Sharif Digital Repository

One of the fundamental steps in drug discovery and development is predicting the binding affinity of the drug to target proteins. Due to the high costs, slow pace, and lack of structural data in experimental approaches, several machine learning and deep learning-based methods have been proposed to date. Machine learning-based methods, which have shown high prediction capabilities, require precise engineering and selection of a wide range of physicochemical, biological, and structural information about proteins and drugs. On the other hand, deep neural network-based methods require the design of numerous complex networks for automatic feature extraction. Therefore, a method that can utilize... 

Content-Externalism is the view according to which, content of mental states are determined by relation that the person has with his environment and content of mental states does not depend on intrinsic properties of subjects. According to this view, if two persons with exactly same intrinsic properties were in different environments, contents of their mental states would be different. On the other hand, the doctrine of privileged access to mental states asserts that if cognitive faculty is functioning properly, then subject can know the content of his mental states a priori. Many critics of externalism believes that accepting externalism along with privileged access terminate to... 

A control strategy for islanded (autonomous) operation of a microgrid consisting of two Distributed Generation (DG) units is proposed in this thesis. The DG units are connected together in a radial configuration. Each DG unit utilizes a voltage-sourced converter (VSC) to interface to its dedicated load. The DG units and the loads are to operate in the islanded mode of operation. To provide autonomous operation for the microgrid, voltage and frequency of the loads should be regulated. The proposed control strategy utilizes (i) an internal oscillator for frequency control in an open loop manner and (ii) a decentralized servomechanism controller to regulate the load voltage. The microgrid is... 

With the introduction of SDN and OpenFlow as novel approaches for better network management and virtualization, it is now easier to perform QoS measurement anywhere, anytime, and anyplace through the use of self-directed, self-tuning mechanisms that continuously monitor and measure network performance and react swiftly to problems. Using programmable interfaces to OpenFlow controllers, software-defined measurement solutions provide consistent traffic measurement of flow parameters, such as bandwidth, packet loss, and latency to support the diversity requirements of next generation network applications and services. The flexibility of software-defined measurement gives the network operator... 

One of the important questions in mathematics is generalized. In case of metric spaces, one of the questions is: Can we extend notions of Riemannian geometry to arbitrary metric spaces smoothly? Ricci curvature is one of the most important concepts in differential geometry. Ricci curvature is defined for the Riemannian manifold and has many applications in mathematics and physics like Einstein’s equation in relativity theory. There is a good notion for a metric space having “sectional curvature bounded below by K” or “sectional curvature bounded above by K”, due to Alexandrov. Can we define the concept of Ricci curvature in metric space? A motivation for this question comes from Gromov’s... 

Seismic design codes reduce loads by using response modification factor. Because of the reserved strength in structural elements and capacity of structure to dissipate energy, structures can be designed for lower seismic loads. This factor has modified over time. In this thesis, the effect of the reduction in behavior factor on the response of two kinds of reinforced concrete systems were evaluated. Moment resisting frames and dual systems with different heights and regularity in plan, heve been design according to the behavior factor which is recommended in the 3rd edition of the Iranian codes of practice for seismic resistance design of buildings (Standard No. 2800). Drift and... 

Generally, nowadays, machine learning methods are used in many different areas for their superiority over other methods of prediction. Although being a tough task, stock market prediction with machine learning approaches is being spread due to satisfying results published ever yday. Machine learning methods usually use varied kinds of data ,including structured data such as market data, technical indicators and some fundamental data as well as unstructured one entailing text and graph data in order to enhance their predictability capacity. In this thesis we aimed to find out more about the importance and the contribution of structured data in prediction and we tried to attain a framework... 

This thesis presents an inventory control system which is based on Meta-heuristic Algorithms.In this thesis we will optimize the input values of our tree-echelon inventory model (keeping costs,stock worth,reorder costs,...) with these Algorithms. The presented method is able to determine the optimal stock level, costs of system and number of shipments in the system. The method is basically a decision support system (DES) and it is able to provide the order scheduling parameters of goods at operational level. The aim of the current research is to demonstrate that a Meta-heuristic algorithmis capable of solving complex inventory problems and with future improvements it is able to achieve... 

Poincare conjecture is one of the rst eorts for classifying 3-manifolds that was stated in the begining of 20th century. Eorts for proving this conjecture continued for about 100 years and nally Perelman has solved it in 2003. He has used Ricci ow which has been invented by Richard Hamilton in the early 80's. In this thesis rst we will introduce Ricci ow and will state the results before Perelman such as short time and long time existence of solution. Then we will mention some applications of Ricci ow and will state an explanation of the proof of uniformization and Calabi conjecture by Ricci ow. After that we start the main part of the thesis. In this part we will montion one of the... 

Nowadays best using of fossil fuels sources of the country (and) importance of comparison against lack of capacity in petrol production make determined the programmers and the directors to foresee and design expanded programs of the goals, to use natural gas for car fuels. To reach fulfillment of these programs, the confirmed needs of the natural gas cylinders are improved and make it essential to invest on producing compressive natural gas cylinders. In this way economical and technical change researches has been done in order to construct on department to produce 200,000 compressive natural gas cylinders in a year during two sets.(shifts) According to the results of technical researches... 

