Bread waste in the form of CoFe2O4@TBW catalyst was used as a green biocatalyst to synthesize pyranopyrazole and tetraketone derivatives

, Article Research on Chemical Intermediates ; Volume 49, Issue 4 , 2023 , Pages 1507-1543 ; 09226168 (ISSN) Moghaddam, F.M ; Aghili, S ; Daneshfar, M ; Moghimi, H ; Daneshfar, Z ; Sharif University of Technology

Springer Science and Business Media B.V 2023

Abstract

Bread scraps with transition metal oxide spinels were utilized to synthesize core–shell magnetic nanocatalyst. The prepared heterogeneous catalyst was characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). This magnetic nanocatalyst opens up a new avenue to introduce a very useful and efficient catalytic system for the one-pot synthesis of tetraketone derivatives via Knoevenagel-Micheal reaction of 1,3 cyclohexanedione and benzaldehyde in ethanol as a green solvent at 50 °C, and one-pot four-component reaction of...

Hydrogen bonding effects on acidity enhancement of barbiturates and their metabolites in gas and solution phase, a DFT study

, Article Computational and Theoretical Chemistry ; Volume 1196 , 2021 ; 2210271X (ISSN) Daneshfar, M ; Fattahi, A ; Sharif University of Technology

Elsevier B.V 2021

Abstract

Density functional theory method and B3LYP/6-31+G(d) level of theory were used to predict the acidity of barbiturates and their corresponding metabolites in the gas and solution phase (H2O). Polarized continuum model was applied to calculate pKa values of barbiturates and metabolites. A comparison between acidity of barbiturates and metabolites in the gas and solution phase indicates that the acidity strength of barbiturates enhances with the increase of intramolecular hydrogen bonds in metabolites. This acidity can increase to 9.47 kcal/mol in gas phase and 2.73 pKa units in solution phase for a typical metabolite of barbiturate due to the effect of intramolecular hydrogen bonds. Also,...

Effect if Strengthening of Continuous RC Beams with FRP Laminates on Moment Redistribution under Vertical Loads

, M.Sc. Thesis Sharif University of Technology Daneshfar, Naser (Author) ; Mostofinejad, Davoud (Supervisor)

Abstract

The continual deterioration and insufficient strength of reinforced concrete (RC) structures has been a vital problem in the field of civil engineering such an extent that traditional methods of strengthening found to be inconvenient. Nowadays by increasing demands for retrofitting of structures, it necessitates the application of efficient, inexpensive and unobtrusive methods of strengthening. Common way on retrofitting was to use of steel plates externally bonded to RC members. Although this technique has proven to be reasonably effective, it has several distinct disadvantages such as susceptibility of the steel plates to corrode and the excessive weight of steel plates when used in...

Synthesis and Application of Transition Metal Spinels (Cu, Ni, Co, Pd and Fe) as a Catalyst in Organic Reactions

, Ph.D. Dissertation Sharif University of Technology Daneshfar, Maryam (Author) ; Matloubi Moghaddam, Firouz (Supervisor)

Abstract

In the first section, due to the important role of nanocatalysts in different fields of chemistry, magnetic metal ferrite nanoparticles were synthesized. Ferrite nanoparticles were synthesized using co-precipitation method and were characterized. Then, these nanoparticles were applied as catalyst system for one-pot β-ketophosphonates and thiophosphate synthesis.This is a green and efficient route for S-P and C-P bond construction using copper ferrite nanoparticles as catalyst. The application of a highly active recyclable heterogeneous nanocopper ferrite catalyst for the oxyphosphorylation reaction of various alkenes was conducted under ligand-free conditions, in acetonitrile as solvent at...

