Sharif Digital Repository

In the first part, a novel electrochemical sensor for clonazepam (CLNP) was fabricated based on immobilizing cellulose nanofibers /carbon nanoparticles (CNFs/CNPs) nanocomposite on glassy carbon electrode (CNFs/CNPs/GCE). The combination of CNFs and CNPs produced a novel kind of structurally uniform and electro-analytically active nanocomposite. The surface morphology of CNFs/CNPs layer deposited onto glassy carbon electrode was characterized by scanning electron microscopy. The results of the voltammetric investigations showed a considerable enhancement in the cathodic peak current of CLNP (up to 60 times) on the surface of CNFs/CNPs/GCE relative to the bare GCE. Under the optimal... 

Chemotherapy is a proven and effective systematic approach to treat various types of cancers. Despite its advantages, chemotherapy would kill healthy as well as cancer cells. To overcome this problem, different controlling strategies are implemented. This study aims to provide a medicine drug delivery schedule for chemotherapy (by designing a proper controlling system) based on the verifiable mathematical models. First, the dynamic model is analysed and stability points are reviewed. The selected model has five state variables and two inputs. In this study, the focus is on dynamic model analysis and obtaining an effective and appropriate treatment pattern by designing a proper controller. To... 

Occurrence of natural disasters such as earthquake could seriously damage most buildings especially those with insufficient resistance located in urban worn-out textures. In order to reduce unpleasant consequences of an earthquake, appropriate policies need to be considered to persuade the beneficiaries to follow retrofitting standards in the process of planning, designing, and construction of buildings. These policies shall be implemented through institutions in arbitrary or obligatory forms, by encouragement or penalty mechanisms. In order to consider these policies, first of all we need to identify the beneficiaries and their particulars. By studying and considering subjects discussed in... 

Environmental issues and energy crisis have led the world attention to the renewable energies; especially wind power, since they have low cost and high reliability. One of the most challenging areas of studying for wind power is to increase the capacity of wind turbines. As a result, over the years, wind turbines have got progressively larger. Vibration is one of the problems that reduces the life and efficiency of wind turbines; and the growing size of the blades has worsen this problem due to the importance of nonlinear effects in large scale wind turbines. Researchers have been constantly working on this issue in order to make the wind turbines more efficient. In this research, a... 

Wind turbines have been the subject of many researches in recent decades. Optimization and continuous improvement of these systems play a decisive role in the development and exploitation of wind farms. Wind turbines can be studied from several aspects such as structure, dynamics, aerodynamics, electricity and control. In this research, robust power control of the wind turbine has been studied with emphasis on accurate 2 DOF mechanical and aerodynamic modeling. Aerodynamic coefficients of the turbine have been calculated using the numerical methods and the effect of this numerical modeling has been studied in comparison with the analytical methods on the turbine power control. Several new... 

In this research, the main purpose of the controller design is in the second region of operation of a wind turbine, which involves absorbing the maximum energy from the wind. WindPACT 1.5MW turbine has been investigated and the power coefficient of this turbine has been obtained using WT-PERF and FAST softwares. Simulations show that the results of both methods are well matched. Then, using ANFIS, a method for estimating the wind speed is derived from the data obtained by FAST. Inputs to the ANFIS system are the turbine aerodynamic power, rotor speed and blade pitch angle while the output of ANFIS system is the estimated wind speed. The maximum power coefficient of the wind turbine occurs... 

Best cancer treatment is the one which reduces the tumor density in minimum time and side effects, considering the input limitations. In this paper, tracking controller and robust controllers are designed to achieve the mentioned objectives, simultaneously. An ODE-based mathematical model of the human body under chemovirotherapy is selected, which includes the uninfected and infected tumor cells, free viruses, immune cells, and a chemotherapeutic drug. For tracking purposes, a servo controller based on the entire eigenstructure assignment (EESA) approach is applied to the model, continuously and discretely. For robust purposes H-infinity and D-K iteration approaches are implemented and... 

Laboratory studies to investigate the effects of different saline concentrations (such as sodium chloride or calcium chloride) on the soil water retention behavior of clayey soils and their volumetric changes have received much attention recently. However, many previous studies have investigated these effects in only one path of the SWRC (wetting or drying path) and the effects of saline concentration on hydraulic hysteresis have not been considered. In addition, researchers have frequently studied these effects on SWRC on clay samples, and little research has been done on collapsible soils. Therefore, the most important purpose of this study is to investigate the effects of increasing... 

