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Development of a Paper-based Microfluidic Device for Biological Assay
, M.Sc. Thesis Sharif University of Technology ; Shamloo, Amir (Supervisor)
Abstract
All the biological diagnostic devices that are introduced to the consumers, must meet WHO criteria. Some of these criteria include being affordable, sensitive and deliverable to the user. In the last twenty years, there have been lots of efforts to use microfluidic devices for biological assay. Due to their expensive price and requirement of complex equipment for their fabrication, polymer-based microfluidic devices have not been able to be used in developing countries. It is to be hoped that introduction of paper for fabrication of microfluidic devices could make microfluidic devices meet WHO criteria. μPADs are divided into well-based and channel-based devices. In the present work, both...
Effects of wax boundaries in combination with evaporation on dynamics of fluid flow in paper-based devices
, Article Surfaces and Interfaces ; Volume 21 , 2020 ; Shamloo, A ; Sharif University of Technology
Elsevier B.V
2020
Abstract
Since their introduction, paper-based microfluidic analytical devices (μPADs) have been ubiquitously utilized for different applications. The spontaneous imbibition of liquids in the paper-based devices that eliminates the requirement of an external pumping system has played a primary role in making paper an appropriate alternative for many other materials in the fabrication of microfluidic devices. Wax patterning is one of the most common methods to fabricate μPADs. Dynamics of the flow in channels with wax boundaries deviate from Washburn's law. Despite some research performed to model the effects of wax boundaries, some gaps remain in the presented models. A more general model is needed...
A comparison of different geometrical elements to model fluid wicking in paper-based microfluidic devices
, Article AIChE Journal ; Volume 66, Issue 1 , 2020 ; Shamloo, A ; Sharif University of Technology
John Wiley and Sons Inc
2020
Abstract
Recently, microfluidic paper-based analytical devices (μPADs) have outstripped polymeric microfluidic devices in the ease of fabrication and simplicity. Surface tension-based fluid motion in the paper's porous structure has made the paper a suitable substrate for multiple biological assays by directing fluid into multiple assay zones. The widespread assumption in most works for modeling wicking in a paper is that the paper is a combination of capillaries with the same diameter equal to the effective pore diameter. Although assuming paper as a bundle of capillaries gives a good insight into pressure force that drives the fluid inside the paper, there are some difficulties using the effective...