3d Design of a Microfluidic Chip for Anticancer Drugs Screening

, M.Sc. Thesis Sharif University of Technology Hashemi, Maryam Sadat (Author) ; Mashayekhan, Shohreh (Supervisor) ; Saadatmand, Maryam (Supervisor)

Abstract

Nowadays, advanced and inexpensive pre-clinical methods for investigating the effects of anti-cancer drugs are expanding. One of the latest three-dimensional laboratory modeling for evaluating the effects of drugs is the use of tumor-on-chip technology, which actually models the physiological system of the body through three-dimensional scaffolds, multicellular cultures, and shaped vascular systems. In this study, three-dimensional culture of cancer cells was performed in the form of spheroids. A chip of U-shaped microstructures with and without gaps was used to trap cells and form cancer spheroids. We simulated the simultaneous effect of drug and oxygen concentration distribution inside the...

Catalyst-Free three-component synthesis of spirobenzimidazolidines bearing an indole scaffold

, Article Synlett ; Volume 29, Issue 17 , 2018 , Pages 2301-2305 ; 09365214 (ISSN) Matloubi Moghaddam, F ; Moafi, A ; Zamani, Z ; Daneshfar, M ; Sharif University of Technology

Georg Thieme Verlag 2018

Abstract

An efficient catalyst-free one-pot three-component reaction was developed for the synthesis of a new family of N- A nd S-containing spirocyclic compounds. Various derivatives of spirobenzimidazolidine containing an indole scaffold were synthesized for the first time in a modestly toxic solvent and under mild reaction conditions. The reaction times were of the order of several minutes, and all the products were obtained in moderate to high yields (overall yields 58-80%). © Georg Thieme Verlag Stuttgart New York

Ferric metformin drug complex supported on magnetic nanofiber cellulose; An efficient access to 4-H pyrans derivatives and determination of their antimicrobial activity

, Article Synthetic Communications ; Volume 52, Issue 7 , 2022 , Pages 974-993 ; 00397911 (ISSN) Matloubi Moghaddam, F ; Daneshfar, M ; Moghimi, H ; Daneshfar, Z ; Sharif University of Technology

Taylor and Francis Ltd 2022

Abstract

Magnetic nanofiber cellulose (NFC) was selected as a biopolymer surface for the reaction with ferric metformin and a novel nanocatalyst was prepared. This green heterogeneous organometallic catalyst was analyzed by physiochemical techniques. The new metformin drug complex supported on magnetic NFC was used as a powerful and efficient catalyst for the synthesis of functionalized 4H-pyrans derivatives. The antimicrobial activity of the products showed excellent activity against all the bacterial and fungal strains (especially compounds 7q and 6r). © 2022 Taylor & Francis Group, LLC

Theoretical Investigation of Hydrogen Bonding Effects on Acidity Enhancement of Cyclic Amides and Barbiturates in Gas and Solution Phase

, M.Sc. Thesis Sharif University of Technology Daneshfar, Maryam (Author) ; Fattahi, Alireza (Supervisor) ; Mahmoodi Hashemi, Mohammad (Supervisor)

Abstract

Hydrogen bonding is an important weak interaction encountered in gas, liquid, as well as solid phase. The hydrogen bond plays a very vital role in many life processes and is one of the most frequently used terms in chemistry and biology. Amides have several applications as drugs, antibacterials and antifungals. Different substituents can affect the acidity of amides. Investigation have shown that hydroxyl function group can increase the acidity of many organic molecules through interamolecular hydrogen bonding. The goal of this project is to investigate the acidity of cyclic amides and barbiturates by adding hydroxyl group in the gas and solution phase. All the gas phase optimizations and...

Model Checking of Stochastic Activity Networks

, M.Sc. Thesis Sharif University of Technology Maryam Bagheri (Author) ; Movaghar, Ali (Supervisor)

Abstract

Modeling and performance evaluation of the real time distributed systems is a significant problem. Stochastic activity network is one of the high level models used for this purpose. This network is an extension of generalized stochastic Petri net which is more powerful and flexible than other Petri net extensions. Checking the satisfiability of properties such as performance, dependability and user's expected properties is considerable in these models. Thus, using the approaches and generating modeling and model checking tools with the mentioned purpose is attractive. A model checker automatically checks the correctness of the system behaviors as properties against the model by getting the...