Different molybdenum oxide nano/micro structure thin films were synthesized by thermal evaporation method under various growth conditions such as deposition time, temperature and evaporation source-substrate distance. Molybdenum oxide nanostructures grown on Si(100) such as nanowalls, nanostars and nanowires were characterized with scanning electron microscopy (SEM), x-ray photoelectron spectroscopy (XPS), x-ray diffraction (XRD), atomic force microscopy (AFM) and high resolution transmission electron microscopy (HRTEM). Shape and type of nanostructures were determined with SEM, AFM and HRTEM analysis. XPS analysis showed that the synthesized nanostructures contained Mo6+, Mo5+, Mo4+ and... 

One of the most important parts of a cement factory is the cement rotary kiln which plays a key role in quality and quantity of produced cement. In this part, the physical exertion and bilateral movement of air and materials, together with chemical reactions take place. Thus, this system has immensely complex and nonlinear dynamic equations. These equations have not worked out yet. Only in exceptional case; however, a large number of the involved parameters were crossed out and an approximation model was presented instead. This issue caused many problems for designing a cement rotary kiln controller. In this thesis, we employed a nonlinear system identification method for identification,... 

Optomechanical systems have attracted considerable attention in the last decade. Such a raising prominence is mainly due to its capability in providing new insight into the quantum behavior of macroscopic objects and exploring the interface between quantum and classical mechanics. Alongside this fundamental quest, cavity optomechanics has many other benefits, ranging from very precise measurements on forces and positions to quantum information processing. In this thesis, we investigate quantum properties of such systems. Particularly, we study cooling of the mechanical resonator toward its ground state and the entanglement between this mechanical resonator and the cavity field. Cooling the... 

Performance of reinforced concrete frames is highly dependent on detailing of the joint connections between its members, such as beams and columns. To have a good structural behavior, joints must show ductile behavior and designed based on the philosophy of strong column-weak beam. In the case of sever lacking ductility, strength or even rigidity of the connections, or having a weak column-strong beam, in the existing structures, there is a need for seismic upgrading of the connection. There are several ways for seismic upgrading of this type of connections.In the last decade Fiber Reinforced Polymer (FRP) widely has been used to strengthening the reinforced concrete (RC) members. Most of... 

Hodge theory is a beautiful synthesis of geometry, topology, and anal- ysis, which has been developed in the setting of Riemannian manifolds. On the other hand, spaces of images, which are important in the math- ematical foundations of vision and pattern recognition, do not fit this framework. This motivates us to develop a version of Hodge theory on metric spaces with a probability measure. We believe that this constitutes a step towards understanding the geometry of vision. We extend the theory of the Laplacian on domains of Euclidean space or on a manifold and next to metric space. Finally we give a beautiful application in web researcher engin.
 

Behran Mehr Peyma (BMP) is an elevator equipment producer and trader in Iran which was established in 2004. At first they are producing some regular parts of elevator and then during these years they are trying to improve their work and expand their business till they have the 15% market share in elevator market in Tehran.In this thesis I am trying to use the SWOT and PETS methods to show the exact situation of BMP comparing to the whole market considering the competitors.During this reduction in the market I suggest to BMP to change some policies and use some of its strength to attract some new customers, changing their brand name and find a relation to contribute in some tenders and... 

Adiabatic logic families are a group of logic circuits which operate based on adiabatic principles to tremendously reduce power consumption. These families have basic difference with common logic families in transistor level structure and there signals are not quadrangular but trapezoidal. Also, in these systems the source lines and clock pulse are the same. Research on Adiabatic families needs theoretical information in reversible computing. So we will start this project with explaining fundamental information in this field. After that some of these logic families are introduced and three important and widely used of them (SCRL-RERL-2LAL) are chosen to simulate. In each of these families... 

According to key importance of bridges in transportation system vital routes, a need to study and survey of bridges against destructive factors exist. Among these, bridges with concrete deck are widely used. One of the most important factors in destruction of these bridges is steel reinforcements corrosion and destruction of bridge deck. So in order to reduce the aggregation of reinforcements in critical sections and performance improvement of deck beams, a reinforcing substance which is not only resistant against corrosion but benefits from high resistance and stiffness is implemented.In this research the case studied bridge is simulated by finite elements software in two cases; reinforced... 

An interesting theoretical and practical set of problems in computer science is concerned with the study of spatial relations among objects in a geometric space. Examples of such problems for a set of points P are finding the closest pair of the points P, partitioning space into regions such that all points of a region have minimum distance to the same point in P, and computing the Euclidean minimum spanning tree on P. Moreover, we need mechanisms to efficiently update these properties when the points P are allowed to move or may be inserted or deleted. This is to avoid re-computation of these properties from scratch. Here, we consider the Euclidean minimum spanning tree (EMST) of a set of...