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    A comprehensive study on a novel chitosan/Ag-MOFs nanocomposite coatings for bone implants: physico-chemical, biological and electrochemical properties

    , Article Materials Chemistry and Physics ; Volume 308 , 2023 ; 02540584 (ISSN) Ahmadi Seyedkhani, S ; Dehnavi, M ; Barjasteh, M ; Sharif University of Technology
    Elsevier Ltd  2023
    Abstract
    The present study developed new multi-functional coatings made of novel silver-based metal-organic frameworks (SOF) distributed within chitosan (CS) nanofibers network for bone implants. The SOFs were synthesized using environmental-friendly materials via a green process. The CS-SOF nanocomposites were deposited on novel hierarchical etched (HE) layers synthesized through a dual surface treatment. In vitro biological evaluation revealed appropriate biocompatibility for the prepared surfaces. Antimicrobial tests exhibited 100-200% effective antibacterial activities along with significant reduction of bacterial colonies. Electron microscopy illustrated proper cell attachment and growth on the... 

    Experimental Study of Partitioning of Lysozyme Enzyme in Aqueous Two-Phase Systems based on Surfactants

    , M.Sc. Thesis Sharif University of Technology Barjasteh, Mahdi (Author) ; Bastani, Dariush (Supervisor) ; Vosoughi, Manochehr (Supervisor)
    Abstract
    In this study, aqueous two-phase systems (ATPS) containing Tween 20 as a biocompatible nonionic surfactant and three different salts (NH4HPO4, NH4CH3COO and Mg(CH3COO)2 ) were prepared and their extractive potential for Lysozyme enzyme was evaluated. These systems have surfactant-rich top phase and salt-rich bottom phase. Phase equilibrium diagrams at 23 ° C were obtained by using the cloud point method and the results were successfully fitted to the Merchuk correlation and their trends were correlated with the effective excluded volume (EEV) parameter. Afterward, the partitioning behavior of the lysozyme and its extraction efficiency in the systems of Tween 20/diammonium hydrogen phosphate,... 

    Green synthesis of PEG-coated MIL-100(Fe) for controlled release of dacarbazine and its anticancer potential against human melanoma cells

    , Article International Journal of Pharmaceutics ; Volume 618 , 2022 ; 03785173 (ISSN) Barjasteh, M ; Vossoughi, M ; Bagherzadeh, M ; Pooshang Bagheri, K ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    In this study, the potential of using MIL-100(Fe) metal–organic framework (MOF) for loading and controlling the release of dacarbazine (DTIC) was evaluated for in vitro treatment of melanoma. The drug loading was performed during the green synthesis of MIL-100(Fe) in an aqueous media without using any harmful solvents, to obtain MIL-DTIC. The surface of this structure was then coated with polyethylene glycol (PEG) in the same aqueous solution to synthesize MIL-DTIC-PEG. The synthesized samples were characterized using various methods. Their release profile was studied in phosphate-buffered saline (PBS) and simulated cutaneous medium (SCM). The cytotoxicity of DTIC and its nano-MOF... 

    MIL-100(Fe) a potent adsorbent of Dacarbazine: Experimental and molecular docking simulation

    , Article Chemical Engineering Journal ; Volume 452 , 2023 ; 13858947 (ISSN) Barjasteh, M ; Vossoughi, M ; Bagherzadeh, M ; Pooshang Bagheri, K ; Sharif University of Technology
    Elsevier B.V  2023
    Abstract
    Dacarbazine (DTIC) is a commonly used anticancer drug that has been found in pharmaceutical and hospital wastewater, posing a risk to human health and aquatic environments. In the present work, MIL-100(Fe) metal–organic framework (MOF) was synthesized using a rapid and green synthesis technique. The crystallinity and the porosity of the synthesized MIL-100(Fe) particles were investigated against air, and the results showed that the prepared particles are stable in air, and their surface area decreased from 1174 m2/g to 638 m2/g after aging for three years. This MOF was applied as an adsorbent to remove DTIC from contaminated water for the first time. The synthesized MOF particles exhibited a... 

