current... 

    Rating EFL Learner's Interlanguag Pragmatic Competence by Native and Non-native English Speaking Teachers

    , M.Sc. Thesis Sharif University of Technology Rezanejad, Atefeh (Author) ; Alemi, Minoo (Supervisor) ; Eslami Rasekh, Zohreh (Co-Advisor)
    Abstract
    Pragmatic assessment and consistency in rating are among the subject matters which are still in need of more in-depth investigations. The significance of the issue is highlighted when remembering that inconsistency in ratings would surely damage the test fairness issue in assessment and lead to much diversity in ratings. The purpose of this study was investigating the criteria that native (American) and non-native (Iranian) English speaking teachers considered while rating the pragmatic productions of Iranian EFL learners regarding the two speech acts of compliment and compliment response. Overall, a hundred and twenty teachers (sixty native and sixty non-native raters) participated in this... 

    Immobilized copper(II) on nitrogen-rich polymer-entrapped Fe3O4 nanoparticles: A highly loaded and magnetically recoverable catalyst for aqueous click chemistry

    , Article Applied Organometallic Chemistry ; Volume 30, Issue 2 , 2016 , Pages 73-80 ; 02682605 (ISSN) Zohreh, N ; Hosseini, S. H ; Pour Javadi, A ; Bennett, C ; Sharif University of Technology
    John Wiley and Sons Ltd  2016
    Abstract
    A heterogeneous magnetic copper catalyst was prepared via anchoring of copper sulfate onto multi-layered poly(2-dimethylaminoethyl acrylamide)-coated magnetic nanoparticles and was characterized using various techniques. The catalyst was found to be active, effective and selective for one-pot three-component reaction of alkyl halide, sodium azide and alkyne, known as copper-catalyzed click synthesis of 1,2,3-triazoles. As little as 0.3 mol% of catalyst was found to be effective under the optimum conditions. The catalyst could also be recycled and reused up to seven times without significant loss of activity. Thermal stability, high loading level of copper on catalyst, broad diversity of... 

    Covalent immobilization of cellulase using magnetic poly(ionic liquid) support: improvement of the enzyme activity and stability

    , Article Journal of Agricultural and Food Chemistry ; Volume 66, Issue 4 , 2018 , Pages 789-798 ; 00218561 (ISSN) Hosseini, H ; Hosseini, A ; Zohreh, N ; Yaghoubi, M ; Pourjavadi, A ; Sharif University of Technology
    American Chemical Society  2018
    Abstract
    A magnetic nanocomposite was prepared by entrapment of Fe3O4 nanoparticles into the cross-linked ionic liquid/epoxy type polymer. The resulting support was used for covalent immobilization of cellulase through the reaction with epoxy groups. The ionic surface of the support improved the adsorption of enzyme, and a large amount of enzyme (106.1 mg/g) was loaded onto the support surface. The effect of the presence of ionic monomer and covalent binding of enzyme was also investigated. The structure of support was characterized by various instruments such as FT-IR, TGA, VSM, XRD, TEM, SEM, and DLS. The activity and stability of immobilized cellulase were investigated in the prepared support. The... 

    Immobilized tungstate on magnetic poly(2-ammonium ethyl acrylamide): A high loaded heterogeneous catalyst for selective oxidation of sulfides using H2O2

    , Article Journal of Industrial and Engineering Chemistry ; Volume 44 , 2016 , Pages 73-81 ; 1226086X (ISSN) Zohreh, N ; Hosseini, S. H ; Pourjavadi, A ; Soleyman, R ; Bennett, C ; Sharif University of Technology
    Korean Society of Industrial Engineering Chemistry  2016
    Abstract
    A heterogeneous tungstate-based catalyst has been prepared for selective oxidation of sulfides to sulfoxides in the presence of 30% H2O2. The catalyst was prepared via immobilization of high amounts of WO4 2− onto the cross-linked poly(ammonium ethyl acrylamide) coated magnetic nanoparticles (MNP). FT-IR, TEM, TGA, VSM, XRD, EDX, and CHN analysis were used for characterization of catalyst. Variety of sulfides successfully converted to the related sulfoxides using 1 mol% of catalyst at room temperature in high yields. The catalyst was easily recovered and reused up to 6 times without loss of activity  

    Tungstate-loaded triazine-based magnetic poly(Bis-imidazolium ionic liquid): An effective bi-functional catalyst for tandem selective oxidation/Knoevenagel condensation in water

    , Article Polymer (United Kingdom) ; Volume 112 , 2017 , Pages 342-350 ; 00323861 (ISSN) Zohreh, N ; Tavakolizadeh, M ; Hosseini, S. H ; Pourjavadi, A ; Bennett, C ; Sharif University of Technology
    Elsevier Ltd  2017
    Abstract
    A novel bi-functional polymeric catalyst was synthesized by immobilization of tungstate anions onto the nitrogen rich poly(ionic liquid)/magnetic nanocomposite. The resulting catalyst has two types of catalytic sites: (i) immobilized WO4 anions with bis-imidazolium ionic liquid cation for selective oxidation of alcohols and (ii) basic amine groups for Knoevenagel condensation between produced aldehyde and malononitrile. Due to the polymeric nature of the catalyst, large amounts of tungstate and basic nitrogen groups were presented on the solid surface which led to a decrease in the applied catalyst mass for catalytic reaction. High catalytic activity and excellent selectivity of catalyst in... 

