Sharif Digital Repository

In this study, a system of dexamethasone sodium phosphate (DEXP)-loaded chitosan nanoparticles embedded in poly-ε-caprolacton (PCL) and gelatin electrospun nanofiber scaffold was introduced with potential therapeutic application for treatment of the nervous system. Besides anti-inflammatory properties, DEXP act through its glucocorticoid receptors, which are involved in the inhibition of astrocyte proliferation and microglial activation. Bovine serum albumin (BSA) was used to improve the encapsulation efficiency of DEXP within chitosan nanoparticles and to overcome its initial burst release. BSA incorporation within the chitosan nanoparticles increased the encapsulation efficiency of DEXP... 

Background: Researchers are trying to study the mechanism of neural stem cells (NSCs) differentiation to oligodendrocyte-like cells (OLCs) as well as to enhance the selective differentiation of NSCs to oligodendrocytes. However, the limitation in nerve tissue acces-sibility to isolate the NSCs as well as their differentiation toward oligodendrocytes is still challenging. Purpose: In the present study, a hybrid polycaprolactone (PCL)-gelatin nanofiber scaffold mimicking the native extracellular matrix and axon morphology to direct the differentiation of bone marrow-derived NSCs to OLCs was introduced. Materials and Methods: In order to achieve a sustained release of T3, this factor was... 

In order to fabricate nanofiber scaffold for bone tissue engineering, electrospinning technique was employed. This technique produces nanofiberous scaffold supporting cell adhesion, migration, and proliferation. Here, we developed a novel conductive scaffold from poly-caprolactone, gelatin, and poly aniline/graphene nanoparticles. In this study, co-electrospinning was utilized to fabricate composite electrospun scaffold. The effect of polyaniline/graphene (PAG) nanoparticles on the mechanical properties and electrical conductivity of this hybrid scaffold was investigated. The result showed that PAG nanoparticles enbance both mechanical properties and electrical conductivity of the scaffolds.... 

Let G be a graph of order n and rank(G) denotes the rank of its adjacency matrix. Clearly, n ≤ rank (G) + rank (over(G, -)) ≤ 2 n. In this paper we characterize all graphs G such that rank (G) + rank (over(G, -)) = n, n + 1 or n + 2. Also for every integer n ≥ 5 and any k, 0 ≤ k ≤ n, we construct a graph G of order n, such that rank (G) + rank (over(G, -)) = n + k. © 2006 Elsevier Inc. All rights reserved  

This study aims to optimize, design, and predict the MTMDs performance in SDOF systems using spectral analysis, and then apply their results to MDOF structures. Given the importance of spectral analysis in the design of new engineering structures, achieving a method for designing TMDs based on this theory can be of great importance for structural designers. In this study, several convenient combinations of MTMDs in an SDOF system are first considered to minimize the maximum displacement. For calculating the frequency ratios of dampers, an innovative technique is adopted in which the values of different modal responses obtained from the spectral analysis are approached together. This... 

Least squares estimation is a widely-used technique for range-based source localization, which obtains the most probable position of mobile station. These methods cannot provide desirable accuracy in the case with a non line of sight (NLOS) path between mobile station and base stations. To circumvent this drawback, many algorithms have been proposed to identify and mitigate this error; however, they have a large run-time overhead. On the other hand, new positioning systems utilize a large set of base stations, and a practical algorithm should be fast enough to deal with them. In this paper, we propose a novel algorithm based on subspace method to identify and eliminate the NLOS error.... 

We derive some bounds on the Optimum Asymptotic Multiuser Efficiency (OAME) of randomly spread CDMA as extensions of the result by Tse and Verdú. To this end, random Gaussian and random binary antipodal spreading are considered. Furthermore, the input signal is assumed to be Binary Phase Shift Keying (BPSK). It is shown that in a CDMA system with K-user and N chips when K and N → 8 and the loading factor, K over N, grows logarithmically with K, the OAME converges to 1 almost surely under some condition. It is also shown that a Gaussian randomly spread CDMA system has a performance close to the single user system at high Signal to Noise Ratio (SNR) when the loading factor is kept less than... 

In this study, the performance of a spectral-amplitude-coding optical code division multiple access (SAC-OCDMA) system in the asynchronous regime is evaluated using a Gaussian approximation of the decision variable for codes with fixed cross-correlation used in SAC-OCDMA systems. The authors consider the effect of phase-induced intensity noise (PIIN), thermal noise and shot noise. Moreover, the validity of the Gaussian approximation is confirmed by a Kolmogorov-Smirnov fitness test. For sake of comparison, the bit error rate (BER) of the asynchronous SAC-OCDMA system is also plotted numerically in comparison with the BER of the synchronous SAC-OCDMA. They show that a SAC-OCDMA system without... 

We extend the result by Tse and Verdú on the optimum asymptotic multiuser efficiency of randomly spread code division multiple access (CDMA) with binary phase shift keying input. Random Gaussian and random binary antipodal spreading are considered. We obtain the optimum asymptotic multiuser efficiency of a K-user system with spreading gain N when K and N → ∞ and the loading factor, (K/N) , grows logarithmically with K under some conditions. It is shown that the optimum detector in a Gaussian randomly spread CDMA system has a performance close to the single user system at high signal-to-noise ratio when K and N → ∞ and the loading factor, (K/N), is kept less than (log3 K/2). Random binary... 

An operationally simple and entirely green protocol for heteropoly acid catalyst conjugate addition of indoles and pyrrole to unsaturated carbonyl compounds and nitro-alkene in water was investigated. It is important that the products arising from 1,2-addition were not observed under the reaction conditions. Pyrroles also readily underwent Michael addition at Α-positions under the same reaction conditions. Indole and many of its derivatives are present in many substances commonly found in nature. Micheal addition reactions are performed in organic solvents with the reactions in water are relatively scarce. The Michael addition between indole and methyl vinyl ketone in the presence of... 

A highly efficient and simple synthesis of dithiocarbamates is possible based on the one-pot reaction of amines, CS2, and alkyl halides without using a catalyst under solvent-free conditions. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates and successfully can be used in high quantities in the pharmaceutical or agrochemical industries  

In this paper, a new disk type variable reluctance (DTVR) resolver is introduced. The proposed resolver works based on the sinusoidal variation of the coupling area between stator and rotor. An analytical model based on winding function theory is proposed for the performance analysis of the sensor. Then, the influence of stator slot shape, radial and peripheral slot width, pole numbers, and slot skewing and harmonic injection into the rotor couture on the accuracy of the proposed resolver is examined. The 3-D time stepping finite element method is used to show the effect of optimizations. Finally, the prototypes of the two-pole, four-pole, and eight-pole DTVR resolvers are constructed and... 

Gold (Au) nanoparticles are widely used in diagnosing cancer, imaging, and identification of therapeutic methods due to their particular quantum characteristics. This research presents different types of aqueous models and potentials used in TIP3P, to study the effect of the particle size and density of Au clusters in aquatic environments; so it can be useful to facilitate future investigation of the interaction of proteins with Au nanoparticles. The EAM potential is used to model the structure of gold clusters. It is observed that in the systems with identical gold/water density and different cluster radii, gold particles are distributed in aqueous environment almost identically. Thus, Au...