Today, cancer mortality is one of the most important problems, even considering the scientific advances that offer more effective solutions to treat some diseases, providing a way to prevent and treat this disease is one of the most important issues that engineers have considered. This is achieved by designing a controller to minimize the size of the cancer tumor population, increase healthy cells, optimize treatment time, and drug dose.To achieve this goal, pharmacokinetic, pharmacodynamic, tumor growth, and healthy cell growth models, and mathematical models for subsystems that affect tumor growth, such as the angiogenic system, have been studied to develop a single mathematical model. In... 

This study proposes a probabilistic framework to quantify the seismic resilience of urban natural gas distribution networks. Infrastructure resilience is defined as the ability to maintain performance after a hazard or, in case of a loss of performance, return to the minimum desired level in the optimal time. The framework presented in this research is comprised of multiple interconnected probabilistic models. These models work in harmony to characterize the impact of the earthquake on various infrastructures such as the buildings and urban gas distribution network components, as well as the probable consequences of the earthquake. The post-earthquake recovery of the gas distribution network... 

Optimal use of available resources for construction projects depends on proper decision-making on how to spend resources. Optimization of resource consumption should be done taking into account project revenue. In this regard, investors need a suitable mechanism to predict the selling price of the construction project and the resulting profit. Therefore, investors and stakeholders need a suitable model with the help of which they can make decisions such as choosing materials to guarantee the desired profit from the sale. This research will provide a framework for constructing models for estimating the price of residential units by considering some features of the building and some economic... 

Understanding many issues related to environmental geotechnics and soil sciences such as: instability and collapse of soil slopes, sinkholes, leakage from landfills and isolation of nuclear landfills, and optimization Agricultural processing depends on our knowledge of the behavior of unsaturated soils and their volume changes. To better understand the behavior of unsaturated soils, it is important to study the soil-water retention curve (SWRC) and the factors affecting it. These include factors such as porosity, grain size distribution, soil minerals, pore size distribution, and pore water chemistry, which affect soil-water retention curves and volume changes. Since the simultaneous effect... 

Power transmission lines, which are responsible for the distribution and transmission of electrical energy from the power plant to the consumer areas, due to their characteristics such as long length and flexibility with low structural damping, face environmental irritations, especially the galloping phenomenon, causing many damages annually. In this study, it has been attempted to reduce the vibrations of power transmission lines by designing a robust active control and by using intermediate actuators in such a way that the failures of these lines can be prevented. For this purpose, linear modeling of the system and designing the controller using the pole replacement method have been done.... 

Soil and water pollution is one of the most common types of pollution in terrestrial and aquatic ecosystems. The development of mines and the oil and petrochemical industry on one hand and the non-compliance with environmental requirements on the other hand have caused large amounts of hydrocarbon pollutants and heavy metals to enter the environment in recent decades. Petroleum materials and heavy metals leak into the surrounding environment during drilling and extraction in oil sites and mines or during land and sea transportation, despite the measures taken to control their pollution. The conducted studies show that human industrial activities are the only cause of environmental pollution... 

The power control of horizontal axis wind turbines can affect significantly the vibration loads and fatigue life of the tower and the blades. In this thesis, we are going to consider both the power control and vibration load mitigation of the tower fore-aft vibration. For this purpose, at first, we developed a fully coupled model of the NREL 5MW turbine. This model considers the full aeroelastic behavior of the blades and tower and is validated by experiment results, comparing the time history data with the FAST (Fatigue, Aerodynamics, Structures, and Turbulence ) code which is developed by NREL (National Renewable Energy Lab in the United States). In the next, to estimate EWV, a novel... 

Nowadays electricity power has a key role in developing various aspects of the world. The great importance of fossil fuel power plants come from their large contribution in electricity power generation. Among the different fossil fuel power generation technologies, supercritical power plants have great advantages. They are an advanced power generation technology with high plant efficiency, high coal utilization and low emission. Their complexity and existing many unavoidable uncertainty sources in their dynamic such as changes of ambient temperature, climate condition and wear of components make their control challenging. To overcome mentioned problems and achieving a good performance, a...