    Synthesis and characterization of iron oxide/functionalized graphene oxide nanocomposites for highly efficient DNA isolation

    , Article Materials Science and Engineering: B ; Volume 292 , 2023 ; 09215107 (ISSN) Akrami, M ; Dehnavi, S. M ; Barjasteh, M ; Jahanfar, M ; Sharif University of Technology
    Elsevier Ltd  2023
    Abstract
    In this research, Fe3O4 nanoparticles/graphene oxide (Fe3O4/GO) and Fe3O4/polypyrrole/graphene oxide (Fe3O4/PPy/GO) magnetic nanocomposites were fabricated for DNA isolation. The prepared aminated nanocomposite conducted perfect DNA isolation characteristics. The results showed that the Freundlich isotherm and the pseudo-second-order models well-matched the equilibrium extraction data and kinetic outcomes, respectively. The electrophoresis findings confirmed the efficacy of as-prepared nanocomposites for DNA adsorption/desorption. In addition, the adsorption capacity was reduced by 8.9% after five cycles, implying that Fe3O4/PPy/GO nanocomposite can maintain increased isolation ability after... 

    Synergistic Wound Healing by Novel Ag@ZIF-8 Nanostructures

    , Article International Journal of Pharmaceutics ; Volume 629 , 2022 ; 03785173 (ISSN) Barjasteh, M ; Mohsen Dehnavi, S ; Ahmadi Seyedkhani, S ; Yahya Rahnamaee, S ; Golizadeh, M ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    In this paper, novel zeolitic imidazolate framework-8 (ZIF-8) functionalized with Ag (Ag@ZIF-8) nanoparticles were synthesized through a green, facile and environmental-friendly process for wound dressing applications. X-ray diffraction revealed that the ZIF-8 and Ag@ZIF-8 were successfully synthesized by green solvents at ambient temperature. Field-emission scanning electron microscopy indicated a homogeneous porous blend of ∼30 nm chitosan/bacterial cellulose (CS/BC) nanofibers embedded with ∼80–110 nm nanoparticles of the ZIF-8 and Ag@ZIF-8. Transmission electron microscopy revealed the Ag@ZIF-8 nanostructures consist of ZIF-8 cores that are covered by 5–20 nm Ag nanoparticles. MTT assay... 

    Improved biological activities of dual nanofibrous chitosan/bacterial cellulose wound dressing by a novel silver-based metal-organic framework

    , Article Surfaces and Interfaces ; Volume 36 , 2023 ; 24680230 (ISSN) Barjasteh, M ; Dehnavi, S. M ; Ahmadi Seyedkhani, S ; Rahnamaee, S. Y ; Golizadeh, M ; Sharif University of Technology
    Elsevier B.V  2023
    Abstract
    The worldwide menace of antibiotic-resistance bacteria could be weakened by development and utilization of impressive and multi-functional bactericidal materials. In this work, a novel silver-based metal-organic framework (SOF) was synthesized via a facile and environmentally-friendly process. Different amounts of the SOF nanoparticles incorporated in dual nanosized chitosan/bacterial cellulose (CS/BC) fibrous composites to make a hybrid antibacterial porous structure for mimicing the skin extracellular matrix. X-ray diffraction revealed the successful synthesis of the SOF and CS/BC-SOF nanocomposites using green solvents at ambient temperature. Energy-dispersive X-ray spectroscopy confirmed... 

    Boosting bone cell growth using nanofibrous carboxymethylated cellulose and chitosan on titanium dioxide nanotube array with dual surface charges as a novel multifunctional bioimplant surface

    , Article International Journal of Biological Macromolecules ; Volume 228 , 2023 , Pages 570-581 ; 01418130 (ISSN) Rahnamaee, S.Y ; Dehnavi, S. M ; Bagheri, R ; Barjasteh, M ; Golizadeh, M ; Zamani, H ; Karimi, A ; Sharif University of Technology
    Elsevier B.V  2023
    Abstract
    One of the most vital aspects of the orthopedic implant field has been the development of multifunctional coatings that improve bone-implant contact while simultaneously preventing bacterial infection. The present study investigates the fabrication and characterization of multifunctional polysaccharides, including carboxymethyl cellulose (CMCn) and carboxymethyl chitosan nanofibers (CMCHn), as a novel implant coating on titania nanotube arrays (T). Field emission scanning electron microscopy (FESEM) images revealed a nanofibrous morphology with a narrow diameter for CMCn and CMCHn, similar to extracellular matrix nanostructures. Compared to the T surface, the roughness of CMCn and CMCHn... 