    TAMER: an adaptive task allocation method for aging reduction in multi-core embedded real-time systems

    , Article Journal of Supercomputing ; 2020 Saadatmand, F. S ; Rohbani, N ; Baharvand, F ; Farbeh, H ; Sharif University of Technology
    Springer  2020
    Abstract
    Technology scaling has exacerbated the aging impact on the performance and reliability of integrated circuits. By entering into nanotechnology era in recent years, the power density per unit of area has increased, which leads to a higher chip temperature. Aging in a chip is originated from multiple phenomena; all of them are intensified by increased temperature. Several circuit- and architecture-level schemes tried to mitigate the aging in the literature. However, these schemes are not sufficient for multi-core systems due to their unawareness of the unique constraints and features of these platforms. In this paper, we propose a system-level aging mitigation method, so-called Adaptive Task... 

    TAMER: an adaptive task allocation method for aging reduction in multi-core embedded real-time systems

    , Article Journal of Supercomputing ; Volume 77, Issue 2 , 2021 , Pages 1939-1957 ; 09208542 (ISSN) Saadatmand, F. S ; Rohbani, N ; Baharvand, F ; Farbeh, H ; Sharif University of Technology
    Springer  2021
    Abstract
    Technology scaling has exacerbated the aging impact on the performance and reliability of integrated circuits. By entering into nanotechnology era in recent years, the power density per unit of area has increased, which leads to a higher chip temperature. Aging in a chip is originated from multiple phenomena; all of them are intensified by increased temperature. Several circuit- and architecture-level schemes tried to mitigate the aging in the literature. However, these schemes are not sufficient for multi-core systems due to their unawareness of the unique constraints and features of these platforms. In this paper, we propose a system-level aging mitigation method, so-called Adaptive Task... 

    Highly dispersible bis-imidazolium/WO4 2 modified magnetic nanoparticles: a heterogeneous phase transfer catalyst for green and selective oxidations

    , Article New Journal of Chemistry ; Volume 40, Issue 12 , 2016 , Pages 10325-10332 ; 11440546 (ISSN) Zohreh, N ; Tavakolizadeh, M ; Hosseini, S. H ; Jahani, M ; Pourjavadi, A ; Bennett, C ; Sharif University of Technology
    Royal Society of Chemistry  2016
    Abstract
    A novel magnetically recoverable catalyst was prepared in which magnetic nanoparticles (MNPs) were functionalized by bis-imidazolium tungstate ionic liquid molecules. The resulting catalyst was highly dispersible in water and selectively oxidized a wide range of alcohols and sulfides using H2O2 as a green oxidant. The catalyst was easily recovered and reused at least 5 times under the described reaction conditions without any significant loss of reactivity  

    Mechanical reinforcement of urinary bladder matrix by electrospun polycaprolactone nanofibers

    , Article Scientia Iranica ; Volume 24, Issue 6 , 2017 , Pages 3476-3480 ; 10263098 (ISSN) Ghafari, A. M ; Rajabi Zeleti, S ; Naji, M ; Ghanian, M. H ; Baharvand, H ; Sharif University of Technology
    2017
    Abstract
    For a successful repair and reconstruction of bladder tissue, fabrication of scaffolds with proper biochemical and biomechanical characteristics is necessary. Decellularized bladder tissue has been proposed in previous studies as a gold standard material for scaffold fabrication. However, weak mechanical properties of such a load-bearing tissue has remained a challenge. Incorporation of both biological and synthetic materials has been known as an effective strategy for improving mechanical and biological properties of the scaffolds. In the present work, a simple process was developed to fabricate hybrid hydrogel scaffolds with a biomimetic architecture from the natural urinary bladder... 

    Multifunctional conductive biomaterials as promising platforms for cardiac tissue engineering

    , Article ACS Biomaterials Science and Engineering ; Volume 7, Issue 1 , 2021 , Pages 55-82 ; 23739878 (ISSN) Mousavi, A ; Vahdat, S ; Baheiraei, N ; Razavi, M ; Norahan, M. H ; Baharvand, H ; Sharif University of Technology
    American Chemical Society  2021
    Abstract
    Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic potential for the heart to self-regenerate. The introduction of novel approaches in cardiac tissue engineering aims to repair damages from cardiovascular diseases. Recently, conductive biomaterials such as carbon- and gold-based nanomaterials, conductive polymers, and ceramics that have outstanding electrical conductivity, acceptable mechanical properties, and promoted cell-cell signaling transduction have attracted attention for use in cardiac tissue engineering. Nevertheless, comprehensive classification of conductive biomaterials from the perspective of cardiac cell function is a subject for...