Sharif Digital Repository

Breast cancer is the fifth cause of death from cancer and one of the most common fatal cancers in women. The commonly drugs used to treat cancer often destroy healthy tissues and cells and cause common side effects. It is also necessary to consume a large amount of the drug to achieve a particular effect. One of the applications of nanotechnology is drug delivery. Niosomes are one of the newest drug delivery systems that are nowadays much more widely considered due to better penetration and controlled release. One of the most effective medicines for treating breast cancer is statins. These drugs are a group of lipids lowering drugs that lower the synthesis of cholesterol by inhibiting the... 

Neural system in human body due to limitated cell proliferation requires high care, because the damage causes serious hurts and disables different tissues. Limit regeneration in central neural system can cause different neural diseases including brain exhaustions specially in old people, but the peripheral neural system may have been disabled and intrupt some other tissue beacuase of possible external injuries before aging. So that while some damages like neural fibers severing, some new medical care methods are required. Some of these methods are outograft, allograft and xenograft which implants neural tissues either between other patient's tissues or from somebody else's; however these... 

Ordinary structures absorb a large amount of input energy by structural elements whereas failure in these elements causes a huge loss in structure and it’s really difficult to repair or unrepairable. Nowadays a wide range of metallic dampers is used in structures as fuse elements. this research evaluates the response of structures that are equipped with a novel steel damper named Telescopic Lead Yield Damper (TLYD) which was introduced by Eskandari in 2018. As TLYD has a different yielding plateau it can tolerate large deformations. In this research firstly this novel damper was introduced and the performance of the damper under cyclic loading was demonstrated. Then a numerical model of 6,... 

It is assumed in many traffic assignment models that people choose their path based on shortest travel time. Few empirical studies of revealed route characteristics have been reported in the literature. In this study, first, an innovative internet-based survey using Google map has been designed and implemented. The sample includes the people who commute to Sharif University of Technology in the morning peak hours. Next, observed routes in 134 valid questionnaires have been analyzed by using Tehran network database and VBA programming. Besides the length and travel time of each path, other characteristics of the observed route such as the number of right, left, and U-turns, number of... 

Enhancement of photocatalytic characteristics of semiconductors have been always a challenge for the researchers. Doping semiconductors for adjusting their energy gap and changing their morphology in order to increase their effective surface area and reaction sites are examples of their endeavor to overcome the challenge. In this research, nanostructured Aluminum Titanate powder was synthesized with Sol-Gel process and by altering synthesis parameters, the best synthesis condition to get the best possible band gap was discovered. Moreover, we examined the photocatalytic properties of the recently developed material “tialite”, which were not studied before and also evaluated the effect... 

Hydrodynamics of flow is affected by physical and biological interactions between flow and aquatic vegetation. This study represents the role of array distribution on lateral dispersion in emergent aquatic vegetation using two flexible and semi-rigid models. Experiments were carried out with three different arrangements, including random, staggered, and in-line. The Reynolds numbers at the stem scale ranged from 120 to 690, and the stem densities were 1% and 1.44%. Furthermore, the effects of stem flexibility and, specifically, stem resonance on lateral dispersion were examined. An image processing technique was used to measure plume width and calculate lateral dispersion. It was found that... 

In this project we plan to propose a mechanism for controlling the profile of vertebra displacment and intera-discal pressure in in-vitro tests. Spineis the one of the most important members of the human musculoskeletal system. Health and stability of the spine help the people to moves on two legs. So any problems with this organ, causing movement problems and pain. For the treatment of spinal diseases, several methods such as surgery, insertion of implants and stabilizing were used. To ensure the accuracy of these methods, laboratory examination is essential. One of the ways to test these interventions, the implementation of in vitro tests on samples obtained from the bodies of the spine.... 

In recent years, advances in medical science and increasing the level of healthcare have increased the life expectancy index; But in the meantime, a phenomenon called “diseases related to life expectancy” has appeared. Bone and skeletal diseases have a significant share in this category because the passage of time reduces bone mineral density and this is the source of many diseases, including osteoporosis. Current bone therapies, which include autologous and allogeneic bone grafts, will not meet this high need. Bone tissue engineering has been proposed as a potential alternative to solve this challenge. In bone tissue engineering, the essential components required for bone formation and...