Robust Estimation and Control of a Planet Lander

, M.Sc. Thesis Sharif University of Technology Ahmadvand, Reza (Author) ; Kiani, Maryam (Supervisor)

Abstract

This study has focused on the important problem of landing on a planet as an important current and future space mission. In this regard, dynamics modeling and integrated state estimation and control problems have been investigated in different views. To this aim, first a novel concurrent representation for translational and rotational kinematics has been developed based on the extension of modified Rodrigues parameters to dual space. This parameter set, called dual modified Rodrigues parameters (DMRP), is then utilized to establish an integrated roto-translational dynamic. The proposed DMRP-based kinematics and dynamics have been verified via comparison to traditional methods of...

Optimal Energy Trading in a Smart Grid Based on Extremum-seeking Algorithm

, M.Sc. Thesis Sharif University of Technology Asgari, Houman (Author) ; Babazadeh, Maryam (Supervisor)

Abstract

Prevalent deployment of Distributed Energy Resources(DERs) in the demand side of electrical energy grids has several advantages such as greenhouse gases emission reduction, mitigation of power losses in the distribution grids and abatement of the dependency on the wholesale generation companies. At the same time, it paves the way for the advent of local interactive energy trading frameworks. In the following thesis, a distributed data-driven algorithm is developed for market-clearing in a community-based local energy market. The social welfare maximization is considered as the objective of the energy trading. The production and demand of electricity are the decision variables of sellers and...

Design of Microfluidic Chip for 3D Cell Culture

, M.Sc. Thesis Sharif University of Technology Ghobadi, Faezeh (Author) ; Saadatmand, Maryam (Supervisor)

Abstract

Understanding biological systems requires extensive knowledge of individual parameters, and to study the processes of cell differentiation and cell behavior, a suitable environment must be created with the physiological conditions of the human body. For this purpose, with the knowledge of microfluidics, a microenvironment can be provided to study the behavior of cells on a small scale. The use of bone tissue model microfluidic chips is an alternative and new method in which it is possible to study the behavior of cells to differentiate into bone and to examine the toxicity of drugs, which in itself can help in the effective and successful treatment of these cases show. Therefore, in this...

Navigation and Control of a Free-Flying Satellite for Cargo Transportation and Placement in Intra-Vehicular Environment

, M.Sc. Thesis Sharif University of Technology Moosavi, Farzan (Author) ; Kiani, Maryam (Supervisor)

Abstract

The main topic of this research is the navigation and control of a free-flying satellite with a robot manipulator while transferring and placing cargo on a space station. After connecting the cargo module, astronauts and robots need to deliver the available loads to the desired modules in a space station. Capturing an object or cargo is a critical issue studied extensively so far. However, delivery and placing of the cargo at the target point have not been investigated yet, to the best of the author’s knowledge; hence, this is a primary motivation for conducting the proposed research. After capturing the payload, the position and attitude of the manipulator with respect to the station’s...

Fabrication the Hydrogel Microfibers Using Bioprinter with Application in Cardiovascular Model

, M.Sc. Thesis Sharif University of Technology Heidari, Faranak (Author) ; Saadatmand, Maryam (Supervisor)

Abstract

Cardiovascular disease (CVD) currently remains a considerable challenge for clinical treatments. CVDs account for N17.5 million deaths per year and will predictably increase to 23.6 million by 2030. The main purpose is to create human model systems to study the effect of disease mutations or drug treatment on the heart. In addition, engineered cardiac tissues are considered promising candidates to be transplanted to improve the function of diseased hearts. For engineered active tissues/organs, 3D bioprinting can fabricate complex tissue architecture with a spatiotemporal distribution of bioactive substances (cells, growth factors, and others) to better guide tissue regeneration. However,...

Utilizing Gaussian Processes to Learn Dynamics of Unknown Torques Acting on a Spacecraft

, M.Sc. Thesis Sharif University of Technology Baradaran, Behdad (Author) ; Kiani, Maryam (Supervisor)

Abstract

Accurate and fast attitude estimation of a rigid body plays an essential role in the performance of a vehicle’s control system, especially aerospace vehicles. Ample works have been done to increase the accuracy and speed of the attitude estimation process, but all have been developed according to a model-based approach. This approach assumes that the torques acting on the body have a known dynamical model that is used for the attitude estimation. The purpose of the present research is to estimate the attitude via a model-free approach, i. e. dynamics of the torques acting on the body are no longer assumed to be known, and its learning is the next step. Thus, the problem formulation of this...

