Sharif Digital Repository

The one-pot, three-component condensation of benzil, benzonitrile derivatives and primary amines on the surface of silica gel under solvent-free conditions and microwave irradiation provided tetrasubstituted imidazoles in high yields. © 2003 Elsevier Science Ltd. All rights reserved  

This study aims to assess the impact of the spacing between cylinders on their dynamic behaviour. Observations during this experiment have helped to identify the effect of spacing on excitation mechanism of each cylinder as well as establishing the relationship between cylinders response and the spacing between them. Arrays of cylindrical Structures in close proximity are common in variety of engineering structures, particularly in the offshore industry. If the cylinders are flexible, and are subject to excitation from fluid flow, then the dynamics is influenced by complex interactions between the cylinders, dependent on a variety of parameters. Two cylinders were flexibly mounted in tandem... 

A molecularly imprinted xerogel (MIX) for fentanyl was successfully prepared on the inner surface of a copper tube by sol-gel technology. Primarily, the tube was treated by self-assembly monolayers of 3-(mercaptopropyl) trimethoxysilane and then [3-(2,3-epoxypropoxy)-propyl]-trimethoxysilane was employed as a precursor for imprinting the template molecule in acidic conditions. During the sol-gel process influential parameters including volume and concentration of fentanyl were carefully investigated to obtain the most efficient and appropriate xerogel. In parallel, a non-imprinted xerogel (NIX) was synthesized in the absence of fentanyl. The extraction efficiencies achieved from MIX and NIX,... 

C14H11ClN2O, triclinic P1̄ (no. 2), a = 9.380(2) Å, b = 17.238(4) Å, c = 17.735(5) A&ring, α = 118.456(4)°, β = 98.935(5)°, γ = 92.811(5)°, V = 2465.5 Å3, Z = 8, Rgt(F) = 0.104, wRref(F 2) = 0.205, T = 200 K. © by Oldenbourg Wissenschaftsverlag  

Migration to the cloud has been a popular topic in industry and academia in recent years. Despite many benefits that the cloud presents, such as high availability and scalability, most of the on-premise application architectures are not ready to fully exploit the benefits of this environment, and adapting them to this environment is a non-trivial task. Microservices have appeared recently as novel architectural styles that are native to the cloud. These cloud-native architectures can facilitate migrating on-premise architectures to fully benefit from the cloud environments because non-functional attributes, like scalability, are inherent in this style. The existing approaches on cloud... 

A nonlinear mathematical model is developed in the time domain to simulate the behaviour of two identical flexibly mounted cylinders in tandem while undergoing vortex-induced vibration (VIV). Subsequently, the model is validated and modified against experimental results. Placing an array of bluff bodies in proximity frequently happens in different engineering fields. Chimney stacks, power transmission lines and oil production risers are few engineering structures that may be impacted by VIV. The coinciding of the vibration frequency with the structure natural frequency could have destructive consequences. The main objective of this study is to provide a symplectic and reliable model capable... 

Microservices architectures are becoming the defacto standard for building continuously deployed systems. At the same time, there is a substantial growth in the demand for migrating on-premise legacy applications to the cloud. In this context, organizations tend to migrate their traditional architectures into cloud-native architectures using microservices. This article reports a set of migration and rearchitecting design patterns that we have empirically identified and collected from industrial-scale software migration projects. These migration patterns can help information technology organizations plan their migration projects toward microservices more efficiently and effectively. In... 

Water-soluble peptidocalix[4]arenes were synthesized by the introduction of arginine-rich narrow groove-binding residues at lower rims through solid-phase synthesis. The study of binding of these water-soluble bidentate ligands to well-matched and mismatched DNA duplexes by fluorescent titrations, ethidium bromide (EB) displacement assays, DNA-melting experiments, and circular dichroism (CD) analysis revealed a sequence-dependent groove-binding mechanism  

A series of 3-cyano-2-pyridone derivatives were synthesized by one-pot four-component condensation reaction involving a benzaldehyde derivative, alkyl cyanoacetate, acyclic or cyclic ketones, and ammonium acetate in reflux condition. The X-ray structure of the products 5a and 5d confirm symmetric dimers via hydrogen bonding interactions between individual pyridine molecules showing, in addition, also π-π stacking interactions  

The novel coumarin-3-carboxamides (=2-oxo-2H-1-benzopyran-3-carboxamides) 5a-5g containing lipophilic spacers were synthesized through the Ugi-four-component reaction (Scheme 1). The reactions of aromatic aldehydes 1, 4,4'-oxybis[benzenamine] or 4,4'-methylenebis[benzenamine] as diamine 2, coumarin-3-carboxylic acid (=2-oxo-2H-benzopyran-3-carboxylic acid; 3), and alkyl isocyanides 4 lead to the desired substituted coumarin-3-carboxamides 5a-5g at room temperature with high bond-forming efficiency. These novel coumarin derivatives exhibit brilliant fluorescence at 544 nm in CHCl 3