    MBBR and MBR Reactor Configuration for Better Performance

    , M.Sc. Thesis Sharif University of Technology (Author) ; Borgheei, Mahdi (Supervisor)
    Abstract
    Membrane bioreactors (MBRs) which are commonly understood as the combination of membrane filtration and biological treatment using activated sludge have several advantages, but membrane fouling reduces the membrane efficiency, permeability and lifetime. An alternative is replacing a moving bed biofilm reactor (MBBR) with the activated sludge system which may reduce the effect of membrane fouling. The sludge produced in MBBRs has poor settling characteristics, therefore, their efficiency is limited by the sedimentation tank performance and they require a larger settling surface. The combination of moving bed biofilm reactors and membrane bioreactors can compensate for the drawbacks of both of... 

    Forecasting the effects of a Canada-US currency union on output and prices: A counterfactual analysis

    , Article Journal of Forecasting ; Volume 32, Issue 7 , 2013 , Pages 639-653 ; 02776693 (ISSN) Mahdi Barakchian, S ; Sharif University of Technology
    2013
    Abstract
    This paper is a counterfactual analysis investigating the consequences of the formation of a currency union for Canada and the USA: whether outputs increase and prices decrease if these countries form a currency union. We use a two-country cointegrated model to conduct the counterfactual analysis, where the conditional forecasts are generated based on the Gaussian assumption. To deal with structural breaks and model uncertainty, conditional forecasts are generated from different models/estimation windows and the model-averaging technique is used to combine the forecasts. We also examine the robustness of our results to parameter uncertainty using the wild bootstrap method. The results show... 

    What is it to be Physical?

    , M.Sc. Thesis Sharif University of Technology Borgheai, Bahram (Author) ; Golshani, Mahdi (Supervisor)
    Abstract
    In this text to find the answer of the question “ what is it to be physical” in a definition form or a scheme of the term physical, firstly we sought for a possible consensus among recent physicists and philosophers. But from their answers not only we did not find any clear consensus but also most of them confess that the term is ambiguous and unclear. In a general aspect, we can categorize the answers to two theoretical and realistic perspective. The theoretical perspective, beside circularity and Hempel’s triviality, seems not to present any criteria for being physical. In realistic perspective, it seems that there is no ontologic constraint for being physical, that is from “being... 

    Biomass Separation in Moving Bed Biofilm Reactors (MBBR) by Natural And Innovative Filters

    , M.Sc. Thesis Sharif University of Technology Ashrafi, Elham (Author) ; Borgheei, Mahdi (Supervisor)
    Abstract
    The application of membranes for separate of particles in mainly microbial flacs , are fast growing in biological treatment systems. Membrane bioreactors are now considered as one of the major new processes in wastewater treatment. However , membranes are expensive and costly. This study is carried out to test an innovative , locally made filters for separation of flocs in an MBBR reactor. This innovative filter is replacing a traditional settling tank. This type of filters is made very cheaply and has important advantages in installing and operation. Experiments were carried out in a laboratory scale MBBR unit. A filter unit consisting of 3 innovative filter tubes were placed and the... 

    Dynamic Security Assessment in Restructured Power Systems

    , Ph.D. Dissertation Sharif University of Technology Kheradmandi, Morteza (Author) ; Ehsan, Mahdi (Supervisor)
    Abstract
    This thesis addresses the problem of dynamic security assessment in power sys-tems with an emphasis on its application in restructured power systems and issues arising in its applications. The new electric utility environment has an immedi-ate consequence of emphasis on reliability and secure operation of power systems. This requires faster and more precise methods to assess the dynamic aspect of se-curity. On the other hand, this issue is becoming challenging when the determined dispatch might not be accommodated due to violation of the limits.This thesis addresses the problem of dynamic security assessment in power sys-tems with an emphasis on its application in restructured power systems... 

    A Study on the Impact of the “Commodities’ Returns"on the Related “Firms’ Stock Returns” in Tehran Stock Exchange

    , M.Sc. Thesis Sharif University of Technology Bigham, Mostafa (Author) ; Barakchian, Mahdi (Supervisor)
    Abstract
    Are the returns of the mineral companies in Tehran Stock Exchange affected by the changes in the commodity price at the Iran Mercantile Exchange? By implementing a Multi-Factor Model we will calculate the firms’ value elasticity to the commodity price changes. We try to explain the estimated elasticities on the basis of the firm’s fundamental variables using a discounted cash flow valuation model. An unbalanced panel data estimation is employed for this purpose. Afterwards, we will suggest a novel model on the ground of the assumption that the commodity prices and firm values follow the Geometric Brownian Motion. The result of the model is that the elasticity can be explained by commodity... 