Stabilization and Pole-Placement by Structurally-Constrained Controllers: A Graph-Theoretic Approach

, M.Sc. Thesis Sharif University of Technology Moushaee, Pegah (Author) ; Babazadeh, Maryam (Supervisor)

Abstract

This thesis presents a new approach to design structural output feedback controllers with stabilization and pole-placement at desired points on the S plane. It is assumed that the linear time-invariant system has no fixed mode corresponding to the specified control structure, outside the desired region of the closed-loop poles, such that the structural controller design problem is theoretically feasible. To this end, the structural output controller design problem is first transformed into a structurally equivalent problem based on the solution of a set of discrete linear programs. Then, by using the resultant structure, a new method is proposed for designing static and dynamic control loops...

Fabrication of Thick Scaffold with Microfluidic Channels by Bioprinter

, M.Sc. Thesis Sharif University of Technology Khalighi, Sadaf (Author) ; Saadatmand, Maryam (Supervisor)

Abstract

Cardiovascular diseases are among the leading causes of death worldwide. For instance, in 2015, almost 31% of the world’s mortality rate was due to these causes. One of these diseases is cardiac coronary vessels’ occlusion which leads to the insufficient blood supply to the heart tissue and cardiomyocytes death after Myocardial Infarction (MI). After MI, a hierarchy of events in the heart tissue changes heart muscle and forms cardiac fibrosis. This fibrotic tissue does not have the native one’s properties and function, so it will cause cardiac arrest and patient death. Therefore, it is obvious that vascular network plays a crucial role in the heart function. The importance of cardiac...

Optimal Control of Unknown Interconnected Systems via Distributed Learning

, M.Sc. Thesis Sharif University of Technology Farjadnasab, Milad (Author) ; Babazadeh, Maryam (Supervisor)

Abstract

This thesis addresses the problem of optimal distributed control of unknown interconnected systems. In order to deal with this problem, a data-driven learning framework for finding the optimal centralized and the suboptimal distributed controllers has been developed via convex optimization.First of all, the linear quadratic regulation (LQR) problem is formulated into a nonconvex optimization problem. Using Lagrangian duality theories, a semidefinite program is then developed that requires information about the system dynamics. It is shown that the optimal solution to this problem is independent of the initial conditions and represents the Q-function, an important concept in reinforcement...

Fixed-Time Consensus Control of Unknown Multi-Agent Systems Based on Distributed Reinforcement Learning

, M.Sc. Thesis Sharif University of Technology Delshad, Aria (Author) ; Babazadeh, Maryam (Supervisor)

Abstract

This thesis introduces a distributed backstepping control strategy based on reinforcement learning to achieve fixed-time consensus in high-order nonlinear multi-agent systems. Each agent, whether a leader or a follower, is modeled using a strict feedback approach, incorporating uncertainties as unknown nonlinear functions and disturbance signals across all state variables. The communication network among agents can be either directed or undirected, with a fixed topology. Each follower employs a control law derived from actor-critic networks, utilizing only the outputs from neighboring agents. The proposed method combines virtual and actual backstepping control laws, formulated from two key...

Application of Machine Learning Algorithms in Analysis and Prediction of Football Goalkeepers Performance and their Valuation in the Transfer Market

, M.Sc. Thesis Sharif University of Technology Zabihi, Matin (Author) ; Radman, Maryam (Supervisor)

Abstract

Football transformation into an industry with extraordinary financial flow has made this popular sport an attractive field for sports analysts. The development of the computer science and data science has led to the emergence of a concept called football match analysis. The goalkeepers, as a unique member of football teams and regrading their unique features and characteristics, play a crucial role in the outcome of competitions and the success of the teams. Therefore, analysis of various aspects of their performance is one of the essential issues in the application of data science in football. In this research, three separate parts have been studied. In the first part, by using pre-match...