    Analytical and Finite Element Modeling of Rubbing Phenomena in Rotors

    , M.Sc. Thesis Sharif University of Technology Alvandi, Mahdi (Author) ; Behzad, Mahdi (Supervisor)
    Abstract
    Rotor contact with a stationary element of a rotating machine and the subsequent rubbing at the contact area is a serious malfunction that may lead to the machine’s catastrophic failure. In the past decades, many studies have been done on the rubbing phenomena, its different regimes and its various consequences on the machine performance and safety. However, most of them have used a simple model to investigate the rubbing interaction between the rotor and the stator. This simple model consists of the Jeffcott rotor, as a model for the real rotors, and a rigid annular block surrounding the rotor, as a model for the real stators. The objective of this thesis is to build an algorithm to... 

    Failure Tolerance of Epidemic Spreading in Complex Network

    , M.Sc. Thesis Sharif University of Technology Mirzasoleiman, Baharan (Author) ; Jalili, Mahdi (Supervisor)
    Abstract
    Complex networks serve as generic models for many social, technological and biological systems that have been shown to share a number of common structural properties such as power-law degree distribution and small-worldness. These networks determine interactions and influence the spread of diseases, behaviours and ideas. Epidemics and failures like new behaviours ideas and innovations can spread throughout a network and prevent it from doing its functionalities. In this work, we investigate error and attack tolerance of epidemic spreading in complex networks. The main content of this thesis is arranged in three sections as follows: Firstly, the effect of random and systematic failures is... 

    Evaluation of Non-linear Combination Method (Neural Network) For Value-at-Risk Forecasting in Market

    , M.Sc. Thesis Sharif University of Technology Rashnavadi, Leila (Author) ; Barakchian, Mahdi (Supervisor)
    Abstract
    Value at risk of an asset, is the asset’s expected maximum loss for a certain period of time and at a specified confidence level. Value-at-Risk can be calculated in the bank with its inter-nal method or standardized method. when a method have more violation number then bank need to keep more daily capital requirements. under the Basel 2 agreement if the violation of method more than 10 times in year, the Bank uses the standardized method.
    There are trade off Between daily capital charge and violations. Therefore, existing methods for calculating the value at risk, usually lead to much daily capital charge or many violations. Studies show with combination of different methods to calculate... 

    Differences Between Standard Quantum Mechanics and Bohm's Quantum Mechanics

    , M.Sc. Thesis Sharif University of Technology Asayesh, Omid (Author) ; Golshani, Mahdi (Supervisor)
    Abstract
    The purpose of introducing this thesis is to review the difference between Standard Quantum mechanics and Bohmian Quantum mechanics. The aim of this dissertation is not only to contrast these theories with respect to formulation, but also to briefly review their historical, philosophical and sociological aspects. This dissertation consists of two main sections. The first section is about reviewing the emergence profile of these theories and the formation of each theory along its historical path. In addition some beliefs about the founders of these theories and the impact of their beliefs on the evolution of their theories are put forward. As a complement to the above, the prevailing social... 

    Evaluation of Caviar Models Incorporated with Intraday Information ,the Case Study:Estimation Value at Risk of Gold

    , M.Sc. Thesis Sharif University of Technology Karimi, Parvane (Author) ; Barakchian, Mahdi (Supervisor)
    Abstract
    Value at risk (VaR) is the maximum loss of the asset portfolio at the specified confidence level and certain time horizon. This tool is used to measure market risk and also used as a basis in determining financial standards for international financial instituation. Conditional Autoregressive Value at Risk models or CAViaR models introduced by Engle and Manganelli (2004). This models calculate VaR base on quantile regession approach and show some promising performance properties.
    In order to propose a more accurate model for calcutating VaR , we develop CAViaR models by incorporating them with intraday information then we calculate VaR with this kind of models and CAViaR... 

    Design and Implementation of a Spectrum Sensor for Cognitive Radio

    , M.Sc. Thesis Sharif University of Technology Safavi, Mahya (Author) ; Shabani, Mahdi (Supervisor)
    Abstract
    Frequency scarcity has emerged the necessity of opportunistic utilization of frequency bands, which can be realized through a cognitive radio system. During an agile communication between unlicensed users, a cognitive radio system must avoid collision with licensed users. Hence it should continuously observe the band of interest and report the presence of licensed user signals. This task is fulfilled by a vital part of a cognitive radio system, called the spectrum sensing core. Recently several techniques have been proposed for the spectrum sensing in literature. Some of them like matched filtering, cyclostationarity based detection are based on primary user signal features. However energy...